#FMT

[fictional-malewife-tournament]

Group 4: round 23

[mostlysignssomeportents]

Monopolizing turds

Update 31 May 2023: an earlier edition of this article identified the price of Rebyota as $20,000; this was the rumored price prior to Rebyota’s release in December  2022, when Stephen Skolnick wrote the article I referenced. When Rebyota was actually released in 2023, the average wholesale price (AWP) was $10,800. Thanks to Benjamin Jolley for catching this error, and to Stephen Skolnick for getting to the bottom of it.

It’s been ten years — to the day! — since I first started writing about the bizarre, amazing world of turd transplants, in which a sick person receives a microbiotic infusion in the form of some processed poop from a healthy person:

https://web.archive.org/web/20130608030455/http://blogs.plos.org/publichealth/2013/05/29/why-diy-fecal-transplants-are-a-thing-and-the-fda-is-only-part-of-the-reason/

Gut biomes are one of those understudied, poorly understood medical areas that are both very promising and also full of sketchy medical claims from “supplement” companies, influencers, quacks and grifters. But in the decade since I first started tracking turd transplants (formally called “Fecal Microbiota Transplants” or FMTs), a growing body of sound science has emerged on the subject.

One thing that’s increasingly undeniable is that the composition of your microbial nation is related in significant ways to both your physical and mental health. What’s more, as antibiotic resistant “super bugs” proliferate, FMTs are becoming increasingly central to treating dangerous gut infections that otherwise stand a high chance of killing you.

“Eat Shit and Prosper” is Stephen Skolnick’s delightfully named newsletter about poop and health science. Skolnick is a physicist by training, but has a long history of collaboration with Openbiome, a nonprofit that coordinates between doctors, patients and donors to provide safe FMTs:

https://stephenskolnick.substack.com/

In an edition of Eat Shit from last December, Skolnick recounts the amazing history and dismaying future of FMTs. In 2013, the FDA announced it would regulate FMTs as “Investigational New Drugs,” which could only be administered as part of a registered clinical trial:

https://stephenskolnick.substack.com/p/a-monopoly-on-poop

At that point, FMTs were already in widespread use by docs to treat otherwise untreatable cases of Clostridioides difficile (C. diff), an antibiotic resistant bacterial infection that literally makes you shit yourself to death. These doctors were in no position to run registered clinical trials, which meant that they would have to stop using the most effective therapy they had for a potentially lethal infection.

Doctors and patients kicked up a fuss, and the FDA walked back its guidance, announcing that it would exercise “discretion” in enforcing its Investigational New Drug rule, giving a pass to docs who were treating C. diff with FMTs:

https://www.federalregister.gov/documents/2013/07/18/2013-17223/guidance-for-industry-enforcement-policy-regarding-investigational-new-drug-requirements-for-use-of

That’s where things have stood for the past decade or so. The “discretion” rule means that patients could still get FMTs, but their insurance wouldn’t cover it. But even if you had cash to pay for an FMT, your doc probably wouldn’t administer it for anything except a C. diff infection, despite the promising signs that FMT can help treat other conditions, and despite the generally safe nature of FMTs.

If your doc did give you an FMT, chances are good that they sourced their poop from Openbiome. Openbiome recruits very healthy people, gets them to poop in a bag, then processes the poop — removing nonbacterial solids, testing it for pathogens, freezing it, portioning it, and sending it to docs. All this is done at cost, and it’s not cheap: $1–2k/treatment, mostly due to cold-chain logistics (the poop is shipped at -80C).

Despite the cost, and despite the limitations on treatment, the Openbiome method has proved very reliable. Indeed, FMTs as a whole are pretty darned safe, with the most common side-effects being transient gas and bloating. In the past decade, there’ve been a total of six “adverse effects” associated with Openbiome’s 5,000+ procedures, all in severely immunocompromised people, and none conclusively linked to the treatment:

https://www.sciencedirect.com/science/article/pii/S0016508522003511/pdf

A decade into this system, the FDA has taken the next step forward — only it’s actually a step backwards.

During this intervening decade, a pharma company called Ferring has conducted clinical trials on FMTs and received approval for an FMT product called Rebyota. The process for making Rebyota is effectively identical to the process used by Openbiome: collect poop, remove solids, test for pathogens, add glycerol, freeze and ship.

The main difference between Rebyota and Openbiome’s poop is price. While Openbiome charges $1–2k per treatment, Rebyota charges $10,800

That’s some expensive shit!

Fine. Getting Rebyota through clinical trials means that insurers might start covering it, and perhaps some patients will prefer brand-name poop to open-source poop. But as part of the FDA’s approval of Rebyota, the agency also rescinded its “discretionary enforcement” guidance, making it illegal for docs to source their poop from Openbiome:

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/enforcement-policy-regarding-investigational-new-drug-requirements-use-fecal-microbiota

For Ferring, this is a monopoly on shit, one that lets them charge patients $10.8k for poop that costs $1–2k to process. The FDA does not claim that this is being done in the name of safety. Instead, an FDA official told Skonick that the goal was to “incentivize innovation without creating an access crisis.”

That is, the FDA changed its guidance and put nonprofit stool banks out of business because it wants to incentivize pharma companies to perform expensive clinical trials, and it believes that these companies won’t pay for trials if they have to compete with the likes of Openbiome, which would make it impossible to charge 900% markups on poop.

Trials are important! Evidence-based medicine is important! But Ferring’s clinical trials didn’t tell us anything we didn’t already know. FMTs were already the best therapy we had for C. diff. Testing Rebyota against a placebo didn’t tell us anything new — unlike testing Rebyota against the existing therapies, e.g. product from open stool banks.

Such a trial might have given rise to a very different regulatory outcome, because the cure rate reported by Rebyota is much lower than the cure rate from Openbiome’s own interventions:

https://link.springer.com/article/10.1007/s40265-022-01797-x

That is, using the $1k poop from Openbiome seems to be much more effective than using the $10.8k poop from Ferring. But Openbiome, a nonprofit, hasn’t been able to perform the kind of rigorous — and expensive — clinical trial that Ferring funded.

This points to a significant problem with the FDA’s model. The agency wants good clinical data for the medicines it regulates, as it should, It presumes that the only way to get that data is through granting commercial exclusivity to a for-profit, which ends up costing patients vast sums, and locking many patients out altogether.

This creates all kinds of new dangers. 150,000 people/year in the US contract Recurrent Clostridium difficile Infection (RCdI). FMT increases the cure rate by 20% relative to antibiotics alone. That means that if everyone with RCdI gets a poop transplant, 30,000 extra people will get better. That’s a big number!

For well insured people, Rebyota probably represents a cash-savings — if your insurance covers the $10,800 procedure, you might pay $500 out of pocket, which is far less than the $1–2K you’d pay to get an Openbiome poop transplant. But if you’re uninsured or underinsured, the FDA’s new enforcement rules mean that you’re now on the hook for $10,800.

The FDA did carve out a loophole: if your doc or their hospital are willing to prepare the poop transplant themselves, they can administer that. On the one hand, preparing a poop transplant isn’t that hard — some people do them at home, on their own:

https://web.archive.org/web/20211015060558/https://thepowerofpoop.com/epatients/fecal-transplant-instructions/

But on the other hand, there’s been exactly one death conclusively linked to FMT, and it was from one of these hospital-prepared transplants (the patient had just had a marrow transplant for cancer that wiped out their immune system, and the donor had a novel pathogen that the hospital failed to test for).

So the FDA has created a situation where, if you can’t afford a $10,800 proprietary formulation, your only option is to convince your doc or hospital to prepare their own poop transplant, which will cost less than the $10.8k for Rebyota, but more than the $1–2k from Openbiome, which has all kinds of economies of scale. And if you do manage it, you’ll be getting a procedure that has a much worse safety track-record than the Openbiome process that the FDA just killed.

The FDA has an important role to play here, but as with so many policy questions, how the FDA plays that role depends on things that are far upstream from the agency and its decisions. The choice to fund medical trials through the promise of exclusivity — and with it, extremely high margins — puts the FDA in the position of choosing winners in the marketplace: Ferring wins, Openbiome loses.

Ironically, this is the thing that exclusivity is supposed to prevent. By using profit to incentivize medical research, the FDA is supposed to be recruiting the Invisible Hand as its partner in regulation. But exclusivity is incompatible with the idea of medicine as a public good. The tens (hundreds) of millions that Americans will pay for $10.8k poop transplants from Ferring will add up to far more than it would cost to underwrite clinical trials for an open process like Openbiome’s.

The result: both Americans’ wallets and Americans’ guts suffer.

Catch me on tour with Red Team Blues in Hay-on-Wye, Oxford, Manchester, Nottingham, London, and Berlin!

If you’d like an essay-formatted version of this post to read or share, here’s a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/05/29/oh-shit/#rebyota

[Image ID: A poop emoji wearing a top hat and a monocle, posed against a backdrop of e coli bacteria seen through a high-resolution microscope.]

[poppysmc]

Forget me too

PART III.a

“Morgan- This is … my daughter, Elizabeth” Poppy’s voice shakes, unsure of the situation. This was not at all how she wanted Morgan to know she has a daughter. Morgan stiffened and looked blankly at her, she had an idea but the confirmation still threw her off.

“You- your daughter…” Morgan trailed off, her gaze fixed on the little girl. Elizabeth looked curiously up at her. Morgan can’t help but smile. “She looks just like you.” Morgan said softly.

"You can call me Lizzy too. I'm five and a half! I want to be a palea-paleontologist when I grow up.”  The girl's face lit up with excitement as she proudly pronounced the words correctly. She looked up to her mother for reassurance. Poppy nodded and smiled softly, Poppy lovingly ran her fingers through her daughter's hair. Morgan watched the soft exchange.

“Hi Lizzy. It’s nice to meet a fellow dinosaur lover.” Morgan shifts her attention back to Lizzy, her smile soft and genuine. Poppy was taken aback by the sight, feeling a twinge of nostalgia as she witnessed Morgan's smile once again, even if it wasn't directed at her. The warmth emanating from Morgan's expression almost took her breath away.

"You look a lot like your Mom," Morgan complimented, still amazed at how much the little girl resembled the woman standing before her. “How rude of me, my name is Morgan.” Morgan smiled as she introduced herself.

"You're Mommy's friend! She's always talking about you." Lizzy's excitement was obvious as she jumped up and wrapped her arms around one of Morgan's legs. Morgan chuckled warmly and patted the little girl’s head, feeling a rush of affection for the adorable little girl.

"Is she?" Morgan

"Liz, why don't we take a seat? Let's not bother..." Poppy began, smiling apologetically at Morgan as she attempted to gently pry Lizzy away. But Lizzy was determined to stay with her “Aunty Morgan."

"I want to sit with Aunty Morgan," Lizzy said shyly, seeking permission from Morgan. Her eyes held a pleading look, and Morgan found herself unable to resist. She had a soft spot for blondes, and Lizzy's charm was hard to resist.

Morgan looked at Poppy stoically, a mile away from the warmth she’d shown her daughter. "It's alright. I don't mind at all," she said, welcoming Lizzy's company. Morgan couldn't help but feel grateful for the unexpected joy that Lizzy brought her.

"It's okay, I still haven't ordered yet. Why don't we find somewhere to sit?" Morgan's warm smile invited both Lizzy and Poppy to join her. Morgan held Lizzy's hand as the little girl giggled, excitedly babbling about everything she could think of. Poppy remained momentarily frozen, her heart conflicted by the emotions that surged within her. Oh, how she wished the scene was how she imagined it, wished the scene meant different things, how good Morgan was with her daughter. How she could have been-

Both Morgan and Lizzy turned to her at once, their expressions similar and curious as to why she wasn't following. Lizzy eagerly spoke up, interrupting Poppy's thoughts. "Mom, let's go!" she exclaimed, reminding her mother to join them.

Snap out of it, Poppy. She chided herself for getting lost in her thoughts. With a smile, she walked over to them, her heart filled with affection for both her daughter and her… Morgan. For a moment Poppy could almost believe that the three of them were a family like she had always dreamt.

"What do you guys want?" Morgan asked, taking Lizzy's order first and then Poppy's. As Poppy moved to stand and go with her to the counter, Morgan's expression turned sour, unnoticed by Lizzy, it made Poppy stop, her hand hovering over her purse. For a moment she had forgotten that she and Morgan had drifted apart.

Poppy glanced at Morgan as she came back to the table, but she quickly looked aside, as if engrossed in her own thoughts. Morgan made an effort to suppress her feelings, her feelings for Poppy were far more complex than she cared to admit.

[rusty25]

Today I've been called "young man" by two different people whom I don't know. One of them was a little girl, a middle schooler and the other was a middle-aged man who sold me my new belt.

Today I did not correct them.

Today I did not say "actually I'm a girl".

Today my heart didn't sink with a painful thud when I heard them refer to me this way. Sweat didn't start dripping down my back, my muscles did not tighten, my mind did not start racing at 1000 mph. I was smiling.

I had been called "young man" before. Countless times growing up, in fact. So I could say I'm used to it.

But I won't say that.

Because today, today it felt different.

It felt like putting on a pair of shoes that I'm finally big enough for. And they fit.

I got there.

[0l0x]

Been feeling like garbage this last week or so. GI issues, extreme fatigue, just generally feeling ill and unable to leave my bed much. Since I'm a cdiff carrier and I did take 2 rounds of antibiotics a few weeks ago, I went ahead and did another FMT today to be safe.

No appetite all week, but within 2 hours of the transplant I'm starving. I'm always amazed how fast these things start working.

We're at transplant #12 so far!

9/7/2023

[vocativocom]

Hospital de Medicina Tropical do Amazonas à beira do colapso

Com a falta de repasses desde agosto de 2023, a Fundação de Medicina Tropical do Amazonas (FMT-AM) já acumula uma dívida superior a 8 milhões. A falta de recursos financeiros já está afetando a assistência a pacientes com HIV/AIDS e Hepatites Virais

[magazinefood]

Tainted Treats: How to Safeguard Against Food Adulteration

Food adulteration is a pervasive issue that poses a serious threat to public health. As consumers, we trust that the food we purchase is safe and of high quality. However, the reality is that unscrupulous practices of adding inferior or harmful substances to food products persist in various parts of the world. This practice not only compromises the nutritional value of the food but also endangers the well-being of those who consume it. In this article, we will explore the menace of food adulteration and discuss ways to safeguard against it.

Understanding Food Adulteration:

Food adulteration involves the addition of impurities or substandard substances to food products. This can occur at any stage of the food production process, from the farm to the table. Common examples include the addition of water to milk, mixing cheaper oils with more expensive ones, or using unsafe colorings and preservatives. The motivations behind such practices are often financial, as unscrupulous individuals seek to maximize profits at the expense of consumer health.

Types of Food Adulteration:

Addition of Harmful Substances: Some adulterants are not only inferior in quality but can also be harmful to health. For instance, adding non-permitted colors, pesticides, or contaminants can have severe consequences.

Substitution: This involves replacing a portion or the entire food product with a cheaper or inferior substitute. For example, substituting pure spices with colored and flavored powders is a common adulteration practice.

Removal of Nutrients: In some cases, essential nutrients are deliberately removed to extend shelf life or to be used in other products. This impacts the nutritional value of the food, deceiving consumers about the actual benefits of the product.

Effects of Food Adulteration:

The consequences of consuming adulterated food can range from mild illnesses to severe health complications. Short-term effects may include gastrointestinal issues, allergic reactions, or food poisoning. Long-term consumption of adulterated food can lead to chronic health problems, organ damage, and even fatalities in extreme cases.

Safeguarding Against Food Adulteration:

Buy from Reputable Sources:

Choose trusted and established retailers and brands when purchasing food products. Reputable establishments are more likely to adhere to quality standards and undergo regular inspections.

Check Labels and Packaging:

Carefully examine product labels for information on ingredients, nutritional content, and any certifications. Legitimate products typically display this information transparently, allowing consumers to make informed choices.

Be Wary of Unrealistically Low Prices:

While budget-friendly options are attractive, prices that seem too good to be true may indicate a compromise in quality. Be cautious when encountering significantly cheaper versions of commonly expensive items.

Click here to know more : -

Support Local and Organic Products:

Local and organic producers often prioritize quality over quantity. By supporting these sources, consumers can reduce the risk of exposure to adulterated products.

Stay Informed:

Stay updated on food safety regulations and recalls. Government health agencies and reputable news sources often provide information on unsafe products or emerging food safety concerns.

Educate Yourself:

Familiarize yourself with common adulteration practices in your region. Understanding the potential risks associated with certain foods can empower you to make safer choices.

Report Suspicious Activity:

If you come across any suspicious food practices or products, report them to local health authorities. Reporting helps in curbing the spread of adulteration and protects the wider community.

Support Regulatory Measures:

Advocate for and support robust food safety regulations. Governments play a crucial role in enforcing standards and conducting inspections to ensure that businesses adhere to quality and safety requirements.

Conclusion

Food adulteration is a critical issue that demands the attention and diligence of both consumers and regulatory bodies. By making informed choices, supporting reputable sources, and actively participating in food safety initiatives, individuals can contribute to creating a safer and healthier food supply. The fight against food adulteration is a collective responsibility that requires ongoing awareness, education, and a commitment to safeguarding the well-being of ourselves and future generations.

Read more : - Bite-sized Bliss: Navigating the Trends in Food and Beverage

[foodmagazineofficial]

Smooth Sailing: Tips and Tricks for Seamless Food Import Clearance

Introduction:

In a world where culinary diversity knows no bounds, the global food market thrives on the import and export of a myriad of gastronomic delights. However, behind the scenes of this culinary exchange lies a crucial process known as the "food import clearance system." Navigating this system efficiently is paramount for businesses involved in the importation of food products. In this article, we'll explore essential tips and tricks to ensure a smooth and seamless experience through the intricate web of regulations and procedures governing the food import clearance process.

Understanding the Food Import Clearance System:

The food import clearance system is a multifaceted framework designed to ensure the safety and compliance of imported food products with local regulations. It encompasses various stages, from documentation and inspection to testing and certification. Failing to navigate this system effectively can lead to delays, financial losses, and, in extreme cases, the rejection of imported goods.

Tips and Tricks for Success:

Comprehensive Documentation:

One of the foundational pillars of a successful food import clearance is accurate and comprehensive documentation. Ensure all required documents, including invoices, certificates of origin, and sanitary certificates, are meticulously prepared. Any discrepancies in documentation can lead to delays in clearance.

Stay Informed on Regulations:

Regulations governing food imports are subject to change. Stay abreast of any alterations in local or international regulations that may affect your imports. Regularly check with relevant authorities to guarantee compliance with the latest standards.

Collaborate with Reliable Suppliers:

Establishing partnerships with reputable suppliers is key to a seamless clearance process. Reliable suppliers are more likely to adhere to quality and safety standards, reducing the likelihood of issues during clearance. Regular communication with suppliers can also help in addressing potential problems at an early stage.

Invest in Quality Packaging:

Adequate and secure packaging not only ensures the safety of the products during transportation but also plays a crucial role in the clearance process. Packaging that complies with international standards and provides clear information about the contents facilitates quicker inspections.

Engage with Customs Brokers:

Customs procedures can be complex, and engaging with experienced customs brokers can significantly ease the burden on importers. These professionals are well-versed in the intricacies of the food import clearance system and can guide businesses through the paperwork and compliance requirements.

Click here to know more : -

Implement Technology Solutions:

Leverage technology to streamline the documentation process. Digitalizing records and using electronic data interchange systems can reduce paperwork, minimize errors, and accelerate the clearance process. This modern approach not only enhances efficiency but also aligns with the global trend toward digitization in trade processes.

Conduct Pre-shipment Inspections:

To preemptively address potential issues, consider conducting pre-shipment inspections. This allows you to identify and rectify any non-compliance before the products are shipped, reducing the risk of rejection or delays during the clearance process.

Invest in Training for Staff:

Ensure that your staff is well-trained on the intricacies of the food import clearance system. Knowledgeable personnel can identify and address issues proactively, contributing to a smoother clearance process.

Conclusion:

In the intricate world of international trade, navigating the food import clearance system demands a strategic and well-informed approach. By prioritizing accurate documentation, staying updated on regulations, collaborating with reliable suppliers, and leveraging technology, businesses can enhance their chances of a seamless clearance process. Engaging with customs brokers, investing in quality packaging, and conducting pre-shipment inspections further fortify the importation journey. Ultimately, a proactive and comprehensive approach to food import clearance is not only a compliance necessity but a strategic investment in the success of global culinary ventures.

Read more : - Sustainable Packaging 101: Navigating the World of Food Packaging Materials

[foodreviews]

Tata Starbucks: A Fusion of Heritage and Coffee Culture

Introduction:

In the dynamic world of coffee culture, Tata Starbucks has emerged as a unique player, seamlessly blending heritage and contemporary coffee experiences. The partnership between Tata Group, one of India's oldest and most respected conglomerates, and Starbucks, the global coffee giant, has given rise to a coffee culture that beautifully marries tradition with modernity.

The Origins of Tata Starbucks:

The collaboration between Tata Group and Starbucks began in 2012 when the two iconic brands joined forces to bring the Starbucks experience to India. This marked Starbucks' entry into the rapidly growing Indian coffee market, and the collaboration has since evolved into a flourishing partnership that goes beyond just selling coffee.

Heritage Meets Modernity:

Tata Group's rich heritage, dating back to 1868, has played a pivotal role in shaping the Tata Starbucks experience. The collaboration is not just a business venture but a fusion of values, with both companies sharing a commitment to excellence, integrity, and community development.

Tata Starbucks stores in India reflect this unique blend of heritage and modernity. The architecture and design draw inspiration from traditional Indian aesthetics, creating a warm and inviting ambiance. The use of indigenous materials and artistry pays homage to the diverse cultural tapestry of India, providing customers with an authentic and culturally rich environment.

The Coffee Experience:

At the heart of Tata Starbucks is, of course, the coffee. The brand emphasizes the use of high-quality Arabica coffee beans sourced from Tata Coffee's estates. This commitment to quality is evident in every cup served, making the coffee experience at Tata Starbucks truly exceptional.

The menu at Tata Starbucks is a testament to the fusion of global and local flavors. While patrons can savor their favorite Starbucks classics, such as the iconic Caramel Macchiato or Pumpkin Spice Latte, there are also offerings inspired by Indian tastes. Regional flavors find expression in beverages like the Tandoori Paneer Roll and the Elaichi Mawa Croissant, creating a menu that caters to diverse palates.

Click here to know more : -

Community Engagement and Sustainability:

Beyond providing a premium coffee experience, Tata Starbucks is deeply involved in community development and sustainability initiatives. The brand's commitment to ethical sourcing and responsible business practices aligns with Tata Group's longstanding dedication to corporate social responsibility.

Tata Starbucks has implemented various programs to support local coffee farmers, promoting sustainable agricultural practices and improving the livelihoods of those involved in coffee cultivation. Moreover, the brand actively engages in community service projects, contributing to education, healthcare, and skill development in the areas surrounding its stores.

Conclusion:

Tata Starbucks stands as a testament to the successful fusion of heritage and coffee culture. The partnership between Tata Group and Starbucks has not only brought a global coffee experience to India but has also created a unique blend of tradition and modernity. The warm ambiance of Tata Starbucks stores, the high-quality coffee sourced from Tata Coffee's estates, and the commitment to community development and sustainability all contribute to making Tata Starbucks a distinctive player in the coffee industry.

As patrons sip on their favorite beverages at Tata Starbucks, they are not just enjoying coffee; they are partaking in a cultural exchange that celebrates the rich legacy of Tata Group and the global coffee phenomenon that Starbucks represents. It's a fusion that goes beyond the cup, creating a space where heritage and coffee culture coalesce to offer an unparalleled experience for coffee enthusiasts across India.

Read more : - The Future is Now: Cutting-Edge Technology in Food Packaging

[kazifatagar]

New: EX LM Editorial Team Member Ranjit Singh Passes Away

Former journalist JS Ranjit Singh, formerly with FMT and other news organizations, passed away at the age of 53 after suffering a heart attack while visiting a friend. He was part of the #latestmalaysia team at its launch in 2021. He will be missed. Social Media Links Follow us on: Instagram Threads Facebook Twitter YouTube DailyMotion Read More News #latestmalaysia LM Editorial His…

[fictional-malewife-tournament]

Group 2: Round 28

Come on quark fans we can do this <3

[ryanvgates]

Terraform Linting in CI

Problem Hashicorp Terraform provides a cli with the command terraform fmt which will format terraform files according to the canonical style. This is a great tool. The challenge is that you don’t want to give yourself or team members one more thing they need to remember to do. It would be ideal to integrate it into the Continuous Integration(CI) system so it would always be run but no one would…

[rusty25]

I've always loved watching how things get made.

I was fascinated by any and every video that depicted how machines, artwork, furniture, clothes, devices, tools, toys get assembled. Even buildings.

Though I had the chance to watch it rarely, I loved "How Is It Made?". I watched How to Train Your Dragon and its subsequent series and films many times more, however, and was always intrigued by how Toothless' tail/Hiccup's leg worked. Same thing with Iron Man's suit.

I, of course, liked imitating what I saw on television. I loved origami (I still do), took apart and put together every single pen in my pencilcase, made airplanes with the help of a ruler, constructed elaborate "artworks" with cardboard and glue.

When I got into video games, the crafting systems piqued my interest the most, especially in Minecraft. I know every common recipe by heart in the game, and in several others.

When I found out about the existence of the Edwardian-Victorian era steampunk genre, I have decided that it would become my favorite (it still is).

Today I cleaned my family's main pc on a whim. I took my screwdriver sets (of course I have two), and carefully took it apart. Not the entire thing, just enough to vaccuum the years' worth of dust collected in there.

And I had so much fun.

Tinkering with stuff has always been a kind of pushed-aside thought at the very edge of my brain. But it still held on and sometimes even announced its existence.

I feel like it is time I bring it closer, or even into, the limelight.

[0l0x]

My stomach issues are acting up again, for the first time in almost a year.

I was perfectly fine after my first transplant back in September 2021, no issues at all. I’ve had 8 transplants since then and they’ve kept my issues under control really well. As soon as the stomach pains started, usually after 2-4 months, I’d do another transplant and feel great again for another few months.

Did my 8th a month ago and it didn’t seem to do anything. This is the only one that’s failed so far. I feel awful. But I’ve had an extremely stressful month so that could be part of it. I’m in a lot of pain. Going to do another transplant in the next few days and hopefully it will solve whatever is going on because it’s unbearable, my dudes.

8/14/2022

[diginerve]

Forensic Medicine is among the subjects that are considered comparatively easy by medical aspirants. Forensic medicine and toxicology cover a significant portion of the MBBS curriculum and a minimum of 8 to 10 questions are asked in the PG entrance examination from the subject. An expert in FMT can have doors of opportunities in various fields.

[magazinefood]

Bite-sized Bliss: Navigating the Trends in Food and Beverage

Introduction:

In a world where culinary innovation knows no bounds, the trends in food and beverage are ever-evolving, shaping the way we experience and enjoy what we consume. The landscape of gastronomy is not just about satisfying hunger; it's an immersive journey that caters to our evolving tastes, lifestyles, and cultural influences. In this exploration of the latest trends, we delve into the bite-sized bliss that defines contemporary food and beverage experiences.

Microgastronomy: The Art of Miniature Delights

One notable trend sweeping the culinary scene is the rise of microgastronomy – an art form that celebrates miniature versions of our favorite dishes. From bite-sized burgers to tiny tacos, chefs are embracing the challenge of creating intensely flavorful, visually stunning morsels that pack a punch. These miniature delights are not only Instagram-worthy but also offer a unique sensorial experience, allowing diners to savor a variety of flavors in a single sitting.

Functional Foods: Nourishing the Body and Mind

As health-conscious consumers continue to prioritize wellness, the concept of functional foods has gained significant traction. Beyond mere sustenance, these foods and beverages are designed to provide specific health benefits. From antioxidant-rich beverages to superfood-infused snacks, the market is flooded with options that not only satiate our taste buds but also nourish our bodies and minds. Expect to see an increasing number of products boasting probiotics, adaptogens, and other wellness-promoting ingredients.

Global Fusion: Culinary Crossroads

The fusion of diverse culinary traditions has become a hallmark of modern gastronomy. Global fusion is not just about blending flavors; it's a celebration of cultural diversity on the plate. Imagine Korean tacos, Indian-inspired pizza, or Thai-infused burgers. As consumers become more adventurous in their culinary preferences, chefs are experimenting with novel combinations that offer a taste of the world in every bite.

Zero-Waste Gastronomy: From Farm to Fork

Sustainability is not just a buzzword; it's a movement that has infiltrated the food and beverage industry. Zero-waste gastronomy focuses on minimizing food waste throughout the supply chain, from production to consumption. Chefs are getting creative with root-to-stem cooking, repurposing ingredients that would typically be discarded. Embracing this trend not only benefits the environment but also challenges chefs to showcase their ingenuity in creating delectable dishes from often-overlooked parts of ingredients.

Click here to know more : -

Artisanal Beverages: Crafted to Perfection

The craft revolution has extended beyond beer and spirits to encompass a wide array of beverages. Artisanal sodas, handcrafted teas, and small-batch juices are gaining popularity as consumers seek unique and authentic drinking experiences. The emphasis is on quality, with a focus on natural ingredients and traditional production methods. Expect to see an influx of small, local producers offering beverages that go beyond the ordinary, inviting consumers to savor the nuances of carefully crafted drinks.

Tech-Infused Dining: A Digital Feast

The digital age has left no stone unturned, transforming the way we dine. From interactive menus and online reservations to augmented reality dining experiences, technology has become an integral part of the food and beverage industry. With the rise of virtual kitchens and food delivery apps, consumers can indulge in their favorite cuisines from the comfort of their homes. As technology continues to advance, we can anticipate even more innovations that blend the virtual and culinary worlds.

Conclusion:

In the ever-evolving landscape of food and beverage, the trends outlined above paint a vivid picture of a dynamic industry that caters to diverse palates and preferences. From the artistry of microgastronomy to the global fusion of flavors, each trend reflects the desire for unique, memorable culinary experiences. As we navigate this gastronomic journey, one bite-sized bliss at a time, it's clear that the food and beverage industry is not just about sustenance – it's an ever-changing canvas of creativity, innovation, and, above all, the joy of savoring the extraordinary in the ordinary.

Read more : - Moo-ving Forward: Trends and Innovations in the Indian Dairy Industry