#she-ra is targeted at like 10-12 year olds and i started it when i was 18 | Explore Tumblr Posts and Blogs

themeltedheadaches · 7 years

Note

ALL THE ASKS DO IT unless ur too busy #collegelife love u ❤❤❤❤

LOVE U BOO never too busy for u (also using this to procrastinate on my french composition so)

1: when you have cereal, do you have more milk than cereal or more cereal than milk?

i eat my cereal………………….dry…………..

2: do you like the feeling of cold air on your cheeks on a wintery day?

YES that’s literally my life now. i love it but also my nose was running today all the way to get coffee in downtown. i was in THREE LAYERS it is not even DECEMBER

3: what random objects do you use to bookmark your books?

answered! :)

4: how do you take your coffee/tea?

if i’m going to be a bitch and just get plain coffee, i’m gonna get it black bc otherwise i’ll just have a white mocha or a cappuccino or something (the ppl at the campus coffeeshop know who i am. they know my order. “one sin-ful latte coming up!” thank u for fueling my Addition.) i take my tea with milk and sugar if it’s black tea ((earl gray)) or with honey if it’s green tea. if it’s white tea i’ll sometimes have it with sugar, and if it’s something like peppermint or lavender or chamomile i’ll just have it plain. IM A PICKY BITCH

5: are you self-conscious of your smile?

i used to be! but now i like it.

6: do you keep plants?

YES pls pray for them

7: do you name your plants?

answered! :)

8: what artistic medium do you use to express your feelings?

poetry! i like to watercolor too, actually, though i left them at home :(

9: do you like singing/humming to yourself?

YES i miss my car bc that’s when i would have Prime Time to sing and hum to myself or along to whatever song i live for at the moment. (i’m into a musical rn and i can’t yell the lyrics out i’m so ANnoyed Always)

10: do you sleep on your back, side, or stomach?

answered!

11: what’s an inner joke you have with your friends?

i have fucking countless at home……. at college there are quite a few too! as in: “hypothetically, vodka?,” “fuckinG,,,WHAT,” “[blow twice] [slurp sound] [tongue click] noice.,” “SHPEAKERSH OHN!,” “over there! like, over there? over there. over there?,” “just going to go kick some nutria,” and of course, the classic, “same, but jewish.”

12: what’s your favorite planet?

URANUS actually tho it’s uranus. i had to do my planet project on it in the 4th grade and i gave my brother AND mother silent treatment for two days bc they laughed at its name. i’m very protective

13: what’s something that made you smile today?

i saw my favorite puppy on campus again today!! he’s grown so much!! also my poetry professor’s wife had a successful surgery! #GoMeredith

14: if you were to live with your best friend in an old flat in a big city, what would it look like?

SO MESSY………………….listen. @michelle i’ve seen ur room, and i would just accept that that is how we live now and it’s fine. it would also be aesthetic as fuck tho tbh. full of yarn and animal fur. and books. and junk food #RIFP

15: go google a weird space fact and tell us what it is!

if saturn’s rings were a meter long, they would be 10000 times thinner than a razorblade! what the fuckkkkkkkkkkk

16: what’s your favorite pasta dish?

UHHHHH fucking;;;;;;;;what how am i supposed to #represent my italian fmaily with this DISGUSTING question,,,,,,,,,,,,,,,,, jk i fuckig love risotto, just ur basic bitch peas and cheese risotto and i’ll cry. also?? gnocchi!! holy shiiiiiiiit.

17: what color do you really want to dye your hair?

my hair has such good color i’d actually rather shave it all off than dye it :/

18: tell us about something dumb/funny you did that has since gone down in history between you and your friends and is always brought up.

HHHHHHHH yesterday. LITERALLY yesterday. there was a french club meeting that served cheese and bread! so i took my Good Friend WIliam (who is not in french, unlike me), and we walk into the room, and i say “helLO!” bc that’s good manners, when you’re going to just get food and leave, and it’s dead silent. i get food and leave. william has told everyone in our entire hall twice.

19: do you keep a journal? what do you write/draw/ in it?

answered!

20: what’s your favorite eye color?

i’m so biased……….but……..brown………..

21: talk about your favorite bag, the one that’s been to hell and back with you and that you love to pieces.

my brown leather one! it’s actually super fake leather and i got it from target!! but it’s cute and small and somehow fits everything i need to put in it, including 3 beers and my wallet and 2 phones last weekend. i’ve had for 4 years now

22: are you a morning person?

yes! i like waking up early actually

23: what’s your favorite thing to do on lazy days where you have 0 obligations?

go on youtube and waste time, or walk around campus/downtown with friends, or shop!

24: is there someone out there you would trust with every single one of your secrets?

yes

25: what’s the weirdest place you’ve ever broken into?

my cousin’s RV

26: what are the shoes you’ve had for forever and wear with every single outfit?

my brown leather boots! wow there’s a trend here lmao. actually i’ve had two pairs of these bc my first was falling apart?? i used them first in a cosplay……in the 7th grade………..(i was matt from death note and to this day i’m STILL not fucking ashamed, i had the wig and goggles and everything.) i love them and wear them all the time, they’re so comfy and warm and stylish and i feel like a hacker badass everytime i wear them. still to this day.

27: what’s your favorite bubblegum flavor?

bubblegum gives me hives i do Not enjoy it :(

28: sunrise or sunset?

sunset!

29: what’s something really cute that one of your friends does and is totally endearing?

one of my friends down the hall will call things/ppl “cute as pie” completely genuinely!! i love her!!

30: think of it: have you ever been truly scared?

oh yeah

31: what is your opinion of socks? do you like wearing weird socks? do you sleep with socks? do you confine yourself to white sock hell? really, just talk about socks.

i fucking love them thanks end of story. wearing them makes me feel cozy and put together and also atm my dorm floor is Disgusting. i sleep with them when it’s cold and my feet are dry! i have so many fun socks it’s great. i love them. socks are highly underrated.

32: tell us a story of something that happened to you after 3AM when you were with friends.

my friend and i were driving around evERYWHRE basically, we went from pasadena/san marino to like. hollywood all the way to beverly hills and back and it was wonderful, we stopped 3 times to chase stray cats, take shitty pictures, go to iHop, and almost died several times bc hE SNAPS AND DRIVES at NIGHT on LA FREEWAYS

33: what’s your fave pastry?

croissants, followed by scones, followed by coffeecake

34: tell us about the stuffed animal you kept as a kid. what is it called? what does it look like? do you still keep it?

bunny the stuffed bunny! she’s pretty large, like as long as my torso! she’s white fabric with colored fluffy bits and very floppy, loose ears. she has green button eyes that i had my grandma sew on bc otherwise she actually scared me a bit when i was a kid, but i loved her anyway bc my great-grandmother sewed her for me in the first place. bunny still lives on my bed at home!

35: do you like stationary and pretty pens and so on? do you use them often?

YES! i ddon’t use them very often though bc i feel like i should save them for something. rip me

36: which band’s sound would fit your mood right now?

stromae hands down

37: do you like keeping your room messy or clean?

clean….i’m so lazy tho

38: tell us about your pet peeves!

sudden loud noises, being startled, being touched physically when i don’t expect it, someone making assumptions about me, being dismissed, being told what i want or what i’m going to do, borrowing something of mine w/o telling me, being interrupted

39: what color do you wear the most?

HONESTLY black bc i’m an emo bitch

40: think of a piece of jewelry you own: what’s it’s story? does it have any meaning to you?

one i’ve been wearing a lot is the fork ring i got from the portland saturday market! it’s literally the tines of a vintage fork separated from the part you hold, sanded down so it’s round, and looped into a ring shape. i fidget with it a lot and it reminds me of my mom and step-dad, bc i got it when i was with them. i wear it mostly everyday tbh

41: what’s the last book you remember really, really loving?

new american best friend by olivia gatwood in general, or thick as thieves by megan whalen turner when i re-read it out loud to my mom on the ride up to college

42: do you have a favorite coffee shop? describe it!

yeeeeeeS i have several! the bistro, which is on campus: it’s so comfortable, it has couches everywhere and board games and so many books and zines and the walls are half chalkboard so there’s always art or snark everywhere. the music is super eclectic (it was lorde yesterday, today when i went in it was old-school 90s rap), plus it’s student run so the coffee and pastries and food are SO GOOD. the archive, which is downtown, is really boujee as fuck but it’s SO COOL. it’s so fucking aesthetic, with brown leather stools and uncomfortable booths and vintage books and stuff everywhere. for half the day, it’s a coffeeshop, and after 7, it becomes a bar. then back home, of course, coffee bean and tea leaf is the classic

43: who was the last person you gazed at the stars with?

half my hall when we went star tripping at the start of the year!

44: when was the last time you remember feeling completely serene and at peace with everything?

honestly the last time it was genuine was probably around…….january? i was in so much emotional pain and grief, but i was surrounded by family who loved me and were in that same pain and were so happy i was with them to help and be there with them. i wasn’t serene per say, or at peace, but there was this equilibrium….

45: do you trust your instincts a lot?

yes!

46: tell us the worst pun you can think of.

my RA told me this one this morning: did you hear about the explosion in the cheese factory in france this morning? de-brie everywhere!

47: what food do you think should be banned from the universe?

tomatoes

48: what was your biggest fear as a kid? is it the same today?

spiders, YES

49: do you like buying CDs and records? what was the last one you bought?

i do…………………….. it was the soundtrack to romeo et juliette (2010)

50: what’s an odd thing you collect?

everything; stickers, pressed flowers, rocks, receipts

51: think of a person. what song do you associate with them?

the easiest one is when i think of my roommate, davey the dog’s barking cover of “do the hustle”

52: what are your favorite memes of the year so far?

53: have you ever watched the rocky horror picture show? heathers? beetlejuice? pulp fiction? what do you think of them?

no, yes, no, no, it was okay

54: who’s the last person you saw with a true look of sadness on their face?

ME, BITCH

55: what’s the most dramatic thing you’ve ever done to prove a point?

chugged an an entire pitcher of water to prove i could, three times

56: what are some things you find endearing in people?

genuineness! vulnerability! eye contact! fidgeting!

57: go listen to bohemian rhapsody. how did it make you feel? did you dramatically reenact the lyrics?

made me feel PUMPED, and of course i did

58: who’s the wine mom and who’s the vodka aunt in your group of friends? why?

i am both

59: what’s your favorite myth?

uHHHHHHHHHH i love the myth of beowulf actually bc i had to do a project on it once, i have a soft spot for it, i love all myths tho wtf

60: do you like poetry? what are some of your faves?

YES,,,,,,,,,,,,,,,, recently some of my favorites are the entirety of a montage of a dream deferred by langston hughes, “totem sonnets” by sherman alexie, “on earth we’re briefly gorgeous” by ocean vuong, “one art” by elizabeth bishop

61: what’s the stupidest gift you’ve ever given? the stupidest one you’ve ever received?

stupid gifts are nonexistent :/

62: do you drink juice in the morning? which kind?

noooo

63: are you fussy about your books and music? do you keep them meticulously organized or kinda leave them be?

yes lmao…….i kinda leave them be but i don’t like it if i let someone borrow them and they trash them uGH

64: what color is the sky where you are right now?

Pitch Black

65: is there anyone you haven’t seen in a long time who you’d love to hang out with?

YES

66: what would your ideal flower crown look like?

morning glories, lavender, baby’s breath!

67: how do gloomy days where the sky is dark and the world is misty make you feel?

very good, thankfully, bc i am in oregon

68: what’s winter like where you live?

in LA, it’s cold and sweet and late and breathless and i adore it

69: what are your favorite board games?

jenga, clue, ??

70: have you ever used a ouija board?

NONONONONO

71: what’s your favorite kind of tea?

peppermint for mornings, earl gray for evenings!

72: are you a person who needs to note everything down or else you’ll forget it?

yes, sadly

73: what are some of your worst habits?

biting the skin around my fingers, bouncing my knees incessantly, procrastinating on my french compositions……

74: describe a good friend of yours without using their name or gendered pronouns.

well there’s this amazing person who i met in freshman year german…….;)

75: tell us about your pets!

i WISH

76: is there anything you should be doing right now but aren’t?

yes :(

77: pink or yellow lemonade?

pink of course

78: are you in the minion hateclub or fanclub?

i am the true hateclub: i don’t react. do not give them power. they Feed off of your Hatred

79: what’s one of the cutest things someone has ever done for you?

get me flowers, surprise me with chocolate, come up to me and compliment me on my writing, etc!!

80: what color are your bedroom walls? did you choose that color? if so, why?

at home my walls are a soft orangey-peach, which is picked bc i love it. here, my walls are very very white, which i did not pick, but am neutral towards.

81: describe one of your friend’s eyes using the most abstract imagery you can think of.

circuit-board chips busted open

82: are/were you good in school?

ehhhhhhh

83: what’s some of your favorite album art?

MELODRAMA

84: are you planning on getting tattoos? which ones?

yes! a minimalistic double-delight rose for my great-grandmother, “love ya!” in my grandpa’s handwriting, maybe a nutshell with a crown over it (for the “king of infinite space” bit in hamllet), possibly “soyez réaliste, demandez l’impossible!” (be realistic, demand the impossible!) from the french student revolution in the 60s

85: do you read comics? what are your faves?

somewhat, def hawkeye or the young avengers bc i’m basic :/

86: do you like concept albums? which ones?

the only one i’ve rlly ever listened to is fucking danger days, so i worship them obviously

87: what are some movies you think everyone should watch at least once in their lives?

i think ppl should make their own agendas :/ however, i have deeply loved secondhand lions, up, moonlight, the grand budapest hotel, and other basic bitch things

88: are there any artistic movements you particularly enjoy?

impressionism!! aaaaaaa!!! also just shove me in front of abstract art and i’ll fall for it!!!

89: are you close to your parents?

so so so so close to my mom and step-dad, on okay terms with my dad

90: talk about your one of you favorite cities.

listen to me. I LOVE SEATTLE. art! fish market! weird side streets! mean street art! bitchy coffee!! neon everywhere!! a big fuckin needle in the sky!

91: where do you plan on traveling this year?

ITALY THIS SUMMER IM SO EXCITED i’m gonna meet all my mom’s friends from her semester abroad that she’s kept, i’m gonna see what she saw when she was my age, i’m gonna see where my dad’s family is from maybe if we go south???, i’m gonna see all the places and things she used to tell me about to get me to dream big and want to see the world and experience what’s out there!! aaaaaaaaaaaaa!!!

92: are you a person who drowns their pasta in cheese or a person who barely sprinkles a pinch?

depends on the pasta

93: what’s the hairstyle you wear the most?

down bc i’m fucking lazy and also inept when it comes to doing things with hair

94: who was the last person you know to have a birthday?

my friend across the hall from me, who is now 19 years of bitchiness!

95: what are your plans for this weekend?

stay in, study, maybe go to a kickback tho

96: do you install your computer updates really quickly or do you procrastinate on them a lot?

lol i put them off until my computer ceases to function altogether

97: myer briggs type, zodiac sign, and hogwarts house?

zodiac obviously

98: when’s the last time you went hiking? did you enjoy it?

fucking…….summer?? i did!

99: list some songs that resonate to your soul whenever you hear them.

“feelings” by hayley kiyoko, “vacation town” by the front bottoms, “february” by beach bunny, “hard feelings/loveless” by lorde, “moon river” by henri mancini, “let me in” by flor, “a million miles away” by the plimsoles, “girls like me” by bonnie hayes, “love my way” by the psychedelic furs, the entire legend of zelda soundtrack, “place, je passe” from the mozart l’opera rock soundtrack, etc etc

#ask

1 note · View note

motheatenscarf · 3 years

Text

IT’S OVER! I’ve officially watched She-Ra.

I liked it in the end! It took... FOREVER for me to get into, but I think that’s mostly just because of a.) personal tastes, and b.) the show clearly having a MUCH younger target audience. This is for like... little little kids, imo, or at least it starts out branding itself that way. Like, 7-10 years old. Maybe younger 12 year olds.

And it’s a good show for kids that age, good for their developing brains to encounter things like, y’know, lets learn you some empathy and forgiveness and establishing healthy boundaries with friends, and maybe introducing the concept that conformity to the point of oppression is a bad thing! But, y’know, not a lot there for adults to latch onto until like... season 3. And it’s rough gettin there if you’re not either nostalgic for She-Ra or down for the whimsy of princess shenanigans.

I’m more personally down for the whimsy of offbeat characters, so I had to latch onto the reject villains to get me through it. I need me some contrast. I can only appreciate ray of sunshine characters when they’re surrounded by misery like Scorpia, can only appreciate unapollogetically enthusiastic characters when they’re surrounded by bleakness like Entrapta. I liked that Catra was allowed to be multifaceted and complex but that was more in anticipation of where it looked like her arc might go than an early appreciation for her in general.

The setting was also hard to get into. Again, it did not feel like with throw cushions and crystal palaces and sparkling magic adventures that these people were a “rebellion” in anything but name as a smart branding move to recruit people to their side. Yeah, we saw the Horde try to conquer shit, but like... y’know... it’s little kid war. You show up and throw a flag on a fort. This ain’t ATLA with it’s mention of refugees, displacement, oppression, losing ground assimilation, supply lines, anything like.... y’know, actual war. It DOES start to do that in season 5 once Horde Prime shows up, but prior to that, the closest we get is the mention of “orphans” being taken in by the Horde to raise as soldiers. It DOES NOT want to make the target demographic uncomfortable. Which is understandable, like I said, I think it’s pretty clearly targeting younger kids, but again, makes it hard for a grownup to watch and not suffer through.

And again, personal tastes, I was never an especially effeminate kid, even as a little little girl. My favorite princess growing up was Queen Amidala not just because she had the best hair and outfits but because she got to run around and play action adventure spy. Before that it was Mulan. The closest my ace little heart ever got to romantic fantasies was thinking about Elisa soaring through the skies on Goliath’s hulking gargoyle wings. I was the gothest little edgelord tomboy. This show would not have been my cup of tea, I cannot even appeal to like, my inner child to try and get into this except for realizing, oh man, baby Caitlin would have imprinted HARD onto Catra, Scorpia, and Entrapta as the bad girl trio. They’d have been my Hex Girls, my Sanderson Sisters, my Raven, okay?

Anyway, all that said, I did like it, but I know me well enough to know I’m probably not watching it again. I did enjoy the ride, Catra and Adora were cute but Scorpia and Perfuma are forever, and I’m also unfortunately here for Entrapta and Hordak, and everything else sure was a thing in this show that I have literally zero response to.

Now I can watch He-Man without guilt.

#Caitlin watches She-Ra

5 notes · View notes

vandykecarolpdrf7 · 7 years

Text

Ketogenic Diet and Brain Cancer

Brain cancers accounts for 1.8% of all cancers worldwide (1). The number of new diagnoses made annually is 2 to 3 per 100,000 people in the US and Europe. Brain and other CNS tumors are the 11th most common cancer in the UK, accounting for 3% of all new cases (2).

Types of Brain Cancers

Primary brain tumors are a varied group of both benign and malignant tumors. There are over 120 types of brain and central nervous system cancers. Some tumors are often given a grade to signify the rate of growth (3).

Grade I is classed as the least malignant with grade IV being classed as the most malignant. Glioblastoma Multiforme (GBM) is the most aggressive type of brain tumor. The average lifespan of patients diagnosed with GBM is between 12-18 months, with less than 10% surviving at 5 years. The survival for low-grade gliomas ranges from 7 to 14 years (4).

Standard Treatment Approaches

The treatment of brain cancers generally involves a multifactorial approach of surgery followed by chemotherapy with or without radiation therapy.

Conventional treatment options for GBM are more regarded as palliative and rarely curative due to their aggressive nature. Likewise, complete surgical resection is often impossible due to GBM’s ability to infiltrate normal brain tissue. Due to this, other types of treatments are being looked at to help with the overall prognosis of these types of cancers.

Proposed Mechanism of the Ketogenic Diet in Cancer

The way in which cancer cells work in the body are very different to that of normal cells. Namely, cancer cells have been shown to exhibit an altered metabolism. Compared to normal cells, cancer cells appear to have a greater glucose uptake, even when oxygen is present. Certain tumors function and thrive purely on glucose.

Image source: Role of ketogenic metabolic therapy in malignant glioma: A systematic review

The “Warburg Effect”

This phenomenon was first coined by a biochemist known as Otto Warburg. He hypothesised and proposed the theory that cancer was a metabolic rather than a genetic problem (5).

Whilst it sparked criticism then, it has generated new interest with it being coined “The Warburg Effect”. Oncologists can use position emission tomography (PET) scans to locate glucose dependent cancers. These scans allow them to detect where the highest amounts of glucose are being used. Further to this, cancer cells exhibit alterations in mitochondrial metabolism due to increased oxidative stress (6).

Mechanisms of The Ketogenic Diet in Primary Brain Cancers

It has been proposed that the ketogenic diet may be a useful tool in exploiting the defects in tumor metabolism, including that of the Warburg Effect.

Both the ketogenic diet and calorie restriction are believed to be the only therapeutic approaches that simultaneously target several of the hallmarks of cancer including glucose uptake, angiogenesis and inflammation (7).

One of the observations with the Warburg Effect, is that the cells not only thrive on glucose, they also lack metabolic flexibility. Unlike normal cells that can switch between using that of glucose and ketone bodies, cancer cells can only use glucose for energy.

By reducing the glucose availability to cancer cells and providing ketone bodies for the energy to normal cells, the ketogenic diet could be used as a therapeutic option, especially in highly glucose dependent cancers such as GBM’s.

The Ketogenic is Working Beyond Just Glucose Levels

However, like with the data we have for its use in epilepsy, the action of the ketogenic diet and its anti-tumor effects are likely to extend beyond just the lowering of blood glucose.

The ketogenic diet not only lowers glucose but also insulin levels in the body. Insulin signalling molecules (including IGF-1, IGF-1R and C-Peptide) and pathways (akt/mTOR and Ras/MAPK) have all been linked to increase cancer risk and promotes the development of cancer cells (8).

Ketone bodies have been shown to be toxic to cancer cells whilst the cells also showing a decreased level of key ketolytic enzymes (9).

Ketone bodies themselves are active signalling metabolites and have demonstrated neuroprotective properties in other brain disorders such as Alzheimer’s Disease and Parkinson’s Disease (10).

As such, another mechanism for the ketogenic diet working within brain cancer is the ability of the ketone bodies to enhance the protection of healthy central nervous system (CNS) from cancer growth (11).

The Human Evidence for the Ketogenic Diet in Primary Brain Cancers

Much of the evidence that we have right now for the ketogenic diet in brain cancer is that of animal and cell culture data. However, there are now small retrospective case studies that have been looked at in humans, with some pre-clinical work now under way.

A recent systematic review (12) analysed all the current evidence on the use of the Ketogenic Diet in brain cancers.

In it they conclude that the literature available and preliminary results from ongoing trials, suggest the safety and feasibility of the ketogenic diet in GBM’s.

They do highlight that the clinical application i.e. the amount of evidence we have in humans, is limited and therefore should be interpreted with caution.

Study 1

The first ever trial looking at the ketogenic diet in brain cancer was carried out in 1995 (13). The study placed 2 young girls on an MCT ketogenic diet (where above 50% of the calories come from MCTs) and followed them for a total of 8 weeks. PET scans revealed a 21.8% average decrease in glucose uptake at the tumor site in both patients.

Study 2

A case report of a 65 year old woman diagnosed with GBM describes her experience of following a classical 4:1 Ketogenic Diet (fat/ protein + carbohydrates) with calorie restriction (600 kcal per day) (14) . She followed this dietary approach for 14 days and then started radiation and chemotherapy treatment. At 2 months, no evidence of either tumor nor associated oedema was apparent and PET scans revealed no recurrent disease.

Study 3

A retrospective study looked at 53 patients with high grade GBM’s being treated with chemoradiotherapy and adjuvant chemotherapy (15). Of the patients, 6 underwent a ketogenic diet during their standard treatment. The diet appeared to be well tolerated and safe, with 4 patients still alive at 14 months follow up.

Study 4

A pilot study from Germany looked at the feasibility of the ketogenic diet in 20 patients with recurrent GBM (16). In this study patients could eat up to 60 grams of carbohydrates per day and there was no restriction on calorie amount. The patients were followed up at 6-8 week intervals. The study could show that the ketogenic diet was safe and relatively well tolerated. Three patients dropped out as they found it too difficult to stick with the diet and only 12 of the patients left could reach a ketogenic state. No severe toxicity or serious diet-related adverse events were identified though.

What Ketogenic Approach Should be Followed?

Since the studies that we have are limited in humans, it means the optimal ketogenic diet to follow for maximal therapeutic benefit is still not known.

The Classical Ketogenic Diet

Many of the mice and cell culture studies have used a classical 4:1 Ketogenic Diet (17, 18). As we know though, this diet for adults to follow can be difficult to achieve and importantly maintain. Likewise, it can bring about some adverse reactions and so proper clinical monitoring is required.

The Modified Atkins Approach

A study from the John Hopkins Adult Epilepsy Diet Centre, looked at a group of adults who had been following the Modified Atkins Approach (19). This approach restricts carbohydrate intake to 20 grams per day with no restriction on calorie or fat content.

The centre identified 8 patients following the dietary approach of whom 7 remained on the diet when they were followed up at 13 months. Overall the diet appeared safe and well tolerated with around 50% of the adults reporting a reduction in the seizures they were experiencing due to their tumors.

The Modified Atkins Approach Combined with Intermittent Fasting

One proposed combination therapy is that of the MAD and intermittent fasting. Given the benefits that appears to arise from extended periods of fasting in cancer risk (20) and the difficulties of following the classical ketogenic diet; following the Modified Atkins Approach with intermittent fasting may offer superior therapeutic potential.

The Ketogenic Diet in Combination with Standard Therapies

Whilst the ketogenic diet may appear to have strong therapeutic potentials for the use in cancer treatment, most of the studies shows this in combination with standard care.

Predominantly all the data presented in this article utilised the ketogenic diet along with other treatment options.

One benefit that appears to be occurring with the ketogenic diet and that of standard care is the diet can help mitigate some of the side effects normally caused. Whilst also helping to enhance the anti-tumor effects of radiation and chemotherapy (21, 22).

Other Possible Co-strategies and Novel Approaches

As well as the ketogenic diet being studied alongside that of standard care, there are other treatment options now being looked at in combination.

Hyperbaric Oxygen Therapy

Due to the nature of rapid growth with cancer cells, tumors quickly exhaust the oxygen supply from the blood vessel. This creates a state known as hypoxia.

Hyperbaric Oxygen Therapy (HBO2T) saturates tumors with oxygen again and can help to reverse this hypoxia.

Whilst HBO2T alone has not been shown to offer great improvements in cancer development, combining it with the ketogenic diet appears to produce significant anti-cancer effects in animal models (23).

Exogenous Ketones

Another specific area of interest is the use of ketone ester supplementation. Over the past few years there have been several companies that have been developing ketone esters and salts to artificially raise ketone levels in the body.

It has been proposed as a potential therapy option within cancer as this population group are known to have difficulties with eating especially when going through active treatment. Being able to artificially raise ketone levels without having to rely solely on diet may therefore be a novel approach to get the body into ketosis.

Administration of ketone esters in animals have shown anticancer effects, independent of glucose levels (24). Likewise, the use of the ketogenic diet, HBO2T and ketone supplementation all in combination has shown a more powerful effect on cancer cell death and overall survival rates than when used individually (25).

Take-Home Message

Whilst the animal and cell data as well as preliminary clinical data appear to show the ketogenic diet offering a therapeutic potential in brain cancers, this needs to be interpreted with much caution.

Firstly, most of the studies that have been done are within animal models. The diet administered to them have been of the most strict, classical ketogenic diet form and so adherence may not be as good in adults if this is the diet that needs to be followed. There is a small amount of data in individuals following the Modified Atkins Diet which may offer better adherence rates but perhaps not be as effective.

Likewise, much of the data we have has also administered the ketogenic diet alongside calorie restriction. This means that as well as following ketogenic principles, a calorie restriction of 600 kcal/day has been put in place. Again, this has mostly been looked at in animals so translation to humans may not be achievable for all.

Cancer is an extremely complex disease. We still do not fully understand all the mechanisms happening with the ketogenic diet within cancer cells. Whilst the theory of the Warburg Effect appears to be gaining traction, we cannot say that this is the only reason for the ketogenic diet having an impact; needless to say like with cancer, it is and will be much more complex than this.

Perhaps the major point that also needs to be emphasised with all of this though is that the ketogenic diet should not be a standalone treatment. To date, most of the work, especially the human data we have, has all been done in combination with standard care. Whilst the ketogenic diet may appear to be a useful tool, it is just that, a tool.

Until there are more robust, clinical trials carried out, we cannot say that it offers a cure nor should it just be used on its own. The other novel therapies that are being studied are also at the very early stages. Much more needs to be understood about their long-term use and combination with the diet before giving a definitive answer on their safety and efficacy in humans.

Currently there are 10 trials listed at Clinicaltrials.gov that are looking at GBMs and the ketogenic diet within humans (26). This will allow the development of more robust data to help answer some of the pressing questions that remain within this topic.

In summary, the ketogenic diet does appear to be useful adjuvant to treatment for brain cancer. However much more clinical work and human studies are still needed in order to fully understand it’s mechanisms, long-term safety and overall efficacy.

http://ift.tt/2utUPif

#Ketogenic Diet and Brain Cancer

0 notes

yes-dal456 · 7 years

Text

Fat Bottom Girl

“Left alone with big fat fanny She was such a naughty nanny Heap big woman you made a bad boy out of me” – Brian May

The sticky, sweet smell of cotton candy combined with the stench coming from the animals, and mixed with the iron taste of diesel fuel. It was an odor particular to the carnival that she would never forget.

The word carnival has two meanings. First, according to Webster:

A period of public revelry each year that takes place before Lent; and second, A traveling amusement show.

Circus folks, whom I have interviewed extensively, are quick to point out the differences between them and carnival folk or more derogatory “carneys.” The circus, burlesque, and other forms of early American pop culture have been the target of my work over the past decade. After meeting someone who essentially grew up on the carnival grounds I thought I should take a look at the life of the showgirls in the carnival. Many of my burlesque ladies had certainly worked the carnival circuit including stars Sally Rand and Gypsy Rose Lee, making gobs of money with their Royal American Girlie Shows. According to Sally Rand’s son Sean, it was Gypsy who encouraged his mother to join the grueling schedule of upwards of 30 shows a day for thousands across America.

But before we get into that let’s examine carnival.

The carnivals were ― and are ― loaded with games of chance, heavily favored on the side of the concessionaires who run, and lure and can cheat the carnival rubes out of hard earned quarters (at least back when a quarter meant something). There was of course the side show with real and bogus “Freaks” and death-defying rides. With its geneses in the Chicago Columbian Exposition of 1893 the carnival would become known as a raucous, popcorn smelling afternoon where one tried to hang on to their wallets walking the midway. Staring in the mid-1920s most carnivals set up in a field or wherever they could for several days and took in thousands in attendance. Folks were bug-eyed over scandalously skimpy-dressed beauties and freaks of nature. Staged shows under the tens included many of the biggest vaudeville acts of the early 20th century. The freak show, which included animals as well, employed many with abnormal physicality, such as Daisy and Violet Hilton, the subject of my documentary “Bound By Flesh.” The Siamese bound sisters were stars on both the vaudeville stage and carnival and circus circuits.

Like in the circus, many who felt they didn’t belong in the “real world” ran away and joined a carnival, sometimes for the first time in their lives finding a home and communion with like people. Oddities, outcasts, disenfranchised. There was every sort from the obvious runaways, drug addicts, perverts, women who had escaped abusive relationships. There were families, perverts. “A lot of temporary and seedy characters.” Everyone was escaping life back home, whether it was too ordinary for them or too troubled. All found a place where they belonged even if just for a season under the canvas amongst others who asked no questions. They were birds of a feather.

When she was about 12 years-old, brown-haired Christy escaped a “mean, drunk little guy” whom her mother had married. “He was beating on my mother,” she recalled, “so I kicked the shit out of him.” Standing 5’8” and weighing between 160 and 170 lbs, her stepfather who stood 5’2” was no match.

Life had been anything but idyllic for Christy in a tiny navy town outside of Seattle, Washington, in the 1950s.

With a beautiful mother who worked various small jobs while raising four kids and an alcoholic stepfather she hated, Christy and her brother Chuckie tried staying out of the way of this pint-sized wife and child beater. Tragedy struck during the summer of Christy’s 8th year of hell on earth. Nine-year-old Chuckie and his best friend Jeff had been goofing around and got hold of a gun which went off in Chuckie’s hand, killing Jeff. It was particularly memorable for Christy, as Jeff had been her first sexual encounter. Yes, at age 8.

Ralph, a family friend, owned a carnival. With the promise that she could work there someday, Christy took to hanging around Ralph and his carney friends. Hanging around the sawdust lots and learning to “buy” a 25-cent soda from a machine for three pennies after shaving the edges to make them the size of dimes she found “sanctuary” from her home life.

Meanwhile, the abuse from her stepfather continued. When he wasn’t drunk, he was regularly beating on his wife and terrorizing the kids.

Running into a travel carnival that pulled into town, Christy begged her mother to let her join. She worked there the entire week the carnival was in town. Soon things went bad at home. “My mom and I decided I shouldn’t be around during the summer.” She turned to Ralph who let her join his operation at age 11 or 12.

She joined the tradition of the roaming life, traveling from town to town, pulling into large lots and anywhere the midway rides could be set. This was in the 1960s when someone her size was not only an oddity but worthy of making a living in the sideshow. By this time in history, the “born freaks” were fewer and far between in the Freak Shows. Still, for a quarter or two one could see two-headed cows, or two-headed chickens. One fake act was the “man eating chicken” who sat and ate a piece of chicken out of the KFC bucket on his lap. Jokes too.

Christy’s size had never bothered her. Everyone in her family was pretty heavy, but Christy was the most eye-catching. She knew people made fun of her. But on the carnival her size brought her a different kind of attention. It was positive and accepting. She would make a successful career both on the midway and on the burlesque stage because of her generous frame and her zest for entertaining.

Christy kept up with her schooling, but started a month late and left a month early until she graduated. By then so in love with her “other life,” she skipped the graduation parties and flew straight to Portland, Oregon, to work a festival and “traveled the rest of [her] life.”

She worked various jobs on the midway; selling tickets, serving food, cooking and counting quarters and rolling them in sleeves. “I loved making money!”

During breaks she rode all the rides, especially thrilling at the Sky Wheel where she could soar above her troubles below. The fun houses with their distorted mirrors was a particular favorite. She learned how the games were rigged. “I was around,” she said, “during the days of big money... and games you could never win.” Though some shows were “Sunday school shows” (meaning honest run) other shows took the rubes for everything which was done by paying off cops and never returning to the town once they pulled up stakes.“Everyone made money.”

Like in the circus, her coworkers were transients. Christy recalled one group of Gypsies from Turkey pickpocketing “marks” on the midway by reading their mannerisms, their clothing, their walk, and even their particular body odors. When not on the midway the Gypsies could be found in the town’s department stores shoplifting (with the help of Christy being the distraction. She would pretend to faint, pulling down a large display case with expensive goods on the way to hitting the ground). So crafty were the Gypsies, sewing inner pockets and such Christy was witness to one girl who carried a television set between her thighs as she coolly walked out the store. It would take a few more heists before Christy’s conscious got the better of her and she quit the extra gig (and the $100 that came with it).

However, her training among the Gypsies educated her in how to read the marks on the midway and she was hired to be what was called an “agent.” An agent leads a customer to a particular game he or she seemed best suited too. They then encourage the mark to spend, spend, spend.

Jamming the midway were kiosks or individual booths. They were plentiful and varied. There were psychic readings of palm and crystal balls, “knife sharpening, religious displays, impromptu artistry, beaded costume jewelry, dancing, magic and of course in the back there was prostitution, drugs and alcohol.”

Ralph essentially mentored Christy. His carnival traveled by truck. Sometimes his smaller carnival (only 12 midway rides) would merge with other carnivals for larger towns and crowds.

Christy met legendary fan dancer Sally Rand who was touring with the prestigious Royal American Shows. The Royal American claimed to be the world’s largest touring midway. Nearly a hundred train cars pulled performers, rides, and the president of RAS and his family. Part of the benefit of train travel ― besides rest for the performers and crew ― was that rides and amusement arrived wholly put together. Their record of unloading from the trains to set up an operation was a fast and furious five hours. Besides Sally Rand, Lois De Fee and Gypsy, Elvis’ manager Colonel Tom Parker began his show business career working for Royal American.

Christy’s job was to patrol the parameter of Rand’s tent to prevent anyone from trying to bypass the front and take a free peek. Christy didn’t consider it work. She thought of it more like fun.

It was at the carnival where Christy got her first look at a girlie show. Run by a dark-haired gal with big boobs who spoke in a little girly voice, she went by the name of Delilah Dante. Delilah ran her own girlie show.

It was a grueling life for the burly girls. When I interviewed Dixie Evans (a.k.a the “Marilyn Monroe of Burlesque”) she talked about loving the carnival and circus route working 30 shows a day and being so tired at the end that all she wanted as she passed out on the ride home was to eat Chinese and count her big, fat bankroll.

Delilah’s show was in a large tent with “plank seating” to accommodate 80 likely horny men. Sometimes more could be squeezed in. It was a 10-minute show that ran 25 times a night. To make the men buy tickets and convince them of the dozens of beauties they would see inside the tent, Delilah would have Christy and anyone else on the midway dress up in elaborate headdresses and stand in half shadows on the stage, where the men could peek through the front flaps and see shadowy figures moving about. After the men paid their quarter, the only eyeful they got was Delilah. But it was with Delilah’s feather boas and running across the sage that Christy felt sexy. She decided she would become a dancer.

Among the various types of misfits running around the midway, Christy noted that the diversity of character created strong bonds. Even with occasionally deep psychological ― sometimes physical ― challenges, they found refuge. Birds of a feather. And, Christy noted after hours, “bed hopping was rampant.” No matter whether it was men with men, women with women or some mix of group sex, it was family. A very close family.

Not only was sex among the carneys a regular occurrence, but they were also targets for the local “lizards.” Lizards could be any man, woman, or teenager who hung around the lot looking for an easy target. A quick, no-hassle one night stand would ensue. There would be no drama as there was always another town calling the carnival away. No bonds, no attachments.

At the end of the season, Christy would take her money and fill coffee cans with the cash, hiding it in her room. When her mother discovered one of the cans, she worried over what type of work Christy was doing to rake in such dough. Over the years, Christy worked the carnival her siblings (she had two half-sisters) and mother also worked, though none of them loved it like she did. Christy was happy as a clam and wanted to soak up everything she could learn about working at the carnival.

Back home, she waded through school and roamed the seedier streets of Seattle, where at 16, she learned to master a sexy street swagger from a prostitute named Tanya. She became friends with Tanya. Tanya thought Christy had what it took to be a hooker and suggested the market would be profitable for a fat girl. Tanya was right. She was a hit and had no competition. She was “so big I was like a billboard on heels.” Her size didn’t make her lack confidence. She knew she was alluring.

Venturing to Hollywood, she had a memorable encounter with Hollywood’s Stanley Kowalski. A man asking for her particular services showed up wearing a floppy hat (obviously to disguise himself) clutching a brown paper bag in his hands. “Nice to meet ya,” he said. Reaching into his bag he pulled out women’s lingerie and a stack of cash. Fannie disappeared to make espresso and when she returned, the world’s greatest actor was nude. As he pulled on a pair of stockings, she told him, “honey you are so sexy.” Turning on a Marvin Gaye tune, she gave him a wig and makeup which she helped apply to his gorgeous face. Thinking he wanted to see himself she held out a hand mirror, but he brushed it aside. Silence followed as he sashayed around her room in heels and lingerie drinking espresso in a “feminine” sort of way. They had no conversation and when he was satisfied with whatever he was exploring he pulled his clothes over the bra and panties kissed Fannie’s hand and left. His latest film “Last Tango in Paris” had been playing and Fannie “figured he was just going through a phase.”

By the time she was 18, she stood 6’2” and weighed 240 pounds. She decided to change her name to Fannie Annie. She got a job working a girlie show. She loved it, especially the pretty clothes. To her, it was ironic that offstage she deflected looks of “disgust,” but onstage the little fat girl ― all grown up ― was adored and accepted. With the help of the Mob and a breast enhancement she became known as “the world’s fattest stripper.”

As Fannie she commanded the stage, she’d hurl insults at customers in the clubs who were “overjoyed” with her “fatness.” She pushed men’s faces into her heaving bosoms. “My size overwhelmed.” It was as if none of them had seen a fat boob before, so she pulled them out of her costume. “The crowd went nuts as they threw money” on the stage. As a finale, Christy would push the man on the floor, lift her skirt, and lower herself onto his face.

The work was nonstop and so was her ballooning size. Soon, she was 400 pounds with an 88-inch waist line. She broke chairs and “fell on [her] ass more times” than she cared to recall. She continued to tour clubs and returned to her first love, carnivals. “It was where I really wanted to be.” One of her signature tricks was to invite a bachelor to the stage where not only did she smother his head between her breasts and “tit slap him,” but also pull his pants and underwear down for a parade around the stage.

By the 1980s, a 600-pound Fannie would own her own kiddy carnival with ponies and a petting zoo. She was still getting little respect in the real world because of her size. I asked her if she ever wanted to change her weight and she told me no. “I just accepted it and lived my life and took advantage of being super sized and made a living out of it.”

And though she enjoyed a long career in the clubs, it was the carnivals she loved for the travel and the money and the camaraderie. (She didn’t as much care for the hot tents and trailers or the lack of restrooms). Little fat Christy had grown into a star. “I really loved all the life lessons. All the carnival and circus people really made me feel like family! How could you not love it!” And though unideal and filled with challenges and grifters with few heart-warming stories, it was a place of belonging for many runaways like Christy and Annie were.

In 1996, Fannie Annie retire from the roaming, performing life. She spends her days making a cruelty-free boa Star Boa for today’s current crop of burlesque dancers.

Leslie Zemeckis is an award-winning documentarian whose film “Behind the Burly Q” chronicles the history of burlesque. Her film “Bound by Flesh” is a Netflix hit about Daisy and Violet Hilton of “Sideshow” fame. Zemeckis authored “Behind the Burly Q, the book based on her film and “Goddess of Love Incarnate” about burlesque stripper Lili St. Cyr. Zemecki. Her current documentary Mabel, Mabel, Tiger Trainer, on the world’s first female trainer Mabel Stark premiered at the Santa Barbara International Film Festival going on to win numerous awards.

She has created the only comprehensive burlesque site bringing together the burlesque community under one roof (www.theburlyq.com) and has create the first line of burlesque, showgirl, pinup (and flamingo) emojis (Burlyqji.)

Zemeckis is currently writing her third book, set to co-star in a film opposite Steve Carell, and developing several other films. She continues to chronicle the vast untouched history of burlesque and has one of the largest personal collections of burlesque memorabilia, with items from Gypsy Rose Lee, Blaze Starr, Lili St. Cyr, Ann Corio and many many more. @Lesliezemeckis, http://ift.tt/1SoCEhC Follow Leslie Zemeckis on IG and Twitter.

type=type=RelatedArticlesblockTitle=Related... + articlesList=5925ca9fe4b0ec129d31c170,58bd973ee4b033be146708b2

-- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.

from http://ift.tt/2sliNMT from Blogger http://ift.tt/2slZF1b

#http://www.happiness2arab.tk/2017/06/fat-bottom-girl.html

0 notes

imreviewblog · 7 years

Text

Fat Bottom Girl

“Left alone with big fat fanny She was such a naughty nanny Heap big woman you made a bad boy out of me” – Brian May

The word carnival has two meanings. First, according to Webster:

A period of public revelry each year that takes place before Lent; and second, A traveling amusement show.

But before we get into that let’s examine carnival.

Life had been anything but idyllic for Christy in a tiny navy town outside of Seattle, Washington, in the 1950s.

Meanwhile, the abuse from her stepfather continued. When he wasn’t drunk, he was regularly beating on his wife and terrorizing the kids.

She worked various jobs on the midway; selling tickets, serving food, cooking and counting quarters and rolling them in sleeves. “I loved making money!”

Ralph essentially mentored Christy. His carnival traveled by truck. Sometimes his smaller carnival (only 12 midway rides) would merge with other carnivals for larger towns and crowds.

In 1996, Fannie Annie retire from the roaming, performing life. She spends her days making a cruelty-free boa Star Boa for today’s current crop of burlesque dancers.

Zemeckis is currently writing her third book, set to co-star in a film opposite Steve Carell, and developing several other films. She continues to chronicle the vast untouched history of burlesque and has one of the largest personal collections of burlesque memorabilia, with items from Gypsy Rose Lee, Blaze Starr, Lili St. Cyr, Ann Corio and many many more. @Lesliezemeckis, http://bit.ly/2rTi0RT Follow Leslie Zemeckis on IG and Twitter.

type=type=RelatedArticlesblockTitle=Related... + articlesList=5925ca9fe4b0ec129d31c170,58bd973ee4b033be146708b2

-- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.

from Healthy Living - The Huffington Post http://bit.ly/2rT91zZ

#Healthy Living - The Huffington Post

0 notes