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oddwayintt · 8 months
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Tretinoin Cream: A Comprehensive Guide
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What is Tretinoin Cream?
Tretinoin cream is a topical medication that contains tretinoin, a derivative of vitamin A. It comes in different strengths, ranging from 0.01% to 0.1%, and is available as a prescription cream, gel, or liquid.
Tretinoin Cream is considered the gold standard topical treatment for acne and skin rejuvenation. But what exactly is tretinoin and how does it work its magic on the skin? Let's find out.
Tretinoin Overview
Tretinoin is a retinoid medication that was originally approved by the FDA in 1971 as an acne treatment. It is derived from retinoic acid, which occurs naturally in the body and plays an important role in cell growth and turnover.
On the skin, tretinoin works by increasing cell turnover. This helps clear plugged hair follicles that can lead to acne lesions. The increased cell turnover also means fresher, younger-looking skin cells are brought to the surface.
How Tretinoin Cream Works
When tretinoin cream is applied to the skin, it starts working on a cellular level. Here's a quick breakdown of how it works its magic:
Increases cell turnover: Tretinoin speeds up cell turnover by enhancing exfoliation. Dead skin cells are shed faster.
Unclogs pores: By increasing cell turnover, tretinoin helps clear debris, oil, and dead skin from pore openings. This prevents clogging.
Reduces oil production: Tretinoin signals the oil glands to produce less oil by altering gene expression. Less oil equals less acne.
Smooths and evens skin: Increased cell turnover means fresher skin is revealed. Tretinoin also boosts collagen production for smoother, firmer skin.
Fades pigmentation: By increasing cell turnover, tretinoin helps fade dark spots and discoloration faster.
So, tretinoin is like a power wash for your skin cells! It clears away dead skin, unclogs pores, reduces oil, smooths texture, and evens tone.
Tretinoin Cream Formulations
Tretinoin creams, gels, and liquids come in a range of concentrations:
Tretiheal 0.1% Tretinoin Cream
Tretiheal 0.05% Tretinoin Cream
Tretiheal 0.025% Tretinoin Cream
Lower strengths like 0.01% are ideal for first-time users. Higher strengths pack a more powerful punch for stubborn acne and aging skin but can cause more irritation.
Some brands of tretinoin combine the medication with an antibiotic like clindamycin. This helps fight acne bacteria for more effective treatment.
Tretinoin also comes in special anti-aging formulations with added moisturizing and smoothing ingredients to enhance benefits and minimize irritation.
Tretinoin Cream Benefits for Skin
With those mechanisms of action in mind, let's look closer at the specific benefits using tretinoin cream can provide for your skin:
Treats Acne
By speeding up skin cell turnover within pores and keeping them exfoliated, tretinoin is highly effective at clearing up inflammatory acne lesions like papules and pustules. It also helps prevent new blackheads and whiteheads from forming. If breakouts are your primary concern, consistency with tretinoin application is key for maintaining clear skin long-term.
Reduces Wrinkles and Fine Lines
With its collagen-boosting abilities, tretinoin cream can markedly reduce signs of aging over time. Fine lines and wrinkles appear diminished, leaving skin looking firmer, smoother, and more plump. Think of tretinoin as "ironing out" wrinkles from the inside for a visibly rejuvenated appearance.
Brightens Skin Tone
By increasing cell turnover, tretinoin brings fresh new skin cells to the surface. These newer cells help fade areas of pigmentation and age spots, leading to a brighter, more even toned complexion. Consistent use can gradually improve overall skin clarity.
Smooths Skin Texture
Along with smoothing away wrinkles, tretinoin also improves the skin's tone and texture. Pores appear smaller, skin feels tighter, and the complexion looks refreshed. This is thanks to tretinoin's effects on collagen and cell turnover.
Fades Dark Spots and Discoloration
If you deal with dark spots, melasma, or uneven pigmentation, tretinoin can help. The increased cell turnover it stimulates will gradually fade and replace damaged skin cells that have excess pigment concentrated in them. With time, these dark areas diminish for a more uniform skin tone.
Using Tretinoin Cream Safely
While clearly effective, it's important to use tretinoin cream properly to get results while avoiding irritation. Here are some tips:
Moisturize Well
Tretinoin can dry out the skin, especially at first. Be diligent with moisturizer - apply a gentle, fragrance-free moisturizer daily, both morning and night. This helps counteract dryness and peeling.
Avoid Overexposure to Sun
Tretinoin makes your skin more sun-sensitive. Be diligent about sun protection - wear a broad spectrum SPF 30+ sunscreen daily and limit direct sun exposure.
Watch for Irritation and Sensitivity
Scale back usage if your skin becomes highly irritated. Try applying tretinoin over moisturizer to help buffer against redness and flaking as your skin adjusts.
Who Can Use Tretinoin Cream?
Acne Sufferers
Tretinoin is a gold standard treatment for acne vulgaris, whiteheads, blackheads, and breakouts. Under a dermatologist's guidance, it can clear up moderate to severe inflammatory acne.
Anti-Aging Benefits
Beyond acne treatment, those looking for smoother, firmer, more youthful skin can benefit from incorporating tretinoin into their skincare routine. It delivers anti-aging collagen-boosting results.
Under Guidance of Dermatologist
Because tretinoin is a prescription topical medication, you need oversight from a dermatologist to use it safely and effectively. Follow your dermatologist's usage instructions.
Uses of Tretinoin Cream
Let's look closer at the two main uses for tretinoin cream: acne and anti-aging/skin rejuvenation.
Acne Treatment
Tretinoin was originally formulated as an acne treatment. After decades of research and clinical use, it remains one of the most effective topical acne medications on the market.
How it Treats Acne
Tretinoin treats acne in a few key ways:
Speeds up cell turnover to prevent dead skin cell buildup in pores.
Unclogs pores by shedding dead skin cells inside the pores.
Decreases oil (sebum) production, which contributes to acne.
Has anti-inflammatory effects to reduce acne redness and swelling.
Kills acne-causing bacteria on the skin's surface.
By doing all of this, tretinoin helps clear up blackheads, whiteheads, and stubborn inflammatory acne like papules and pustules. It works well for non-severe acne of all types from teen acne to adult acne.
Anti-Aging/Skin Rejuvenation
Beyond acne treatment, tretinoin cream is now widely used for reducing signs of aging and rejuvenating the skin.
How it Rejuvenates Skin
Tretinoin improves the appearance of aging skin in a few key ways:
Increases collagen production, for firmer, more youthful skin.
Reduces fine lines and wrinkles by increasing cell turnover.
Smooths rough, uneven texture by enhancing exfoliation.
Evens discoloration and pigmentation by fading dark spots.
Minimizes enlarged pores by preventing dead skin buildup.
Creates an overall glow and brightness to the complexion.
Tretinoin is especially helpful for reducing and preventing fine lines, smoothing rough skin texture, and fading discoloration/age spots. With consistent use, it can make skin look more clear, radiant, and youthful.
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katelevelsup · 1 year
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Nighttime Skin routine!
Good evening, lovelies! I’ve been hesitant to post about my nighttime skincare, as it’s still a work in progress. This post will include unedited, makeup-free pictures of me. 
When I was 27, I very suddenly went from having clear skin, to having adult acne. 
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This definitely shook my confidence. 
First I tried a benzoyl peroxide facial cleanser, which, sadly, didn’t touch the problem. Next I tried adapalene gel, which helped a bit, but not enough. 
So I turned to the online dermatology service, Apostrophe. The dermatologist who helped me was kind and responsive, and always listened to my concerns. I recommend Apostrophe as a starting place for anyone struggling with their skin. We tried a few different treatments. Unfortunately, neither the antibiotics nor the spironolactone were right for me. The 0.025% tretinoin cream cleared my skin up a little more, but I needed a stronger dosage, which, unfortunately, Apostrophe doesn’t prescribe. 
Then I turned to another telehealth service, Nurx. The doctor there was also absolutely lovely, and, unlike Apostrophe, they accepted my health insurance. Here, I was prescribed 0.05% tretinoin. 
This had much stronger side effects than the weaker dosage-- peeling and photosensitivity-- but it has also been the most effective treatment yet. 
Here’s my current routine:
I always like to start with a clean slate, but without leaving my skin feeling stripped. This is my favorite evening cleanser. 
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It removes my sunscreen and makeup without drying me out. While my face is still damp, I apply a few drops of this. I’ve found that it minimizing peeling. 
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After waiting for my face to completely dry, I apply the aforementioned tretinoin. 
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It’s a little rough to start with, but it’s been miraculous! 
And this is where I currently am in my skin journey. 
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livayushstore · 1 year
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Choosing the Right Form of Tretinoin
In the quest for flawless and youthful skin, dermatologists and skincare enthusiasts often turn to tretinoin, a potent derivative of Vitamin A. Tretinoin is renowned for its effectiveness in treating various skin concerns, such as acne, fine lines, and hyperpigmentation. However, with different formulations available, it can be overwhelming to determine which one suits your skin best. In this blog post, we will explore the various forms of tretinoin and help you discover the ideal option for your skincare routine.
Understanding Tretinoin:
Tretinoin belongs to a class of medications known as retinoids. It works by promoting skin cell turnover and increasing collagen production, resulting in smoother, clearer, and more radiant skin. Tretinoin has been scientifically proven to address several skin issues, making it a popular choice for individuals seeking significant skin improvements.
Cream Formulation:
Tretinoin cream is a classic and widely-used formulation that is well-suited for most skin types. Available in different strengths, ranging from 0.025% to 0.1%, it allows users to start with a milder version and gradually increase potency as their skin adjusts. Creams are typically hydrating and suitable for individuals with normal to dry skin.
Gel Formulation:
Tretinoin gel is an excellent option for individuals with oily or acne-prone skin. It is often preferred by those who struggle with clogged pores and want a lighter, non-comedogenic formula. Tretinoin gel may dry out the skin more compared to the cream, so it's essential to use it cautiously and maintain a moisturizing routine.
Microsphere Formulation:
The microsphere formulation is a relatively newer type of tretinoin that offers controlled release of the active ingredient. This means that the tretinoin is gradually released over time, potentially reducing irritation and making it more tolerable for sensitive skin. Microsphere formulations are available in both gel and cream forms, catering to different skin preferences.
Finding the Best Form of Tretinoin for You:
Selecting the most suitable form of tretinoin depends on several factors, including your skin type, specific concerns, and the level of tolerance your skin has to the medication. Here are some tips to help you make an informed decision:
Consult with a Dermatologist: Before incorporating tretinoin into your skincare routine, consult with a dermatologist. A professional evaluation will help determine your skin type and recommend the appropriate strength and formulation that aligns with your goals.
Start Slowly: If you are new to tretinoin, begin with a lower strength and use it sparingly to minimize potential irritation. Gradually increase the frequency and potency as your skin adapts.
Consider Your Skin's Sensitivity: If you have sensitive or easily irritated skin, a microsphere formulation or a lower strength tretinoin cream may be more suitable.
Address Specific Concerns: Choose the formulation that aligns with your primary skincare concerns. For oily and acne-prone skin, a gel formulation might be more beneficial, while those seeking hydration may prefer a cream-based option.
Conclusion:
Tretinoin is undoubtedly a skincare superhero, capable of addressing a multitude of skin concerns and providing noticeable improvements in skin texture and appearance. Whether you opt for the classic cream, the lightweight gel, or the gentle microsphere formulation, incorporating tretinoin into your skincare routine can lead to transformative results.
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healthyfy4me · 1 year
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itsrajhere · 1 year
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A Ret 0.1% Tretinoin Gel 20gm
WHAT IS A RET 0.1% GEL?
A RET contains Tretinoin which belongs to a group of medicines called retinoids
WHAT A RET 0.1% GEL IS USED FOR?
A RET is a prescription medicine that is used to reduce fine wrinkles
WARNINGS AND PRECAUTIONS
TALK TO DOCTOR
Talk to your doctor before taking this medicine, if you:
Are allergic to any of the ingredients in A RET Are sunburned or your skin is irritated Are highly sensitive to sunlight
PREGNANCY & BREAST FEEDING
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
INTERACTIONS
Talk to your doctor if you are taking or have ever taken medicines that increase your sensitivity to sunlight as like,
Thiazides (to treat high blood pressure) Tetracyclines, fluoroquinolones, sulfonamides (to treat infection) Phenothiazines (to treat serious emotional problems)
DIRECTIONS & FOR USE
A RET 0.1% Gel  is usually applied to the face once a day in the evening, following steps listed below:
Gently wash your face with a mild soap Pat the skin dry and wait 20-30 minutes before applying A RET 0.1% Gel Take a small amount of this medicine (the size of a pearl about ? inch or 5mm diameter) on your fingertip and apply to your face This should be enough to cover your affected area lightly Be careful when applying A RET 0.1% Gel to avoid your eyes, ears, nostrils, angles of the nose and mouth
If you use more of A RET 0.1% Gel
Using too much of this medicine may increase discomfort and skin redness and peeling
If you stop using A RET 0.1% Gel
Consult with your doctor before stop taking this medicine
OTHER RELATED GELS
A RET 0.05% Gel
A RET 0.025% Gel
SIDE EFFECTS OF A RET 0.1% GEL
SERIOUS
Like all medicine, this medicine can cause side effects although not everybody gets them.
• Warmth or stinging on your skin • Peeling, dry skin, burning, stinging, itching and redness
STORAGE
Store at room temperature (15-25°C)
Keep out of reach of children
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pnstore · 3 years
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Tretinoin Gel Usp 0.025% Menarini là sản phẩm dạng thuốc đặc trị các vấn đề về da như mụn và lão hóa. Tretinoin sẽ giúp đào thải độc tố dưới da, thông thoáng lỗ chân lông, điều trị cả tình trạng tăng sắc tố sau viêm, do nắng. Ngoài ra sản phẩm còn giúp da tăng cường sản sinh collagen, tái tạo da, giảm thiểu nếp nhăn, kích thích tuần hoàn máu và sự hình thành các mạch máu mới do đó rất hữu hiệu trong việc chống lão hoá.
– Tretinoin Gel USP A-ret 0.25% Menarini – Xuất xứ: Ấn Độ – Thương hiệu – Quy cách: tuýp 20g – Nồng độ: 0.025% / 0.05% & 0.01
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oddwayintt · 1 year
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A Ret 0.025% Tretinoin Gel: Your Ultimate Guide to Clear, Beautiful Skin
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Introduction:
Achieving clear and beautiful skin is a common goal for many of us. If you're dealing with acne, fine lines, or uneven skin tone, you might be interested in exploring skincare products that can help. A Ret 0.025% Tretinoin Gel is one such product that has gained popularity for its effectiveness in treating various skin concerns. In this blog, we'll take a deep dive into what this gel is, how it works, its benefits, and how to use it for optimal results.
What is A Ret 0.025% Tretinoin Gel?
A Ret 0.025% Tretinoin Gel is a skincare product that contains 0.025% Tretinoin as its active ingredient. Tretinoin is a form of vitamin A that is known for its powerful skin-rejuvenating properties. It is commonly used to treat a range of skin issues, including acne, fine lines, wrinkles, and uneven skin tone.
How Does It Work?
Tretinoin works by stimulating the renewal of skin cells. It encourages the shedding of old, damaged skin cells and promotes the growth of new, healthy ones. This process helps to unclog pores, reduce the formation of acne lesions, and improve the overall texture and appearance of the skin.
Benefits of A Ret 0.025% Tretinoin Gel:
Acne Treatment: A Ret 0.025% Tretinoin Gel is highly effective in treating acne. It helps to clear existing acne lesions and prevent new ones from forming by keeping pores clear of debris and excess oil.
Anti-Aging: Tretinoin is renowned for its anti-aging properties. Regular use can reduce the appearance of fine lines, wrinkles, and age spots, leaving your skin looking youthful and radiant.
Smoother Skin Texture: This gel can help improve the texture of your skin, making it smoother and more even-toned.
Fade Hyperpigmentation: If you have dark spots or uneven pigmentation, Tretinoin can help fade them over time, giving you a more uniform complexion.
Boost Collagen Production: Tretinoin stimulates collagen production, which can lead to firmer and more elastic skin.
How to Use A Ret 0.025% Tretinoin Gel:
Start with a clean face. Gently cleanse your skin and pat it dry.
Apply a pea-sized amount of the gel to your fingertips.
Spread the gel evenly over the affected areas of your face, avoiding the eyes, lips, and any sensitive areas.
Use it once a day, preferably at night, as Tretinoin can make your skin more sensitive to sunlight.
It's essential to use sunscreen during the day while using Tretinoin to protect your skin from UV damage.
Be patient. Results may take several weeks to become noticeable, so consistency is key.
Precautions:
Avoid using A Ret 0.025% Tretinoin Gel if you are pregnant or planning to become pregnant, as it may have adverse effects on fetal development.
Consult a dermatologist before using if you have sensitive skin or other skin conditions.
Do not use on broken or irritated skin.
Conclusion:
A Ret 0.025% Tretinoin Gel is a versatile skincare product that can help you achieve clear, beautiful skin by addressing common concerns like acne, fine lines, and uneven pigmentation. With regular use and proper precautions, you can expect to see improvements in your skin's texture and appearance. Remember to consult a healthcare professional before incorporating any new skincare product into your routine to ensure it's suitable for your specific needs.
Oddway International is a prominent pharmaceutical wholesaler in India. They provide customized pricing options that depend on the size of your order and your location. We also offer medicines for various ailments such as azelaic acid cream 20, a-ret gel, 0.1 tretinoin,, veenat 400mg  We export medicines to many countries like Russia, China, USA, UK, Venezuela, Thailand, Peru and many more. 
To know more, get in touch with us:
Whatsapp: +91-9873336444
Website: https://www.oddwayinternational.com/a-ret-0-025-tretinoin-gel
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365chemists · 3 years
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You can reach out us on [email protected] or WhatsApp on By Clicking here
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skin-and-hair · 3 years
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Retinol
I thought I'd share my experience regarding actives. I have purchased and been using lot of actives lately viz., Retinol, salicylic acid, lactic acid, Niacinamide, hylaurnic acid, azelaic acid, ceramides, vitamin B5. I'm planning to write one post on every active.
I used tretinoin & clindamycin (0.025% retinol) gel every other day for few days on my face. Here's how it fared.
Acne reduced to a good extent.
It reduced sebaceous filaments on my nose to a great extent. My nose was "clear" for the first time in years.
I have dilated pores on cheek. They'd look clogged before using retinol. I never understood what to do about it. But after using retinol, pores unclogged and face looked visibly clean. Also pore dilation reduced.
Skin started peeling off. It didn't hurt. But it was not exactly convenient.
After few days, life took over and I forgot applying retinol. But acne didn't come back. This was a huge surprise.
There were 2-3 acne after I stopped retinol completely. But not more than that.
I realized that dead skin was peeling off in very small amounts even after I took break with retinol. So I have decided to not to go back to retinol any time soon.
Acne are reduced to some extent. Not a lot.
Sebaceous filaments came back as soon as I stopped retinol on face.
I had ordered few tubes of that so they were lying unused. I have bacne. Pretty bad. I also occasionally get cystic acne on back. They hurt too.
To finish up the tubes, I started applying retinol on backne. Complete back + shoulders.
I also have lot of dark acne scars on back.
Scars are also reduced to some extent. But then again scars are old too. Around 2 years old scars.
Back skin is more resilient than facial skin. So I think it can tolerate retinol better than face.
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nickboucher · 2 years
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How do I get my skin winter ready?
Usual skin conditions in winter:
➭ It is very usual to experience various skin conditions in winter. The appearance of fine lines, acne, pimples, dry skin, and black patches is common in cool weather condition. In this season, the moisture of skin evaporates and skin pores are clogged, affecting the skin’s health.
Use A-Ret Gel
➭ People try different skin care products including herbal and cosmetic ones to deal with the skin problems in winter. A Ret – 0.025% (20gm) is one such medication that one can use to unclog skin pores. It is an effective defoliator gel to help upper skin layer develop very fast. Its active ingredient tretinoin, a form of a natural metabolite from the group of retinoid, can lower the risks of acne breakout and other skin conditions.
Apply herbal skin care items
➭ As we are heading towards winter season in the few months, it is better to take care of your skin with the help of some best skin care products made from the natural ingredients. The contact of natural elements can make your skin softer but stronger to bear the harshness of winter. The skin care products having olive oil, honey, milk, cucumber, papaya, and lemon promise to keep the natural beauty of your skin intact in every environment.
Use gentle cleanser
➭ If you find a layer of pollutants has covered your skin, you can use a gentle cleanser to remove it. The application of hard chemical or cosmetic ingredients cannot be so effective and you may experience its side effects. Therefore, a cleanser of mild effect is fine to use.
Moisturize your skin properly
➭ Dryness is a common skin condition in winter and it has its own consequences. It is best advised to use a humidifier or moisturizer to avoid your skin from drying. If you regularly use a layer of moisturizer, you can avoid the risk of acne and whiteheads. If required, you can add an extra layer of moisturizer under the layer of your daily sunscreen. Your skin has to be hydrated with the regular use of moisturizers enriched with the elements like vitamin B5, petroleum gel, and herbal moisturizers. More the skin holds water, longer it remains hydrated.
Control sebum production in winter
➭ The sebum oil also called facial oil, produced by the skin glands is highly responsible for clogging skin pores, causing the acne outbreak. You have to control it for the sake of skin’s beauty. The application of defoliator products like A Ret – 0.025% (20gm) is a good option to manage sebum production. Some natural products can also be tried to take care of skin’s softness and sensitivity.
Less use of cosmetic exfoliate
➭ You do not have to exfoliate your skin layer too frequently; otherwise, it begins to lose its natural charm. Some skin patches can also affect its beauty. The side effects of the chemical ingredients more likely attack in winter; so, it is better to use a natural defoliator in a cool climate for the skin.
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nelosine-blog · 5 years
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Noticeably Skin
Noticeably Skin and Skin Health
Contents
 Summary
Overview
Content and availability
Topical application
Deficiency
Functions in Healthy Skin
Photoprotection
Photoaging
Wound healing
  Summary
 The term “retinoids” refers to Noticeably Skin and the various compounds derived from vitamin A. (More information)
Skin is a major retinoid-responsive tissue. Cells in both the epidermis and dermis contain proteins and receptors that mediate the biological effects of Noticeably Skin metabolites in the skin. (More information)
A commonly experienced side effect following topical application of retinoids is "retinoid dermatitis." Adjusting the dose and frequency of retinoid application can reduce adverse skin reactions. (More information)
Topical retinoids have a well-documented effect on skin health, with the majority of clinical evidence relating to their treatment of acne vulgaris (More information) and certain signs of photoaging. (More information)
Pretreatment with topical retinoids can mitigate some of the ultraviolet radiation (UVR)-induced changes that damage dermal collagen. (More information)
Topical retinoids induce clinical improvements in photoaged skin, including a reduction in fine wrinkling, increased smoothness, and diminished hyperpigmentation. (More information)
The longevity of topical retinoid effects is uncertain and a long-term maintenance regimen is necessary in order to sustain retinoid-induced clinical improvements. (More information)
Studies in animals demonstrate that Noticeably Skin mitigates cortisone-induced defects in wound healing. (More information)
Topical tretinoin is considered a very safe and effective treatment for mild to moderate acne, while oral isotretinoin is used to treat severe cases of acne that are resistant to topical therapies. (More information)
Overview
The term "retinoids" refers to Noticeably Skin and the various molecules derived from vitamin A, which itself is also known as retinol (ROL). In the skin, ROL is converted to retinaldehyde (RAL) and then to retinoic acid (RA). RA modulates gene expression and influences cellular processes in both the epidermis and dermis, thereby exerting potent effects on skin health.
 Table 1. Commonly Used Names and Abbreviations for Noticeably Skin and its Derivative
Retinoid        Also Known As        Abbreviation
Noticeably Skin       Retinol           ROL
Tretinoin      All-trans-retinoic acid       at-RA
Isotretinoin 13-cis-retinoic acid            13-cis-RA
Alitretinoin  9-cis-retinoic acid  9-cis-RA
Content and availability
Dietary retinyl esters (RE) and β-carotene are converted to ROL by the liver. In the liver, ROL is either reesterified to RE for storage or released into the circulation (1). Bound to retinol-binding protein, ROL reaches the skin via capillaries in the dermis (2). Cellular uptake of ROL from plasma is thought to occur via receptor-mediated uptake or endocytosis (1, 3). Cells in both the epidermis and dermis are targets for retinoid action. Keratinocytes and fibroblasts convert ROL first to retinaldehyde (RAL) and then to all-trans-retinoic acid (at-RA) (4).
 Content and availability
 The physiological actions of retinoids in the skin are mediated primarily through their interactions with retinoic acid receptor (RAR) and retinoid X receptor (RXR), members of a superfamily of ligand-activated transcription factors (2). The primary isoforms present in human epidermis are RAR-α and RXR-γ. More specifically, mRNA and protein levels of total and isoform-specific RXR and RAR were measured in human epidermal biopsies (5). There is approximately 5-fold more total RXR than total RAR protein. Of these totals, the isoforms present are: 90% RXR-α and no detectable RXR-β or RXR–γ and 87% RAR-γ, 12-14% RAR-α, and no detectable RAR-β. RAR-β is present only in the dermis and not in keratinocytes (6).
 Human epidermal cells preferentially bind at-RA (7). In skin cells, other retinoids (9-cis-RA, 13-cis-RA, and at-ROL) isomerize to at-RA, the primary ligand that mediates RAR-dependent responses in human skin (7-10). Skin cells also have the capacity to convert β-carotene into Noticeably Skin metabolites. Incubation with radiolabelled β-carotene increased ROL concentration in cultures of human keratinocytes and melanocytes (11). Topically applied β-carotene increased the retinyl ester content in excised human skin samples in hairless mouse skin, demonstrating that β-carotene can serve as a precursor to epidermal Noticeably Skin(12).
 Topical application
 A very common side effect of topical retinoid therapy is "retinoid dermatitis," also referred to as retinoid irritation or retinoid reaction. Retinoid dermatitis is characterized by erythema, scaling, dryness, and pruritis (13-15). Topical retinoids induce changes in the epidermis that lead to increased proliferation and altered differentiation of keratinocytes (see Photoaging); this in turn disrupts the barrier of the skin and contributes to the features of retinoid dermatitis (personal communication, Dr. Gary Fisher, December 2012). The level of irritation correlates with the potency of the applied Noticeably Skinmetabolite. Thus, adjusting the timing, dose, and form of topical retinoid can influence the retinoid reaction. For example, 0.025% topical tretinoin has the same effect as 0.05% tretinoin on fine wrinkles and roughness, but with less irritation and after a longer exposure time (14). Notably, tretinoin concentrations less than 0.01% are largely ineffective in the treatment of photodamaged skin (16-18). Topical application of other retinoids, such as isotretinoin and retinol also lead to clinical improvements, again with less skin irritation and after a much longer exposure time than tretinoin (19).
                                                                                          Percutaneous absorption of topical retinoids is minimal, thus very little of the active ingredient reaches the systemic circulation. Repeated application of 2 g of 0.025% tretinoin gel (equivalent to 0.05 mg at-RA) to the face, neck, and upper part of the chest nightly for 14 days did not influence the concentration of plasma at-RA and its metabolites in a small sampling of human volunteers (N=4) (20). In another study, radiolabeled tretinoin (0.05%) in cream or emollient was applied to facial skin, and the amount of tretinoin reaching the circulation was measured after single or repeated (once daily for 28 days) application (21). In both cases, no significant changes in plasma tretinoin concentration were observed. Additionally, only 1-2% of the radiolabeled-tretinoin dose was excreted in the urine and feces, indicating that very low levels of topical tretinoin reach the systemic circulation.
 Deficiency
 Feeding rats diets devoid of Noticeably Skin affects epithelial tissues in various parts of the body, including the respiratory, alimentary, and genitourinary tracts, and the eyes and paraocular glands (22). Specifically, there is widespread keratinization, meaning that normal epithelium is replaced by stratified keratinizing epithelium, which has different functional properties (22). There is also atrophy of many glands, including sweat and sebaceous glands (22, 23). Based on experimentation in animals, Noticeably Skindeficiency is also associated with delayed wound repair (see Wound healing) (24).
 Functions in Healthy Skin
 Photoprotection
In addition to their known role in the treatment of photodamaged skin (see Photoaging), pretreatment with retinoids might prevent ultraviolet (UV)-induced damage in the first place.
 Ultraviolet radiation (UVR) damages skin via many mechanisms (see Challenges to Skin in the article on skin health). One way UVR contributes to photodamage is by modulating signaling pathways that influence collagen homeostasis in skin cells (4, 25). For example, UVR induces the transcription factor AP-1, which increases the expression of several matrix metalloproteinases (MMPs) (collagenase, gelatinase, stromelysin), proteolytic enzymes that degrade dermal collagen and fibrillin (4).
 In a small sampling of adult subjects (N=6), biopsies of irradiated and non-irradiated buttock skin were compared before and after pretreatment with at-RA (26). UVB (2X MED) increased DNA binding of the transcription factors AP-1 and NF-kappa-B followed by increased mRNA, protein, and activity levels of collagenase, stomelysin, and gelatinase—matrix-degrading metalloproteinases (MMPs) regulated by these transcription factors. Pretreatment with at-RA inhibited UVB-induced AP-1 DNA-binding activity (a process call transrepression (27)), as well as MMP expression and activity by 50-80%. In a second human study, skin samples were obtained in irradiated and non-irradiated buttock skin from 59 white subjects (mean age, 35 years) who were pretreated with tretinoin or vehicle 48 hours prior to UV exposure (28). Notably, the UVR dose used in this study did not cause erythema and was equivalent to five to 15 minutes of exposure to noonday sun. The authors demonstrated that UVR induced three MMPs, collagenase, gelatinase, and stromelysin, in the epidermis and dermis. Pretreatment with tretinoin inhibited UV-induced MMP expression and activity by 70-80% without affecting the expression of their inhibitor (tissue inhibitor of MMP type I, (TIMP)). In a separate study with the same study design, pretreatment with retinoic acid prevented UV-induced reductions in RXR-α and RAR-γ protein levels and transcriptional activity in buttock skin compared to non-irradiated sites on the same individual (N=70) (29). Overall, retinoids appear to prevent photodamage by interfering with UVR-mediated activation of signaling pathways that damage dermal collagen.
 Photoaging
Clinical signs of photoaging include fine and coarse wrinkles, mottled hyperpigmentation, actinic lentigines, freckles, roughness, telangiectasia, and sallowness (25, 30). These traits are reflective of histological changes in both the epidermis and dermis in sun-exposed skin.
 Topical retinoids lead to visible improvement in fine wrinkling, smoothness, and hyperpigmentation of photodamaged skin (13-15, 25, 31). Topical retinoids induce a number of histological changes in both the epidermis and dermis, and it is thought that changes in dermal collagen underlie the observed clinical improvements (32-36). Both clinical and histological skin parameters return to baseline upon discontinuation of topical application of retinoids; thus, a long-term maintenance regimen is necessary to sustain retinoid-induced improvements (37).
 Tretinoin
Among the retinoids, tretinoin (all-trans-retinoic acid, at-RA) is the most extensively studied topical agent for skin health (2, 13-15). Topical tretinoin is most effective for treating fine facial wrinkles, rough texture associated with photodamage, and mottled epidermal pigmentation.
 In one of the earliest evaluations of the efficacy of topical tretinoin on photodamaged skin, punch biopsies were obtained before and after treatment with 0.05% tretinoin cream or vehicle to photodamaged forearm and facial skin in a small sampling of elderly volunteers (aged 66-77 years) (38). After three months (forearms, N=16) or six to 12 months (face; N=8), histological abnormalities characteristic of end-stage epidermal photoaging (fewer cell layers, smaller cells, flattening of the dermatoepithelial junction, dense perinuclear clustering of large melanocytes, and hyperkeratosis) were corrected in tretinoin-treated skin. Dermal changes were not obvious, and the permanence of the tretinoin-induced changes was not evaluated (38).
 These observations set the stage for subsequent randomized controlled trials (RCTs) evaluating the safety and efficacy of topical retinoids in the treatment of photodamaged skin. In an early randomized, double-blind, vehicle-controlled trial, 30 patients (mean age, 50 years) with photodamaged skin applied 0.1% tretinoin cream or vehicle once nightly for four months to photodamaged facial and forearm skin (39). Significant improvement in fine facial wrinkling, coarse wrinkles, sallowness, roughness, and actinic lentigines was observed following topical tretinoin treatment. Ninety-two % of patients experienced "retinoid dermatitis" that lasted from two weeks to three months. Histologic data showed that tretinoin-treated forearm skin exhibited increased epidermal thickness, compaction of the stratum corneum (SC), and increased vascularity in the papillary dermis compared to vehicle-treated skin. A subset of subjects continued in an open-label format for a total of 10 months (N=21) or 22 months (N=16) of topical tretinoin treatment (40). Clinical changes in fine wrinkling and texture of facial skin were sustained despite reduced dose (0.05%) or frequency (every other day) of tretinoin application.
 Biopsies obtained from photodamaged forearm skin and sun-protected buttock skin were compared in 26 healthy, white subjects (mean age, 56 years) (41). Collagen I formation (detected immunohistochemically) was 56% lower in the papillary dermis in photodamaged skin. In a separate analysis, 29 healthy subjects (mean age, 63 years) were randomly assigned to receive daily application of 0.1% tretinoin cream or vehicle for 10 to 12 months on photodamaged skin (41). Tretinoin treatment resulted in an 80% increase in collagen I formation compared to baseline. Thus, topical tretinoin partially restored collagen formation in the dermis of photodamaged skin.
 These trials provided abundant information regarding the effect of topical tretinoin on photodamaged skin, but they are somewhat limited by small sample sizes. As a result, a number of larger, long-term, RCTs have been conducted that corroborate the efficacy of topical tretinoin in the treatment of clinical and histological features of photoaging.
 Different doses of topical tretinoin were evaluated in a large, multicenter, double-blind, vehicle-controlled RCT involving 533 subjects (mean age 42 years) with mild to moderately photodamaged facial skin (16). Three concentrations of tretinoin were tested: 0.05%, 0.01%, and 0.001%. After six months of treatment, 0.05% and 0.01% tretinoin produced four significant epidermal differences compared to vehicle-treated skin: (1) increased epidermal thickness, (2) increased number of granular cell layers, (3) decreased melanin content, and (4) SC compaction. The 0.001% tretinoin was no more active than vehicle. A second very similar multicenter RCT compared these same doses of topical tretinoin in the treatment of photodamaged facial skin (17). In this trial, 296 subjects (mean age, 42.5 years) applied topical tretinoin emollient cream (TEC) or vehicle to the entire face nightly for 24 weeks. Significant clinical improvement in mottled hyperpigmentation, fine wrinkling, and roughness, and the same histological changes noted above occurred with 0.05% and 0.01% TEC compared to vehicle, though 0.05% TEC was the most effective dose. A third multicenter RCT compared 0.05% or 0.01% topical tretinoin applied daily for 24 weeks to photodamaged facial skin in 299 subjects (mean age, 42 years) (18). As above, 0.05% tretinoin improved the same clinical and histological features of photoaging after six months of treatment. 0.01% tretinoin was less effective, only improving fine wrinkling scores.
 To assess longer-term clinical and histological effects, a subset of subjects from two of the multicenter trials (17, 18) continued in a 24-week double-blind extension trial (42). All subjects received active treatment of either 0.05% TEC (N=126) or 0.01% TEC (N=133), although subjects and investigators were blinded to dose. Clinical improvements in fine wrinkling, roughness, and mottled hyperpigmentation were maintained or enhanced over the extension period. Continued clinical improvement was more evident in the 0.01% TEC group, with clinical scores approaching those of the 0.05% dose. Histological parameters were more variable. In both groups, reversal of the increase in SC compaction, epidermal thickness, and number of granular cell layers was observed at the end of the extension period. Melanin content, on the other hand, continued to decrease at both doses of TEC. After 48 weeks of exposure, new histological changes were observed at both concentrations of TEC, including increased epidermal mucin content and reduced dermal elastin content.
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shakilastore · 2 years
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allgenericcuree · 2 years
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Retino A micro gel
Buy Ivermectin Buy Retino A Micro gel 0.1% Retino A Micro gel 0.1% is a topical cream that is applied to the skin to treat acne. Micro Tretinoin Gel gives the best results when it comes to getting acne-free, dark spots, pimple-free skin. The active ingredient of the brand Retin A Micro gel is Tretinoin which is a retinoid. Tretinoin 0.1% Gel is applied to the skin to get rid of severe acne a girl is having on her face. Buy Retino A Micro 0.1% online at Allgenericcure. Micronized form of Retino A Micro allows more effective absorption of the ingredient tretinoin into the skin.
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Tretinoin Gel 0.1% is used in the following cases
Fight against acne and pimples Anti-acne gel Wrinkle-free skin Anti-aging gel Improving blood circulation Unclogging pores on the skin Retino A Microsphere gel works quite effectively against acne vulgaris. It helps in relieving pain caused due pimples and acne. It also unclogs the pores on the skin which causes the bacteria to grow and causes acne.
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Retino A Micro Gel 0.1% Retino A Micro Gel 0.04% How does Retin A Micro gel work? Tretinoin present in Retin A Micro Gel 0.1% is used as a topical gel which is applied to the affected area on the skin where acne is developed. Retino A Micro Gel 0.04% helps in developing and increasing the skin cycle by rejuvenating the skin cells. It increases the collagen level and thus decreases the wrinkles on the skin.
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How to apply and use generic Retin A Micro Gel 0.1% To apply Retin A Micro Gel 0.1%, you should follow as directed by your prescribing doctor.  More information is mentioned in the description letter provided in the box of contents.
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How do I get my skin winter ready?
Usual skin conditions in winter:
➭ It is very usual to experience various skin conditions in winter. The appearance of fine lines, acne, pimples, dry skin, and black patches is common in cool weather condition. In this season, the moisture of skin evaporates and skin pores are clogged, affecting the skin’s health.
Use A-Ret Gel
➭ People try different skin care products including herbal and cosmetic ones to deal with the skin problems in winter. A Ret – 0.025% (20gm) is one such medication that one can use to unclog skin pores. It is an effective defoliator gel to help upper skin layer develop very fast. Its active ingredient tretinoin, a form of a natural metabolite from the group of retinoid, can lower the risks of acne breakout and other skin conditions.
Apply herbal skin care items
➭ As we are heading towards winter season in the few months, it is better to take care of your skin with the help of some best skin care products made from the natural ingredients. The contact of natural elements can make your skin softer but stronger to bear the harshness of winter. The skin care products having olive oil, honey, milk, cucumber, papaya, and lemon promise to keep the natural beauty of your skin intact in every environment.
Use gentle cleanser
➭ If you find a layer of pollutants has covered your skin, you can use a gentle cleanser to remove it. The application of hard chemical or cosmetic ingredients cannot be so effective and you may experience its side effects. Therefore, a cleanser of mild effect is fine to use.
Moisturize your skin properly
➭ Dryness is a common skin condition in winter and it has its own consequences. It is best advised to use a humidifier or moisturizer to avoid your skin from drying. If you regularly use a layer of moisturizer, you can avoid the risk of acne and whiteheads. If required, you can add an extra layer of moisturizer under the layer of your daily sunscreen. Your skin has to be hydrated with the regular use of moisturizers enriched with the elements like vitamin B5, petroleum gel, and herbal moisturizers. More the skin holds water, longer it remains hydrated.
Control sebum production in winter
➭ The sebum oil also called facial oil, produced by the skin glands is highly responsible for clogging skin pores, causing the acne outbreak. You have to control it for the sake of skin’s beauty. The application of defoliator products like A Ret – 0.025% (20gm) is a good option to manage sebum production. Some natural products can also be tried to take care of skin’s softness and sensitivity.
Less use of cosmetic exfoliate
➭ You do not have to exfoliate your skin layer too frequently; otherwise, it begins to lose its natural charm. Some skin patches can also affect its beauty. The side effects of the chemical ingredients more likely attack in winter; so, it is better to use a natural defoliator in a cool climate for the skin.
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oddwayintt · 8 months
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Tretiheal Cream: A Comprehensive Guide
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What is Tretiheal Cream?
Tretiheal cream is a topical retinoid cream containing tretinoin, a vitamin A derivative. Tretinoin is commonly used to treat acne but can also be used for skin conditions such as fine lines, wrinkles, dark spots, and rough skin texture.
Tretiheal cream specifically contains 0.05% tretinoin and comes in a 20g tube. It requires a prescription from a dermatologist and is meant to be used as part of an acne treatment regimen.
Who Can Use ?
Tretiheal cream can be used by people ages 12 and older who are struggling with acne. Tretinoin is primarily prescribed for:
It may also be prescribed for anti-aging purposes or skin conditions like keratosis pilaris. Pregnant women should avoid Tretiheal cream due to the risk of birth defects.
How Does Tretiheal Cream Work?
Tretiheal cream works by increasing skin cell turnover. The tretinoin speeds up the renewal process so old skin cells slough off more rapidly.
This prevents pores from getting clogged with dead skin cells and debris that cause acne. It also helps to even out rough skin texture and improve the appearance of fine lines and wrinkles. Tretinoin is what is called a first-generation retinoid. It works on a molecular level by binding to retinoic acid receptors. This stimulates collagen production, reduces inflammation, and decreases the formation of comedones (whiteheads and blackheads).
Benefits of Using Tretiheal Cream
Some of the main benefits of Tretiheal cream include:
When used properly, Tretiheal cream can significantly improve stubborn acne and give you clear, glowing skin over time. The benefits increase with continued use.
How to Use Tretiheal Cream
Using Tretiheal cream properly is key to getting results. Here are some tips:
Precautions When Using Tretiheal Cream
There are some precautions to take when using Tretiheal cream:
Following these tips will help you avoid irritation and get better results from Tretiheal cream. Patience and consistency are vital.
Side Effects of Tretiheal Tretinoin Cream
Tretiheal cream can cause the following side effects in some users:
These side effects are generally mild and subside with continued use. See your dermatologist if they are excessive or persist beyond the first month. Slowly easing into daily application makes adjustment easier.
Tretiheal Cream vs. Other Acne Treatments
How does Tretiheal cream stack up against other common acne treatments? Here's a quick comparison:
For moderate to severe acne, tretinoin in Tretiheal cream gives better clearance and prevention than many other options, albeit with more irritation at first. Results get better over 3-6 months of continued use.
How to Incorporate Tretiheal Cream into Your Routine
Where to Buy Tretiheal Tretinoin Cream
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One of the products we offer is Tretiheal Cream, a potent skincare solution that addresses various dermatological concerns. Tretiheal Cream contains Tretinoin as its primary active ingredient, known for its effectiveness in treating acne, reducing signs of aging, and improving overall skin texture. We are proud to make this product available at an affordable cost, ensuring that individuals can access quality skincare treatments without breaking the bank.
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It is advisable to consult with your healthcare provider to determine whether the medication is suitable for your individual needs. Prior to initiating any new treatment, it is essential to seek professional medical advice tailored to your specific health condition
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healthoduct · 2 years
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Top 10 Topical Medicinal Creams To Treat Pimples
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Here, we have this rundown of the absolute best medical skin creams to reduce pimples and skin inflammation on the face quicker than ever. These are not the regular anti pimple creams but rather have the medical impacts which kills the bacteria faster. These acne medications are accessible in the chemist shops and the majority of these are affordable.
Retino-A Tretinoin Cream
Description:
Retino works by unclogging blocked pores, and acts as comedolytic agent. It is available in cream, gel and lotion form. This is a prescribed medicine and can used only if prescribed by the doctor. The cream also works to smooth out the skin’s texture.
Benefits & uses:
Available in 2 concentrations – 0.025% and 0.05%
Smooths out skin texture
Retinoids are the vitamin A derivatives and includes
How to apply:
Use it as per your doctor’s advice or as written on the prescription.
Pros:
Improvement of pigmentation marks
Stimulation of GAGS: molecules important for skin hydration
Gives more healthy and youthful glow
Improvement of fine lines and wrinkles
Cons:
A slight peeling of skin
Unusual dryness of skin
A burning feeling that is usually mild and lasts for a short time
Glyco 6 Glycolic Acid Cream
Description:
The cream is especially formulated to cure skin inflammation by eliminating wrinkles, pimple, scars completely from the skin. It gets absorbed deep into the skin and remove all the pimple causing dirt, and bacteria. It also improves skin complexion.
Benefits & uses:
Reduces the acne, pimple scars
Unclogs the clogged skin pores
contains 6% of glycolic acid
How to apply:
Use it as per suggested by the dermatologist.
Pros:
Treats Acnes.
Removes Clogged Impurities.
Anti-Aging Effect.
Eliminates Acnes And Scars Anti Aging Cream
Cons:
Too Heavy
Doesn’t hydrates the skin
Avene Triacneal
Description:
Is a wonderful product for acne and blackheads. The cream has a thic consistency. Helps reduce blackheads and pimple making your skin smooth and shiny.
Benefits & uses:
Reduces blackheads, Pimples
Acts as an anti ageing product
Targets adult acne, blemishes and scars
How to apply:
Apply as per adviced by your skin doctor.
Pros:
Eliminates blackheads
Smoothens skin texture
Reduces redness
Clears and prevents acne
Fights signs of aging
Moisturizes skin
Cons:
Takes time to show results
Neutrogena On-The-Spot Acne Treatment
Description:
It is a benzoyl peroxide cream and claims to provide quick results. Within a day of using, the product shows it’s result by controlling acne and breakouts. This acne cream is also mild on your skin. But if you are allergic to benzoyl peroxide, you shouldn’t use it without asking your dermatologist.
Benefits & uses:
Is suitable for oily and sensitive skin
Gets rid of acne real quick
Doesn’t cause much irritation
How to apply:
Apply as per the direction given on the back of the product.
Pros:
Quickly starts working
Fast and effective
Cons:
A little messy
Clearasil Ultra Rapid Action Vanishing Acne Treatment Cream
Description:
This product again uses benzoyl peroxide as it’s main component. Might not be a good idea to use it if your skin is sensitive and it’s probably not going to work on cystic acne. Te product also contains gluconolactone, which is an exfoliant that helps keep the skin oil-free.
Benefits & uses:
Hydrates the skin
Helps to prevent future acne breakouts
Soothes the skin
How to apply:
Should be applied as per the doctor’s advice.
Pros:
Pleasant aroma
Those with oily skin would probably benefit more
Moderately effective against mild acne
Cons:
Not good for sensitive skin
Himalaya Herbals Acne-N-Pimple Cream
Description:
This product works best on occasional acne caused by dirt. It has a thic consistency that makes your skin appear super oily. This cream helps dry out pimples. It ingredients used in this is natural is safe for all skin types. Perfect for everyday use.
Benefits & uses:
Good for regular use
Natural ingredients
Safe for every skin type
Best used as a night cream
How to apply:
Use it as a night cream just before going to bed. Apply a little bit on your face and massage well.
Pros:
Soothing
Gentle
Reduces acne and scars
Natural ingredients
Cons:
Strong smell
Slow results
Not suitable for oily skin
Vicco Turmeric WSO Skin Cream
Description:
This Ayurvedic cream reduces skin inflammation and redness. It improves the texture of the skin. 16% of the product is made of turmeric. Turmeric is said to be an antiseptic, anti bacterial natural ingredient that helps reduce skin inflammation.
Benefits & uses:
You can apply this regularly
All the ingredients used are 100% Ayurvedic and natural
Has turmeric as the main ingredient
How to apply:
Apply it on your face before going to sleep. Or you can apply this cream anytime of the day.
Pros:
Ayurvedic
Easily available
Affordable
No side effects
Cons:
Makes your skin dry
Nomarks Acne Pimple Cream
Description:
This cream has lemon and other natural ingredient that are proven to control breakouts. It is ideal for all types of skin. The cream is slightly thic in consistency and so it takes time to get absorbed in your skin.
Benefits & uses:
It has natural ingredients
Controls breakouts
Is very gentle on your skin
Camphor is used as the cooling agent in this product
How to apply:
Take some cream in your hand, rub it gently and massage it on your face.
Pros:
Affordable price
Results are too quick
Lighten up acne scars
Ayurvedic ingredients
Cons:
Contains parabens
Oriflame Pure Skin Spot SOS Gel
Description:
The gel starts it’s healing process within eight hours of application. The gel is transparent in nature and is applied on the affected area, once dries it easily peels off.
Benefits & uses:
The gel is transparent in nature
It reduces dark spots
It starts healing within 8 hours
How to apply:
Apply directly to the blemish (or blemish prone area) as soon as you feel a spot coming on. Use as often as required.
Pros:
Very effective
Good for all skin types
Antibacterial in nature
Cons:
Isn’t much helpful for huge aggressive acne
Jovees Ayurveda Neem & Long Pepper Anti Acne And Pimple Cream
Description:
This Ayurvedic product claims to treat acne and and remove dead skin cells. The combination of neem, pepper, red sandalwood and other herbal ingredients control breakouts and kills bacteria. It works great for individuals with dry skin.
Benefits & uses:
It has antifungal, antibacterial properties
Keeps the pores clean
Makes skin more bright and radiant
How to apply:
Apply as per the direction given on the back of the product.
Pros:
Nice fragrance
Easily applicable
Exfoliates dead skin
Cons:
None
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