#Budding Solutions (MD)

[mrselnox]

Big Bad Sour Bears: The Tangy Treat Taking the Snack World by Storm

If you've ever found yourself in the candy aisle, paralyzed by the overwhelming array of choices, you're not alone. But amidst the sea of sweet treats, one confection stands out with its bold flavor and daring bite: Big Bad Sour Bears. These sour gummy bears are not for the faint of heart, and they're rapidly becoming the go-to snack for thrill-seekers and flavor enthusiasts alike. Let's dive into what makes these tangy treats so irresistible.

A Flavor Explosion

Big Bad Sour Bears are not your average gummy bears. Each bear is packed with an intense sour punch that hits your taste buds like a flavor explosion. The secret lies in the perfect balance of acidity and sweetness, creating a mouth-puckering sensation that leaves you craving more. Unlike some sour candies that lose their tanginess after the first bite, these bears maintain their sour intensity from start to finish.

The Science of Sour

What exactly makes these bears so sour? The answer lies in their unique coating. Big Bad Sour Bears are dusted with a special blend of citric acid and malic acid, two ingredients known for their sharp, tart flavors. This combination not only gives the bears their signature sourness but also enhances the fruity flavors of the gummy. Each bear comes in a variety of flavors, including classic favorites like lemon, lime, and cherry, as well as more adventurous options like green apple and blue raspberry.

The Perfect Snack for Any Occasion

Whether you're looking for a mid-afternoon pick-me-up or a late-night treat, Big Bad Sour Bears are the perfect solution. Their compact size and resealable packaging make them easy to carry around, so you can enjoy a sour kick whenever the mood strikes. Plus, they're great for sharing! Bring a bag to your next movie night or road trip, and watch as your friends' faces light up with delight (and a bit of surprise) at the first taste.

A Nostalgic Twist

For many, gummy bears are a nostalgic treat, reminiscent of childhood trips to the candy store. Big Bad Sour Bears take this nostalgia and give it a modern twist. They offer the same chewy, fruity goodness that you remember, but with an added layer of complexity and excitement. It's a grown-up version of a childhood favorite, perfect for those who still have a sweet tooth but are looking for something with a bit more zing.

Healthier Than You Think

While Big Bad Sour Bears are definitely a treat, they come with some surprising health benefits. Unlike many other candies that are loaded with artificial colors and flavors, these bears are made with real fruit juices and natural flavors. They also contain no high-fructose corn syrup, making them a slightly better choice for those who are health-conscious. Of course, moderation is key, but it's nice to know that your favorite sour snack isn't completely devoid of nutritional value.

Join the Sour Revolution

Big Bad Sour Bears are more than just a candy; they're a revolution in the snack world. With their bold flavors, perfect balance of sour and sweet, and nostalgic appeal, it's no wonder they're quickly becoming a favorite among candy lovers everywhere. So, next time you're in the mood for something that packs a punch, skip the ordinary and reach for a bag of Big Bad Sour Bears. Your taste buds will thank you.

Conclusion

In a market saturated with sugary sweets, Big Bad Sour Bears offer a refreshing change. They cater to a growing demand for bold, intense flavors and bring a touch of excitement to the world of confections. Whether you're a lifelong candy enthusiast or just looking for a new snack to try, these sour bears are sure to leave a lasting impression. Embrace the sour, and let Big Bad Sour Bears take your taste buds on an unforgettable journey.

Also Look The Business Details

Name             -  Mr. Nice Guys Bmore Weed Dispensary

Address         - 1100 Light St suite a, Baltimore, MD 21230

Phone no      -   6673033176

[infinite-money-glitch]

Latest NBFC Sector Trends Revealed

The world of Non-Banking Financial Companies (NBFCs) is buzzing with activity as new trends emerge and reshape the financial landscape. In this article, let’s take a dive into the latest NBFC sector trends that are making waves in India. So, if you're keen on staying ahead of the financial curve, keep reading!

Digital Transformation

One of the most significant trends in the NBFC sector is the rapid digital transformation. NBFCs are embracing technology to streamline their operations, improve customer service, and enhance decision-making processes. This means faster loan approvals, hassle-free documentation, and personalized financial solutions at your fingertips.

Also Read: Exchange-Traded Funds (ETFs) - The Good and Bad

Microfinance and Small Business Loans

Microfinance institutions within the NBFC sector are witnessing a surge in demand. They play a vital role in supporting micro-entrepreneurs and small businesses. With simplified lending processes and customized loan products, they're aiding the growth of the Indian economy from the grassroots. H.P. Singh, Chairman & MD of Satin Creditcare Network Limited, emphasizes that NBFCs play a vital role in India's economic progress.

Customer-Centricity

NBFCs are putting the customer at the center of their operations. They are not just providers of financial services but also advisors. NBFCs are investing in customer education, making sure borrowers understand the terms and conditions of their loans. This customer-centric approach fosters trust and transparency.

Eco-Friendly Financing

The environment is a growing concern, and NBFCs are taking it seriously. They are offering eco-friendly financing options for initiatives such as solar energy projects, electric vehicles, and sustainable agriculture. Going green not only helps the planet but also provides financial benefits in the long run.

Data Analytics and AI 

Data is the new gold, and NBFCs are mining it to make informed decisions. Abhay Bhutada says advanced data analytics and artificial intelligence are helping NBFCs assess creditworthiness accurately. This results in reduced risk and better loan management.

Financial Literacy Programs

To empower borrowers and potential customers, NBFCs are conducting financial literacy programs. These programs help individuals understand financial concepts, manage their money, and make informed decisions.

Also Read: Investor's Playbook on Taxation Strategies

Conclusion

In the dynamic world of finance, NBFCs are at the forefront of change. They are embracing digitalization, expanding their reach, and focusing on customers like never before. Whether you're a budding entrepreneur in a small town or a green-conscious consumer, the latest NBFC sector trends have something for everyone.

[themoneyguru1]

A Comprehensive Guide To Fund Your Business

Are you an aspiring entrepreneur looking to turn your business dreams into reality? One of the biggest challenges you might face is finding the funds to get your venture off the ground. But fear not! In this comprehensive guide, you’ll get to know four ways to fund your business and help you make informed decisions to fuel your entrepreneurial journey.

1. Government Schemes

The Indian government offers numerous schemes and initiatives to support entrepreneurs. Programs like the Pradhan Mantri Mudra Yojana (PMMY) and Stand-Up India aim to provide financial assistance and promote entrepreneurship.

These schemes offer loans at subsidized interest rates, making them an attractive option for budding entrepreneurs. Stay updated with the latest government schemes and take advantage of the opportunities available.

Also Read: What Is Recession And How Can It Impact The Indian Economy?

2. Business Loans

Business loans are a popular option for funding in India. With a plethora of banks and financial institutions offering loans tailored for small and medium-sized enterprises (SMEs), it's a viable solution for many entrepreneurs.

A business loan, according to Abhay Bhutada, MD of Poonawalla Fincorp, is a lending alternative that gives funds to business owners without requiring collateral.

3. Crowdfunding

In recent years, crowdfunding has emerged as an innovative way to fund businesses. Platforms like Kickstarter and Ketto enable entrepreneurs to pitch their ideas to a large audience, who can contribute financially to bring the project to life. This method not only provides funds but also helps validate your business concept and build a community of supporters.

4. Angel Investors And Venture Capitalists

If you have a unique and scalable business idea, angel investors and venture capitalists can be your ticket to substantial funding. These individuals or firms invest in promising startups in exchange for equity or ownership stakes.

However, securing funding from these sources often requires a compelling pitch, a solid business plan, and a persuasive vision for growth.

Also Read: The Rise of Digital Lending in India: A Game Changer for Borrowers and Lenders

Summing Up

In conclusion, funding your business can be a daunting task, but with the right approach, it's entirely achievable. Remember to thoroughly research, compare options, and assess the financial impact on your business before making any decisions. Take the plunge, explore these funding avenues, and turn your entrepreneurial dreams into a thriving reality.

[rockvillesposts]

Cost-Effective Marketing: The Value Of Vehicle Wraps In Rockville, MD

If you’re not taking advantage of vehicle wrap marketing, you’re leaving money on the table! Today’s post reviews peer-reviewed research from 4 studies highlighting the value of “mobile billboards” for both mass marketing and targeted marketing in Rockville, MD.

Read on or call (240)-246-7423 to speak directly with a vehicle wrap specialist in Rockville, MD.

Studies Show Cost-Effectiveness Of Vehicle Wrap Mass Marketing

Whether you’re trying to boost your general brand recognition or get the word out about specific sales or events, custom vehicle wraps offer unparalleled mass marketing performance. But don’t take our word for it—the cost-effectiveness of vehicle wrap marketing is borne out by several studies, including:

A Media Asset-Value Comparison conducted by 3M manufacturers, which calculated the average vehicle     wraps’ cost per mile (CPM) at only $0.48, making vehicle wraps advertising nearly 50-times more cost-effective than television commercials.

A new study by the Journal of Community Theory and Research, which found that vehicle wraps were “regularly” spotted by 56% of daily commuters, and “always” noticed by another 38.6% of respondents.

A survey by the Journal of Scientific & Engineering Research, which estimated that the average vehicle wrap generated “over 100 thousand views per month” when traveling outside of metropolitan areas.

Increase Your Targeted Marketing Returns With Custom Vehicle Wraps

Vehicle wraps aren’t just for mass-marketing; they’re also one of the most cost-effective targeted marketing tools out there.

“Fleet graphics offer a great deal of targeting flexibility,” write 3M researchers in a new vehicle wrap report . “You can select routes and messages to target specific demographic groups, and GPS technology can help optimize your routes and provide information.”

For example, you might adopt any of the following targeted marketing tactics with your new vehicle wraps:

Drive your custom vehicle wraps past Strayer University or Montgomery College to target postsecondary students and budding professionals

Drive your custom vehicle wraps past the Rockville Senior Center during an outdoor event to get your message in front of aging Baby Boomers and other members of the 65+ demographic

Drive your custom vehicle wraps through the Rockville Business District to target business professionals

Drive your custom vehicle wraps through Rockville’s industrial districts to boost B2B sales

Park your custom vehicle wraps at a local sporting event to target specific sports fans and athletes

If you need more help with targeted marketing ideas or how to design your vehicle wraps to appeal to specific demographics, get in touch with our team.

Free Quote On Custom Vehicle Wraps In Rockville, MD

Rockville Sign Company is a leading provider of custom vehicle wrap solutions for small businesses, national brands, and private buyers throughout Rockville, MD and all the surrounding communities, including:

Gaithersburg

Germantown

Potomac

Aspen Hill

North Bethesda

Rollins Park

Twinbrook, and beyond

To start your free vehicle wrap consultation, call (240)-246-7423 or request a quote online by filling out our short contact form.

[breakinglivenewsheadlines]

Jabra enhances its professional lineup with Evolve2 TWS earbuds

Jabra on Tuesday launched a new professional range of TWS earbuds Evolve2 for hybrid work style. The in-ear earbuds comes with certified virtual meeting apps including Microsoft Teams and Zoom support.

The Danish audio brand also unveiled hosts of other hybrid working solutions such as PanaCast 50, PanaCast 20, Evolve2 85, Evolve2 75, Speak 750.

The Evolve2 Buds come with an adjustable Active Noise Cancellation (ANC) which can be personalised. The Evolve2 Buds also come with a sealing test feature called MyFit, as well as SafeTone with PeakStop, for enhanced hearing protection and the optimal seal for good ANC experience.

Evolve2 buds claims high-quality conversations with Jabra MultiSensor Voice. It uses a combination of four microphones, bone conduction sensors, and algorithms to block out the surrounding noise so the user can be heard clearly.

The Evolve2 has the range up to 20 meters, claims 5 hours of talk time and a total of 33 hours including the charging case. It can be connected to two devices simultaneously. The Evolve2 buds will retail at ₹39,122 by the end of November 22.

“Employees have settled into the flexibility and freedom that comes with Hybrid working and expect things to be much more pliable than they were pre-pandemic. With all that in mind, we are happy to launch our newest offering Jabra Evolve2 Buds that is aesthetically suited for working professionals on the go,” said Peter Jayaseelan, VP & MD, South Asia and Head, Public Sector (APAC), Jabra.

Source

[cannabisbusinessexecutive]

Cannabis Trade Federation Announces Full Board, Readies Inclusive Membership Options

Cannabis Trade Federation Announces Full Board, Readies Inclusive Membership Options

What started with the formation of the New Federalism Fund back in March of 2017, has taken on increasing momentum as the Cannabis Trade Federation (CTF) has clearly emerged as the professional “Voice of the Cannabis Industry”. After many months of building a formidable team to represent the Cannabis Industry’s interests at the federal level on Capitol Hill, CTF, which was founded on 4/20/2018…

[ghdjhdfhgkdmoved]

Henrik!! Or Marvin!!

favorite thing about them - he's so GOOFY and DUMB and i LOVE HIM. also he's a bastard doctor and apparently my favorite type of character is bastard doctor

least favorite thing about them - how do you expect me of all people to say anything negative about dr henrik von schneeplestein md phd mvp ffs

favorite line - "CANNOT PUT LUNG IN ASS" or "when the doctor is here, death is near"

brOTP - him nd chase!! or him nd jack. they're all best buds nd i love them

OTP - once again, him nd marv. i love those two so much u guys have no idea

nOTP - nnone

random headcanon - he is uhhhhhh. definitely on the run from the police. for committing crimes such as Murder, Tax Fraud, and Identity Fraud. someone stop this man

unpopular opinion - everyone portrays henrik as super serious nd that concerns me greatly. henrik is the goofiest man alive i will not tolerate such blatant lies

song i associate with them - both "cotard's solution" and "dr sunshine is dead" by will wood remind me of him!!! they r good songs go listen to them Now

favorite picture of them

himb...................

[smvdu]

National Engineer’s Day 2022 Celebrated at SMVDU

 The National Engineer’s Day 2022 was celebrated by Faculty of Engineering at SMVD University, while paying tribute to Civil Engineer, Bharat Ratan, Sir Mokshagundam Visvesvaraya (1861-1962). Dr. Balbir Singh, Program Coordinator, welcomed dignitaries and participants and briefed them about the event.Chief Guest, VC, SMVDU, Prof. R. K. Sinha threw light on the importance of Engineers in our life in providing sustainable solutions. Guest of Honour, Dr. Shiva S., IIT Jammu, delivered a talk on various technologies such as 3D printing, digital twins, IoT, etc.  Further, Guest of Honour from Industry Mr. Karanveer Singh Gujral, MD, T.V. Super Filter Industries, Jammu talked about the importance of Engineers in progressive performance and various national awards earned by company.  Students presented ‘Smart Engineering for Better World’ under the guidance of Dr. Ankush Raina, wherein 1st, 2nd and 3rd prize won by students  Mr. Hriday Vasudeva (B.Tech. ME, SMVDU), Mr. Karanvir Singh (B.Tech. University of Buffalo, NY, USA), Mr. Prince Kumar shared with Mr. Saurabh Kumar (B.Tech. ECE) respectively. Other dignitaries from SMVDU including  Dr. Ajay Kaul, Dean, Faculty of Engineering, Prof. Eswaramoorty Muthuswamy, Head, School of Mechanical Engineering, Dr. Manish Sabraj, Head, School of Electronics and Communication congratulated budding engineers and spoke on Engineer's Day. Dr. Balbir Singh highlighted about the new Professional club from School of Mechanical on Automation and Emerging Technology (SMVDU AET Club) which was inaugurated by Chief Guest on the occasion. The vote of Thanks was delivered by Program Secretary, Dr. Mir Irfan Ul Haq, Assistant Professor from School of Mechanical Engineering, SMVDU. 

[theverdegroupcom]

Window Replacement Oliver, Baltimore, MD

4 Easy Facts About Best Door Replacement Berea, Baltimore Md Described

If you're aiming to update your home's entranceway with a solid storm door, our tornado doors can be found in a selection of designs and also shades. They are designed to give the appearance, ventilation, and all-natural light you deserve. Our specialists will aid you pick the right choice for your residence and also deal with the procedure from beginning to end up.

We provide full replacement door solutions, as well as our professionals will certainly aid you obtain the best door for your home. Call us online to obtain started or obtain a totally free price quote for your home (top berea, baltimore md door replacement).

The Ultimate Guide To Door Replacement Berea, Baltimore Md

In the average house, virtually 10% to 25% of warm gets away from old doors and windows. This can cause energy costs to increase while likewise making your residence uncomfortable during the wintertime. The ideal method to battle this loss is by purchasing substitute doors and home windows.

Old windows and doors are susceptible to having spaces as well as splits that water can permeate right into and damage the inside of your residence. If water is permitted to continue obtaining in, in time you might start seeing harmful mold growth or rot. If a wall is harmed sufficient, it might require substantial repair in order to fix it totally.

Getting My Door Replacement Berea, Baltimore Md To Work

From tiny insects to rodents, you can be accidentally giving them a simple means in when you fail to change your old home windows and also doors. Substitute windows as well as doors nip these troubles in the bud as well as guarantee that no water or pests can get in as well as no energy can get away.

Setting up brand-new replacement home windows can include worth to your residence in a range of methods. Obviously, they can enhance the total visual allure of your outside. Plus, if your existing windows are obsoleted, they may also conserve you money in the lengthy term. Here are 3 advantages that brand-new replacement home windows can use your home.

What Does Berea, Baltimore Md Door Replacement Do?

New technology, coupled with enhanced production techniques, has led to even more innovative products that can protect your home better than ever before. Most importantly, much better insulation implies costs less cash on warmth and also a/c. 2. Curb Allure It must come as not a surprise that the best-looking residences command the highest possible rates on the actual estate market.

Given that windows are just one of the most visible elements of every home, they additionally play a famous duty in determining the curb charm of every home. . Maintenance Amongst property owners who make a decision to invest in replacement home windows, plastic is the most popular product. That's due to the fact that plastic windows are both budget friendly and inconvenience cost-free, needing little to no upkeep.

The Ultimate Guide To Berea, Baltimore Md Door Replacement

Replacing your home windows is among the ideal financial investments you can make in your home - best door replacement berea, baltimore md. While they may not always be the initial thing you think of when you are aiming to make enhancements to your house, they can supply your residence with a significant roi. Below, we will be discussing the various advantages you can get from buying home window glass replacements.

While all-natural light is something that everyone yearns for in their home, having also much sunlight entering your house can be hazardous to every person in it, and it can cause issues with your floorings, furnishings, and also much more. Ultraviolet rays can create fading of your costly carpets, furnishings, and much more. Due to this, you desire to be positive concerning decreasing the too much exposure of these rays

What Does Berea, Baltimore Md Door Replacement Do?

Basically it functions as highly efficient sun block for your windows. One more benefit that you are mosting likely to be able to obtain from making an investment in replacement glass for your windows would certainly be the capacity to accomplish enhanced privacy. With a financial investment in glass block home windows, you will certainly be able to include additional privacy and also safety to your home. We will make certain to give you with the best solution for your needs.

Unknown Facts About Best Door Replacement Berea, Baltimore Md

No matter just how pricey a door is, you may not take pleasure in all its advantages if it is installed inaccurately. Read on to find out why you should work with an expert for household door substitute.

That's since the cool air in your living room will continually get away in the direction of the outdoors, making your cooling and heating system work harder. For this factor, it's necessary to change your door if you always feel cold drafts whenever you are close to it. Having a professional lug out the installation guarantees that the door fits perfectly.

4 Simple Techniques For Best Door Replacement Berea, Baltimore Md

While all-natural light is something that everybody longs for in their house, having excessive sunlight entering your house can be harmful to every person in it, as well as it can trigger troubles with your floors, furniture, and much more. Ultraviolet rays can create fading of your expensive rugs, furnishings, and a lot more. As a result of this, you wish to be positive concerning decreasing the overexposure of these rays.

Essentially it functions as highly reliable sun block for your windows. Another benefit that you are going to have the ability to get from making an investment in replacement glass for your home windows would certainly be the ability to attain improved privacy. With a financial investment in glass block home windows, you will certainly be able to include added privacy and safety and security to your house.

See This Report on Best Door Replacement Berea, Baltimore Md

We will be certain to supply you with the best solution for your requirements. Keep in mind that it's just an expert that should set up, repair, or change a door. Regardless of just how expensive a door is, you may not enjoy all its advantages if it is set up improperly. Keep reading to find out why you must collaborate with a professional for domestic door substitute. As a prudent property owner, insulation is a facet that you shouldn't disregard.

Some Ideas on Best Door Replacement Berea, Baltimore Md You Need To Know

That's due to the fact that the air-conditioned air in your home will constantly run away in the direction of the outside, making your heating and cooling system job harder. Therefore, it's crucial to replace your door if you constantly really feel cold drafts whenever you are close to it. Having a specialist accomplish the installation ensures that the door fits perfectly.

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[sayantandodo]

Where you can meet co-founders and CEO’s who may help you to build new career plans!

SkillPal is the best platform where you can meet co-founders and CEO’s. It is the best beneficial stage where a person meets his or her dream expert to reach the goal. There are many Mentors who provide knowledge and suggestions to the mentees on the stage of SkillPal, I am giving a little description of where you can get some ideas.

Avelo Roy is a Serial Tech Entrepreneur, Keynote Speaker, and Investor who started his first startup at the age of 19 that became valued at multi-million dollars by the time he was 22. He currently is the MD of Kolkata Ventures (Kolkata), Director, ECC Engineering Pvt. Ltd (Kolkata), and has been an advisor for multiple organizations like Amity University Online, Comedy Munch (New Delhi) etc.

Rajnish Pandey a senior L & D professional with vast experience of more than 20+ years in the learning and skill development arena. He's also a Certified & Empanelled Trainer for many reputed Corporate & Banking Companies like HDFC Bank, ICICI Bank, Axis Bank, Asian Paints, Hindustan Petroleum, Tata Youth Development Program.

Sanjeev Dawar has over 30 years of experience in working in the finance field with companies Like Tata Group. Using his experience and expertise, he is now a full-time consultant for people who are trying to make their personal financing better.

Vagisha Arora: Vagisha is a full-time freelance content writer and marketer who helps startups and businesses to enhance their online visibility through user-friendly, interactive, engaging blog posts and articles. She has been featured on publications like Hackernoon, Thrive Global, Medium, BBN Times, etc. She has also been associated with renowned brands like HT, Bonobology, Shiksha, Myntra, Amazon, etc. She is also the editor of The Growth Hacking Book 2.

Krisha Lal: Krisha mentors early-stage startups and new professionals on product design and development. She has 6+ years of industry experience and 5+ years of experience in startups (including a Y Combinator startup). She is passionate about building user-centric product experiences and currently works at Google.

Mayur Chettri: Mayur, better known as "sir.creative" among his 20K+ Instagram followers is loved for his amazing design skills and creative takes on what's happening around the world. Mayur also runs his own design agency.

Choosing a mentor is not easy. But it is easy if you go through SkillPal. Here you can get the most important feedback of your work and knowledge. They are the most important pal of your skills. A mentor is someone whose life or work you value and admire, and who you think might be a good guide. These days, a mentor can be any age, in any field, so we encourage you not to think of a mentor in traditional terms. Too often we limit our mentors to those in more senior positions. Don’t let a person’s age, title, or experience pigeonhole your thinking.

Suppose somebody needs guidance regarding his or her plan, where should they go! To a mentor of course. Everybody needs to make a good relationship with his or her mentor. A mentor can show a young guy the right choice. A right decision needs to come from the right person at the right time. Most of the time the young members make mistakes and therefore time and money everything gets wasted. So, a mentor’s perception is very important in every category. If you are searching for a mentor SkillPal is the best way. Effective mentoring requires more than common sense. Research indicates that mentors and mentees who develop and manage successful mentoring partnerships demonstrate a number of specific, identifiable skills that enable learning and change to take place.

Actually, SkillPal is the only mentorship platform where you can find a specific solution for your business and yourself. Having a mentor relationship is often a dream come true. A mentor is a teacher, a trusted advisor that a budding entrepreneur can turn to with questions and get valuable advice, tailored directly to their industry and specific business situation. But, how do you actually go about finding a mentor? While sometimes the relationship forms organically, it’s too much to hope that the perfect mentor will simply drop into your lap.

[frankkjonestx]

A glowing zebrafish wins the 2020 Nikon Small World photography contest

While seeking answers to scientific questions, it’s worth sometimes taking a step back to appreciate the world’s exquisiteness.

For developmental biologists Daniel Castranova, Bakary Samasa and Brant Weinstein, some of that delicate beauty is inside a zebrafish. While working in Weinstein’s lab at the National Institutes of Health in Bethesda, Md., Castranova and Samasa snapped a stunning photograph of a young zebrafish, illuminating never-before-seen parts of its lymphatic system.

The photo comes from research that sought to determine whether zebrafish have lymphatic vessels inside their skulls. The lymphatic system helps clear toxins and waste from the body, and previously researchers thought only mammals had such structures close to the brain.

But zebrafish have those vessels too, Castranova and colleagues report in preliminary research posted in May at bioRxiv.org. The team used fish that had been genetically modified to have lymphatic vessels that fluoresce orange under certain conditions, with skeletons and scales that glow blue. Because fish are easier than mammals to raise and image in the lab, Castranova says, the finding could help scientists more easily study the role of the brain’s lymphatic system in neurological diseases like brain cancer or Alzheimer’s.

After taking the photo — a composite of 350 images taken with a confocal microscope — on a busy work day, “I never even looked at the picture for a couple of weeks,” Castranova says. “And then when I looked at it at some point post-data processing, I was like ‘Wow.’”

Even if it took Castranova a bit to appreciate what he had in hand, judges for the 2020 Nikon Small World photomicroscopy competition realized that it was a winner. The photo snagged first place in the 46th annual contest.  The results were announced October 13.

Here are some our favorite photographs from this year’s competition.

Inside a clownfish egg

A developing clownfish (Amphiprion percula) embryo won second place in the contest. The series of photos documents the embryo’s growth (from left to right) on day one, morning and evening of day three, day five and day nine.Daniel Knop/Natur und Tier-Verlag NTV

Over nine days, German photographer Daniel Knop watched an embryo grow from a striking golden yolk sac into a baby clownfish (Amphiprion percula) to produce this second place–winning photo.

The composite image, created by stacking together multiple photos that had been taken while the embryo was in motion, documents stages of the embryo’s development from left to right. The first snapshot shows the newly growing fish hours after fertilization, with a cluster of extra sperm cells (white splotch) still on the outside of the first egg (clear bubble) on the left. The subsequent images depict the fish twice on the third day of development (morning and evening), as well as the fifth and ninth days, hours before the fish hatched.

Tongue of a snail

This colorful depiction of part of a snail’s tongue, at 40 times magnification, shows its structure in three dimensions. Sections colored blue are farthest from the viewer and those colored hot pink are closest. The image placed third in the competition.Igor Siwanowicz/HHMI

When neurobiologist Igor Siwanowicz’s lab mate’s aquarium was taken over by freshwater snails, Siwanowicz decided to snap a photo of part of one snail’s tongue, earning him third place in the competition.

The appendage, magnified 40 times, was photographed in layers with a laser to reconstruct the tongue in three dimensions. The pieces closest to the viewer are colored hot pink; the farthest bits are blue. The tongue’s comblike projections scrape algae off of surfaces for food.

“I chose this image to show that in nature, beauty can be found in the most unexpected places, like a snail’s mouth,” says Siwanowicz, of the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Va., and second-place winner in the 2019 contest (SN: 10/21/19).

Lab-grown hairs

Shown at 20 times magnification, this skin organoid (colored blue) sports human hair follicles (stubby projections) and nerves (red). The image earned an honorable mention.Karl Koehler and Jiyoon Lee/Boston Children’s Hospital & Harvard Medical School

Neuroscientist Karl Koehler and biochemist Jiyoon Lee, both of Boston Children’s Hospital and Harvard Medical School, captured this image of human hair follicles (stubby blue-colored projections) budding off of a cluster of lab-grown skin cells, broadly called an organoid, in a lab dish. Other types of organoids exist for various parts of the body, such as the gut and brain.  

It takes about four to five months for a skin organoid to grow in the lab. The structures develop nerves (red) that connect specialized cells in hair follicles, much like the neural circuit system that allows us to feel touch, and could one day help develop better skin grafts. This lab-grown skin develops inside-out, Koehler says. So the surface that grows hair is inside the clump of cells, and viewers see the base of hair follicles. The team published their findings June 3 in Nature.

Majestic moss

Moss capsules, like the one pictured here at 10 times magnification and shown in false-color, release hundreds of thousands of spores that are carried by the wind to new parts of the forest to grow. The photo is an Image of Distinction in this year’s Nikon Small World photo contest.Miroslav Žít

Miroslav Žít, an amateur photographer from Prachatice in the Czech Republic, snapped this photo of a stunning moss capsule packed with spores almost ready to take flight. Capsules perch on top of stems that extend from blankets of moss.

The spores ride the wind once released, sometimes traveling long distances and staying dormant until conditions are right for growth.

Viral infection

This mouse paw has been infected with the Chikungunya virus (colored pink), a pathogen that causes painful inflammation of the joints. The rodent’s immune response to the virus, in the form of immune cells called microphages, is shown in blue and general tissue is colored orange. The image won an honorable mention.Jonard Corpuz Valdoz, Pam Van Ry and Richard Robison/Brigham Young Univ.

Researchers at Brigham Young University in Provo, Utah combined more than 2,200 photos taken with a confocal microscope to create this vivid shot of a 1-centimeter-long mouse paw infected with the Chikungunya virus.

Chikungunya is a disease that can result in debilitating joint pain. Biochemists Jonard Corpuz Valdoz and Pam Van Ry teamed up with microbiologist Richard Robison to take a peek at how a mouse responds to the infection, in the hopes of shedding light on how the virus spreads in animals, including humans. Immune cells called macrophages (colored blue) rush to the paw to fight the virus (pink), amid a background of general tissue (orange).

Baby bat

This image of a Seba’s short-tailed fruit bat embryo (Carollia perspicillata) was artificially colored to show its skeleton in green and cartilage in orange; it placed 20th in the photo competition.Dorit Hockman/ Univ. of Cape Town, , Vanessa Chong-Morrison/UCL

While participating in an embryology course at the Marine Biological Laboratory in Woods Hole, Mass., Vanessa Chong-Morrison, a developmental biologist then at the University of Oxford, prepared this image of a Seba’s short-tailed fruit bat (Carollia perspicillata) embryo for picture day.

Chong-Morrison, now at University College London, and Dorit Hockman of the University of Cape Town in South Africa took snapshots of the developing bat’s skeleton, capturing small areas at a time. Hockman is also a developmental biologist who studies how bat hands grow into “impressive wings.” The pair then stitched together the images to produce the final photo, which was edited to show the bat’s bones in green and cartilage in orange.   

A work of amino acid art

When in a warm solution of ethanol and water, amino acids L-glutamine and beta-alanine form crystals, photographed here in a 13th place–winning photo at four times magnification.Justin Zoll/Justin Zoll Photography

No, this photo isn’t an abstract painting. It’s a portrait of the crystals that form after two amino acids — L-glutamine and beta-alanine — are heated in a solution made of ethanol and water. One of the compounds, L-glutamine, is a building block for proteins and ensures that the immune system can function. The other, beta-alanine, helps with muscle endurance.

Justin Zoll, a photographer based in Ithaca, N.Y., merged multiple images of crystals taken at four times their normal size into a panorama to show the crystals’ intricate details in a wider field of view. When the crystals interact with a multiple beams of polarized light, the arrangement of their molecules reflects stunning colors, he says.

from Tips By Frank https://www.sciencenews.org/article/2020-nikon-small-world-photo-contest-glowing-zebrafish-wins

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Reference Manuals May Be Facing Obsolescence

We must ensure their relevance to contemporary patient care

By LONNY REISMAN, MD

It’s 1992 and disruptive technologies of the day are making headlines: AT&T releases the first color videophone; scientists start accessing the World Wide Web; Apple launches the PowerBook Duo.

In healthcare, with less fanfare, a Harvard physician named Dr. Burton “Bud” Rose converts his entire nephrology textbook onto a floppy disk, launching the clinical tool that would ultimately become UpToDate. Instead of flipping through voluminous medical reference texts, such as the Washington Manual, doctors could for the first time input keywords to find the clinical guidance they needed to make better treatment decisions.

The medical community embraced UpToDate’s unique ability to put knowledge at their fingertips. Today more than 1.7 million clinicians around the world use UpToDate to provide evidence-based patient care with confidence. For many, it along with other reference sources has become foundational to providing high quality medical care.

More than just an easy-to-use reference, UpToDate has gone on to improve patient outcomes, according to the Journal of Hospital Medicine.

In the new era of 21st century digital medicine, however, there are opportunities to go further in support of clinicians and patients. Reference tools must be powered by predictive and prescriptive analytics, be personalized to individual patient circumstances, and be integrated into clinician workflow. In some cases, clinicians may be unaware of which questions to ask of a computerized reference manual, or how to incorporate the nuances of an individual patient’s case into the general insights of a reference. Searching for heart failure treatment, for example, may be too broad a query and the resulting recommendations therefore may not provide optimal care for a specific patient’s unique medical circumstances. New digital health solutions that consider patients’ co-illnesses, contraindications, symptomatology, current treatment regimens, and hereditary risks are essential.

Additionally, the pace of change in medical science continues to accelerate, and with it, the proliferation of life-saving treatments and diagnosis. When I enrolled in med school in the 1970s, medical knowledge was doubling every seven years; now it’s closer to every two months. That makes it virtually impossible for clinicians to truly be informed regarding the latest studies and guidelines – therefore making it ever more challenging to effectively query medical reference materials.

This heightened pace of evidentiary change has exacerbated the historically slow diffusion of new medical knowledge into general practice, to the detriment of patients. As a member of the American College of Cardiology’s Science and Quality Committee, I spend countless hours each year reviewing the guidelines for cardiac care, knowing full well that it will be years before these new evidentiary approaches become adopted into mainstream practice.

We need 21st century solutions to support increasingly complex medical care. Just as we made the leap from paper to floppy disks to apps, we must now take advantage of recent developments in clinical AI to make another leap: this time to a dynamic and proactive approach to applying medical guidelines to individual patients.

Here’s how clinicians can bring the reference manual truly “UpToDate” for our modern medical times:

1. Personalize for Every Patient

Historically, clinical decision support tools have been used for universal, population level alerts or gaps in care based on simplistic quality measures that apply to all patients…smoking cessation, healthy diets, and exercise. With the advances in AI, nuanced medical guidelines can now follow each patient.

For example, clinical AI tools now exist that can interrogate a variety of patient data – such as electronic health records (EHRs), insurance claims, and patient-generated data – and drill down into clinical, genomic, social and behavioral factors to align patient care with the individualized guideline-directed treatment. This individualized approach ensures each patient receives optimal diagnostic and therapeutic care that is designed to improve outcomes.

2. Dynamically  and Proactively Deliver within Clinical Workflow

Today, most clinicians live their daily lives toggling between their EHR, reference apps like UpToDate and a myriad of other portals. Have a question about the best treatment for your patient with atrial fibrillation and a high bleeding risk? Open a reference app and you will find a multitude of articles to read which may not provide all pertinent information. For example, you may not know to search for “non-pharmacologic treatment” to find information on Left Atrial Appendage Closure (LAAC) device alternatives for a particular patient who is unsuitable for long-term oral anticoagulation. A clinician cannot know to query what they don’t know exists as an alternative for a patient.

Clinical AI tools can proactively deliver these patient-specific recommendations based on the latest medical guidelines directly within a clinician’s workflow, thereby eliminating the need to go searching for the optimal treatment for patients with complex medical needs.

 3. Apply the Guidelines for On-Demand Care

Clinical decision support tools have largely been limited to use at the point of visit, but traditionally offer little insight into recommended patient care outside the four walls of an office visit. Today’s technology can continually analyze new patient data, identify rising health risks,  and promote opportunities to provide optimal care. When lab results, new medications, EHR orders, or third-party data from wearable devices indicate an alteration in patient health status that warrants consideration of a guideline-directed diagnostic or treatment intervention, new guidance can be proactively sent to the clinician and patient – driving purposeful virtual or in-person engagement.

Digitized reference materials have come a long way, but clinicians and health systems today must evolve these capabilities to continually and efficiently apply the medical guidelines – the bedrock of medicine – for the patients they serve.

Dr. Lonny Reisman is the founder and CEO of HealthReveal, and former chief medical officer of Aetna

The post Reference Manuals May Be Facing Obsolescence appeared first on The Health Care Blog.

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