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Cepharanthine

As a drug that may inhibit the COVID_19, cepharanthine is the main active ingredient extracted from Stephania, a traditional Chinese medicine. Chinese patent medicine has been listed in China and abroad for more than 40 years.

On May 10, 2022, Chinese scientists discovered a treatment for covid_ 19 new drugs that have obtained national invention patents. The patent specification shows that 10 μM (micromol / L) cepharanthine inhibits coronavirus replication by 15393 times.

Yunnan Hande Bio-tech Co., Ltd. is a manufacturer and supplier with 28 + experience in high concentration extraction and separation of plants. We patented the extraction method of Cepharanthine as early as August 2011. Our patent describes in detail how cepharanthine is extracted. If you need Cepharanthine in this regard, don't hesitate, please contact us immediately.

www.handebiotech.com

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Paclitaxel liposome is a targeted drug carrier, which is easier to penetrate into tumor tissues from blood vessels than ordinary paclitaxel. It can make drugs accumulate mainly in tissues and organs such as liver, spleen, lung and bone marrow, so as to improve the therapeutic index of drugs, reduce the therapeutic dose of drugs and reduce the toxicity of drugs. It shows unique advantages in improving the tolerance of patients. The indication is that this product can be used for the first-line chemotherapy of ovarian cancer and the treatment of ovarian metastatic cancer in the future. As the first-line chemotherapy, it can be combined with cisplatin for the first-line chemotherapy of patients with non-small cell lung cancer who cannot be operated on for radiotherapy.

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Paclitaxel Injection is highly lipophilic and insoluble in water. The injection needs desensitization treatment before use. First line and follow-up treatment of advanced ovarian cancer. Adjuvant therapy is performed in patients with lymph node positive breast cancer after chemotherapy with adriamycin standard regimen.

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Paclitaxel is a chemotherapeutic drug with good antitumor effect in clinic. However, its poor water solubility and some serious toxic effects greatly limit the wide clinical application of paclitaxel. The emergence of a series of new dosage forms such as liposomes, micelles, microspheres and nanoparticles provides hope to break these restrictions.

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Application of paclitaxel:

1. Anticancer

Paclitaxel is the first line drug for ovarian cancer and advanced breast cancer. The National Cancer administration began human clinical trials as early as 1983 to test its toxicity and anticancer activity.

Paclitaxel is mainly used in ovarian cancer and breast cancer through the second - and third clinical study. It also has some effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor.

2. Antitumor

Paclitaxel is the first choice of anti-tumor drugs in hospitals all over the world. It can promote the assembly of microtubules by promoting the polymerization of spindle tubulin subunits. It is an anti-microtubule antitumor drug.

3. Treatment of rheumatic arthritis

Studies have shown that taxol has been approved by FDA for rheumatoid arthritis, and paclitaxel gel is a topical preparation for paclitaxel in rheumatoid arthritis.

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Paclitaxel is a monomer diterpenoid extracted from the bark of Natural Plant Taxus. It is a complex secondary metabolite. It is also the only drug known to promote microtubule polymerization and stabilize polymerized microtubules. Isotope tracing showed that paclitaxel was only bound to polymerized microtubules and did not react with unpolymerized tubulin dimers. After contacting paclitaxel, cells will accumulate a large number of microtubules in cells. The accumulation of these microtubules interferes with various functions of cells, especially stops cell division in the mitotic stage and blocks normal cell division.

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Taxus chinensis (Yew), an ancient tree species left behind after the Quaternary glacier, has been listed as the world's rare and endangered plants and the world's top ten endangered species. It is a national first-class protected tree species and is known as the "plant giant panda".

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Factory 98% high-purity white crystalline powder 10-DAB semi-synthetic paclitaxel API

Product Informations

Established in 1993, Yunnan Hande bio-tech Co., Ltd. is a leading Paclitaxel APIs manufacturer with a great fame over the world, the company located at Kunming, Yunnan, P.R. China, owned China GMP certificate, CEP, and approved by US FDA and TGA, also entered U.K, India , Japan, Canada, Singapore, South Korea, Taiwan China, Malaysia, Russia, Turkey and Zimbabwe, in the records. The new manufacture base covers an area of 20 acres with over 10,000 square meters of factory buildings. Equipment includes the international standard testing room, covering liquid, gas, metal elements, infrared, microbes, moisture determination, All inspection items such as stability inspection, using all-in-one testing equipment, complete data integrity IT system, efficient & fully enclosed separation and purification production line, and clean factory buildings. Company production capacity of natural paclitaxel increased to 500kg per year, 10-DAB III increased to 1000kg per year. The company's paclitaxel APIs have been widely used in customers’ anti-cancer injections, such as polyoxyethylene castor oil injections, liposome injections, albumin injections, and oral solutions. it is also used in Drug eluting stent and Drug-coated balloons to treat coronary heart disease and peripheral vascular disease. For 28 years, Hande has continuously provided customized product solutions for customers in different stages such as R&D, small test, pilot test, and commercial batch.

 Product Parameters

COMPANY PROFILE Product Name 10-Deacetylbaccatin III Hande Country Kunming, BASIC INFORMATION Synonyms 10-DB III10-deacetyl-baccatine III10-deacetylbaccatin III10-deacetylbaccatine III Structure

Weight 544.597 Certificates DMF Assay 98.0%-99.0% Appearance White or off-White Powder Method of Extraction Natural extract from high content Taxus wallichiana Zucc. The paclitaxel effective content of yew is more than 6‰. Annual Capability 1500kgLogistics Multiple erms Accept customer audit all the time; Assist clients with regulatory registration. Read the full article

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Rosemary extract has the characteristics of high efficiency and safety. It is widely used in cosmetics, perfume, soap, air freshener, insect repellent, medicine, animal and vegetable fats, animal feed, meat products, seafood, flour, sauce, seasoning, baked food, fried products, natural pigment, essence, biological pesticide, tobacco, etc., especially for treating malignant tumors, cardiovascular disease, cancer, etc. Inhibition of HIV infection, treatment of indigestion, prevention of Alzheimer's disease, heart disease, hyperuricemia, and respiratory diseases have brought many conveniences to production and life.

In Europe, rosemary has a long history as a food flavor, and has been used in cosmetics, food and medicine. Existing studies have shown that rosemary has obvious effects in preventing oil oxidation and maintaining meat flavor. Japan has developed a series of rosemary antioxidant products.

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1. Rosmarinic acid can effectively remove reactive oxygen species in environmental pollution, inhibit the formation of melanin, and has an excellent whitening and moisturizing effect. Rosmarinic acid also has strong anti-inflammatory activity, which can protect skin, strengthen skin, promote blood circulation and promote skin function.

2. It also has antibacterial, antiviral and antitumor effects.

3. Rosmarinic acid can inhibit acute and chronic infections, has resistance to ultraviolet light and inhibits the degradation of elastin.

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Water soluble rosemary extract (rosmarinic acid): mainly used in fresh-keeping processing of aquatic products, natural pigments, oral liquid, shower gel, shampoo, beverages, wines and transparent packaged foods.

Fat soluble rosemary extract (Carnosol): widely used in oil and fat food, chemical industry, cosmetics and feed. It is a natural green food additive.

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Rosemary extract has antibacterial, anti-inflammatory, antiviral, anti-tumor, anti allergic, antioxidant, antithrombotic, anti platelet aggregation, anti radiation and immunosuppressive effects. Rosemary acid has an anti anxiety effect on the nervous system and protective effect on cell damage. In addition, the product is used to delay food deterioration; Safe and non-toxic; Bacteriostasis; High temperature resistance; It has the characteristics of pigment color protection. It is used in all kinds of baked foods, halogenated foods, aquatic products, condiments, high-grade candy, drugs, health products, all kinds of cosmetics and washing products, biological pesticides and other products.

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The United States and Japan were the first countries to study rosemary antioxidants. Japan uses rosemary 95% acetic acid extract to prevent essence flavors from spoilage additives, and add natural carotenoids and other natural food colorants to prevent oxidation and fading. After more than a decade of rosemary research, China Academy of Sciences has not only completed the experiments of introduction and cultivation, but also achieved encouraging results in the extraction, isolation and structure identification, antioxidant efficiency test, production process and supercritical CO2 extraction technology, and the research of aroma components of rosemary essential oil.

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The analysis and determination methods of rosemary extract mainly include: high performance liquid chromatography, micellar electrokinetic chromatography, ultraviolet spectroscopy, infrared spectroscopy, capillary electrophoresis (CE), gas chromatography, mass spectrometry, nuclear magnetic resonance spectroscopy, etc. at present, the most used analysis method is high performance liquid chromatography.

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Rosmarinic acid is an important component in rosemary extract. It has strong antioxidant activity, which is stronger than vitamin E, caffeic acid, chlorogenic acid, folic acid and so on. It can effectively remove reactive oxygen species from environmental pollution, inhibit the formation of melanin, and has excellent whitening and moisturizing effects. At present, rosmarinic acid has shown its important application value in the field of skin care products.Carnosic acid is a chemical substance, which is suitable for the antioxidation of oil-soluble components. Used in seasoning sauce, pet food and feed, it has antioxidant and anti-aging effects; Strong weight loss and lipid-lowering effect; Treatment of cardiovascular disease and anticancer effect.Carnosol, as an antioxidant and antimicrobial additive, has been widely used in the food and pharmaceutical industry.

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Rosemary extract is a natural antioxidant extracted from rosemary plants. Rosmarinus officinalis is a versatile cash crop, which can extract antioxidants, rosemary essence oil and so on. Rosemary is native to Europe, North Africa and the Mediterranean coast. It is planted in Yunnan, Guangxi, Hainan, Hunan, Sichuan, Guizhou, Fujian and other provinces and regions in China. Rosemary is mainly because it has whitening, freckle removal, anti allergy, anti infection and a unique beauty effect on the skin. Now many cosmetics contain rosemary.

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Pharmaceutical industry: enhance immunity, eliminate depression and protect the cardiovascular system.

Cosmetics: make-up water, lotion, cream, facial cream, facial mask, sunscreen, etc.