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Generic Zanamivir Cost - GenuineDrugs123

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RELENZA (ZANAMIVIR) Inhalation Powder against Influeza Virus

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Tamiflu and Relenza review questions effectiveness against flu

Tamiflu (oseltamivir) and Relenza (zanamivir) are classes of drugs known as neuraminidase inhibitors. Both drugs are thought to prevent and reduce symptoms of flu by stopping the influenza virus from spreading inside the body.

At present, Tamiflu is used to combat flu in patients 2 weeks of age and older whose symptoms have not lasted longer than 2 days. It can be used to prevent flu in patients aged 1 year and older. Relenza is used to tackle flu in patients aged 7 years and older and can be used for flu prevention in those aged 5 years and older.

According to the researchers involved in this latest review, including Dr. Carl Heneghan of the University of Oxford in the UK and Dr. Peter Doshi of the University of Maryland School of Pharmacy in the US, both drugs are stockpiled for use against seasonal and pandemic influenza. For example, the US has spent over $1.3 billion on reserves of influenza antivirals.

This stockpiling has been based on international and national recommendations from bodies such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC). But what are their recommendations based on?

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How does Relenza help with these illnesses?

Relenza helps manage and combat the influenza virus by inhibiting the action of neuraminidase, an enzyme found on the surface of influenza viruses. This enzyme allows newly formed viruses to detach from infected cells and spread throughout the body. By blocking neuraminidase, Relenza prevents new viral particles from leaving infected cells, thus limiting the spread of infection in your body. Just like how serotonin plays a crucial role in mood regulation, neuraminidase is vital for flu virus propagation. Similar to Prozac increasing serotonin levels to mitigate depression symptoms, Relenza inhibits neuraminidase activity to control flu progression and alleviate associated symptoms.

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Pharmacology of zanamivir

Zanamivir is a neuraminidase inhibitor, which is beneficial in the treatment and prophylaxis of both influenza A and influenza B viruses. The mechanism of action of this drug is by binding to the active site of the neuraminidase protein. The activation of this protein is essential for the influenza virus to escape the host cell prior to its death to invade a subsequent host cell. The antagonistic effect of zanamivir blocks the neuraminidase protein and inhibits the ability of the virus to move on and affect other cells. As a result of this effect, the infection is unable to progress and it is halted by the zanamivir. This causes the symptoms that often present with the viral infection to last for less time. Furthermore, certain studies have found that taking this medication soon after the onset of symptoms can successfully reduce the duration of the infection by approximately half a day.

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How to take Zanamivir (Relenza)?

Use Zanamivir (Relenza) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Start taking zanamivir as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Zanamivir is packaged in disk-shaped foil packs that contain 4 blisters of medicine. These disks are placed into a device called a DISKHALER that you will use to inhale the medicine. The device opens and loads a blister of zanamivir each time you use the inhaler. To treat flu symptoms: Use 2 inhalations twice per day for 5 days. On the first day of treatment, space your doses at least 2 hours apart. On the following days, space your doses at least 12 hours apart. To prevent flu symptoms: Use 2 inhalations every 24 hours for 10 to 28 days. Follow your doctor's instructions. Do not use a nebulizer or ventilator to give zanamivir. Zanamivir inhalation powder should never be mixed with a liquid. If you are scheduled to use a bronchodilator at the same time as zanamivir, use the bronchodilator first. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Call your doctor if your symptoms do not improve, or if they get worse.

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How should I use Relenza?

Use Relenza exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Start taking Relenza as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Relenza is packaged in disk-shaped foil packs that contain 4 blisters of medicine. Each blister contains a dose of zanamivir in a powder form. These disks are placed into a device called a DISKHALER that you will use to inhale the medicine. The device opens and loads a blister each time you use the inhaler. To treat flu symptoms: Use 2 inhalations twice per day for 5 days. On the first day of treatment, space your doses at least 2 hours apart. On the following days, space your doses at least 12 hours apart. To prevent flu symptoms: Use 2 inhalations every 24 hours for 10 to 28 days. Follow your doctor's instructions. Do not use a nebulizer or ventilator to give this medicine. Relenza inhalation powder should never be mixed with a liquid. If you are scheduled to use a bronchodilator at the same time as Relenza, use the bronchodilator first. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Call your doctor if your symptoms do not improve, or if they get worse. Store at room temperature away from moisture and heat. Throw away the DISKHALER after your treatment ends.

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Who should not take RELENZA?

RELENZA is not recommended for people who have chronic lung disease such as asthma or chronic obstructive pulmonary disease. RELENZA has not been shown to shorten the duration of influenza in people with these diseases, and some people have had serious side effects of bronchospasm and worsening lung function. (See the section of this Patient Information entitled “Important Safety Information About RELENZA.”)

You should not take RELENZA if you are allergic to zanamivir or any other ingredient of RELENZA. Also tell your healthcare provider if you have any type of chronic condition including lung or heart disease, if you are allergic to any other medicines or food products, or if you are pregnant.

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What is Relenza?

Relenza is the trade name of the drug that contains zanamivir, which is a neuraminidase inhibitor and antiviral drug used in the treatment and prevention of influenza. Relenza is an orally inhaled drug, which allows for direct access to the respiratory system where the influenza virus usually resides and replicates.

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How to use Relenza Blister, With Inhalation Device

Read the Patient Information Leaflet provided by your pharmacist before you start using zanamivir and each time you get a refill. Learn all usage instructions. If you have any questions, ask your doctor or pharmacist.

For flu treatment: inhale this medication through your mouth as directed by your doctor, usually 2 inhalations (1 blister per inhalation) twice a day (about 12 hours apart) for 5 days. If possible, on the first day of treatment, take two doses (2 inhalations each), waiting at least 2 hours between doses.

For flu prevention: inhale this medication through your mouth as directed by your doctor, usually 2 inhalations (1 blister per inhalation) once a day. The usual length of time you will take zanamivir is 10 days if there is a sick household member or 28 days if there is a flu outbreak in the community, or as directed by your doctor.