#CureSearch

[barbielore]

February 4th is World Cancer day so I wanted to take a moment to briefly acknowledge this. As I have posted about before last October, Barbie has a history with the subject of cancer as her creator Ruth Handler was herself a survivor. As a result it is no surprise that Barbie has had tie-in dolls with the Susan G Komen foundation.

Also worth noting is that Mattel has an ongoing collaboration with CureSearch, a childhood cancer charity. Mattel's contribution here is with Brave Barbie, a doll line now running for over 10 years.

To quote the Executive Director of Mattel Children's Foundation and Corporate Philanthropy, Nancy Molenda, as quoted in the linked article on the CureSearch website:

Brave Barbie is given to children that are going through difficult cancer treatments so that they can see themselves and feel comforted that they’re not going through this alone.

Brave Barbies are donated to children fighting childhood cancer and depict either a light-skinned or a darker-skinned doll with no hair as well as a 'natural' coloured wig, a cute multi-coloured wig and a bandanna.

Mattel has also produced another doll in a similar range; friend of Barbie Ella, who was not for retail sale, but available only by donation to childrens hospitals, and depicted a friend of Barbie experiencing hair loss due to chemotherapy.

Cancer is a tragedy that affects many people and I am not going to ask you to donate to any particular charity or to engage in any particular kind of activism but I do encourage you to seek out a charity that suits you and that you personally would like to see support behind, if you are in a position where charity work or donations are right for you at the moment.

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[foundationsearch]

Investing in Hope: How Foundations Are Changing the Landscape of Childhood Cancer Treatment

Investing in Hope: How Foundations Are Changing the Landscape of Childhood Cancer Treatment

Childhood cancer remains one of the most challenging medical battles, affecting thousands of families every year. While medical advancements have improved survival rates, the funding needed to support research, treatment, and care remains inadequate. Philanthropic foundations are playing a vital role in bridging this gap, transforming the landscape of pediatric cancer treatment through grants and strategic investments.

The Funding Need

Despite the significant impact of childhood cancer, federal funding for pediatric oncology research remains disproportionately low. Less than 4% of the U.S. federal cancer research budget is allocated to childhood cancer, leaving a substantial funding gap that nonprofit organizations and private donors must fill. Limited funding restricts the development of new therapies, delays clinical trials, and reduces access to comprehensive treatment programs.

Who Is Impacted?

Children with Cancer

Children diagnosed with cancer often face limited treatment options, particularly for rare and aggressive cancers. Insufficient research funding means fewer breakthroughs in targeted therapies and an increased reliance on decades-old treatments with severe side effects.

Families

The financial burden on families affected by childhood cancer can be overwhelming. From medical bills to travel expenses for specialized treatment, the costs quickly add up. Many families turn to nonprofit organizations for financial aid, lodging assistance, and emotional support.

Researchers

Oncologists and medical researchers struggle to secure consistent funding for innovative projects. With grants being highly competitive, many promising studies remain underfunded or abandoned altogether, slowing down potential life-saving discoveries.

Philanthropic Support: Grants and Impact

Philanthropic organizations are stepping up to address the funding shortfall. Nonprofits such as the Pediatric Cancer Research Foundation, Alex’s Lemonade Stand Foundation (ALSF), and CureSearch have collectively invested millions in pediatric oncology research. These organizations provide grants to early-career researchers, fund clinical trials, and support survivorship programs that improve long-term outcomes for children in remission.

Future Trends in Philanthropic Funding

The landscape of nonprofit funding for childhood cancer research is evolving. Several key trends are shaping the future of philanthropic investments:

Increased Reliance on Private Funding – With limited government resources, nonprofit organizations are launching large-scale fundraising campaigns to secure sustainable funding for research and patient support.

Focus on Hard-to-Treat Cancers – Foundations are prioritizing research on aggressive and rare pediatric cancers, ensuring that children with the highest need receive targeted treatment options.

Collaborative Efforts – Many organizations are partnering with research institutions, hospitals, and governmental agencies to maximize impact and share resources efficiently.

Support Beyond Research – In addition to funding scientific advancements, nonprofits are expanding their focus to include family assistance programs, mental health resources, and post-treatment survivorship care.

Conclusion

Philanthropic foundations play a crucial role in transforming childhood cancer treatment. Through sustained financial support, research funding, and direct aid to families, these organizations are changing lives and offering hope to those affected by pediatric cancer. As reliance on private funding grows, collaborative efforts and a focus on underfunded areas will be key to driving innovation and improving survival rates for children battling cancer.

[camp-counselor-life]

estranging-unity

Girl Scouts is your favorite organization??

Hmmmm, I don't know that I have a favorite organization. It's definitely not GSUSA, that's for sure. [Council] I do like, and I feel like I have at least some say in making things better. If you can separate out my camp from council, that would probably be my favorite.

In other lines of work, I'm a fan of NAMI and International Bipolar Foundation, as they all do great work. CureSearch and St Baldricks are also a top contender.

I think it's important to be able to separate mission from people carrying out the mission of your favorite organization, at least a little bit.

You can still love what your old camp stands for, even when they have a director that you don't like.

You can still love your former youth organization, even if the CEO's vision doesn't match what you believe in.

Your memories, your love, your passion, none of that goes away because other people do something different.

You can love your memories, and hate the modern, love something you hated when you were younger, or love them at both times, in different ways, and all of that is valid.

[webercreative]

What does the nick of time really mean

What does the nick of time really mean

Not in the literal sense. I fancy myself a wordsmith, one who understands layers of poetry in its layers of truth and expression, so I choose my words specifically, if not always wisely. But as I sit in semi-darkness, listening to music to drown out the clouds for a moment, a song. Isn’t that what great music (one of those layers of poetic expression previously mentioned) peels back? A song for…

[phillygrub]

Iron Hill Partners with CureSearch on new Chocolate Peanut Butter Porter

Beer & Dessert For a Good Cause: @IronHillBrewery Partners with @CureSearch on new Chocolate Peanut Butter Porter!

Iron Hill Brewery will release Kick Cancer’s Peanut Butt-er Porter brewed in collaboration with CureSearch for Children’s Cancer, a nonprofit working to end childhood cancer by driving targeted and innovative research with measurable results in an accelerated timeframe. Additionally, throughout September, Iron Hill is asking guests to “Eat Dessert” first or include in initial order in the name…

[ncfbpodcastblr]

Pimiento Tea Room

Christy & Matt Griffith are using their gifts & talents to make not only downtown Holly Springs, but the world a better place!

Messy sandwiches, infused tea cocktails set in a refurbished 19th century landmark house. Need I say more?

Matt and Christy exude craft and hospitality at the Pimiento Tea Room, Check it out! 

Come to their Curesearch for children's cancer dinner on this Monday night 9/27 at 6:30, Matt is providing the wines and guest "somming" for the night! Limited tickets available. Call them to purchase tickets at 984.225.4213.

Support our Sponsors:

The official Vodka of the NC F&B Podcast: BLUE SHARK VODKA, all the taste without the bite!

SPOT ON Tech that helps your business grow. Call Tanya 858-213-7820 or email her tanyam@spoton.com

Drink Joe Van Gogh Coffee!

Exhale and turn your home into a haven! Visit Exhaleathome.com

Proof Alcohol Ice Cream Think Differently About Dessert

Triangle Wine Company Use promo code 'NCFB' at checkout!

The NC F&B Podcast is Produced and Engineered by Max Trujillo of Trujillo Media

For booking or questions about the show, contact: max@ncfbpodcast.com or matt@ncfbpodcast.com 

Check out our latest episode!

[hoofheartedyt]

BRONYCON SHOWS THE BEST OF BALTIMORE WITH NEW THURSDAY EVENTS

(BALTIMORE) - BronyCon is in the fast lane towards Friday, July 27. But some of our friends who beat the traffic and arrive a day early need things to do once they arrive in Baltimore. We’re happy to announce we’ve partnered with four organizations to bring both attendees and interested locals the best of the city with this year’s Thursday events!

First, BronyCon is happy to announce a fundraising venture between the convention and the Baltimore Orioles of Major League Baseball. As one of the U.S.’s best baseball cities, the team has always enjoyed a rich fanbase. We’re offering attendees a chance to be a part of this group with a special ticket offer. Those who purchase a ticket for the Thursday night game against the Tampa Bay Rays through our website will have $5 of their cost given directly to CureSearch for Cancer Research. The game is also a giveaway night, with attendees possibly receiving a shirt upon entry to the park. Camden Yards sits next door to the Baltimore Convention Center and tickets are in section 342 of the ballpark.

Those looking for a fun night on the town can enjoy a returning favorite: BronyCon’s yearly Bar Trot. The trot will visit numerous bars within the Fells Point area of Baltimore and will be done on foot with help from Food Tour Corp. There are 75 spots available for the trot and admission costs $16 per person.

A family favorite event returning this year is our cupcake decorating class with Charm City Cakes. Decorators will learn the basics during a fun cupcake class running from 6:00 PM to 7:30 PM. Students will each receive 4 cupcakes, and learn how to cut, and prepare fondant to create their favorite MLP characters. Space is limited so act fast!

We’re happy to announce that BronyCon and Charm City Clue Room will once again be teaming up to put attendees mind’s to the test! Attendees have 60 minutes one of four rooms, including two brand new rooms: "Dark Carnival" and "Poe: Oval Portrait.” Discounted rates are available all weekend with promo codes located on our website. Charm City Clueroom is located at 6 Market Place in the Inner Harbor at Power Plant Live. Clue Room will also be at BronyCon in person holding a separate escape room event as a activity for attendees to try out.

Finally, after last year’s successful PokémonGO walk, another is being spearheaded by enthusiastic Trainers and BronyCon staff. A start time and place has not been finalized, however interested parties can visit our Discord server at https://discord.gg/cRYyPNQ to discuss meeting up and potential ideas.

All information and related links regarding these activities can be found at http://bronycon.org/events/thursday.

To register, visit BronyCon’s registration page. Badges for BronyCon will cost more at the door, so don’t wait! Also make sure you are following BronyCon on Facebook, Twitter, and Telegram to be the first to hear our latest announcements.

About BronyCon: Based in Baltimore, Md., the tenth iteration of BronyCon is scheduled for July 27-29, 2018 at the Baltimore Convention Center. The convention features special guests, diverse programming, events, and a multi-night music festival featuring 12 hours of live music from some of the greatest fandom musicians. For more information, check out bronycon.org.

[americascharities]

In recognition of Month America's Charities is celebrating the following agents of change who we are proud to call our members: @curesearch, @rmhcglobal, @TheChildrensInn, @BelieveinTmw, @livestrong, @makeawish, @WishMidAtlantic. These nonprofits are dedicated to funding research to find treatments and cures for children's cancer, as well as providing programs that provide hope, joy, housing, and other types of support and resources for families with children facing cancer. https://qoo.ly/388yjd

[soundcheckentertainment]

Introducing Hadley Park

I’ve always had a passion for discovering new artists and helping get their music heard. In the music industry today it’s very difficult for new artists to make their mark and get traction. Since founding Sound Check Entertainment we’ve prided ourselves in seeking out and promoting new artists. Just some of the artists we told you about first, and continue to promote, include Meghan Patrick, Abby…

[neptunecreek]

Childhood Cancer Awareness Month

Every September, childhood cancer organizations around the world come together in recognition of Childhood Cancer Awareness Month, with a goal to increase awareness and raise funds for those affected by childhood cancer. According to CureSearch, each year more than 15,000 children in the U.S. alone are diagnosed with cancer.

from News & Views https://ift.tt/3hGQH3Q

[abrreports-blog]

Neuroblastoma Treatment Market Key Trends, Drivers, Growth Opportunities, and 2025 Industry Chain Structure Analysis

The research study Neuroblastoma Treatment market 2020 launched by ABRReports.com provides the detailed analysis of current market status, investment plans, production and consumption, price trends, leading key companies, growth drivers and future prospect. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025

 Get the Sample Copy of Neuroblastoma Treatment market report at https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-neuroblastoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report?form=request-report-sample

 The segmentation of Neuroblastoma Treatment study as mentioned below:

By Market Players:

Seattle Children’s, CureSearch, Texas Children’s, NANT

 By Application

Hospitals, Clinics, OthersCombination Chemotherapy, Monoclonal Antibody Therapy, Vaccine Therapy, Others

 The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data from 2014 to 2019 and forecast data from 2020 to 2025.

 The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail. Data and information by manufacturer, by region, by type, by application and etc, and custom research can be added according to specific requirements. The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

 Click to access full report and Table of Content at https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-neuroblastoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report

 The key objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

 Purchase the research study @  https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-neuroblastoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report/checkout?option=one

 Key pointers of the Table of Contents:

Chapter 1 Industry Overview

Chapter 2 Major Segmentation (Classification, Application and etc.) Analysis

Chapter 3 Production Market Analysis

Chapter 4 Sales Market Analysis

Chapter 5 Consumption Market Analysis

Chapter 6 Production, Sales and Consumption Market Comparison Analysis

Chapter 7 Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 8 Marketing Channel Analysis

Chapter 9 Industry Chain Analysis

Chapter 10 Global and Regional Market Forecast

Chapter 11 Major Manufacturers Analysis

Chapter 12 New Project Investment Feasibility Analysis

Chapter 13 Conclusions

Continued…

 About Us:

ABR Reports (Advanced Business Research Reports) is the premium market research reselling company which offers market research reports to individuals, organizations and industries to enhance and strengthen the decision making process. With associate thoroughgoing list of market research Publishers we tend to cut across over all the business verticals covering 5000+ micro markets and offer market size and share analysis, industry trend, information on products, regional market and keen business insights to our clients.

 Contact Us:

Scott Harris

Sales Manager

Email ID: sales@abrreports.com

Phone No.: +1-561-448-7424 

[sanybaby]

Tweeted

This years @BronyCon #charity broke every record set in the #pony fandom. We raised over 80k (still finalizing) for @CureSearch. I am so proud of my charity team @foalpapers, @Dusty_Kat, @buttonlovesyou, @MelodyHusky for being the best we can ever be. Thank you 💜💜💜💜

— Reiuiji 💜 (@reiuiji) August 4, 2019

[hoofheartedyt]

BRONYCON LAUNCHES PRESS APPLICATIONS, CHARITY SUBMISSIONS, TELEGRAM CHANNEL, AND BADGE FLASH SALE

(BALTIMORE) - While we anxiously await our next special passengers to join us on the road to BronyCon 2018, we’ve got a slew of announcements for you. Today, BronyCon is officially launching press applications and charity item submissions. We’ve also have a new announcement channel on Telegram that we’ve rolled out with exciting exclusives and are currently running a flash sale on 3-Day badges until June 2nd.

The application for members of the press to apply for credentials at our July event can do so at bronycon.org/press. Members of the press who are accepted will have access to press conferences with select guests of honor and will be given a distinct badge at the convention to aid them in their coverage of the event.

Press applications will be open for one month and close on June 25. After that, the accepted groups will be notified and given further instructions and details regarding what to do in Baltimore.

BronyCon has once again partnered with Maryland-based CureSearch for Children's Cancer to host this year’s annual Charity Auction. All the proceeds will go directly to CureSearch and any interest persons can donate an item to the auction. Accepted items can include include art (posters, prints, plushies, etc), unique merchandise and must be G to PG rated items. One of the highlights from last year’s auction  was a 14k white, yellow and rose gold Rainbow Dash cutie mark pendant by artist Silver Slinger.

Those interested in more information or having their work featured in the show can visit bronycon.org/events/charity.

In other news, BronyCon has launched an announcement channel on Telegram! Those with accounts on the service will be able to keep up with the latest BronyCon announcements including those related to guests and events. BronyCon Design Team member Trish Forster has also created a unique set of stickers for users to have access to on the app featuring Hoof Beatz, Mane Event and Blank Canvas.

One of those announcements is also that BronyCon is giving those who haven’t bought a badge to BronyCon a reason to do so this week. Our standard 3-Day badge will increase in price on Saturday, June 2nd. Until then, those who wish to purchase a either a standard 3-Day badge or a 3-Day PLUS badge can get $5 off by heading to https://bronycon.org/redeem and using the code word “horse.”

To register, visit BronyCon’s registration page. Badges for BronyCon will cost more at the door, so don’t wait! Also make sure you are following BronyCon on Facebook, Twitter, and Telegram to be the first to hear our latest announcements.

About BronyCon: Based in Baltimore, Md., the tenth iteration of BronyCon is scheduled for July 27-29, 2018 at the Baltimore Convention Center. The convention features special guests, diverse programming, events, and a multi-night music festival featuring 14 hours of live music from some of the greatest fandom musicians. For more information, check out bronycon.org.

[options2eat-blog]

#tbt Chef Martin and Pack850 Cubscouts grilling burgers for Curesearch Walk Miami 2017 #options2eatmiami #options2eat #pack850miami #curesearchforchildrenscancer