#pharma school

[virtuosicstudyblr]

my desk constantly looking like this because I need to study for biology 😬🌿

[science-lover33]

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

[bagofbonesmp3]

idk if you guys remember my Viagra notepad but the reason I had that is that I have a psychiatrist godmother and since I was pencil holding age she has gifted me all the gift bags she gets at medicine congresses. this months notepad is sponsored by Ritalin

[lord-squiggletits]

Pharma's place in a Functionist society (headcanon)

So I've talked in some previous posts about all the reasons that Pharma isn't a functionist because canon never showed him espousing functionist ideals + he's actually in a place to be a victim of functionism. And I've been working on a Pharma-centric oneshot that made me put into words the best metaphor I can think of for Pharma's relationship with Functionism:

He doesn't support Functionism, but is simultaneously a beneficiary of it and also marginalized by it, because his position of being forged both a doctor and a jet basically turns him into a "token minority" of sorts.

I know that sounds kind of silly or maybe like a clumsy political allegory, but hear me out. There are a couple facts about Pharma and the circumstances of his forging that put him at the crossroads between privilege and marginalization within Functionism:

Tyrest says that Pharma was "famous for being forged." Not famous for being a forged medic-- otherwise surely Ratchet would be just as noteworthy-- but famous for being FORGED. But also, note that this is an opinion that SOCIETY had about Pharma, not something that Pharma espouses about himself. (For the sake of an example, Pharma isn't Starscream, who has an explicit, deep-seated need for others' love and approval. Pharma himself doesn't express any opinions on his own popularity or convey that fame/adoration is something he wants.)

Functionism on Cybertron held that if someone was born with a certain alt-mode, they can/should only have certain jobs. For people born with flight alt-modes, those people were almost always regulated to military or transportation/courier jobs

SIMULTANEOUSLY, Pharma was forged with medic hands, which under a Functionist society were viewed as the peak of medical care and all the best doctors were forged or at least had a "special something" that non-forged hands lacked (according to Ratchet).

So taken in combination, this means that from the moment of Pharma's birth, he straddled a line of Functionism between two different "predestined" paths for him, where he was simultaneously forged to be a doctor and also forged to fly, fitting into BOTH of these categories despite norms of Functionism which say you're one or the other. And I speculate that the reason Pharma is "famous for being forged" is precisely because of those lines he straddles: his very existence is a contradiction, but he was also FORGED that way. The same creed that dictated the two different functions of "hands" and "alt-mode" also says that Pharma should be what he was born to be. What he was born to be was a forged medic jet.

In my opinion, I think that being "famous for being forged" is sort of like a token-minority situation for Pharma, where perhaps Pharma was seen as a curiosity or even something exotic, not just as a person. Maybe because he was a jet and people assumed jets were only soldiers/transportation, a lot of his achievements were put in the light of "Oh, he's a really amazing doctor, for a jet" or "It's crazy that he's a doctor AND a jet at the same time". The attention Pharma received for the unique circumstances of his birth WAS positive, but it would've likely been framed in a bit of a condescending way, as if Pharma is noteworthy and famous not for being a good doctor, but for being a good doctor despite being born a jet.

So I would say that as far as Pharma's personal experience with Functionism, he simultaneously experienced privilege and marginalization. He enjoyed the privileges of being a medic while avoiding the restrictions of being a flight frame. However, a lot of the idolization and attention he received would have also come from a place of tokenizing Pharma: he's "famous for being forged," because in this society he's defying expectations merely for existing as himself. That is to say, Pharma in a Functionist society wasn't treated as remarkable because of who he is as a person and how hard he worked to be a good doctor; he was treated as remarkable for the circumstances of his forging, something he had no control over and can't change, and apparently Pharma being a forged medic jet is such a noteworthy origin that he's "famous" for it.

The above paragraph is purely headcanon, of course, but I like to imagine that part of Pharma's reason for having a big ego isn't out of simple vanity or insecurity, but because of a sort of "gifted student" syndrome, in a sense. From the moment he was forged he was treated as a rarity and an incredible phenomenon, and he would have had to work incredibly hard to be seen as "an incredible doctor" in his own right rather than just "that forged medic jet." Maybe, as a jet, he also had something to prove; he had to show to a Functionist society that being a jet doesn't make him an inferior doctor and that his alt-mode has nothing to do with his skills at his profession.

That is to say, I don't think Pharma would have been openly anti-Functionist, or had many opinions about it at all. I actually lean towards the interpretation that Pharma basically saw himself as getting lucky with the way he was forged and being content with the fact that he'd managed to carve out a reputation for himself as being incredibly skilled. However, Pharma not getting involved politically in Functionism doesn't change the fact that he WOULD have had a very complicated relationship with Functionism, in that alt-mode discrimination would have had an effect on him even though he was in the scientific/medical class and supposedly privileged.

[mantareidraws]

Graduated cum laude today!! 🥳🎉

[writtenroses1813]

So I’ve had my mind made up about becoming a pharmacologist since the fourth grade and I thought to myself continuously “what do I have to show for it?? I have no tragic backstory when people ask why I went into it. No fireman’s ‘my childhood apartment burnt down’ or policeman’s ‘my father was killed by a gang’ or any other good reason for wanting to save the world. What do I say? ‘It seemed pretty cool’? How could I compare to the others with such greater troubles and backgrounds?”

Turns out I didn’t have to worry about it at all because wouldn’t you know it a life-altering (and threatening) disability that had to be heavily medicated hit me like a truck. So yeah. Turns out I do have a tragic backstory.

[heardatmedschool]

“If I ever see you prescribing a dual antidepressant for a first episode, I’ll know you’re definitely bought by the industry.”

[prettyboysdontlookatexplosions]

it is sometimes challenging in this present moment to be someone who both like believes in the benefits of medication, to the extent that i think the question of “necessity” is honestly kind of a distraction, and also thinks that we as a culture should be like 200% less confident than we are in whatever we are being told the medical establishment has deemed factual at any given time

[studymedisina]

november 20, 2022;; 11:45pm

pictured is one of the many brief review pages i made for my pharma exam last friday. it’s very messy and colorful, but it helped in drilling in the concepts that i needed to focus on. i don’t make these types of extra notes for all of my subjects, but pharma is notably memorization-heavy AND a pain to pass.

song of the day: let me entertain you by robbie williams

[buzwit]

Debunking the Myth: Google Does Crawl iFrames – Insights from SEO Experts

In recent discussions among search engine marketing experts on Reddit, a thread sparked a dialogue about whether Google ignores iframes. The belief that Google doesn’t crawl frames has been a long-standing assumption in the SEO community, but is this true? Let’s dive into the facts, examine Google’s own Webmaster Trends Analyst, Mueller’s response, and explore the SEO impact of iframes.

The Fable: Google Doesn’t Crawl iFrames.

Earlier, search engines found it difficult to crawl and index content within iframes. Search engine bots were unable to access the content inside iframes, and sometimes couldn’t exit the iframe to continue crawling the rest of the website. Additionally, the content within iframes was often considered to belong to a different website, which led to uncertainty about whether it should be indexed.

The Actuality: Google Can & Does Crawl iFrames.

Contrary to the belief of some Reddit users, Google has made significant advancements in crawling iframes. Currently, Google has the capability to directly render the iframe and inject its content as part of the hosting page, a process known as “DOM Flattening.” Mueller addressed this issue by providing insights in the thread, stating that “Google does attempt to crawl iframed content and include it in the indexed page, if it’s allowed. It’s not always trivial though, and I don’t know how other search engines handle it. If you have something that you absolutely want indexed within the context of a page, I’d work to include it directly rather than relying on iframes.“

Mueller also provided further advice for those who use embedded or iframed content on their pages:

Use the “x-frame-options” header to block iframing completely if it’s not desired.

Use “noindex” robots meta tags or “x-robots-tag” if neither the embedded content nor the relevant page should be indexed.

Use “indexifembedded” along with “noindex” if the embedded page itself should not be indexed, but its content can be included in a page that’s iframing it.

To check if Google can see the content in iframes, you can use the “mobile-friendly test” in Search Console.

iFrames Not Generally advocated.

Due to the potential indexing challenges with iframes, Google recommends minimizing their use as much as possible. Including trivial content straightaway on the page or using other embedding techniques could churn out better SEO results and will make sure that Google can accurately index the content.

Stay Ahead of the game with best SEO practices at BUZWIT DIGITAL STUDIO

While iframes may have posed challenges for search engines in the past, advancements in technology and search engine algorithms have improved their ability to crawl and index iframe content. After all, in the ever-evolving world of SEO, staying ahead of the game means keeping up with the latest developments and best practices. Happy optimizing! So, dear webmasters, take heed and tread carefully when it comes to using iframes in your web design endeavors. At BUZWIT DIGITAL STUDIO, we use the right approach and understanding, and you can ensure that your content gets the visibility it deserves in search engine results.

BUZWIT DIGITAL STUDIO offers best SEO tactics and practices.

In today’s digital age, SEO (Search Engine Optimization) is critical to the success of any online business. By optimizing your website for search engines, you can increase your visibility and attract more targeted traffic to your site. But with so many SEO tactics and strategies to choose from, it can be difficult to know where to start.

That’s where BUZWIT DIGITAL STUDIO comes in. As a leading digital marketing agency, we specialize in helping businesses stay ahead of the game with the best SEO practices.

Here’s how we work effectively to help our clients achieve their SEO goals:

conduct comprehensive SEO audits.

Before we begin any SEO campaign, we conduct a comprehensive audit of our client’s website to identify any issues that may be impacting their search engine rankings. This includes analyzing factors such as website structure, content, keywords, and backlinks.

developing customized SEO strategies.

Based on the results of our audit, we develop customized SEO strategies that are tailored to our client’s unique needs and goals. This includes optimizing website content, building quality backlinks, and improving website structure and navigation.

We stay up to date with the latest SEO trends.

SEO is a constantly evolving field, and it’s important to stay up to date with the latest trends and best practices. At BUZWIT DIGITAL STUDIO, we are always on the cutting edge of the latest SEO trends, and we use this knowledge to deliver results for our clients.

We track and analyze performance.

We monitor the performance of our SEO campaigns closely, tracking key metrics such as search engine rankings, website traffic, and conversion rates. This allows us to make data-driven decisions and adjust our strategies as needed to achieve the best possible results.

The myth that Google doesn’t crawl iframes has been debunked by Google’s own Webmaster Trends Analyst, Mueller. Google has the capability to crawl iframed content and include it in the indexed page, but it’s not always straightforward. To ensure proper indexing and SEO performance, it’s recommended to use iframes sparingly and follow Google’s advice on how to handle iframed content. Keeping up to date with Google’s guidelines and best practices is crucial for search engine marketers to stay ahead in the ever-evolving world of SEO. Don’t let the myth of Google ignoring iframes impact your SEO strategy — stay informed and make informed decisions.

In conclusion, SEO is essential to the success of any online business, but it can be a complex and ever-changing field. At BUZWIT DIGITAL STUDIO, we work effectively to help our clients stay ahead of the game with the best SEO practices. By conducting comprehensive audits, developing customized strategies, staying up to date with the latest trends, and tracking performance closely, we deliver real results for our clients. Contact us today to learn more about how we can help you achieve your SEO goals.

(Source: reddit)

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Plot:50, 4th Floor, Behind Raheja Mindspace, Gafoornagar Village, Madhapur, Hyderabad, Telangana 500081.

[ava-dance-music]

A major arpeggio sweep and two hand tapping hands crossover flashy play

[virtuosicstudyblr]

state exam days 7/37

breaks in the botanical garden 🪴🍃

[vicemirrored-a]

𝐐𝐔𝐎𝐓𝐄 𝐒𝐄𝐍𝐓𝐄𝐍𝐂𝐄 𝐒𝐓𝐀𝐑𝐓𝐄𝐑𝐒.  /  @hidefire​ asked: ❛ you wouldn’t understand. ❜

standoffish. not the sort of patient that he particularly liked to deal with, but certainly not anything new. all things considered, it was more surprising when patients considered for these trials were not a little wary. the smile that he fixed on his face in reply, as he leaned back in his seat with a shrug, was as friendly and pleasant as he could make it. “ perhaps i wouldn’t. perhaps i would. either way, i can only help if you try to tell me. ”

[deus-ex-mona]

throwback to when the sus subs on bilibili matched up with the on-screen happenings

[lord-squiggletits]

Galaxy brained realization that the Vocaloid song Matryoshka fits post-Delphi Pharma perfectly.

Maybe for one of my Pharmay arts I'll draw Pharma in the art style from that music video

[onetruelurker]

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