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Medical Device Genotoxicity Testing Services

Genotoxicity testing is an important aspect of the safety evaluation of medical devices, aimed at detecting any potential genetic damage caused by the device or its components. This type of testing assesses the ability of a substance to cause mutations, chromosomal damage or other changes in the DNA of living cells, which can lead to cancer or hereditary diseases.

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Background of Microbial Limit Test

Microbial testing is a testing method with a wide range of functions and uses. First, it can be used for sanitation testing in food production to ensure food quality and safety. Second, it can be used in the medical field, such as testing microorganisms in medical devices, drugs, and patient samples to ensure patient safety and health. In addition, it can also be used for environmental monitoring to detect microbial contamination in water sources and air. CD Bioparticles provides medical device microbial testing services.

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Conjugated Upconverting Nanoparticles

Upconverting nanoparticles (UCNPs) are mainly composed of oxides, fluoride, halogen oxides and other matrix doped with trivalent rare-earth (lanthanide) ions like ytterbium (Yb³⁺), erbium (Er³⁺), thulium (Tm³⁺), or holmium (Ho³⁺), which enable the upconversion process. They have the ability to absorb two or more low-energy photons (usually infrared or near-infrared light) and emit a higher-energy photon, typically in the visible or ultraviolet range. Conjugated UCNPs with biomolecules, such as antibodies, proteins, peptides, nucleic acids, or other targeting ligands, facilitate binding to specific cells, tissues, or biomolecular targets. UCNPs are usually excited with near-infrared light (NIR), which has deep tissue penetration. They can be used in biological applications like in vivo imaging, where conventional fluorophores may not work due to tissue absorption or scattering. CD Bioparticles provides conjugated upconverting nanoparticles with different ligands used in various applications like bioimaging, sensing, and photodynamic therapy.

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Clipos™ Nanoliposomal Phenylethyl Resorcinol

Clipos™ Nanoliposomal Phenylethyl Resorcinol has a particle size of less than 30nm, and enables the phenylethyl resorcinol to be steadily encapsulated in nano-carriers, greatly improving the absorption efficiency and bioavailability. Clipos™ Nanoliposomal Phenylethyl Resorcinol is amphiphilic and suitable for both water-soluble and oil soluble systerm, allowing a wide range of uses. Phenylethyl resorcinol is a new high-efficiency skin whitening agent derived from silver pine, it has also been clinically proven to its whitening ability is equivalent to that of hydroquinone, getting permission from various countries and gradually used in cosmetics.

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Clipos™ Nanoliposomal Retinaldehyde

Clipos™ Nanoliposomal Retinaldehyde has a particle size of less than 30nm, and enables the retinaldehyde to be steadily encapsulated in nano-carriers, greatly improving the absorption efficiency and bioavailability. Clipos™ Nanoliposomal Retinaldehyde is amphiphilic and suitable for both water-soluble and oil soluble systerm, allowing a wide range of uses. Retinaldehyde (RAL), also known as vitamin A aldehyde, is a derivative of retinol after oxidation. It can be used as a skin care product to produce a variety of effects such as anti-aging, skin rejuvenation, whitening, anti-wrinkle, acne, keratin, etc. It is an emerging high-efficiency natural active substance.

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Plain Polyethylene Terephthalate (PET) Particles

DiagPoly™ Plain Polyethylene Terephthalate (PET) Particles, 50-350 nm

Polyethylene Terephthalate (PET) particles, average diameter 50 -350 nm, 1%w/v

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Reagents/Assays

By providing novel insights into cellular function and tissue regeneration, bioactive matrix reagents/assays have transformed biological and biochemical research. The extracellular matrix (ECM), which surrounds cells in living organisms, has a complex microenvironment that may be replicated using these cutting-edge techniques. Bioactive matrix reagents/assays allow for the controlled laboratory investigation of cell migration, signaling pathways, and tissue regeneration by simulating the physiological circumstances and characteristics of the ECM.

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Bioinks

3D bioprinting is an emerging technology that prints scaffolds conducive to cell survival, proliferation, migration and differentiation. It is mainly used to fabricate functional tissue structures to replace damaged or diseased tissues, which can be widely used in research in biomedical fields such as tissue engineering, stem cells, oncology, and drug screening.

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Biotin Magnetic Particles

Biotin magnetic particle are magnetic particles designed with biotin on the surface. Biotin (molecular weight 244.31Da) is widely distributed in animal and plant tissues and is often extracted from yolk and liver tissues. Biotinylation reaction is rapid, efficient and not susceptible to interference. Biotinylated molecules can bind efficiently and specifically to streptavidin and avidin through biotin, and the reaction process is not affected by high temperature, pH and proteolysis.

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Drug Delivery Nanoparticles Formulation

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

Drugs/Active pharmaceutical ingredient (API) which are hard to be dispersed or dissolved in different solvent systems

Limited options for drug/API encapsulation into different formats (size, structure, crystallization)

Limited options of drug/API loading carriers for different types of drugs/API

Low specificity of the targeting

High dosage required for treatment

High side-effect of the toxic chemotherapeutic agents

Tedious materials synthesis, modification, and production

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Yellow Fluorescent Size Standard Polystyrene Particles

DiagPoly™ Yellow Fluorescent Size Standard Polystyrene Particles, Flow Cytometry Grade, 0.1-0.3 μm (# DNS-SP02) are designed to determine the precision, sensitivity, and accuracy of flow cytometers in applications with challenging submicron size requirements. It provides a submicron size stardardization tool for flow cytometers.

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Poly(ε-caprolactone) PCL Microspheres

DiagPoly™ Poly(ε-caprolactone) PCL Microspheres, 1 μm

Poly(ε-caprolactone) PCL Microspheres, 1 μm, Density 1.145 g/mL, Supplied as 1% solid suspensions.

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4-Arm Poly(ethylene glycol) acrylate

CDA-A4003-4-Arm-PEG-Acrylate

4-Arm PEG-acrylate (4-arm PEG-ACRL) is a multiarm PEG derivative with acrylate groups at each terminal of the four arms connected to one pentaerythritol core.

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Plain Fluorescent Polystyrene Particles

DiagPoly™ Plain Fluorescent Polystyrene Particles, Blue, 5 μm (# DFB-M008) are encapsulated with blue fluorophores (excitation: 330 nm, emission: 392 nm) and there is no additional coatings or special functional groups on the surface. The density of liquid suspension is 1.05-1.06 g/mL. Sonicate/Vortex the microspheres before each use.

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MagIso™ Anti-SARS-CoV-2 (2019-nCoV) Spike RBD Magnetic Particles Immunoprecipitation (IP) Kit

MagIso™ Anti-SARS-CoV-2 (2019-nCoV) Spike RBD Magnetic Particles Immunoprecipitation (IP) Kit

The Anti-Coronavirus spike magnetic particles, conjugated with Anti-Coronavirus spike antibody, are used for immuneprecipitation (IP) of Coronavirus spike proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing Coronavirus spike proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound Coronavirus spike proteins are dissociated from the magnetic particles using an elution buffer.

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Aptamer Screening Service

CD Bioparticles offers aptamer screening services to provide rapid and accurate screening for aptamers with high affinity and specificity, resulting in cost savings for our customers' experimental projects. We provide an one-stop in vitro aptamer screening service that flexibly exploits the natural evolution of ligand systems through our exponential enrichment (SELEX) approach. Choose to work with us and you will get the ideal results.

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DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 0.02 μm

DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 0.02 μm (# DCFG-L001) are encapsulated with green fluorophores (excitation: 460 nm, emission: 500 nm) and functionalized with carboxyl groups (COOH) on the surface for the covalent attachment of proteins, peptides and nucleic acids. The density of liquid suspension is 1.05-1.06 g/mL. Sonicate/Vortex the microspheres before each use.