#Adenovirus Vector Vaccine Market Challenges

[lalsingh228-blog]

Adenovirus Vector Vaccine Market Projected to Show Strong Growth

The Latest research coverage on Adenovirus Vector Vaccine Market provides a detailed overview and accurate market size. The study is designed considering current and historical trends, market development and business strategies taken up by leaders and new industry players entering the market. Furthermore, study includes an in-depth analysis of global and regional markets along with country level market size breakdown to identify potential gaps and opportunities to better investigate market status, development activity, value and growth patterns. Access Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/165891-global-adenovirus-vector-vaccine-market

Major & Emerging Players in Adenovirus Vector Vaccine Market:- Creative Biolabs (United States), Sartorius AG (Germany), Lonza (Switzerland), Merck KGaA (Germany), Cobra Biologics (United States), Thermo Fisher Scientific (United States), Boehringer Ingelheim (Germany), Oxford Biomedica (United Kingdom), Advanced Bioscience Laboratories (United States). The Adenovirus Vector Vaccine Market Study by AMA Research gives an essential tool and source to Industry stakeholders to figure out the market and other fundamental technicalities, covering growth, opportunities, competitive scenarios, and key trends in the Adenovirus Vector Vaccine market. Adenovirus represents the class of the genetically diverse DNA viruses that can cause non-life-threatening infections related to eyes, respiratory system, gastrointestinal lining and other parts. These viruses represent promising results as a vector for delivering target antigens to various hosts due to excellent ability induce immune response. Due to these property, the new studies concluded positive results for use of adenovirus for both gene therapy and vaccine production. Adenovirus-based vectors shows various benefits when compared to other viral vectors such as wide range of tissue tropism, ease of genetic manipulation especially for large transgene DNA insertions, superior ability to induce robust transgene-specific T cell and antibody responses, easy production of the adenovirus based vaccines at large scale. Due to this, it has emerged as a preferred choice for delivering vaccine for both humans as well as animals.

In February 2021, the Janssen Biotech, a part of Johnson and Johnson submitted Emergency Use Authorization (EUA) to the US Food and Drug Administration (FDA), for its investigational single-dose coronavirus 2019 (COVID-19) vaccine candidate. The vaccine Ad26.COV2.S, is a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike (S) protein

In January 2021, Thermo Fisher Scientific, a company offering range of instrumentation, reagents and consumables, and software and services acquired the viral-vector manufacturing business of the Novasep, a pharmaceutical company for approximately USD 875 million in cash. This acquisition is a step towards expanding Thermo Fisher capabilities in the cell and gene vaccines and therapies worldwide. The titled segments and sub-section of the market are illuminated below: by Type (Adenovirus-based tuberculosis vaccine, Adenovirus-based HIV vaccine, Adenovirus-based influenza vaccine, Others), Application (Human, Animals), End-user (Hospitals, Ambulatory Surgical Center, Research Institutes, Others) Market Trends: Increasing investment in vaccine and drug development

Rising collaboration between the pharmaceutical companies and CROs for development of adenovirus vector vaccine

Opportunities: Emergence of adenovirus vectored vaccines for COVID-19      

Production of low cost adenovirus vaccines

Market Drivers: Growing prevalence of chronic medical conditions

Rise in demand for efficient vaccines to treat infectious diseases Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/165891-global-adenovirus-vector-vaccine-market Some Point of Table of Content: Chapter One: Report Overview Chapter Two: Global Market Growth Trends Chapter Three: Value Chain of Adenovirus Vector Vaccine Market Chapter Four: Players Profiles Chapter Five: Global Adenovirus Vector Vaccine Market Analysis by Regions Chapter Six: North America Adenovirus Vector Vaccine Market Analysis by Countries Chapter Seven: Europe Adenovirus Vector Vaccine Market Analysis by Countries Chapter Eight: Asia-Pacific Adenovirus Vector Vaccine Market Analysis by Countries Chapter Nine: Middle East and Africa Adenovirus Vector Vaccine Market Analysis by Countries Chapter Ten: South America Adenovirus Vector Vaccine Market Analysis by Countries Chapter Eleven: Global Adenovirus Vector Vaccine Market Segment by Types Chapter Twelve: Global Adenovirus Vector Vaccine Market Segment by Applications What are the market factors that are explained in the Adenovirus Vector Vaccine Market report?

– Key Strategic Developments: Strategic developments of the market, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors.

– Key Market Features: Including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, import/export, supply/demand, cost, market share, CAGR, and gross margin.– Analytical Tools: The analytical tools such as Porter’s five forces analysis, SWOT analysis, feasibility study, and investment return analysis have been used to analyze the growth of the key players operating in the market. Buy This Exclusive Research Here: https://www.advancemarketanalytics.com/buy-now?format=1&report=165891 Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market. Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia. Contact US : Craig Francis (PR & Marketing Manager) AMA Research & Media LLP Unit No. 429, Parsonage Road Edison, NJ New Jersey USA – 08837 Phone: +1 201 565 3262, +44 161 818 8166 sales@advancemarketanalytics.com

[pharmanucleus1]

Viral Vector Gene Delivery Market: Advancements, Opportunities, and Future Trends

Market Overview 

Viral vector is the most sought-after way to transfer genes to specific cell types or tissues and manipulate them to express therapeutic genes. Currently, there are several types of viruses, such as adenovirus, adeno associated virus, baculovirus and retrovirus, which are being investigated in order to deliver the genes to required cells. This process can provide permanent as well as transient transgene expression.

Market Dynamics 

Viral vectors are primarily used in the development of various gene therapies and are showing great promise in disease landscape. Moreover, during the unprecedented times of COVID-19, the development of adenovirus-vector vaccine has helped to mitigate the dangerous risks associated with the pandemic.? 

Since the viral vector-based gene therapies have shown promising results in the past, the developers are exploring its full potential to reach to its long-term success. With the ongoing rise in demand, the service providers are continuously expanding their facilities to meet the numbers. In August 2022, Thermofischer has expanded its cell and gene therapy capability by opening the new viral vector manufacturing facility in Massachusetts, US. 

In June 2022, VIVEbiotech has completed the acquisition of its lentiviral vector manufacturing capabilities to support the customers throughout the development cycle. 

In June 2022, Avid Bioservices expanded its viral vector focused facility with 53,000 sq. ft. area to address the demand of viral vector production at commercial scale. 

The increasing prevalence of various genetic disorders and target diseases increased funding availability for development of gene therapy, research efforts in the field of viral vector-based cell and gene therapies, and increasing efficacy of viral vectors in delivering gene therapy are fueling growth in the global viral vectors manufacturing market. 

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Challenges 

The ongoing challenge, which is linked with its ability to pass the immune system and high number of doses are some of the limiting factors delaying the success of such therapies. Further, the quality of transgene expression plays another crucial role for the desired clinical effect. The combinatorial factors demand innovations at the R&D scale, which will gain traction in investment from various organizations. 

In June 2022, NSW Government of Australia allocated USD 101.4 million to the commercial facility of viral vector manufacturing. This clearly indicates the need to improve the viral vector-based therapy due to its significant potential to cure multiple indications.?? 

Development Landscape: 

Biotech and pharmaceutical businesses are adopting both organic and inorganic growth strategies to advance their pipeline and gain competitive edge in the market over the peers. 

In April 2022, ProteoNic and NecstGen announced a collaboration, wherein the respective players will utilize their proprietary platforms to advance the AAV and LV viral vector manufacturing technology. 

Till now, only eight viral vector-based gene therapies have been approved by the US FDA, which were developed using three viral vectors- adeno associated virus, lentivirus and herpes simplex virus. 

As of September 2022, over 145 clinical trial studies are going on with over 10,000 patients worldwide. The exploratory pipeline of viral vector-based therapy continues to grow across the indications and targets with promising results. 

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Key players: 

Lonza (Switzerland), Merck (Germany), Oxford BioMedica (UK), CGT Catapult (UK), Cobra Biologics (UK), uniQure (Netherlands), FUJIFILM Diosynth Biotechnologies (US), and Spark Therapeutics (US) 

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https://www.pharmanucleus.com/reports/viral-vector-gene-delivery

Upcoming players: 

TBD 

Regional Analysis: 

North America?is anticipated to capture the highest share of this market over the forecast period (2022-2027), with U.S. accounting for the maximum contribution. Presence of most number of manufacturing facilities and key players, some of the best research universities and an encouraging start-up eco system provides an ideal environment for research leading to more successful assets in pipeline. Macro-economic factors such as large population and growing economy, high prevalence of cancer and infectious diseases, better access to insurance, availability of crowd funding and support from various stakeholders’ fuels US as a commercially attractible market. 

In 2019, the New Jersey Innovation Institute signed an agreement with Pall Corporation to develop a BioPharmaceutical Innovation iLab to help fix the viral vector shortage using continuous manufacturing. 

Thermo Fisher Scientific opened a cGMP manufacturing facility in Plainville, US which helped double the company’s commercial viral vector capacity?and?meet rising demand for the development and manufacturing of gene therapies and vaccines. 

Europe?also remains a favourable region on par with the North American region. Presence of highly skilled researchers, well-developed R&D ecosystem, support from government agencies and regulatory bodies are the major driving factors in Europe. 

In 2021, Yposkesi announced that its bioproduction project has been selected for the French government’s “Plan de Relance” initiative, which is an economic stimulus package aimed at making the nation’s bioproduction industry strategically more robust and economically resilient is investing USD6 million in its “Boost” project to develop a new generation 1000-L, GMP platform with optimized manufacturing and control processes for efficient viral vector production from the thawing of cells up to the aseptic filling of the end product. 

Asia-Pacific?region is expected to pick up pace over the next few years due to favourable regulatory climate, increasing investments to drive market access in key markets such as Japan, China, Australia, Singapore and India. The market is focusing on Asia-Pacific as a destination for outsourcing and trying to gain foothold through mergers, collaborations, and strategic acquisitions. 

In 2022, National Cancer Center Japan and GenScript ProBio entered into research collaboration agreement for a plasmid and lentiviral vector CMC development to develop plasmid and lentiviral vector for cell therapy to aim on FDA acceptance of IND applications. 

In 2022, VectorBuilder, a CDMO announced an investment of USD 500m for China viral vector plant. The campus will include 30 production suites designed to manufacture lentivirus, plasmids, messenger RNA (mRNA), adeno-associated virus (AAV), cell lines and other types of viral and non-viral vectors. 

[esglatestmarketnews]

Viral Vector—Perusal on Adeno-associated Viruses (AAVs) in Gene Therapy Development

The medical industry expects viral vectors to grow in prominence in transferring genetic material into the genetic composition of cells. Adeno-associated Viruses (AAVs) have become sought-after in gene therapy as they can deliver genetic material to cells and do not cause disease. Predominantly, adenovirus, retrovirus, herpes simplex virus and lentivirus, among others, are used to transfer genetic material into cells’ genetic composition. Technological advancements in manufacturing AAV vectors have encouraged stakeholders to boost their portfolios. An uptick in research activities in viral vector-based cell and gene therapies has redefined the global landscape. For instance, in 2020, over 100 gene-therapy products were observed in clinical trials.

Pharma companies, investors, venture capitalists and other stakeholders will possibly explore the growth potential in viral vectors. The final report, along with the database, will deep-dive into the following industry dynamics:

• AAV vectors approved by governing bodies, including FDA and the European Medicines Agency. Zolgensma was approved by EMA and FDA in 2020 and 2019, respectively, while Luxturna received the green signal from FDA in 2017 and EMA in 2018. 

• Insights on potential challenges for AAV manufacturers, such as cost, degradation during supply chain and preparation of stable viral vectors.

• Influence of the COVID-19 pandemic on vaccine development.

• Acquisitions of biotech startups

Get your copy or request a free sample of the report “Viral Vector Development - Focus on Adeno-associated Virus, 2018 – 2021,” compiled and published by Grand View Research.

Viral Vector Report Scope

Attribute

Details

Market Lineage

% Captured by AAV within Viral Vectors

Understanding of the parent market and ancillary industries

Plasmid DNA Contract Manufacturing

Cell & Gene Therapy Clinical Trials Market

Industry Dynamics

Viral Vector based gene therapy development

AAV Development workflow

Pipeline for AAV

Capitalist funding in the industry

Development Process

Deep dive Analysis

Understanding of AAV v/s Lentiviral v/s other viral vectors

Cost of manufacturing (based on batch size) - a case study

Case study on setting up a development plant

Competition Analysis in CDMOs

Companies with products in clinical trials

Various bioreactors used for development

Strategic initiatives undertaken in the last 5 years

Observation and Recommendations

This section will summarize the entire study and provide analyst insights with regards to key methods of development, technological advancements, and competitive profiling

Get more insights from our in-depth market intelligence report “Viral Vector Market Size, Share & Trends Analysis Report By Vector Type (Adeno-associated Virus (AAV), Adenovirus, Lentivirus, Retrovirus, Others), By Application, By End-user, By Region, And Segment Forecasts, 2023 – 2030”

About Us

Grand View Research, Inc. is a market research and consulting company that provides off-the-shelf, customized research reports and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and energy. With a deep-seated understanding of varied business environments, Grand View Research provides strategic objective insights.

Find More information @ https://www.grandviewresearch.com/info/trend-reports

[balrajgis]

Viral Vectors And Plasmid DNA Manufacturing Market overview by recent opportunities, growth size, regional analysis and forecasts to 2031 | Genelux Corporation, Kaneka Eurogentec S.A., Lonza Group AG

Global Viral Vectors And Plasmid DNA Manufacturing Market report from Global Insight Services is the single authoritative source of intelligence on Viral Vectors And Plasmid DNA Manufacturing Market. The report will provide you with analysis of impact of latest market disruptions such as Russia-Ukraine war and Covid-19 on the market. Report provides qualitative analysis of the market using various frameworks such as Porters’ and PESTLE analysis. Report includes in-depth segmentation and market size data by categories, product types, applications, and geographies. Report also includes comprehensive analysis of key issues, trends and drivers, restraints and challenges, competitive landscape, as well as recent events such as M&A activities in the market.

A viral vector is a virus that has been genetically modified to carry a foreign gene into a cell. The foreign gene may encode a protein that confers a new property to the cell, such as resistance to a particular drug. Alternatively, the foreign gene may be a piece of DNA that the researcher wishes to insert into the cell’s genome.

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Key Trends

The key trends in viral vectors and plasmid DNA manufacturing technology are:

1. Increasing use of viral vectors and plasmid DNA for gene therapy and vaccine development

2. Improvements in vector design and manufacturing processes

4. Decreasing costs of viral vectors and plasmid DNA

Key Drivers

There are several key drivers of the Viral Vectors and Plasmid DNA Manufacturing market. One of the most important drivers is the increasing demand for gene and cell therapies. Gene therapies are becoming more prevalent as treatments for a variety of conditions, including cancer, genetic disorders, and infectious diseases. In addition, cell therapies are being developed for a variety of applications, including regenerative medicine and immunotherapy.

Key Segments

By Vector Type

Adenovirus

Retrovirus

By Workflow

Upstream Manufacturing

Downstream Manufacturing

By Application

Gene Therapy

Cell Therapy

By End-Use

Pharmaceutical & Biopharmaceutical Companies

Research Institutes

By Region

North AmericaThe U.S.

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Key Players

Genelux Corporation

Kaneka Eurogentec S.A.

Lonza Group AG

MaxCyte, Inc.

Merck KGaA

Novasep Inc.

Vector Biolabs

Vigene Biosciences, Inc.

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[researchcognizance]

Global Viral Vector Vaccines Market Expected to Witness Rapid Expansion by the End of 2027

The recent report on “Global Viral Vector Vaccines Market Report 2021 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2027” offered by Axel Reports, comprises a comprehensive investigation into the geographical landscape, industry size along with the revenue estimation of the business. Additionally, the report also highlights the challenges impeding market growth and expansion strategies employed by leading companies in the “Viral Vector Vaccines Market”.

An exhaustive competition analysis that covers insightful data on industry leaders is intended to help potential market entrants and existing players in competition with the right direction to arrive at their decisions. Market structure analysis discusses in detail Viral Vector Vaccines companies with their profiles, revenue shares in the market, comprehensive portfolio of their offerings, networking and distribution strategies, regional market footprints, and much more.

Download Sample PDF+ All Related Graphs & Charts (Including COVID19 Impact Analysis) @: https://axelreports.com/request-sample/55827

By Market Players: Advanced Bioscience Laboratories Creative Biogene Boehringer Ingelheim Sanofi Brammer Bio Pfizer GE Healthcare

By Type Adenovirus Fowlpox Virus Attenuated Yellow Fever Vaccinia Virus Vectors Others By Application Hospitals Clinics Others

(Note: The sample of this report is updated with COVID-19 impact analysis before delivery)

Key Questions Covered in the Report :

What is the total market value of the Global Viral Vector Vaccines Market report?

What would be the forecast period in the market report?

What is the market value of the Global Viral Vector Vaccines Market in 2021?

What is the Key Industry Leader’s opinion for the Global Viral Vector Vaccines?

Which is the base year calculated in the Global Viral Vector Vaccines Market Report?

What are the key trends in the Global Viral Vector Vaccines Market Report?

What are the market values/growth % of emerging countries?

Which market holds the maximum market share of the Global Viral Vector Vaccines Market?

Some Point from Table of Content:

Market Overview: It includes six chapters, research scope, major manufacturers covered, market segments by type, Viral Vector Vaccines market segments by application, study objectives, and years considered.

Market Landscape: Here, the competition in the Worldwide Viral Vector Vaccines Market is analyzed, by price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Profiles of Manufacturers: Here, leading players of the global Viral Vector Vaccines market are studied based on sales area, key products, gross margin, revenue, price, and production.

Market Status and Outlook by Region: In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Viral Vector Vaccines Market is deeply analysed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User: This section of the research study shows how different end-user/application segments contribute to the global Viral Vector Vaccines Market.

Market Forecast: Production Side: In this part of the report, the authors have focused on production and production value forecast, key producers forecast, and production and production value forecast by type.

Research Findings and Conclusion: This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

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[bbcbreakingnews]

Sputnik’s ‘efficacy at 95%’, to be cheaper than US vaccines

MUMBAI: Russia’s Sputnik V Covid-19 vaccine, that reported an efficacy of over 95%, will be twice as cheap as those by Pfizer and Moderna with similar positive results. Sputnik V, developed by Gamaleya Institute and RDIF (Russian Direct Investment Fund), will be priced under $20 per person for the two doses in global markets, including India, and may be available here by February. The vaccine is still to undergo trials in India and will be manufactured by domestic companies. Hyderabad-based Dr Reddy’s and RDIF have entered into a partnership to conduct clinical trials and distribute it in India. Though the vaccine has a price advantage against the above two firms, there could be a challenge in its distribution as it requires a specialised cooling chain, experts say. The efficacy of the Sputnik V vaccine is 91.4%, based on the second analysis of interim data obtained 28 days after administering the first dose (7 days after the second dose). Preliminary data obtained 42 days after the first dose indicates an efficacy above 95%, a statement said. Sputnik V, a two-dose vaccine on the human adenoviral vector platform, will soon initiate Phase II clinical trials on 100 subjects in India, while Phase III trials will involve 1,500 participants. In October, Dr Reddy’s and RDIF received approval from the Drugs Controller General of India to conduct adaptive phase II/III human clinical trials for the vaccine in India. As part of the partnership, RDIF will supply 100 million doses of the vaccine to Dr Reddy’s. The first international deliveries of the Russian Sputnik V vaccine will be made in January 2021 based on the existing partnerships with foreign manufacturers, the statement adds. Details about the vaccine, trials and manufacturers in India are still sketchy. “There are two forms of the vaccine, one of which requires -18°C (liquid) and must be transported in special refrigerators. Second form is lyophilised (freeze-dry) and can be stored at +2 to -8°C. We expect that the freeze-dry version will be supplied in large quantities to many countries including India in February,” a RDIF spokesperson told TOI. “The uniqueness of the vaccine lies in the use of two different vectors based on the human adenovirus, which allows for a stronger and longer-term immune response as compared to vaccines using one and the same vector for two doses,” the statement added. The existing agreements between RDIF and leading foreign pharmaceutical companies allow the Sputnik V vaccine to be produced abroad for 500 million people per year, starting from 2021.

source https://bbcbreakingnews.com/2020/11/25/sputniks-efficacy-at-95-to-be-cheaper-than-us-vaccines/