#christina engelhardt

[may8chan]

Demonia - Lucio Fulci 1990

[unknownmisworld]

[myfeeds]

Inhalation drug prevents severe pneumonia: Sugar molecule accurately delivers RNA drug to target cells

Overly active immune cells are often behind lung damage in diseases such as Covid-19. Researchers at the Technical University of Munich (TUM) have developed an RNA agent for a lung spray that slows the activity of these cells, known as macrophages. A new, sugar-based transport mechanism is especially effective in bringing the therapeutic to its target. The team led by Stefan Engelhardt, Professor of Pharmacology and Toxicology, has developed an RNA-based active ingredient called RCS-21 to prevent severe lung inflammation and fibrosis, i.e. scarring of the lung tissue, for example in SARS-CoV2 infections. In the cell, RCS-21 stops the activity of the molecule microRNA 21. This nucleic acid, which Engelhardt and his team have been researching for a long time, is one of the triggers for the excessive activity of macrophages in severe lung infections. Drug docks onto sugar receptors In the scientific journal Nature Communications, the team now describes how the active substance RCS-21 is delivered to its target particularly effective via an inhaler. To do this, the researchers took advantage of a special feature of macrophages. These scavenger cells are also present in large numbers in the healthy lung. There, they perform the important task of destroying bacteria and fungal spores as quickly as possible. The macrophages identify their targets among other things based on complex sugar molecules on the surface of the invaders. “We have determined in single cell analyses that the corresponding sugar receptors are, on the one hand, among the most common receptors on macrophages,” says Stefan Engelhardt. “On the other hand, the receptors are, in a sense, a unique feature of macrophages — they hardly occur anywhere else.” Therefore team coupled its active ingredient to a sugar molecule, or more precisely: to trimannose. This approach had so far only been pursued with chemically less complex active ingredients. Studies with mice produced clear results. “When the drug was administered as a spray, macrophages took up the active ingredient significantly better than without sugar molecules. In contrast, other cell types even outright exclude the molecules,” says Christina Beck, first author of the article together with Deepak Ramanujam. Active substance successfully tested In experiments with mice, RCS-21 ensured that microRNA 21 was reduced by more than half compared to control animals. Fibrosis and inflammation were also significantly reduced after treatment. Increased microRNA-21 activity was also stopped by treatment with RCS-21 in samples of human lung tissue infected with the SARS-CoV-2 coronavirus in the laboratory. advertisement Funded by Federal Ministry of Education and Research Studies to prove the drug’s safety are already underway, the first clinical trials in humans are targeted for 2024. Responsibility lies with RNATICS, a TUM spin-off. In 2021 the start-up received around 7 million euros in funding from the German Federal Ministry of Education and Research (BMBF) to support the development of the drug. RNATICS co-founder Stefan Engelhardt sees great potential in the mannose technology: “We were able to show that nucleic acid-based active substances can be used in a very targeted manner, at least in the lungs. This technology opens up a wide field for the development of novel RNA-based drugs. I expect a lot to happen in this area in the next few years.”

[mariocki]

Demonia (1990)

"If you try to find out more, when you think you're about to discover something, that's the moment you find a lot of nothing. These people only know one answer, the silent kind. There's something I've learned during my stay, and I hope you'll believe me: they'd kill to keep their secrets safe."

[jerseydeanne]

Former model who features in explosive new Woody Allen documentary says the Hollywood director seduced her when she was 16... and he was 41

Former model who features in explosive new Woody Allen documentary says the Hollywood director seduced her when she was 16… and he was 41

Christina Engelhardt claims she had a secret relationship with Woody Allen Pair, with 25-year age gap, first met at a New York restaurant when she was 16    She also claims his long-term partner Mia Farrow knew about their relationship

[badmovieihave]

Bad movie I have Skinner 1993

[rahella-khan]

Model says she had AN affair with Woody Allen when she was sixteen - however has 'no regrets'

Model Christina Engelhardt told the Hollywood newsperson she had Associate in Nursing affair with Allen once she was sixteen and he was forty one, and 'I haven't any regrets.' A Golden State girl says she had a years-long affair with director movie maker that began once she was simply sixteen and he was forty one. In associate degree interview with the Hollywood communicator, Christina Engelhardt same she became knowledgeable about Allen at his Manhattan lodging whereas she was still sixteen – beneath the legal status of consent in ny – however she doesn’t feel exploited by the moviemaker. I'm not assaultive Woody," Engelhardt, now 59, told the magazine in associate degree interview printed Mon. "This isn't 'bring down this man.' i am talking concerning my romance. This created ME World Health Organization i'm. i've got no regrets." She same they were along for eight years, and generally engaged in threesomes with alternative girls, together with histrion Mia Farrow. She same she found the experiences “interesting – a ‘70s exploration.” Engelhardt – associate degree histrion associate degreed a model – same she was one among the inspirations for the teen character Allen's author character had an affair with in his 1979 show “Manhattan.” Reps for Allen, 83, and Farrow, 73, failed to answer requests for comment. Engelhardt isn’t the primary girl to mention she had associate degree affair with Allen whereas in highschool throughout that point frame — histrion Stacy Nelkin has same she did similarly, however that their relationship began once she was seventeen.

Nelkin whom Allen has acknowledged geological dating, has conjointly claimed to be the inspiration for the Mariel writer character in “Manhattan.” Nelkin told NBC News on Mon that she’d ne'er detected of Engelhardt, however that Allen might need been seeing alternative girls throughout that point amount “doesn’t surprise ME.” Like Engelhardt, Nelkin remembers her relationship with Allen — whom she same she continues to be shut friends with — warmly. The time Woody and that i spent along was marvelous and unforgettable. That being same, I actually wouldn’t need either of my daughters thus far somebody twenty four years their senior,” she said. Engelhardt failed to answer letter of invitation for treat the THR story. Image Christina EngelhardtChristina Engelhardt attends the 2006 metropolis fete - start - when Party Hosted by LA Confidental Magazine at Writers club Theater in metropolis, California.Michael Bezjian / WireImage/Getty pictures file Engelhardt told the magazine she was already operating as a model once she caught sight of Allen in known writers’ resort Elaine’s — a brand new royal house town bar and building — in 1976. She same she born him a note at his table along with her sign that scan, “Since you’ve signed enough autographs, here’s mine!” She same he known as her shortly when and invited her to his avenue apartment, and that they became physically intimate weeks later. She same he ne'er asked her her age, however was aware she was still in highschool. Engelhardt same Allen unbroken their relationship quiet by invariably having her over to his lodging and ne'er taking her out. She same she had no downside with him business the shots. I was a entertainer, agreeable," she said. "Knowing he was a director, I did not argue. i used to be returning from an area of devotion." In the THR interview, Engelhardt same she believes Hemingway’s “Tracy” character relies on a composite of girls, however one among them was her. She conjointly same she’d had no advance warning concerning what the show was concerning. I cried through most of the show, the dayspring of realization slowly subsidence in as my greatest fears crept to the surface," she wrote during a memoir manuscript she shared with the magazine. "How was our partnership not one thing over simply a fling? we tend to had shared such a special bond right from the beginning, one thing witching, and currently here was his interpretation of ME and North American nation on the large screen for all to determine in black-and-white. however may he interpret my temperament and our life along as if it were just a few fictional creation for art house fatheads to pore over?" She same that once she next saw Allen, she told him she saw plenty of similarities between Hemingway's character and her. "I thought you'd," she same he responded. That was it," she wrote in her manuscript. "That was all i might ever get out of him concerning the film, and searching back currently, i'm therefore angry with myself for not being stronger." She same she eventually left Allen and ny. I thought i used to be special, so i noticed he is a giant person and he is got a giant life — i am in his life," she said. "It's a rainbow with several colours, and i am one among them." And whereas she has heat recollections of their time along, she same she was upset when looking for concerning Allen's relationship with Farrow's much-younger adopted girl Soon-Yi Previn. I felt pitying Mia," she told the magazine. "I thought, 'Didn't Woody have enough 'extra,' with or while not her, that the final thing he had to try and do was to travel for one thing that was whole hers?' "It was total disrespect," she said. Allen and Previn are married for twenty one years. you liked article, this then please subscribe to our YouTube Channel for WordPress video tutorials. You can also find us on Twitter and Facebook. Read the full article

[dickiebhee]

Woody Allen Did NOT Choose "Or Pass"

Woody Allen Did NOT Choose “Or Pass”

One of the questions I’d love to hear asked about the #MeToo movement is who’s really behind it?

I mean, I know we’re supposed to believe that it’s organic, this while also realizing that the media is still male-dominated.

That being the case, we’d be complete and luscious fools to imagine that the male sacrificial lambs being offered up to us as sexual offenders of the highest order haven’t…

[may8chan]

Demonia - Lucio Fulci 1990

[unknownmisworld]

❤️ I have totally lost my heart to this girl and all the things that she needs to go through and she is still standing

[usatodaytrendingnewsworld-blog]

Model says she had an affair with Woody Allen when she was 16 — but has ‘no regrets’ Author: Dareh Gregorian Model Christina Engelhardt told the Hollywood Reporter she had an affair with Woody Allen when she was 16 and he was 41, and 'I have no regrets.'

[giallofever2]

1990 (Internationa Vhs & Dvd Covers)

Demonia

Also Known As (AKA)

(original title) Demonia

Japan (video title) Shin demonzu

Japan (English title) (video title) New Demons

Portugal Freiras Demoníacas

Soviet Union (Russian title) Демония

Others Liza

Release Dates

Italy October 1990 (video premiere)

USA 26 June 2001 (DVD premiere

Filming Dates

January 1990 - March 1990

Filming Locations

Syracuse, Sicily, Italy

Directed by Lucio Fulci

Music by Giovanni Cristiani

Writing Credits

Piero Regnoli... (screenplay)

Lucio fulci... (story screenplay)

Antonio Tentori ... (story) (uncredited)

technical specifications

Runtime 1 hr 25 min (85 min)

cast

Brett Halsey ... Professor Paul Evans

Meg Register ... Liza Harris

Lino Salemme ... Turi DeSimone

Christina Engelhardt ... Susie

Pascal Druant ... Kevin

Grady Clarkson ... Sean (as Grady Thomas Clarkson)

Ettore Comi ... John

Carla Cassola ... Lilla the Medium

Michael Aronin ... Lt. Andi (as Michael J. Aronin)

Al Cliver ... Porter (as Al Clever)

Isabella Corradini ... Nun

Paola Cozzo ... Pregnant Nun

Bruna Rossi ... Nun

Paola Calati ... Nun

Lucio Fulci... Inspector Carter (uncredited)

ANTONIO TENTORI... Man at 'Bar Sicilia' (uncredited)

[maswartz]

Ew

[cskyan]

'Allen v. Farrow': Woody Allen Sexual Assault Claim Supported in Never-Before-Seen Dylan Farrow Videos  Hollywood Reporter

Dylan Farrow Speaks Out About Home Video of Her at Age 7 Discussing Alleged Woody Allen Abuse  PEOPLE

Dylan Farrow Speaks Out Before Tonight’s Airing Of Her 7-Year-Old Self On HBO’s ‘Allen V. Farrow’  Deadline

A Full Timeline of Woody Allen & Christina Engelhardt's Relationship  Bustle

Mia Farrow Says She 'Encouraged' Woody Allen to Bond with Daughter Soon-Yi Previn Before Discovering Their Affair  PEOPLE

View Full Coverage on Google News

[may8chan]

Demonia - Lucio Fulci 1990