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One to one is a slightly acidic disinfectant with a sterilization rate of up to 99.999%. One to one can stably and efficiently kill various pathogenic bacteria, viruses and various organic pollutants in the environment. Non-toxic and harmless, no load on the environment. The products have passed the testing and certification of authoritative organizations, and have been recognized as food additive-grade antibacterial agents by the Japanese Ministry of Health, Labor and Welfare and the US Food and Drug Administration (FDA). One to one are widely used in daily life, learning, working environment sterilization, deodorization, and have achieved remarkable results.

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one to one

One to one is a slightly acidic disinfectant with a sterilization rate of up to 99.999%. It can stably and efficiently kill various pathogenic bacteria, viruses and various organic pollutants in the environment. Non-toxic and harmless, no load on the environment.One to one is a biomimetic disinfection technology developed to mimic the immune mechanism of human leukocytes. It is powerful, but it is friendly to the human body and the environment. It does not produce drug resistance. After the action, it is reduced to water and a very small amount of salt.One to one allows its hypochlorous acid molecules to be stored at room temperature with its patented manufacturing process technology .The 24 month decay rate is less than 5%, paving the way for large-scale promotion of one to one. The sterilization ability of one to one is the result of millions of years of natural evolution in humans and most mammals. Human neutrophils (a type of white blood cells) secrete hypochlorous acid, penetrate bacteria and viruses, and destroy their core structure. Become an important mechanism of the human immune system.

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A new type of sterilization spray that is safer and more environmentally friendly than the usual disinfection products.

One to one is a slightly acidic disinfectant with a sterilization rate of up to 99.999%. It can stably and efficiently kill various pathogenic bacteria, viruses and various organic pollutants in the environment. Non-toxic and harmless, no load on the environment.

One to one is a biomimetic disinfection technology developed to mimic the immune mechanism of human leukocytes. It is powerful, but it is friendly to the human body and the environment. It does not produce drug resistance. After the action, it is reduced to water and a very small amount of salt.

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One to one Hypochlorous ACID Biological Sterilization Principle :Biological Mechanisms Derived From the Human Immune System ,The human neutrophils (white blood cells) secrete hypochlorous acid, which strongly infiltrates the peripheral structures of microbial cells (bacteria and viruses) such as cell walls and cell membranes, destroying the structure of the inner core (DNA) and inactivating it.

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What is ONE TO ONE? A New Generation of Biological Sterilization Products. Is provided with Deep Health、Green Environmental Protection、Lmmunological DNA Strategy、Food Grade Safety、No pollution, No residue, Non-Chemical、Molecular Biological Mechanism of Hypochlorous ACID

[onetooneltd-blog]

What is ONE TO ONE?

A New Generation of Biological Sterilization Products. Is provided with Deep Health、Green Environmental Protection、Lmmunological DNA Strategy、Food Grade Safety、No pollution, No residue, Non-Chemical、Molecular Biological Mechanism of Hypochlorous ACID

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Why isn’t Hypochlorous Acid everywhere?

The overwhelming impediment to its widespread use has been a lack of shelf stability. HOCl is the most reactive ROS (Reactive Oxygen Species). This means it react very easily and will quickly turn back into salt water. HOCl solutions have been used for over 100 years, in the early 1900\'s during the World Wars, HOCl solutions were used for disinfecting medical equipment and dressing wounds. However, until recently, HOCl solutions would only remain stable for about 90 minutes before turning back into salt water.

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What has changed?

HOCl is now manufactured in a way that allows the solution to be stable for much longer than previously available. This has allowed for product to be carefully bottled and made available across the world. Although producing HOCl solutions is not challenging, stabilizing the solution is very difficult. In fact, at Pure&Clean our quality ingredients and unique process produce an unmatched product. This is proven by our HOCl industry-best 18-month (not impacted by opening) FDA cleared shelf life on all of our FDA cleared products. Furthermore, we do not add unnecessary ingredients to stabilize or preserve our product stability. The Pure&Clean solution is so stable that we are able to provide a very unique and rare HOCl Hydrogel product - which proves to have a massive impact across a number of medical applications.

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What can kill pathogens?

Hypochlorous acid is a naturally occurring small molecule generated by white blood cells during the oxidative burst to kill pathogens. It has been shown in independently published in vitro studies to be highly effective in killing drug-resistant bacteria and essentially all human pathogens

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HCLO

Researchers investigate the magnitude of bacterial load reduction on the surface of the skin 20 minutes after application of saline containing 0.01% pure hypochlorous acid as the preservative to the skin below the lower eyelid. Reviewed by Arthur B. Epstein, OD Phoenix—An eyelid wash preserved with pure hypochlorous acid (Avenova with Neutrox, NovaBay Pharmaceuticals) can significantly reduce the bacterial load on the surface of the eyelid.

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Uses of Hypochlorous Acid

Hypochlorous Acid (HOIC) is a more powerful oxidizer than chlorine and a very effective sanitizing agent. It is used to make sodium hypochlorite (NaOCl) and calcium hypochlorite, (Ca(OCl)2), which are used in the making of bleaches, disinfectants and deodorants. Hypochlorous acid is the active sanitizer used in swimming pools. It is also used as a wound disinfecting agent, and a skin cleansing agent in cosmetics.

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Protein unfolding and aggregation

HOCl is known to cause post-translational modifications to proteins, the notable ones being cysteine and methionine oxidation. A recent examination of HOCl's bactericidal role revealed it to be a potent inducer of protein aggregation.Hsp33, a chaperone known to be activated by oxidative heat stress, protects bacteria from the effects of HOCl by acting as a holdase, effectively preventing protein aggregation. Strains of Escherichia coli and Vibrio cholerae lacking Hsp33 were rendered especially sensitive to HOCl. Hsp33 protected many essential proteins from aggregation and inactivation due to HOCl, which is a probable mediator of HOCl's bactericidal effects.

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Inhibition of DNA replication

Recently it has been proposed that bacterial inactivation by HOCl is the result of inhibition of DNA replication. When bacteria are exposed to HOCl, there is a precipitous decline in DNA synthesis that precedes inhibition of protein synthesis, and closely parallels loss of viability.During bacterial genome replication, the origin of replication (oriC in E. coli) binds to proteins that are associated with the cell membrane, and it was observed that HOCl treatment decreases the affinity of extracted membranes for oriC, and this decreased affinity also parallels loss of viability. A study by Rosen et al.[49] compared the rate of HOCl inhibition of DNA replication of plasmids with different replication origins and found that certain plasmids exhibited a delay in the inhibition of replication when compared to plasmids containing oriC. Rosen’s group proposed that inactivation of membrane proteins involved in DNA replication are the mechanism of action of HOCl.

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HCIO

Hypochlorous Acid (HOIC) is a more powerful oxidizer than chlorine and a very effective sanitizing agent. It is used to make sodium hypochlorite (NaOCl) and calcium hypochlorite, (Ca(OCl)2), which are used in the making of bleaches, disinfectants and deodorants. Hypochlorous acid is the active sanitizer used in swimming pools. It is also used as a wound disinfecting agent, and a skin cleansing agent in cosmetics.

[onetooneltd-blog]

HCIO

Hypochlorous Acid (HCIO) is a weak, unstable acid occurring only in solution and used as a bleach, oxidizer, deodorant, and disinfectant. It has strong antimicrobial and antibacterial properties. It is often used as a safe disinfectant to treat water supplies, irrigation systems, and food preparation surfaces. Hypochlorus acid is also used to sanitize water used in hydroponic growing systems.