#membranous neuropathy

[unhonestlymirror]

Around 40 000 years ago, Homo Sapiens came to Europe and genocided Homo Neanderthalensis (Adams event?). Thus, all modern humans in Europe and Northern Africa have a bit of Neanderthals DNA.

Logically, the Neanderthals DNA should have disappeared completely in modern humans by now... but it didn't. Why? Most likely because of adaptive introgression: process by which adaptation occurs via genetic variants that were introgressed into the recipient population from the donor population (introgression - incorporation of DNA from one species to the gene pool of another). Sapiens really needed some Neanderthals genes for protection from European infections.

The problem, however, is that Neanderthals genes protect us from infections in a short run. In a long run, our Sapiens bodies start to consider Neanderthals DNI as the alien DNI, causing rejection, which leads to different autoimmune disorders and sometimes even cancer. The bloodline curse we have to bear is paying for sinners of our ancestors...

In particular, biologists and archaeologists established a connection between Neanderthals DNI and kidney membranous neuropathy: the more you have Neanderthals genes, the higher the chance to develop such unpleasant disorder. COVID-19 severity is also dependent on the Neanderthal genome.

Neanderthals had lived in quite cold places in those times, and thus, they had to eat more meat. "Alas, though fat is easier to digest, it’s scarce in cold conditions, as prey animals themselves burn up their fat stores and grow lean. So Neanderthals must have eaten a great deal of protein, which is tough to metabolize and puts heavy demands on the liver and kidneys to remove toxic byproducts. In fact, we humans have a “protein ceiling” of between 35 and 50 percent of our diet; eating too much more can be dangerous. Ben-Dor thinks that Neanderthals’ bodies found a way to utilize more protein, developing enlarged livers and kidneys, and chests and pelvises that widened over the millennia to accommodate these beefed-up organs. To cope with the fat famine, Neanderthals probably also specialized in hunting gigantic animals like mammoths, which retain fat longer in poor conditions and require greater strength but less energy and speed to kill."

Since Neanderthals had such large kidneys, they needed a greater scale of kidney cleansing. And that's why they ate a lot of cranberries and lingonberries: even nowadays, cranberries extract is sold in pharmacies to people with kidney problems.

Cranberries properties: rich in antioxidant compounds, prevention of urinary tract infections, support anti-aging, skin health, heart health, reduce the risk of stomach ulcers, antibacterial properties, protect against certain cancers, support eye health and vision, promote a healthy immune system, etc.

Lingonberries are especially high in the antioxidant "anthocyanins," which is known to prevent oxidation of blood cholesterol and aid in keeping blood vessels healthy. Researchers believe these potent antioxidants may be able to help reduce the risk of heart disease and even some cancers.

Thus, people with kidney memranous neuropathy or with high risk of its development, people with severe post-COVID complications, people with high levels of Neanderthals DNI should come to Lithuania! :D We have a lot of cranberries and lingonberries sold not in pharmacies at wild prices but in average grocery stores! :D

[froody]

please help my scruggly cat

Tommy, Tumblr micro-celebrity famous for featuring/being the muse for hit posts such as ‘father is…evil?’ and ‘my cat can tell when I’m sad and instinctively bites my toes’ and ‘frustrating each other is our love language’ needs a little financial support. Please consider donating to my ko-fi or buying something from my teespring store.

Tommy was diagnosed with diabetes earlier this year under dramatic circumstances that involved a week long intensive care vet stay. She has stomatitis (an inflammation of the gums and mucus membranes) that she was on steroids for and the steroids may have damaged her pancreas. Since her diagnosis we’ve had a hard time controlling her blood sugar. Her insulin dose goes up and up. The vet thinks she has a good chance of stabilizing, that diabetic cats can and do live long, healthy and happy lives. She’s only 5. Her 6th birthday is later this month. She’s fighting. She wants to live.

Each insulin vial costs $160. Her prescription cat food is $35 for a 4 pound bag. She’s also on gabapentin for her pain and neuropathy and she’ll probably need another course of antibiotics. She currently goes to the vet every two weeks and the cost of that varies immensely. Basically, she’s a much more expensive cat than she was before and the cost of living for me has risen as well. It’s not an immediate emergency but we need funds. I’m disabled, I have an autoimmune disease that attacks my colon, I have a hard time working outside of the home or even at all because my health fluctuates and my energy levels are low. I’m trying so desperately to get better but for now I’m living in my mom’s house and sponging off my loved ones and tapping into my meager savings.

I know what you’re thinking, the thing people always comment on donation posts about pets, “if you can’t afford to care for your cat, why do you still have your cat?” and as biting as that question is, I know it’s a valid one and I’ve thought about it myself. I still have her because I need her and she needs me. She’s like my soulmate animal. We met when I was 16 and she was about 4 weeks old. There was no way I could have known we’d both be struggling sick moneypits in 5 years. I’m trying to give her the best life I can and she’s trying to give me her best self. I’m her person. I’m home 24/7 so we’re so used to having each other. She brings me immense joy and I know she’s brought a lot of other people joy. If you’re one of those people, please consider giving a couple of dollars. If you can’t afford to, that’s fine. Thank you for reading anyway.

TL;DR: cat sick. I’m sick. please help.

[globalgrowthinsights]

Cyclodextrin Market Trends, Demand & Future Scope till 2032

Cyclodextrin Market provides in-depth analysis of the market state of Cyclodextrin manufacturers, including best facts and figures, overview, definition, SWOT analysis, expert opinions, and the most current global developments. The research also calculates market size, price, revenue, cost structure, gross margin, sales, and market share, as well as forecasts and growth rates. The report assists in determining the revenue earned by the selling of this report and technology across different application areas.

Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Cyclodextrin in these regions till the forecast period

North America

Middle East and Africa

Asia-Pacific

South America

Europe

Key Attentions of Cyclodextrin Market Report:

The report offers a comprehensive and broad perspective on the global Cyclodextrin Market.

The market statistics represented in different Cyclodextrin segments offers complete industry picture.

Market growth drivers, challenges affecting the development of Cyclodextrin are analyzed in detail.

The report will help in the analysis of major competitive market scenario, market dynamics of Cyclodextrin.

Major stakeholders, key companies Cyclodextrin, investment feasibility and new market entrants study is offered.

Development scope of Cyclodextrin in each market segment is covered in this report. The macro and micro-economic factors affecting the Cyclodextrin Market

Advancement is elaborated in this report. The upstream and downstream components of Cyclodextrin and a comprehensive value chain are explained.

Browse More Details On This Report at @https://www.globalgrowthinsights.com/market-reports/cyclodextrin-market-100564

 Global Growth Insights

Web: https://www.globalgrowthinsights.com

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[shamistate]

Shamis Tate Shares What Supplements Do and Do Not Work for Neuropathy

Neuropathy, a condition characterized by nerve damage that leads to pain, numbness, and weakness, affects millions of people worldwide. Managing neuropathy often requires a multifaceted approach, and dietary supplements can be crucial. However, not all supplements are created equal. In this comprehensive guide, we will explore the effectiveness of various supplements in neuropathy management, drawing on the expertise of Shamis Tate, a renowned authority in holistic health.

Understanding Neuropathy and Its Challenges

Neuropathy can result from various causes, including diabetes, infections, and autoimmune diseases. The condition disrupts the normal functioning of nerves, leading to a range of symptoms that can significantly impact quality of life. Traditional treatments include medications, physical therapy, and lifestyle changes. However, many patients seek alternative or complementary approaches, including dietary supplements, to alleviate their symptoms.

The Promise of Alpha-Lipoic Acid

Alpha-lipoic acid (ALA) is one of the most researched neuropathy supplements. This powerful antioxidant is known for reducing oxidative stress and improving nerve function. Studies have shown that ALA can help alleviate pain and improve nerve conduction, making it a promising option for neuropathy sufferers. Shamis Tate emphasizes that ALA is particularly beneficial for diabetic neuropathy, as it can help enhance insulin sensitivity and reduce blood sugar levels.

The Benefits and Limitations of B Vitamins

For the health of the nerves, B vitamins are crucial, especially B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin). Deficiencies in these vitamins are linked to nerve damage and neuropathy. Supplementing with B vitamins can help restore nerve function and reduce symptoms. However, it's crucial to use the right forms and dosages. Shamis Tate advises that while B12 is generally safe, excessive intake of B6 can cause nerve toxicity and worsen neuropathy symptoms. Therefore, it's essential to consult a healthcare professional before starting any B vitamin regimen.

Exploring the Potential of Acetyl-L-Carnitine

Acetyl-L-Carnitine (ALC) is another supplement gaining attention for its potential benefits in neuropathy management. ALC is an amino acid that supports energy production and mitochondrial function, which are vital for nerve health. Research suggests that ALC can reduce pain, improve nerve regeneration, and enhance overall nerve function. She notes that ALC is particularly effective in chemotherapy-induced and diabetic neuropathy. However, more extensive clinical trials are needed to fully understand its long-term efficacy and safety.

Curcumin: Nature’s Anti-Inflammatory Powerhouse

Turmeric's key ingredient, curcumin, is well known for having anti-inflammatory and antioxidant qualities. Chronic inflammation is a significant contributor to nerve damage in neuropathy. Curcumin helps combat this by reducing inflammatory markers and oxidative stress. Several studies have indicated that curcumin supplementation can alleviate pain and improve nerve function in neuropathy patients. Shamis Tate highlights that while curcumin is generally safe, its bioavailability is a concern. Therefore, formulations with enhanced absorption, such as curcumin with piperine, are recommended.

Omega-3 Fatty Acids: Essential for Nerve Health

Omega-3 fatty acids, found in fish oil and flaxseed oil, are vital for maintaining nerve cell membranes and reducing inflammation. These fatty acids have been shown to support nerve repair and reduce neuropathic pain. She points out that omega-3 supplementation can be beneficial for various types of neuropathy, including diabetic and idiopathic forms. However, it’s important to ensure a high-quality source to avoid contaminants like mercury, which can exacerbate nerve damage.

[tejalbele-2024]

Pain Management drugs Market valued at $71,431.85 million in 2019, and is projected to reach $91,649.16 million

The global pain management drugs market was valued at $71,431.85 million in 2019, and is projected to reach $91,649.16 | CAGR of 3.8% from 2020 to 2027.

PORTLAND, OREGON, UNITED STATES, February 1, 2024 /EINPresswire.com/ -- Pain is a disturbing sensory and emotional sensation that results from tissue damage or disease. In addition, different disorders may cause discomfort, such as multiple sclerosis, osteoarthritis, stomach ulcer, chronic arthritis, fibromyalgia, diabetic neuropathy, and cancer. The length of pain ranges from acute pain for short term to chronic pain for long term. Acute pain can be mild and lasts for only a moment or for weeks, or months. Chronic pain is caused by aged bone & joint conditions, nerve damage, or injury. A variety of drugs are used to manage pain resulting from inflammation in response to tissue damage, chemical agents/pathogens (nociceptive pain) or nerve damage (neuropathic pain). Most drugs act by binding to protein targets on cell membranes and affecting biochemical processes of the body.

𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐒𝐚𝐦𝐩𝐥𝐞 𝐂𝐨𝐩𝐲 𝐨𝐟 𝐑𝐞𝐩𝐨𝐫𝐭: https://www.alliedmarketresearch.com/request-sample/404

Rise in geriatric population is the major factor that drives growth of the global pain management drugs market as aged people are more prone to suffer from joint pain and other chronic conditions. Moreover, surge in prevalence of chronic diseases, such as cancer, diabetic neuropathy, and osteoarthritis propels the market growth. Furthermore, rise in number of surgical procedures and rise in healthcare expenditure are expected to fuel growth of the pain management drugs market. However, drug exploitation, patent expiration of prescription pain medication drugs, and availability of substitutes such as pain relief devices restrain the market growth.

𝐃𝐫𝐮𝐠 𝐜𝐥𝐚𝐬𝐬 𝐬𝐞𝐠𝐦𝐞𝐧𝐭 𝐫𝐞𝐯𝐢𝐞𝐰 By drug class, the opioids segment was the largest contributor to the market in 2019, owing to high efficiency of opioids to relieve pain in major chronic conditions. The anesthetics segment is anticipated to possess highest growth rate during the forecast period.

𝐃𝐨 𝐘𝐨𝐮 𝐇𝐚𝐯𝐞 𝐀𝐧𝐲 𝐐𝐮𝐞𝐫𝐲 𝐎𝐫 𝐒𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐑𝐞𝐪𝐮𝐢𝐫𝐞𝐦𝐞𝐧𝐭? 𝐀𝐬𝐤 𝐭𝐨 𝐎𝐮𝐫 𝐈𝐧𝐝𝐮𝐬𝐭𝐫𝐲 𝐄𝐱𝐩𝐞𝐫𝐭: https://www.alliedmarketresearch.com/purchase-enquiry/404

𝐊𝐞𝐲 𝐌𝐚𝐫𝐤𝐞𝐭 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 ELI LILY AND COMPANY MERCK & CO. INC. PFIZER INC. ABBOTT LABORATORIES GLAXOSMITHKLINE PLC (GSK) MYLAN N.V. NOVARTIS INTERNATIONAL AG PURDUE PHARMA L.P. JOHNSON & JOHNSON ENDO HEALTH SOLUTIONS INC. (ENDO INTERNATIONAL PLC.)

𝐊𝐞𝐲 𝐁𝐞𝐧𝐞𝐟𝐢𝐭𝐬 𝐅𝐨𝐫 𝐒𝐭𝐚𝐤𝐞𝐡𝐨𝐥𝐝𝐞𝐫𝐬 The study provides an in-depth analysis of the global pain management drug market along with the current trends and future estimations to elucidate the imminent investment pockets. A comprehensive analysis of the factors that drive and restrict the pain management drugs market growth is provided in the report. The pain management drugs market forecast is studied from 2020 to 2027 Comprehensive quantitative analysis of the industry from 2019 to 2027 is provided to enable the stakeholders to capitalize on the prevailing market opportunities. Extensive analysis of the key segments of the industry helps to understand the application and products of pain management used across the globe. Key market players and their strategies have been analysed to understand the competitive outlook of the pain management drugs market.

𝐀𝐧𝐚𝐥𝐲𝐬𝐭 𝐑𝐞𝐯𝐢𝐞𝐰 The demand for pain management drugs has increased rapidly over recent years. Pain can be caused due to various reasons such as chronic diseases, cancer, and surgeries. Thus, these segments are the largest contributors to the market growth. Presence of large geriatric population base, rise in global prevalence of cancer, and availability of pipeline drugs that pose to be promising treatment options for patients with chronic diseases contribute to growth of the market.

However, patent expiration of major best-seller drugs such as pregabalin and duloxetine by Pfizer and Eli Lilly & Co., respectively, and availability of alternative therapies such as acupuncture, massage, and medical devices hamper the market growth.

Employment of pain management drugs is the highest in North America, owing to increase in adoption of these drugs, high prevalence of chronic diseases, and increase in disposable income of customers. In addition, presence of a large geriatric population and favorable regulatory & healthcare reforms such as the U.S. Patient Protection and Affordable Care Act of 2010 supplement the market growth.

Although the use of pain management drugs in Asia-Pacific and LAMEA is low, the adoption rate is expected to increase, owing to rise in disposable income and surge in incidences of chronic diseases. China and India are potential markets in Asia-Pacific. Moreover, increase in R&D investments, upsurge in healthcare expenditure, and rise in government funding & initiatives propel the market growth in Asia-Pacific.

[marketsndata]

Global Nortriptyline Hydrochloride Market Size, Share and Forecast, 2031

Global nortriptyline hydrochloride market is projected to witness a CAGR of 2.3% during the forecast period 2024-2031, growing from USD 239.7 million in 2023 to USD 287.52 million in 2031F. The market growth is aided by increasing incidences of nerve pain and the rising prevalence of mood disorders such as depression.

Nortriptyline inhibits the reuptake of norepinephrine and serotonin by the presynaptic neuronal membrane, resulting in an increased concentration of these neurotransmitters in the synapse. Nortriptyline also inhibits the activity of acetylcholine, histamine, and 5-hydroxytryptamine. The increasing prevalence of depression in various regions around the globe is one of the major market trends that is fostering market growth. For instance, according to the estimates of the World Health Organization (WHO), approximately 5% of the adult global population suffers from depression. It is 50% more common in women as compared to men. This increase in the number of individuals suffering from depression will provide lucrative growth opportunities to the market as nortriptyline hydrochloride, an active metabolite of amitriptyline acts as a tricyclic antidepressant and is used for treating major depression.

The rise in incidences of individuals suffering from neuropathic pain is another major factor bolstering the global nortriptyline hydrochloride market size. Nortriptyline reduces neuropathic pain by increasing noradrenaline levels that act within the dorsal root ganglia on β2-adrenoceptors expressed by the non-neuronal satellite cells. Stimulating β2-adrenoceptors results in the reduced neuropathy-induced production of TNFα, thereby relieving neuropathic pain. Nortriptyline is usually administered orally as a solution or a capsule. The capsule is available in varying strengths including 75 mg, 50 mg, 25 mg, and 10 mg and the solution is available in the composition of 10mg/ 5mL (473 mL). Hence, due to the increasing cases of individuals suffering from neuropathic pain, the requirement for nortriptyline hydrochloride is rising to support the production of medication for pain management, thereby providing lucrative growth opportunities to the market.

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Growing Prevalence of Depression Supports Global Nortriptyline Hydrochloride Market Growth

The nortriptyline hydrochloride treats depression by increasing the quantity of norepinephrine and serotonin in the brain, the substances that are responsible for regulating mood. Thus, supporting the market's growth by propelling the demand for nortriptyline hydrochloride. The dosage of the medication is based on the condition of the patient and their response to the treatment. The dose of the medication is directed at a lower range which is then increased gradually to reduce the risk of side effects associated with the medication.

The susceptibility of the contemporary population to depression is growing due to several factors including intense individual competitiveness, rising social failure, low social support, and increased inequality. For instance, according to the estimates of the World Health Organization (WHO), approximately 3.8% of the population suffers from depression. This includes 5% of the adult population of which 5.7% are older than 60 years. Nearly 280 million individuals across the globe are living with depression. Hence, this increase will augment the requirement for nortriptyline hydrochloride as the product belongs to a group of medications that are known as tricyclic antidepressants.

Increasing Incidences of Diabetic Neuropathy Boosts Global Nortriptyline Hydrochloride Market Demand

The presence of high blood glucose levels and fats, including triglycerides in blood due to diabetes can result in nerve damage causing diabetic neuropathy. High blood sugar levels can also cause damage to the blood vessels that provide the nerves with nutrients and oxygen. For instance, according to the estimates of the National Institute of Diabetes and Digestive and Kidney Diseases, approximately 30% of the individuals suffering from diabetes have automatic neuropathy. This, in turn, is bolstering the requirement for nortriptyline hydrochloride to support the production of medication for managing diabetic neuropathy. Henceforth, augmenting the market demand in various regions across the globe.

Meanwhile, the rising consumption of food products with high amounts of sugar and carbonated beverages coupled with changing lifestyle patterns are increasing the number of individuals suffering from diabetes. This, in turn, is propelling the incidences of diabetic neuropathy, bolstering the product demand to ensure the production of appropriate medication to support the management of the condition. For instance, according to the projections of the International Diabetes Federation, by 2045, approximately 783 million people, 1 in 8 adults, will be living with diabetes. As the incidences of diabetes increase, the cases of diabetic neuropathy will also increase, thus augmenting the global nortriptyline hydrochloride market growth.

North America Accounts for Significant Market Share

The presence of a well-established healthcare sector and increasing investments by various pharmaceutical, healthcare, and biotechnology companies towards research and development activities is bolstering the demand for nortriptyline hydrochloride in various countries in North America. The increasing prevalence of depression in the region is further supporting the market expansion. For instance, according to the estimates of Mental Health America, more than 8% of American adults, approximately 21 million individuals are affected by depression. This increased prevalence coupled with the easy accessibility to various medications that help in treating depression are supporting the market growth as nortriptyline hydrochloride works as a tricyclic antidepressant. Therefore, the increasing incidences of individuals suffering from chronic pain is another major factor supporting the market expansion in the region, as the product finds applications in various medications that are used for treating chronic pain.

Rising Demand for More than 99% Nortriptyline Hydrochloride Boosts Market Growth

The increasing requirement for nortriptyline hydrochloride with more than 99% purity can be attributed to their rising demand by academic and research institutions and medicine manufacturing facilities in various regions across the globe. The pharmaceutical sector is significantly growing in various regions, for instance, according to the estimates of The Association of the British Pharmaceutical Industry, the pharmaceutical industry spends approximately USD 160 billion every year on research and development activities as the development of novel medications involves significant rates of failure. Due to such growing efforts and investments in medicine manufacturing, the requirement for nortriptyline hydrochloride will increase, thus propelling the growth of the market. The preference for nortriptyline hydrochloride with more than 99% purity can also be attributed to the high efficacy offered by the product as opposed to their counterparts, thus augmenting their demand, and supporting the expansion of the market.

Capsules Account for Significant Global Nortriptyline Hydrochloride Market Share

The expansion of the segment can be attributed to the higher bioavailability offered by the capsules as opposed to their counterparts, making them more effective than tablets. The nortriptyline hydrochloride capsules contain various inactive ingredients including sodium lauryl sulfate, colloidal silicon dioxide, pregelatinized starch, and magnesium stearate. For instance, the 75 mg, 50 mg, 25 mg, and 10 mg capsule shells contain titanium dioxide, gelatin, sodium lauryl sulfate, propylparaben, and methylparaben. They can also contain edetate calcium disodium, benzyl alcohol, silicon dioxide or sodium propionate, and butylparaben. The 75 mg, 25 mg, and 10 mg capsule shells also contain FD&C Blue No. 1 and D&C Yellow No. 10. The nortriptyline hydrochloride is usually prescribed for the smallest quantity of capsules with good patient management, to reduce the risk of overdose. Thus, the increased accessibility to nortriptyline hydrochloride capsules coupled with the rising awareness about mental health and depression are supporting the growth of the segment, thus boosting the market expansion.

Future Market Scenario (2024–2031F)

According to the global nortriptyline hydrochloride market analysis, the demand for nortriptyline hydrochloride will increase over the forecast period due to increasing research and development activities and utilization of the product for drug repurposing. Various studies are being conducted to evaluate the potential candidacy of nortriptyline hydrochloride for repurposing of drugs. For instance, according to an article published by researchers from the Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao, China, nortriptyline hydrochloride exhibits significant antitumor activities in both in-vitro and in-vivo. The product can inhibit gastric cancer by inducing oxidative stress and apoptosis. Conduction of such studies will bolster the requirement for nortriptyline hydrochloride over the forecast period by academic and research institutions augmenting the market demand.

Report Scope

“Nortriptyline Hydrochloride Market Assessment, Opportunities and Forecast, 2017-2031F”, is a comprehensive report by Markets and data, providing in-depth analysis and qualitative and quantitative assessment of the current state of global nortriptyline hydrochloride market, industry dynamics, and challenges. The report includes market size, segmental shares, growth trends, opportunities, and forecast between 2024 and 2031F. Additionally, the report profiles the leading players in the industry mentioning their respective market share, business model, competitive intelligence, etc.

Click here for full report- https://www.marketsandata.com/industry-reports/nortriptyline-hydrochloride-market

Contact

Mr. Vivek Gupta 5741 Cleveland street, Suite 120, VA beach, VA, USA 23462 Tel: +1 (757) 343–3258 Email: info@marketsandata.com Website: https://www.marketsandata.com

[pronerv6]

ProNerve6: The Advanced Nerve Support Formula for Optimal Neural Health

Neuropathy and nerve pain are debilitating conditions that affect millions of people worldwide. ProNerve6, a cutting-edge supplement, is designed to address these issues head-on, offering a comprehensive solution to support and enhance nerve health. This article will explore the benefits of ProNerve6, its unique blend of ingredients, and how it can significantly improve your quality of life.

What is ProNerve6?

ProNerve6 is a dietary supplement that has been scientifically formulated to support nerve health and combat the symptoms of neuropathy. This supplement contains a potent mix of vitamins, antioxidants, and herbal extracts that work synergistically to strengthen nerve function, alleviate pain, and promote neural healing.

How Does ProNerve6 Work?

The efficacy of ProNerve6 comes from its carefully selected ingredients, each playing a vital role in nerve health:

Alpha Lipoic Acid (ALA): Known for its antioxidant properties, ALA helps to protect nerves from damage and improve nerve function.

Benfotiamine: A derivative of Vitamin B1, benfotiamine is highly effective in increasing nerve regeneration and reducing pain and inflammation associated with nerve damage.

Turmeric and Curcumin: These compounds have strong anti-inflammatory effects, which can reduce pain and swelling in nerve tissues.

Omega-3 Fatty Acids: Essential for neural health, omega-3s help to build and repair nerve cell membranes.

Acetyl-L-Carnitine: Known to enhance nerve regeneration and improve symptoms of neuropathy.

Herbal Extracts: Including passionflower and Chinese skullcap, known for their nerve-calming properties and ability to decrease symptoms of anxiety and insomnia related to nerve pain.

Key Benefits of ProNerve6

Enhanced Nerve Function: By nourishing the nerves with essential nutrients, ProNerve6 helps improve their function and resilience.

Pain Relief: Ingredients in ProNerve6 are chosen for their effectiveness in reducing neuropathic pain, offering a natural alternative to pharmaceutical painkillers.

Improved Mobility: With reduced pain and enhanced nerve health, mobility often improves, allowing for a better quality of life.

Antioxidant Protection: Antioxidants in ProNerve6 help protect nerves from environmental toxins and oxidative stress, preventing further damage.

User Experiences with ProNerve6

Many users of ProNerve6 report significant reductions in pain and discomfort associated with neuropathy. Testimonials often highlight improved sleep, increased activity levels, and overall enhanced daily functioning. These personal accounts underscore the potential of ProNerve6 as a vital tool in managing nerve health.

Integrating ProNerve6 into Your Health Regimen

Incorporating ProNerve6 into your daily routine is simple:

Consistent Usage: For best results, it's recommended to take ProNerve6 as directed on the packaging.

Combine with a Healthy Diet: Eating a diet rich in vitamins and antioxidants supports nerve health.

Regular Exercise: Gentle exercise can improve circulation and natural nerve repair.

Frequently Asked Questions

Who can benefit from ProNerve6? Individuals experiencing symptoms of neuropathy or those looking to prevent nerve damage can benefit from ProNerve6.

Are there any side effects? ProNerve6 is made with natural ingredients and typically does not cause adverse side effects. However, it’s always recommended to consult with a healthcare provider before starting any new supplement.

How long before I see results? While individual results vary, some users report feeling benefits within a few weeks of regular use.

Conclusion

ProNerve6 is more than just a supplement; it's a comprehensive approach to nerve health, providing the necessary nutrients to alleviate pain, enhance nerve function, and protect against future damage. Whether you're dealing with neuropathy or seeking to maintain healthy nerve function, ProNerve6 offers a promising solution.

[jhavelikes]

Brain metastasis of advanced breast cancer often results in deleterious consequences. Metastases to the brain lead to significant challenges in treatment options, as the blood–brain barrier (BBB) prevents conventional therapy. Thus, we hypothesized that creation of a nanoparticle (NP) that distributes to both primary tumor site and across the BBB for secondary brain tumor can be extremely beneficial. Here, we report a simple targeting strategy to attack both the primary breast and secondary brain tumors utilizing a single NP platform. The nature of these mitochondrion-targeted, BBB-penetrating NPs allow for simultaneous targeting and drug delivery to the hyperpolarized mitochondrial membrane of the extracranial primary tumor site in addition to tumors at the brain. By utilizing a combination of such dual anatomical distributing NPs loaded with therapeutics, we demonstrate a proof-of-concept idea to combat the increased metabolic plasticity of brain metastases by lowering two major energy sources, oxidative phosphorylation (OXPHOS) and glycolysis. By utilizing complementary studies and genomic analyses, we demonstrate the utility of a chemotherapeutic prodrug to decrease OXPHOS and glycolysis by pairing with a NP loaded with pyruvate dehydrogenase kinase 1 inhibitor. Decreasing glycolysis aims to combat the metabolic flexibility of both primary and secondary tumors for therapeutic outcome. We also address the in vivo safety parameters by addressing peripheral neuropathy and neurobehavior outcomes. Our results also demonstrate that this combination therapeutic approach utilizes mitochondrial genome targeting strategy to overcome DNA repair–based chemoresistance mechanisms.

Simultaneous targeting of peripheral and brain tumors with a therapeutic nanoparticle to disrupt metabolic adaptability at both sites | PNAS

[manjeet1994]

Managing and Understanding Chemotherapy Side Effects.

One of the mainstays of cancer treatment is chemotherapy, which is used to find and kill cancer cells all over the body. Chemotherapy has several side effects that can affect patients physically and psychologically, although it can be very helpful in battling cancer. An important part of cancer care is being aware of these side effects and knowing how to control them. Fatigue is among the most frequent side effects of chemotherapy. Extreme fatigue is a common side effect of chemotherapy that can impair the quality of life and everyday activities for many people. Patients should emphasize rest, save energy, and, when feasible, partake in mild exercise to manage fatigue. In addition, eating a balanced diet and drinking plenty of water can help prevent weariness. Common side effects of chemotherapy include nausea and vomiting, especially in the days right after treatment. Antiemetics are medications that assist prevent and treat these symptoms. Eating short, bland meals and avoiding harsh smells might also help those who are experiencing nausea.

Hair loss is another well-known side effect of chemotherapy, which can be emotionally challenging for many patients. While not all chemotherapy drugs cause hair loss, those that do can lead to partial or complete baldness. Wigs, scarves, and hats can provide physical coverage, while support groups and counseling can offer emotional support during this time. Additionally, chemotherapy might impair immunological function, making patients more vulnerable to infections. Patients must maintain proper hygiene, stay away from sick people, and heed their doctor's advice regarding immunizations and infection control measures. Other common side effects of chemotherapy include neuropathy (nerve damage), mucositis (inflammation of the mucous membranes), and changes in appetite and weight. These side effects can vary depending on the specific chemotherapy drugs being used and the individual patient's response to treatment. Patients receiving chemotherapy should take care of their emotional and psychological needs in addition to addressing any physical side effects. Numerous cancer treatment facilities provide patients with emotional support through counseling, support groups, and integrative therapies.

In general, people can manage the adverse effects of chemotherapy with the aid of many tactics and tools, even if it can be a challenging element of cancer treatment. Patients can reduce the negative impacts of chemotherapy side effects and concentrate on their healing and rehabilitation by collaborating closely with their healthcare team, asking for help from family and friends, and using community services. we can also take mistletoe therapy in place of chemotherapy because it reduces side effects It's believed that mistletoe extracts, as scientists continue to investigate their medicinal potential, could eventually prove to be a valuable tool in the fight against cancer.

[abdominalpaintreatment]

When Do You Need a Spinal Cord Stimulator?

Chronic pain can significantly impact a person's quality of life, challenging even simple daily activities. When traditional pain management methods fail to provide adequate relief, alternative treatments may be considered. One such option is a spinal cord stimulator (SCS). 

Dr. Dipty Mangla of Mainland Pain Management, who provides the best spinal cord stimulator in New Jersey, explains about how spinal cord stimulators work and the concept of a spinal cord stimulator. In this blog, let us discuss the conditions that may require Spinal Cord Stimulator use, and examine its potential benefits.

Understanding Spinal Cord Stimulator

A spinal cord stimulator is a device that delivers low-level electrical impulses to the spinal cord, specifically targeting the nerves responsible for transmitting pain signals to the brain. The device consists of a small generator implanted under the skin, usually in the abdomen or buttock area, along with thin wires carrying electrical impulses to the spinal cord.

Conditions that May Need a Spinal Cord Stimulator

Failed Back Surgery Syndrome: Failed Back Surgery Syndrome (FBSS) refers to the persistence or recurrence of chronic pain following spine surgery. In cases where traditional treatments and additional surgeries have not provided relief, a spinal cord stimulator is a viable option.

Complex Regional Pain Syndrome (CRPS): CRPS is a chronic pain condition typically affecting an arm, leg, hand, or foot, usually after an injury or trauma. Spinal cord stimulation can help alleviate the pain associated with CRPS and improve overall function and quality of life.

Neuropathic Pain: Neuropathic pain is caused by damage or dysfunction of the nerves, resulting in a chronic pain condition. Spinal cord stimulation has shown effectiveness in managing neuropathic pain caused by peripheral neuropathy, diabetic neuropathy, and nerve injuries.

Peripheral Vascular Disease: Peripheral Vascular Disease (PVD) refers to the narrowing or blockage of blood vessels in the extremities, resulting in pain and reduced circulation. Spinal cord stimulation can help alleviate the pain associated with PVD and improve mobility.

Arachnoiditis: Arachnoiditis is a rare condition characterized by inflammation of the arachnoid membrane, one of the protective layers surrounding the spinal cord. Spinal cord stimulation is a treatment option for managing chronic pain associated with arachnoiditis.

Potential Benefits of Spinal Cord Stimulator:

Pain Relief: The primary benefit of a spinal cord stimulator is pain relief. By delivering electrical impulses to the spinal cord, the device can help interrupt or block the pain signals from reaching the brain, reducing pain perception.

Reduced Medication Dependency: Spinal cord stimulation can reduce the need for pain medications, including opioids, which can have significant side effects and the risk of dependency.

Improved Function and Quality of Life: A spinal cord stimulator can help improve overall function and quality of life by managing chronic pain. With reduced pain, individuals may engage in activities they previously could not perform, enhancing their physical and emotional well-being.

Reversible and Adjustable: One advantage of a spinal cord stimulator is its reversible and adjustable nature. If the device does not provide the desired level of pain relief, it can be turned off or removed. Additionally, the stimulation parameters can be adjusted to better target the specific areas of pain.

Improved Sleep and Mental Health: Chronic pain can significantly impact sleep patterns and contribute to mental health issues such as anxiety and depression. By effectively managing pain, a spinal cord stimulator can help improve sleep quality and alleviate the emotional burden associated with chronic pain, leading to enhanced mental well-being.

Enhanced Physical Function: Chronic pain often limits physical function and mobility, making engaging in daily activities and exercise difficult. By reducing pain, a spinal cord stimulator can improve physical function, allowing individuals to participate in activities they enjoy and maintain a more active lifestyle.

Personalized Pain Management: Spinal cord stimulation offers the advantage of customization. The device can be programmed and adjusted to meet an individual's specific pain management needs. This personalized approach allows optimal pain control, as stimulation settings can be modified based on changes in pain patterns or individual preferences.

Non-Destructive Alternative: Unlike certain surgical interventions involving permanent alterations to the body or high-dose pain medications, spinal cord stimulation offers a non-destructive alternative. It provides pain relief without permanently altering the anatomy or relying solely on medications, making it appealing for individuals seeking conservative treatment options.

Conclusion:

A spinal cord stimulator is a potential treatment option for individuals suffering from chronic pain conditions that have not responded to other conventional methods. The device can help manage pain, reduce medication dependency, and improve overall function and quality of life by providing electrical impulses to the spinal cord.

However, consulting with a pain management physician in New Jersey is essential to determine if a spinal cord stimulator is the appropriate choice for your specific condition. They can evaluate your individual needs, discuss the potential benefits and risks, and guide you through the process to make an informed decision about this intervention for chronic pain management.

If you are looking for the best spinal cord stimulator, Dr. Dipty Mangla, a leading pain management physician in New Jersey of Mainland Pain Management can be consulted.

[drcpanda12]

Introduction to HbA1c Hemoglobin (Hb) that has been chemically bonded to sugar is known as glycated hemoglobin (HbA1c). When present in the bloodstream, the majority of monosaccharides, including glucose, galactose, and fructose, spontaneously and non-enzymatically bind with hemoglobin. Galactose and fructose are more likely than glucose to do so (13% and 21%, respectively), which is why glucose serves as the main metabolic fuel in humans. When the sugar-hemoglobin link forms, it means there is too much sugar in the blood, which is frequently a sign of high-concentration diabetes (HbA1c >6.4%). Due to its simplicity of detection, A1C is of great interest. Glycation is the process by which sugars bind to hemoglobin, and the reference system is based on HbA1c, which is defined as a component of beta-N-1-deoxy fructose hemoglobin. HbA1c is primarily evaluated to identify the three-month average blood sugar level, but it can also be used to diagnose diabetes mellitus and monitor a patient's glycemic control if they already have the disease. The test is restricted to a three-month average since a red blood cell typically lives for four months. Since different red blood cells have different lifespans, the test is only used with a three-month limit. A normal amount of glycated hemoglobin is produced by normal glucose levels. The fraction of glycated hemoglobin rises predictably as the average plasma glucose level rises. Higher levels of glycated hemoglobin in diabetes have been linked to cardiovascular disease, nephropathy, neuropathy, and other complications. The name HbA1c comes from the cation exchange chromatography separation of hemoglobin type A. HbA0 was given to the first fraction to separate, which was probably thought to be pure hemoglobin A. HbA1a, HbA1b, and HbA1c were given to the subsequent fractions in the order in which they were eluted. Huisman and Meyering used a chromatographic column to isolate hemoglobin A1c from other types of hemoglobin for the first time in 1958. In 1968, Bookchin and Gallop classified it as a glycoprotein for the first time. Samuel Rahbar and colleagues initially noted the rise in diabetes in 1969. In 1975, Bunn and his colleagues described the processes that led to its creation. Anthony Cerami, Ronald Koenig, and colleagues introduced the use of hemoglobin A1c for assessing the level of control of glucose metabolism in diabetic patients in 1976. Why is it important for managing diabetes? Cell membranes of red blood cells change as a result of glycated hemoglobin's rise in highly reactive free radicals. As a result, blood viscosity and blood cell aggregation rise, impairing blood flow. Glycated hemoglobin can also harm cells by causing inflammation, which leads to the development of atherosclerotic plaque (atheroma). The amount of glucose that binds to hemoglobin in red blood cells increases with the duration of blood hyperglycemia, as does the amount of glycated hemoglobin. A hemoglobin molecule becomes glycated and stays that way forever. Hence, a buildup of glycated hemoglobin inside the red cell represents the typical level of glucose the cell has been exposed to throughout its life cycle. Glycated hemoglobin testing evaluates treatment efficacy by keeping track of long-term serum glucose control. The A1c test measures the weighted average of blood glucose levels throughout the red blood cells' lifetime 117 days for men and 106 days for women. As a result, the level of A1c is significantly influenced more by the glucose levels on days close to the test than by those on days further away. Data from clinical practice showed a significant improvement in HbA1c levels 20 days following the initiation or intensification of treatment for diabetes. What do HbA1c test results mean? Depending on the analytical method, the subject's age, and biological variance between individuals, laboratory results may vary. Those with

diabetes mellitus or other conditions that cause consistently high blood sugar have higher levels of HbA1c. Treatment objectives for diabetes patients might vary, but many of them include a target range of HbA1c levels. An HbA1c level that is close to or within the reference range is indicative of a diabetic with good glucose management. HbA1c values below 6.5% are advised by the International Diabetes Federation and the American College of Endocrinology, however, the American Diabetes Association advises HbA1c values below 7.0 % for the majority of patients. Patients with an HbA1c greater than 6.5 % had an increased risk of death, according to a retrospective study of type 2 diabetes patients aged 50 and older. Consistently high blood sugar levels and, consequently, HbA1c)raise the risk of long-term vascular consequences of diabetes, such as gastroparesis, gangrene, coronary disease, heart attack, stroke, heart failure, kidney failure, blindness, and erectile dysfunction. Moreover, the risk of immediate postoperative problems including slow wound healing is increased by poor blood glucose control. Those with conditions that cause premature red blood cell death, such as glucose-6-phosphate dehydrogenase deficiency, sickle cell disease, or any other ailment, can have lower-than-expected levels of HbA1c. Red blood cells will be quickly replaced by newly produced ones after blood donation. HbA1c will overestimate the real average levels because these additional RBCs will have only been present for a brief length of time. In several situations, such as those involving blood loss, surgery, blood transfusions, anemia, high erythrocyte turnover, chronic renal or liver disease, the administration of large doses of vitamin C, or erythropoietin therapy, the results may not be accurate. The typical reference range found in healthy young people is between 4.9 and 5.2%. How are HbA1c levels interpreted? The monitoring of blood sugar control in individuals with more high levels, known as diabetes mellitus, as well as those who may be prediabetic, is advised by glycated hemoglobin testing. It offers significantly more illuminating data on glycemic behavior for a single blood sample than a fasting blood sugar reading. However, while choosing a course of treatment, fasting blood sugar testing is essential. Similar to other guidelines, the American Diabetes Association recommends that the glycated hemoglobin test be carried out quarterly in patients with diabetes whose therapy has changed or who are not meeting glycemic goals and at least twice a year in patients with diabetes who are meeting treatment goals and who have stable glycemic control. When a dietary or medical treatment adjustment has been made within the last six weeks, a glycated hemoglobin measurement is not acceptable. The HbA1c test is not appropriate for individuals with recent blood loss, hemolytic anemia, or genetic variations in the hemoglobin molecule (hemoglobinopathy), such as sickle-cell disease and other diseases. .

[knewtoday]

Introduction to HbA1c Hemoglobin (Hb) that has been chemically bonded to sugar is known as glycated hemoglobin (HbA1c). When present in the bloodstream, the majority of monosaccharides, including glucose, galactose, and fructose, spontaneously and non-enzymatically bind with hemoglobin. Galactose and fructose are more likely than glucose to do so (13% and 21%, respectively), which is why glucose serves as the main metabolic fuel in humans. When the sugar-hemoglobin link forms, it means there is too much sugar in the blood, which is frequently a sign of high-concentration diabetes (HbA1c >6.4%). Due to its simplicity of detection, A1C is of great interest. Glycation is the process by which sugars bind to hemoglobin, and the reference system is based on HbA1c, which is defined as a component of beta-N-1-deoxy fructose hemoglobin. HbA1c is primarily evaluated to identify the three-month average blood sugar level, but it can also be used to diagnose diabetes mellitus and monitor a patient's glycemic control if they already have the disease. The test is restricted to a three-month average since a red blood cell typically lives for four months. Since different red blood cells have different lifespans, the test is only used with a three-month limit. A normal amount of glycated hemoglobin is produced by normal glucose levels. The fraction of glycated hemoglobin rises predictably as the average plasma glucose level rises. Higher levels of glycated hemoglobin in diabetes have been linked to cardiovascular disease, nephropathy, neuropathy, and other complications. The name HbA1c comes from the cation exchange chromatography separation of hemoglobin type A. HbA0 was given to the first fraction to separate, which was probably thought to be pure hemoglobin A. HbA1a, HbA1b, and HbA1c were given to the subsequent fractions in the order in which they were eluted. Huisman and Meyering used a chromatographic column to isolate hemoglobin A1c from other types of hemoglobin for the first time in 1958. In 1968, Bookchin and Gallop classified it as a glycoprotein for the first time. Samuel Rahbar and colleagues initially noted the rise in diabetes in 1969. In 1975, Bunn and his colleagues described the processes that led to its creation. Anthony Cerami, Ronald Koenig, and colleagues introduced the use of hemoglobin A1c for assessing the level of control of glucose metabolism in diabetic patients in 1976. Why is it important for managing diabetes? Cell membranes of red blood cells change as a result of glycated hemoglobin's rise in highly reactive free radicals. As a result, blood viscosity and blood cell aggregation rise, impairing blood flow. Glycated hemoglobin can also harm cells by causing inflammation, which leads to the development of atherosclerotic plaque (atheroma). The amount of glucose that binds to hemoglobin in red blood cells increases with the duration of blood hyperglycemia, as does the amount of glycated hemoglobin. A hemoglobin molecule becomes glycated and stays that way forever. Hence, a buildup of glycated hemoglobin inside the red cell represents the typical level of glucose the cell has been exposed to throughout its life cycle. Glycated hemoglobin testing evaluates treatment efficacy by keeping track of long-term serum glucose control. The A1c test measures the weighted average of blood glucose levels throughout the red blood cells' lifetime 117 days for men and 106 days for women. As a result, the level of A1c is significantly influenced more by the glucose levels on days close to the test than by those on days further away. Data from clinical practice showed a significant improvement in HbA1c levels 20 days following the initiation or intensification of treatment for diabetes. What do HbA1c test results mean? Depending on the analytical method, the subject's age, and biological variance between individuals, laboratory results may vary. Those with

diabetes mellitus or other conditions that cause consistently high blood sugar have higher levels of HbA1c. Treatment objectives for diabetes patients might vary, but many of them include a target range of HbA1c levels. An HbA1c level that is close to or within the reference range is indicative of a diabetic with good glucose management. HbA1c values below 6.5% are advised by the International Diabetes Federation and the American College of Endocrinology, however, the American Diabetes Association advises HbA1c values below 7.0 % for the majority of patients. Patients with an HbA1c greater than 6.5 % had an increased risk of death, according to a retrospective study of type 2 diabetes patients aged 50 and older. Consistently high blood sugar levels and, consequently, HbA1c)raise the risk of long-term vascular consequences of diabetes, such as gastroparesis, gangrene, coronary disease, heart attack, stroke, heart failure, kidney failure, blindness, and erectile dysfunction. Moreover, the risk of immediate postoperative problems including slow wound healing is increased by poor blood glucose control. Those with conditions that cause premature red blood cell death, such as glucose-6-phosphate dehydrogenase deficiency, sickle cell disease, or any other ailment, can have lower-than-expected levels of HbA1c. Red blood cells will be quickly replaced by newly produced ones after blood donation. HbA1c will overestimate the real average levels because these additional RBCs will have only been present for a brief length of time. In several situations, such as those involving blood loss, surgery, blood transfusions, anemia, high erythrocyte turnover, chronic renal or liver disease, the administration of large doses of vitamin C, or erythropoietin therapy, the results may not be accurate. The typical reference range found in healthy young people is between 4.9 and 5.2%. How are HbA1c levels interpreted? The monitoring of blood sugar control in individuals with more high levels, known as diabetes mellitus, as well as those who may be prediabetic, is advised by glycated hemoglobin testing. It offers significantly more illuminating data on glycemic behavior for a single blood sample than a fasting blood sugar reading. However, while choosing a course of treatment, fasting blood sugar testing is essential. Similar to other guidelines, the American Diabetes Association recommends that the glycated hemoglobin test be carried out quarterly in patients with diabetes whose therapy has changed or who are not meeting glycemic goals and at least twice a year in patients with diabetes who are meeting treatment goals and who have stable glycemic control. When a dietary or medical treatment adjustment has been made within the last six weeks, a glycated hemoglobin measurement is not acceptable. The HbA1c test is not appropriate for individuals with recent blood loss, hemolytic anemia, or genetic variations in the hemoglobin molecule (hemoglobinopathy), such as sickle-cell disease and other diseases. .

[prnlive]

Gary Null’s Show Notes 02 03 23 P

If you listen to Gary’s show, you know that he begins with the latest findings in natural approaches to health and nutrition. Starting this week, we will make some of those findings available each weekday to subscribers to the Gary Null Newsletter.

Berry compounds’ heart health benefits linked to impact on platelets

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid 

Going for a walk outside found to have more mental health benefits than walking indoors

Supplementation with amino acid serine eases neuropathy in diabetic mice

High Consumption of Sugar-Sweetened Beverages Is Associated with Low Bone Mineral Density in Young People

Prolonged exposure to work-related stress thought to be related to certain cancers

Berry compounds’ heart health benefits linked to impact on platelets

Sun Yat-sen University (Taiwan), January 18, 2023

The potential cardiovascular benefits of anthocyanins may be associated with their ability to influence the expression of chemicals by platelets in the blood, says new data from a randomized, double-blind, placebo-controlled trial.

The  study, published in Nutrition & Metabolism , deepens our understanding of the heart health benefits of anthocyanins, pigments found in many fruit like black raspberries, blueberries, blackberries, and blackcurrants.

Chinese scientists report that 320 mg per day of purified anthocyanins, equivalent to about 100 g of fresh blueberries and blackcurrants, for 24 weeks were associated with significant reductions in platelet chemokine levels, which correlated to lower levels of inflammatory markers in people with elevated cholesterol levels.

“Platelet chemokines are involved in inflammatory reactions, immune responses, and other aspects of the development of atherosclerosis,” explained researchers from Sun Yat-sen University.

“In the present study, we found that the decreased levels of some platelet chemokines after anthocyanin treatment were closely correlated with the serum lipid and inflammatory molecule levels.

“These results indicated that anthocyanins exerted beneficial effects on the platelet chemokine levels, serum lipids and inflammatory factors, thereby inhibiting atherosclerosis.”

Results showed that a number of platelet chemokines decreased after anthocyanin intake, including CXCL7 (12.3% decrease versus a 4% increase in the placebo group), CXCL5 (10% decrease vs 2% increase), CXCL8 (6% decrease vs. 0.7% increase), CXCL12 (8.1% decrease vs. 5.4% increase) and CCL2 levels (11.6% decrease vs. 12.8% increase.

“Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1β (IL-1β) levels after anthocyanin supplementation for 24 weeks,” said the researchers.

In addition, lower CXCL8 levels were correlated with increased HDL-Cholesterol levels, and with lower levels of soluble P-selectin (sP-selectin).

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid 

University of Seville (Spain), January 17, 2023

In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. 

The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. 

OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). 

Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. 

The beneficial effects of olive oil may be related to the actions of OEA. 

New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. 

We conclude that OA is an immunomodulator with an anti-inflammatory function that, along with an unsaponifiable fraction from olive oil, supports the use of this dietary fat in the Mediterranean diet. 

Going for a walk outside found to have more mental health benefits than walking indoors

University of Victoria (Canada), January 24, 2023

A team of researchers at the University of Victoria, working with a colleague from York University, both in Canada, has found that going for a short walk outdoors provides people with more mental health benefits than going for a same-length walk inside. In their study, published in the journal Scientific Reports, the group asked volunteers to walk indoors or outdoors and tested them before and after their walk.

Prior research has shown that regular exercise can provide both mental and physical health benefits for most people. But as the researchers with this effort note, little research has been conducted to find out if exercising in some environments compared to others is more or less beneficial. To address this gap, the researchers designed and carried out a study that involved 30 college student volunteers.

Each of the volunteers took two 15-minute walks, either inside or outside. Each also had electroencephalography exams before and after each walk. To assess whether walking had any impact on mental performance, the researchers used grades on the oddball task and changes in amplitude of neural response measured using the electroencephalography exams

The researchers found improvements in response time on the oddball task after walks regardless of where they occurred. But they only found changes in amplitudes, which measure neural response, in those people who had walked outside. All such changes were represented by increases, which prior research has shown indicates heightened attention and better memory skills.

The researchers suggest that people gain more mental health benefits (cognitive function) if they go for a short walk outside rather than a walk indoors. They do acknowledge that their study was limited and suggest that larger experiments might confirm their findings. They also note that it is still not clear if such differences might exist for longer walks or when engaging in more strenuous exercise.

Supplementation with amino acid serine eases neuropathy in diabetic mice

Salk Institute, January 25, 2023

Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy—weakness, numbness, and pain, primarily in the hands and feet. The condition occurs when high levels of sugar circulating in the blood damage peripheral nerves. Now, working with mice, Salk Institute researchers have identified another factor contributing to diabetes-associated peripheral neuropathy: altered amino acid metabolism.

The team found that diabetic mice with low levels of two related amino acids, serine and glycine, are at higher risk for peripheral neuropathy. What's more, the researchers were able to alleviate neuropathy symptoms in diabetic mice by supplementing their diets with serine.

The study, published  in Nature, adds to growing evidence that some often-underappreciated, "non-essential" amino acids play important roles in the nervous system. The findings may provide a new way to identify people at high risk for peripheral neuropathy, as well as a potential treatment option.

"We were surprised that dialing up and down a non-essential amino acid had such a profound effect on metabolism and diabetic complications," says senior author Christian Metallo, a professor in Salk's Molecular and Cell Biology Laboratory. "It just goes to show that what we think of as dogma can change under different circumstances, such as in disease conditions." Metallo led the study with first author Michal Handzlik, a postdoctoral researcher in his lab.

To determine whether long-term, chronic serine deficiency drives peripheral neuropathy, Metallo's team fed mice either control or serine-free diets in combination with either low-fat or high-fat diets for up to 12 months. The researchers were surprised to find that low serine, in combination with a high-fat diet, accelerated the onset of peripheral neuropathy in the mice. In contrast, serine supplementation in diabetic mice slowed the progression of peripheral neuropathy, and the mice fared better.

The researchers also tested the compound myriocin, which inhibits the enzyme that switches out serine for another amino acid as sphingolipids are assembled. Myriocin treatment reduced peripheral neuropathy symptoms in mice fed a high-fat, serine-free diet. These findings underscore the importance of amino acid metabolism and sphingolipid production in the maintenance of a healthy peripheral nervous system.

Serine deficiency has also been associated with various neurodegenerative disorders. For example, Metallo and collaborators previously found a link between altered serine and sphingolipid metabolism in patients with macular telangiectasia type 2, a condition that causes vision loss. In mice, reduced serine led to increased levels of atypical retinal sphingolipids and reduced vision. Serine is currently being tested in clinical trials for its safety and efficacy in treating macular telangiectasia and Alzheimer's disease.

Peripheral neuropathy is typically managed with dietary changes to reduce blood sugar levels, as well as pain relievers, physical therapy, and mobility aids, such as canes and wheelchairs. Foods naturally rich in serine include soybeans, nuts, eggs, chickpeas, lentils, meat, and fish, and serine supplements are inexpensive and available over the counter.

Yet the researchers say it's premature to advise people with diabetes to take serine supplements to prevent neuropathy.

"You would likely need to take a lot to make a difference, and not everyone needs extra serine," Metallo says. "We need more time to understand serine physiology in humans and explore potential downsides to supplementation."

High Consumption of Sugar-Sweetened Beverages Is Associated with Low Bone Mineral Density in Young People

Federal University of Maranhao & University of Pelotas (Brazil), January 14, 2023

Sugar-sweetened beverages (SSB) consumption may be associated with a reduction in bone mineral density (BMD). 

The aim of this study was to evaluate the association between the consumption of SSB and BMD among young people. 

We performed a cross-sectional study that evaluated 6620 young people (18–23 years of age) from three Brazilian birth cohorts (Ribeirão Preto, Pelotas, and São Luís). We analyzed the daily frequency and the amount and energy contribution of the SSB, which were obtained through a food frequency questionnaire. Total body and lumbar spine BMD (g/cm2), measured by dual-energy X-ray absorptiometry, were the outcomes. Unadjusted linear regression models, adjusted for sex, socioeconomic class, physical activity, smoking, alcohol consumption, and body mass index were used. 

The highest tertile of SSB consumption frequency (2.1–16.7 times/day) was associated with a lower lumbar spine BMD (β = −0.009; 95% CI: −0.017; −0.001; standardized β = −0.03). This association persisted after adjustment for confounders (β = −0.008; 95% CI: −0.016; −0.001; standardized β = −0.03). No association was observed between SSB consumption frequency and total body BMD or between the amount and energy contribution of SSB and total body or lumbar spine BMD. A high frequency of SSB consumption was associated with a low lumbar spine BMD.

Prolonged exposure to work-related stress thought to be related to certain cancers

University of Montreal, January 17, 2023 

For men, prolonged exposure to work-related stress has been linked to an increased likelihood of lung, colon, rectal, and stomach cancer and non-Hodgkin lymphoma. The findings are among the results obtained by researchers at INRS and Université de Montréal who conducted the first study to assess the link between cancer and work-related stress perceived by men throughout their working life. The research results were published in Preventive Medicine.

On average, the study participants had held four jobs, with some holding up to a dozen or more during their working lifetime. Significant links to five of the eleven cancers considered in the study were revealed. These links were observed in men who had been exposed to 15 to 30 years of work-related stress, and in some cases, more than 30 years. A link between work-related stress and cancer was not found in participants who had held stressful jobs for less than 15 years.

The most stressful jobs included firefighter, industrial engineer, aerospace engineer, mechanic foreman, and vehicle and railway-equipment repair worker. For the same individual, stress varied depending on the job held. Researchers were able to document changes in perceived work-related stress.

The study also shows that perceived stress is not limited to high work load and time constraints. Customer service, sales commissions, responsibilities, the participant's anxious temperament, job insecurity, financial problems, challenging or dangerous work conditions, employee supervision, interpersonal conflict, and a difficult commute were all sources of stress listed by the participants.

"One of the biggest flaws in previous cancer studies is that none of them assessed work-related stress over a full working lifetime, making it impossible to determine how the duration of exposure to work-related stress affects cancer development. Our study shows the importance of measuring stress at different points in an individual's working life," explain the authors of the study.

About Gary Null

An internationally renowned expert in the field of health and nutrition, Gary Null, Ph.D is the author of over 70 best-selling books on healthy living and the director of over 100 critically acclaimed full-feature documentary films on natural health, self-empowerment and the environment. He is the host of ‘The Progressive Commentary Hour” and “The Gary Null Show”, the country’s longest running nationally syndicated health radio talk show which can be heard daily on here on the Progressive Radio Network.

Throughout his career, Gary Null has made hundreds of radio and television broadcasts throughout the country as an environmentalist, consumer advocate, investigative reporter and nutrition educator. More than 28 different Gary Null television specials have appeared on PBS stations throughout the nation, inspiring and motivating millions of viewers. He originated and completed more than one hundred major investigations on health issues resulting in the use of material by 20/20 and 60 Minutes. Dr. Null started this network to provide his followers with a media outlet for health and advocacy. For more of Dr. Null’s Work visit the Gary Null’s Work Section or Blog.GaryNull.com In addition to the Progressive Radio Network, Dr. Null has a full line of all-natural home and healthcare products that can be purchased at his Online Store.

Find articles, videos, back radio broadcasts, books, and more at GaryNull.com.

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[julimazi]

What Are the Best Anti-Inflamatory Supplements?

The best anti-inflammatory supplements can be hard to come by, but with some research, you will find a few options. There are some great Omega-3 fatty acids, Alpha-lipoic acid, and Cannabidiol. Additionally, you'll find some options for the antioxidants Spirulina and Celery seed extract.

Omega-3 fatty acids are known for their anti-inflammatory properties, and their health benefits are well documented. But, there are also some concerns about omega-3 fatty acid supplements. More research is needed to determine the most appropriate dose of these nutrients for a patient with a specific health condition.

Regarding rheumatoid arthritis, there is some evidence that fish oil supplements may reduce inflammation and pain. In addition, fatty acids are thought to play a protective role in other conditions, including osteoporosis and lupus.

Alpha-lipoic acid, also called ALA, is a fat-soluble antioxidant. It helps convert blood sugar into energy and may help to protect the brain, nerves, and heart. In addition, it is said to be an effective treatment for certain diseases, such as diabetic neuropathy.

There are many foods rich in alpha-lipoic acid. Some of them are fish, red meat, wheat germ, and yeast. However, you can also take supplements of this vitamin-like compound.

One study suggests that it can promote the healing and regeneration of muscles after an injury. The supplement also improves the endothelial function of the brachial artery.

Curcumin is an effective antioxidant and anti-inflammatory agent that's used to treat a variety of ailments. It is a natural compound extracted from turmeric, a spice often found in Indian curry.

It is used for several health benefits, including the treatment of arthritis, neurodegenerative diseases, and chronic inflammation. There's also preliminary evidence that curcumin may help protect the heart. However, the scientific literature still needs to be substantiated better.

Its ability to block free radicals is one reason it's considered a powerful antioxidant. Free radicals can damage cell membranes, causing cell death. They can also tamper with DNA and other molecules.

Cannabidiol (CBD) has garnered a lot of attention in the scientific community. Its anti-inflammatory properties have become the subject of several studies. As such, several different types of CBD are available on the market. From CBD oil to CBD balm, there is a product to suit your specific needs.

As with any pharmaceutical, the best way to determine the right choice is to speak to your physician. While many studies have questioned the effectiveness of CBD, several high-quality clinical trials have demonstrated that it is an effective pain reliever.

Spirulina is an oxygenic photosynthetic bacterium found in fresh and marine water glasses. Its nutrient composition is rich in vitamins, essential fatty acids, and minerals. It is also rich in antioxidants.

Although the role of spirulina in preventing cardiovascular disease is not well-established, studies have shown that spirulina supplementation may lead to decreased oxidative stress. Oxidative stress causes diseases like rheumatoid arthritis and cardiovascular diseases. In addition, spirulina may lower the incidence of cancer.

The anti-inflammatory effects of spirulina have been demonstrated in various animal models. For example, spirulina reduced lipid peroxidation in rats and mice. This is because spirulina contains a plant-based protein called phycocyanin, which is known to have powerful antioxidant and anti-inflammatory properties.

The celery seed extract is a natural supplement that relieves arthritic pain and inflammation. It also supports healthy digestion and heart and kidney health. In addition, it can help you fight infections and prevent a variety of illnesses.

Celery seeds contain several antioxidants. These include polyphenols, which protect your bones and prevent some cancers. There are also terpenes, which have antibacterial effects.

Anti-inflammatory drugs can be an excellent way to treat pain and inflammation but can also cause side effects. Many people opt for celery seed extract instead.

Organixx Magi-Complex anti-inflammatory supplements help to support the health of the immune system and heart. They are made with pure and organic plant extracts. These ingredients have been scientifically studied and proven to work.

The three main ingredients in this supplement are turmeric, frankincense, and myrrh. Each of these ingredients provides a powerful anti-inflammatory effect. When used together, the supplement helps reduce inflammation, which is caused by various conditions.

The Magi-Complex is available in a powder capsule or essential oil form. Each supplement contains no fillers, binders, or artificial additives. It is manufactured in GMP-certified laboratories.

[pathologyucgconference]

Similar to optical microscopes, electron microscopes (EMs) analyse samples to determine their structure and composition by "imaging" them with a focussed electron beam rather than a photon beam.

For the study of biopsy samples of peripheral nerves (mainly sural nerves) from patients with a range of neuropathies, electron microscopy is a helpful adjunct. Examples include the discovery of earlystage Büngner's band formation in axonal atrophy onion bulbs (concentric Schwann cells), a feature of demyelination and remyelination seen in Dejerine-Sottas, hypertrophic Charcot-Marie Tooth, and Refsum's diseases; and uncompacted myelin lamellae found in POEMS syndrome (polyneuropathy, organomegaly, endo

For more info join us: at the 10th World Digital Pathology & AI UCGCongress on April 04-06, 2023 in Berlin, Germany

The transmission electron microscope is comparable to a high-magnification, high-resolution light microscope in terms of the pathologist's ability to see minute intracellular and extracellular structures in great detail. Examples include mitochondria (organelles), melanosomes, and various secretory granules (inclusions), as well as the cytoskeleton's microtubules, microfilaments (such as actin), and intermediate filaments. Other examples include cilia, microvilli, and intercellular junctions (cell surface specialisations), as well as extracellular components like basement membranes, collagen, and amyloid.

The scanning electron microscope is the second and most modern type (SEM). Microorganisms can be seen in three dimensions thanks to the reflection of the electrons as they pass over the specimen. The same palladium or gold staining is used.

There are numerous applications for electron microscopy. The ideal would be to

identify the conformation of flexible protein structures and complexes

investigate the in vivo molecular processes of disease

examine the three-dimensional architecture of tissues and cells;

observe specific viruses and macromolecular assemblies in their innate biological environments.

What is meant by surgical pathology? To assist in the diagnosis of a disease and the formulation of a treatment strategy, surgical pathology is the study of tissues taken from living patients during surgery. In a number of organ systems and medical subspecialties, the surgical pathologist frequently offers consultation services.

Surgical pathologists offer second opinions or diagnostic information. For instance, a surgical pathologist's examination of the tissues removed during surgery can assist the surgeon in deciding whether or not to remove lymph nodes under the arm as well when performing breast cancer surgery.

Join us to learn more about it at the 10DIGIPATH2023.

Both a visual examination of the tissue with the unaided eye and a microscopic examination of processed tissue are included in surgical pathology. The examination of tissue and cell samples using new techniques involves molecular diagnostics (DNA/RNA analysis). Analyzing blood proteins and DNA is necessary for this.

Surgery pathology Samples can be taken from any area of the body, including the.

A. Noticable lumps, 

1. breast

2. lymph nodes

3. masses of soft tissue.

4. Thyroid.

The complex pathophysiological process known as a concussion (or mild traumatic brain injury) affects the brain and is brought on by traumatic biomechanical stresses due to direct or indirect forces to the head. frequently accompanied with conventional structural imaging results, and injury

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Reference Digital Pathology UCGConferences press releases and blogs

[shalinijainsamyak]

Fundus Examination | Samyak Eye Care Clinic

Fundus Examination

People with type 1 and type 2 diabetes are at a heightened risk for eye complications and peripheral neuropathy.

You may have heard that diabetes causes eye problems and may lead to blindness. People with diabetes do have a higher risk of blindness than people without diabetes. But most people who have diabetes have nothing more than minor eye disorders over time.

With regular checkups, you can keep minor problems minor. And, if you do develop a major problem, some treatments often work well if you begin them right away.

How the eye works

Understanding what happens in eye disorders, helps to understand how the eye works. The eye is covered with a tough outer membrane. The covering in front is clear and curved. This curved area is the cornea, which focuses light while protecting the eye.

After light passes through the cornea, it travels through a space called the anterior chamber (which is filled with a protective fluid called the aqueous humor), through the pupil (which is a hole in the iris, the colored part of the eye), and then through a lens that performs more focusing. Finally, light passes through another fluid-filled chamber in the center of the eye (the vitreous) and strikes the back of the eye, the retina.

The retina records the images focused on it and converts those images into electrical signals, which the brain receives and decodes.

One part of the retina is specialized for seeing fine detail. This tiny area of extra-sharp vision is called the macula. Blood vessels in and behind the retina nourish the macula.

Glaucoma

People with diabetes are more likely to suffer from glaucoma than people without diabetes. The longer someone has had diabetes, the more common glaucoma is. Risk also increases with age.

Glaucoma occurs when pressure builds up in the eye. The pressure pinches the blood vessels that carry blood to the retina and optic nerve. Vision is gradually lost because the retina and nerves are damaged.

There are several treatments for glaucoma. Some use drugs to reduce pressure in the eye, while others involve surgery.

Cataract

Many people without diabetes get cataracts, but people with diabetes are more likely to develop this eye condition. People with diabetes also tend to get cataracts at a younger age and have them progress faster. With cataracts, the eye’s clear lens clouds, blocking sight.

To help deal with mild cataracts, you may need to wear sunglasses more often and use glare-control lenses in your glasses. For cataracts that interfere greatly with vision, doctors usually remove the lens of the eye and replace it with a new artificial lens. In people with diabetes, retinopathy can get worse after the removal of the lens, and glaucoma may start to develop.

Retinopathy

Diabetic retinopathy is a general term for all disorders of the retina caused by diabetes. There are two major types of retinopathy: nonproliferative and proliferative.

Nonproliferative retinopathy

In nonproliferative retinopathy, the most common form of retinopathy is capillaries in the back of the eye balloon and forming pouches. Nonproliferative retinopathy can move through three stages (mild, moderate, and severe), as more and more blood vessels become blocked.

Macular edema

Although retinopathy does not usually cause vision loss at this stage, the capillary walls may lose their ability to control the passage of substances between the blood and the retina. Fluid can leak into the part of the eye where focusing occurs, the macula. When the macula swells with fluid, a condition called macula edema, vision blurs and can be lost entirely. Although nonproliferative retinopathy usually does not require treatment, macular edema must be treated, but fortunately, treatment is usually effective at stopping and sometimes reversing vision loss.

Proliferative retinopathy

In some people, retinopathy progresses after several years to a more serious form called proliferative retinopathy. In this form, the blood vessels are so damaged they close off. In response, new blood vessels start growing in the retina. These new vessels are weak and can leak blood, blocking vision. The new blood vessels can also cause scar tissue to grow. After the scar tissue shrinks, it can distort the retina or pull it out of place, a condition called retinal detachment.

How is retinopathy treated?

Huge strides have been made in the treatment of diabetic retinopathy. Treatments such as scatter photocoagulation, focal photocoagulation, and vitrectomy prevent blindness in most people. The sooner retinopathy is diagnosed, the more likely these treatments will be successful. The best results occur when sight is still normal.

In photocoagulation, the eye care professional makes tiny burns on the retina with a special laser. These burns seal the blood vessels and stop them from growing and leaking.

In scatter photocoagulation (also called panretinal photocoagulation), the eye care professional makes hundreds of burns in a polka-dot pattern on two or more occasions. Scatter photocoagulation reduces the risk of blindness from vitreous hemorrhage or detachment of the retina, but it only works before bleeding or detachment has progressed very far. This treatment is also used for some kinds of glaucoma.

Side effects of scatter photocoagulation are usually minor. They include several days of blurred vision after each treatment and possible loss of side (peripheral) vision.

In focal photocoagulation, the eye cares professional aims the laser precisely at leaking blood vessels in the macula. This procedure does not cure blurry vision caused by macular edema, but it does keep it from getting worse.

When the retina has already detached or a lot of blood has leaked into the eye, photocoagulation is no longer useful. The next option is vitrectomy, which is surgery to remove scar tissue and cloudy fluid from inside the eye. The earlier the operation occurs, the more likely it is to be successful. When the goal of the operation is to remove blood from the eye, it usually works. Reattaching a retina to the eye is much harder and works in only about half the cases.

There are two types of treatment for macular edema: focal laser therapy that slows the leakage of fluid, and medications that can be injected into the eye that slow the growth of new blood vessels and reduce the leakage of fluid into the macula.

A newer retinopathy treatment involves injecting medication directly into the eye. The injection contains a drug that blocks the activity of vascular endothelial growth factor (VEGF). This hormone promotes the growth of new blood vessels and plays a key role in retinopathy by promoting the growth of weak, leaky blood vessels. Anti-VEGF drugs put a stop to problem vessels, improving vision in people with retinopathy. In many cases, these treatments have to be repeated every few months (sometimes every month) to decrease the inflammation in the eye.

There are also some other new treatments with substances that are put into the back of the eye to help it heal. All of these advances in eye care have made a big difference in helping people’s eyes. Prevention is always first, but if damage happens, it can be treated.

Am I at risk for retinopathy?

Several factors influence whether you get retinopathy:

blood sugar control

blood pressure levels

how long you have had diabetes

genes

The longer you’ve had diabetes, the more likely you are to have retinopathy. Almost everyone with type 1 diabetes will eventually have nonproliferative retinopathy. And most people with type 2 diabetes will also get it. But the retinopathy that destroys vision, proliferative retinopathy, is far less common.

People who keep their blood sugar levels closer to normal are less likely to have retinopathy or to have milder forms.

Your retina can be badly damaged before you notice any vision change. Most people with nonproliferative retinopathy have no symptoms. Even with proliferative retinopathy, the more dangerous form, people sometimes have no symptoms until it is too late to treat them. For this reason, you should have your eyes examined regularly by an eye care professional.

Visit the Focus on Diabetes site for more information regarding eye health and diabetes.

high blood pressure and other disorders, because many diseases can have an impact on vision and eye health