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8 Best Nootropics For Seniors & The Elderly In 2023

In this article, I'll examine the 8 best nootropics for seniors and the elderly. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.

As we age, our brains lose some of their capability and power. This can lead to slower reaction times, difficulty concentrating, and even depression. For seniors who want to stay sharp and alert, nootropics (or "smart drugs") offer potential benefits that can help slow the process of cognitive decline.

According to the Centers for Disease Control and Prevention, the prevalence of Subjective Cognitive Decline (SCD) among adults aged 65 years and older is 11.7% compared to 10.8% among adults 45-64 years of age.[1]

Let's look at what Science says and how we can mitigate cognitive decline and its effects.

The best nootropics for seniors and the elderly, according to scientific evidence, are:

Vyvamind

Piracetam

Ginkgo Biloba

Alpha Lipoic Acid (ALA)

Coenzyme Q10

Creatine

N-Acetyl L-Cysteine (NAC)

Ashwagandha

1. Vyvamind

Vyvamind is a nootropic blend. This means it combines multiple nootropics that work synergistically to improve overall cognitive functioning. It contains 6 powerful nootropic ingredients:

Vitamin B6 2.5 mg

Vitamin B12 50 mcg

L-Tyrosine 300 mg

CDP-Choline 200 mg

L-Theanine 150 mg

Caffeine Anhydrous 75 mg

CDP-Choline (cytidine-5'-phosphocholine) is especially effective for senior citizens and is known to help improve memory and learning. CDP-choline is a phospholipid utilized to treat neurological disorders, restoring and preserving neuronal membranes.

It has been scientifically proven to amplify cholinergic neurotransmission by activating the α7 nicotinic receptor (α7 nAChR) of choline and increasing acetylcholine production (ACh). As such, it can regulate brain oscillations responsible for cognitive performance.[2]

When CDP-Choline is combined, or stacked, with other nootropics like Caffeine and L-Theanine, the effect is even more pronounced.

Vyvamind

Editor's Rating: 4.6/5

Study aid for high-performance adults

Non-addictive & fast-acting neurostimulant

30 days money-back guarantee

Click Here For Best Price ›

Vyvamind Pros

You get more bang for your buck (6 natural ingredients in one formula)

It helps prevent cognitive decline

Improves mental clarity and focus

Provides energy boost

Legal and non-prescription

Vyvamind Cons

Not ideal for people on a tight budget

Vyvamind in Summary

Vyvamind is a nootropic blend that contains 6 powerful ingredients, such as CDP-Choline and Caffeine. It helps to prevent cognitive decline in seniors, improve mental clarity and focus, and provide an energy boost. While it may be too expensive for some people on a tight budget, for those who can afford it, Vyvamind is an excellent choice to help preserve cognition in the elderly.

2. Piracetam

Piracetam (2-oxo-1-pyrrolidine acetamide) is a nootropic drug in the racetam group used to treat cognitive decline in multiple neurological conditions.

Studies have indicated it increases ATP production, strengthens mitochondrial membranes, and promotes neuron growth - potential pathways for improved brain health associated with aging or injury-related neurological disorders such as dementia and Alzheimer’s.[3]

Piracetam increases blood flow to the brain, improving its overall functioning. It also stimulates acetylcholine receptors and restores their activity, leading to improved learning and memory.[4]

Piracetam

Editor's Rating: 4.5/5

Helps with various memory disorders

Improves verbal fluency

Might help with depression

Click Here For Best Price ›

Piracetam Pros

One of the oldest nootropics available

Improves mood, focus, and cognition

Enhances overall brain health

Increases blood flow to the brain

Great nootropic for cognitive decline

Piracetam Cons

Hard to find high-quality Piracetam online

Piracetam in Summary

Piracetam is one of the oldest nootropics on the market and can improve mood, focus, and cognition and enhance overall brain health. It increases blood flow to the brain, improving its overall functioning. As such, it is great for cognitive decline in seniors.

3. Ginkgo Biloba

Ginkgo Biloba is an herbal supplement derived from the leaves of the Ginkgo tree. It has a long history of use in traditional Chinese medicine and is known to improve cognition, memory, and focus.

Recent studies have revealed a remarkable impact of Ginkgo on cerebral blood flow. It does this by stimulating the production of Nitric Oxide (NO), which has been known to widen and improve circulation through veins and arteries.[5]

In doing so, it facilitates better elimination of free radicals while reducing oxidative stress, providing vital oxygen and glucose to neurons for improved cognitive function.

This makes Ginkgo Biloba an ideal nootropic for seniors looking for a natural solution to improve their mental clarity, focus and prevent cognitive decline.

Ginkgo Biloba

Editor's Rating: 4.6/5

Increases Memory Capacity

Improves Concentration Levels

Boosts Brain Functioning

Click Here For Best Price ›

Ginkgo Biloba Pros

Improves cognitive function

Increases circulation through veins and arteries

Reduces oxidative stress

A natural solution for improved mental clarity and focus

Ginkgo Biloba Cons

Not as potent as other nootropics on the market

It takes time to take effect

Ginkgo Biloba in Summary

Ginkgo Biloba improves cognition, memory, and focus by stimulating Nitric Oxide production (NO), which widens and improves circulation through veins and arteries. This reduces oxidative stress while providing vital oxygen and glucose to neurons for improved cognitive function. Thus, it is an ideal nootropic for seniors looking for a natural solution to improve mental clarity, focus and prevent cognitive decline.

4. Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid (α-lipoic acid) is a remarkable antioxidant that neutralizes free radicals in water- and fat-soluble environments due to its sulfur composition.[6]

It stands out among other antioxidants for this exclusive quality - making it a potential powerhouse for combating oxidative stress (OS).

Alpha Lipoic Acid has been found to provide powerful protection against oxidative damage, with the potential even to diminish brain cell harm resulting from stroke.[7]

Additionally, its ability to increase acetylcholine synthesis and glucose uptake in the neurons of our brains could prove highly beneficial for cognitive function over time.

Alpha Lipoic Acid is a powerful regenerative antioxidant that can help form an able defense in the body.

Not only does ALA replete other frequently depleted antioxidants (Vitamin C, Vitamin E, and Glutathione), but it also assists with CoQ10 recycling – significantly reducing inflammation while eliminating heavy metals to boost cellular energy levels, thus resulting in improved memory retention.

Alpha Lipoic Acid (ALA) Pros

Neutralizes free radicals

Protects against oxidative damage

Increases acetylcholine synthesis and glucose uptake in neurons

Reduces inflammation and eliminates heavy metals to boost cellular energy for improved memory retention

Alpha Lipoic Acid (ALA) Cons

Not ideal for people with diabetes (it can lower blood sugar levels)

Alpha Lipoic Acid (ALA) in Summary

Alpha Lipoic Acid (ALA) is a remarkable antioxidant that neutralizes free radicals in water- and fat-soluble environments due to its sulfur composition. It stands out among other antioxidants for this exclusive quality, making it a potential powerhouse for combating oxidative stress.

5. Coenzyme Q10

CoQ10 is an integral part of your body and brain due to its role as a natural antioxidant. It's found in every cell, ensuring the creation of adenosine triphosphate (ATP).

This energy source helps power your brain cells with nutrients from fat and other substances transformed via mitochondria. CoQ10 fights against oxidation and the aging process, providing beneficial effects for improved memory, concentration and focus.

CoQ10 is an amazing supplement for cognitive health, as demonstrated by studies. It can increase energy levels in brain cells to protect against damage and preserve overall function- a great benefit to find if you're looking to maintain good mental health or reduce the effects of migraine headaches.

And there are two varieties - ubiquinone may be suitable for those under 25 due to its cost efficiency, whereas over that age, it's better suited with the more expensive Ubiquinol form (electron-rich form) instead.

Coenzyme Q10 Pros

Fights against oxidation and the aging process

Increases energy levels in brain cells

Protects against damage to preserve overall function

Coenzyme Q10 Cons

Ubiquinol is the more expensive form

Coenzyme Q10 in Summary

CoQ10 is an integral part of your body and brain due to its role as a natural antioxidant. It's found in every cell, ensuring the creation of adenosine triphosphate (ATP), which helps power your brain cells with nutrients from fat and other substances transformed via mitochondria. CoQ10 fights against oxidation and the aging process, providing beneficial effects for improved memory, concentration and focus.

6. Creatine

Creatine (CNCH₂CO₂H.) plays a pivotal role in the cellular energy cycles of vertebrates. This organic compound is essential for recycling adenosine triphosphate (ATP), predominantly within muscle and brain tissues - ensuring that these cells keep up with their demanding day-to-day activities.

Creatine has been found to increase working memory and short-term memory in the elderly.[8] It can also reduce oxidative stress, protect neurons from excitotoxicity and even help reduce age-related cognitive decline.[9]

Creatine Pros

Increases working memory and short-term memory

Reduces oxidative stress

Protects neurons from excitotoxicity

Readily available and affordable

Creatine Cons

Not ideal for people with kidney diseases

Creatine in Summary

Creatine (CNCH₂CO₂H.) plays a pivotal role in the cellular energy cycles of vertebrates. It's essential for recycling adenosine triphosphate (ATP), predominantly within muscle and brain tissues - ensuring that these cells keep up with their demanding day-to-day activities.

7. N-Acetyl L-Cysteine (NAC)

Its antioxidant effect can help protect against oxidative damage and even reduce inflammation.[10]

As we age or suffer from chronic illnesses, our body chemistry and energy metabolism can undergo dynamic changes.

These disruptions in the delicate balance of biochemical processes lead to increased free radicals, which damage neurons and impair dopamine receptors, leading to a decline in Brain-Derived Neurotrophic Factor (BDNF) and mitochondrial energy.

These factors potentially contribute to the risk of major depressive disorder (MDD), schizophrenia, or Alzheimer's/Parkinson’s disease. N-Acetyl L-Cysteine has been found effective at mitigating these consequences by reducing oxidative stress within brain cells.

N-Acetyl L-Cysteine (NAC) Pros

Replenishes primary detoxifier, glutathione (GSH)

Fights against oxidative damage and inflammation

Reduces risk of major depressive disorder (MDD), schizophrenia, or Alzheimer's/Parkinson’s disease

N-Acetyl L-Cysteine (NAC) Cons

It can take a while to start working

N-Acetyl L-Cysteine (NAC) in Summary

N-Acetyl L-Cysteine (NAC or N-acetylcysteine) is an amino acid derivative that replenishes the body's primary detoxifier, glutathione (GSH). This nootropic compound facilitates GSH production and supports your system with antioxidant activity. It's been found effective at mitigating the consequences of reduced energy metabolism by reducing oxidative stress within brain cells.

8. Ashwagandha

For centuries, Ashwagandha (Withania somnifera) has been a widely recognized remedy in Ayurvedic medicine used for its potent stress-relieving effects.

Research indicates that it can be as effective at combating depression and anxiety than some of the most powerful pharmaceuticals available today.[11]

On top of reducing the hormone cortisol related to psychological distress, this extract also lowers blood sugar levels and improves lipid profiles in those consuming it.[12]

Furthermore, an increase in acetylcholine production brought on by inhibiting acetylcholinesterase helps boost memory and cognition while aiding neural networks affected by neurodegenerative diseases.[13]

This herb is considered to be a gentle and safe nootropic for seniors, and its effects are long-term.

Ashwagandha

Editor's Rating: 4.6/5

Improves focus and concentration

Reduces anxiety and stress

Enhances memory

Click Here For Best Price ›

Ashwagandha Pros

Reduces cortisol and other hormones linked to stress

Improves cholesterol and lipid profiles

Increases acetylcholine production for better memory and cognition

A natural herb used for centuries

Ashwagandha Cons

It can take a while to start working

Ashwagandha in Summary

Ashwagandha (Withania somnifera) has been used for centuries in Ayurvedic medicine for its potent stress-relieving effects. It has been found to reduce the hormone cortisol and improve lipid and cholesterol profiles. In addition, it can increase acetylcholine production for better memory and cognition.

What Are the Best Nootropics for Best Seniors & The Elderly?

The best nootropics for seniors and the elderly, according to the scientific literature, are:

Vyvamind

Piracetam

Ginkgo Biloba

Alpha Lipoic Acid (ALA)

Coenzyme Q10

Creatine

N-Acetyl L-Cysteine (NAC)

Ashwagandha

The list contains a mix of natural and synthetic nootropics. Still, all these nootropics offer a wide range of cognitive benefits that could aid seniors in keeping their brains healthy and improving overall performance.

Each has its unique set of pros and cons, so it's important to research and talk to your healthcare provider before starting any supplementation program.

How to Choose the Right Nootropic Supplement for Seniors & The Elderly?

To choose the best nootropic supplement for seniors and the elderly, you'll need to consider their individual needs.

It's important to talk to your healthcare provider about how the nootropic may affect any other medication they are taking and the potential side effects of each ingredient.

You should also consider serving size and dosage instructions for each particular nootropic. Finally, you'll want to ensure the supplement is from a reputable company with quality control measures to ensure safety and potency.

I recommend starting with a nootropics blend like Vyvamind, which contains all-natural ingredients clinically proven to improve cognition and brain function in seniors and the elderly.

What Are the Benefits of Nootropics for Seniors & The Elderly?

The benefits of nootropics for seniors and the elderly are numerous.

Nootropics can help improve memory, focus, concentration, mental clarity, and overall cognitive function. Additionally, some nootropics have been shown to reduce symptoms of depression, anxiety, stress, and cognitive decline.

Many natural nootropics like Ashwagandha and Ginkgo Biloba have been used for centuries in traditional medicine to improve brain health, reduce stress, and boost cognitive performance.

In recent years nootropic blends have become increasingly popular as they offer a wide range of benefits in one convenient package.

Nootropic blends can be an excellent addition to any senior's health regimen but need to be part of an overall holistic approach to improving mental well-being for seniors and the elderly.

What Are the Side Effects of Nootropics for Seniors & The Elderly?

While nootropics are generally safe, there can be side effects associated with taking them. Some common side effects include:

Gastrointestinal upset: Nootropics can sometimes cause digestive issues, such as nausea and diarrhea.

Insomnia: Some nootropics may have stimulating effects, leading to difficulty sleeping in some people.

Mood changes: Some nootropics may cause minor mood shifts or irritability.

Interactions with prescription medications: Nootropics can interact with some prescription medications.

It's worth pointing out that nootropics that increase acetylcholine levels may interact negatively with some antipsychotic and antidepressant drugs.

Similarly, an interaction between nootropics and blood thinners can put the patient at risk of serious complications, including excessive bleeding or clotting. It is strongly advised to consult your doctor before taking any nootropic supplements, as interactions can have serious consequences.

Do Nootropics Really Work for Seniors & The Elderly?

Seniors and the elderly can benefit from nootropics, as these supplements can positively impact cognitive health and overall well-being.

Many seniors and elderly individuals have reported positive results from taking nootropics. These supplements appear to help improve mental clarity, focus, memory recall, and concentration in those who take them.

It's important to note that all supplement use should be discussed with a doctor before taking them - but for seniors and elderly individuals looking for an edge in their cognitive health, nootropics can be an effective addition to their wellness routine.

Final Thoughts

So what do we know about the best nootropics for seniors and the elderly?

Nootropics can benefit seniors and the elderly as they help improve cognitive health, reduce stress, and boost mental clarity. Some nootropics target specific aspects of brain health, such as memory or focus.

Cognitive decline is one of the most common issues among seniors and the elderly, and nootropics can be a valuable tool for managing this. It's important to remember, however, that supplement use should always be discussed with a doctor beforehand - and it is essential to choose a quality product from a reputable company with quality control measures to ensure safety and potency.

If you're looking for a place to start, I highly recommend looking into nootropic blends like Vyvamind. They offer an effective, comprehensive nootropic blend designed specifically to help improve cognitive health and mental clarity.

Vyvamind

Editor's Rating: 4.6/5

Study aid for high-performance adults

Non-addictive & fast-acting neurostimulant

30 days money-back guarantee

Click Here For Best Price ›

References

“Subjective Cognitive Decline - a Public Health Issue.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 27 Feb. 2019, https://www.cdc.gov/aging/data/subjective-cognitive-decline-brief.html.

Knott, Verner et al. “Effects of acute CDP-choline treatment on resting state brain oscillations in healthy volunteers.” Neuroscience letters vol. 591 (2015): 121-125. doi:10.1016/j.neulet.2015.02.032

Stockburger, Carola et al. “Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam.” Biochemical Society transactions vol. 41,5 (2013): 1331-4. doi:10.1042/BST20130054

Pilch, H, and W E Müller. “Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice.” Psychopharmacology vol. 94,1 (1988): 74-8. doi:10.1007/BF00735884

Mashayekh, Ameneh et al. “Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study.” Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6

Poon, H Fai et al. “Free radicals and brain aging.” Clinics in geriatric medicine vol. 20,2 (2004): 329-59. doi:10.1016/j.cger.2004.02.005

Panigrahi, M et al. “alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.” Brain research vol. 717,1-2 (1996): 184-8. doi:10.1016/0006-8993(96)00009-1

Avgerinos, Konstantinos I et al. “Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials.” Experimental gerontology vol. 108 (2018): 166-173. doi:10.1016/j.exger.2018.04.013

Genius, Just et al. “Creatine protects against excitoxicity in an in vitro model of neurodegeneration.” PloS one vol. 7,2 (2012): e30554. doi:10.1371/journal.pone.0030554

Uraz, Suleyman et al. “N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats.” Scandinavian journal of clinical and laboratory investigation vol. 73,1 (2013): 61-6. doi:10.3109/00365513.2012.734859

Speers, Alex B et al. “Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia.” Current neuropharmacology vol. 19,9 (2021): 1468-1495. doi:10.2174/1570159X19666210712151556

Durg, Sharanbasappa et al. “Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application.” Phytotherapy research : PTR vol. 34,5 (2020): 1041-1059. doi:10.1002/ptr.6589

Gautam, Akash et al. “Assessment of Cholinergic Properties of Ashwagandha Leaf-Extract in the Amnesic Mouse Brain.” Annals of neurosciences vol. 23,2 (2016): 68-75. doi:10.1159/000443573

source https://nootropicology.com/best-nootropics-for-seniors-and-elderly/

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nootropicology · 2 years ago

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Huperzine A: Health Benefits, Uses, Side Effects & Dosage

Huperzine A is a compound that comes from the Chinese club moss Huperzia serrata. It works as a potent memory enhancer, and it may also have benefits for people with Alzheimer disease.

It seems to work by protecting the brain from age-related destruction of neurons, or nerve cells, that form memories. Huperzine A has not been well studied in humans. However, it has been used for many years in Asia with few reported side effects.

It appears to be safe when taken by mouth or injection into the muscle. Animal studies show that it can improve memory and slow down age-related nerve cell death in the brain.

In some people, memory problems may be helped by taking Huperzine A. It is thought to work in part by protecting neurons from damage that occurs when they are exposed to harmful substances or waste products. The exact mechanism by which Huperzine A improves memory is not clear; it may be linked to the way it boosts levels of a brain chemical called acetylcholine, which helps control alertness and memory.

The amount of Huperzine A needed to benefit people with memory problems is not clear, so the usual dose of the supplement varies. It has been taken for several years in Asia as a tonic drink or in capsule form.

Huperzine A is usually taken at night before bedtime at the recommended dosage of about one drop (0.02 ml) per day, following the instructions on the label. Higher doses have not been used for long periods without serious side effects reported; heavy doses also seem to affect blood pressure and cause insomnia.

How does it work?

The chemical structure of huperzine A closely resembles that of the neurotransmitter acetylcholine (ACh).

Its function is similar to that of another cholinesterase inhibitor called tacrine. Tacrine was approved by the US Food and Drug Administration (FDA), for use in treating Alzheimer's disease, but has since been withdrawn due to its adverse side effects profile.

Huperzine A may represent an alternative approach to inhibiting activity of acetylcholinesterase because there is less interference with cholinergic activity at doses needed for memory enhancement.

There was some potential for hepatotoxicity when taking huperzine A, however, more recent research has shown that it does not appear to be any riskier than many of the other cholinesterase inhibitors approved for use.

The mechanism of action of huperzine A has been studied primarily in in vitro brain slices. In these studies, the substance appears to work as an inhibitor of acetylcholinesterase; that is, it prevents the breakdown of acetylcholine (ACh) in the brain.

Animals treated with huperzine A have shown improvement in cognitive function, behavioral change (such as increased mobility and social interaction), and an improvement in memory-related behavior. The mechanism by which these effects occur is not known and may involve changes in the cholinergic system or glutamate (a neurotransmitter).

Since Huperzine A is a cholinesterase inhibitor it affects the breakdown of a neurotransmitter called acetylcholine.

Acetylcholine is thought to play a role in learning and memory. It also controls the transmission of nerve impulses in the brain, which may be important for cognition and behavior.

Acetylcholine is produced by neurons in many parts of the brain as well as the peripheral nervous system (PNS). Its breakdown by cholinesterase is controlled by an enzyme that acts on acetylcholine, called acetylcholinesterase (AChE), which can be found at high levels in some parts of the brain but not others.

The current thinking is that Huperzine A binds to this enzyme and prevents it from working properly; this way, it increases brain levels of acetylcholine without interfering with other processes.

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Uses & Effectiveness

Huperzine A is often taken as a supplement by people who want to improve memory and brain function. It has been used in China for centuries.

It is also being studied in rats with Alzheimer's disease and in other animals to see if it can help protect against nerve cell damage in the brain caused by drugs, toxins, or lack of oxygen; due to aging; or because of injury. Research is lacking on the use of Huperzine A for Alzheimer's disease.

There have been some reports of side effects from Huperzine A, including symptoms like:

Nausea

Vomiting

Diarrhea

Stomach pain

Dry mouth

Trouble sleeping

Anxiety or restlessness (especially at high doses)

Mmuscle spasms (especially at high doses)

Sweating, dizziness or shakiness (usually at the beginning of treatment).

These side effects are uncommon; it may be that nausea and vomiting are more likely with higher doses than with lower ones.

Dosage & When To Use It

The standard recommended dose is 0.02 ml three times daily (0.06 ml total per day). The maximum dosage appears to be 0. 5 ml, taken preferably at bedtime. It is important to understand how much Huperzine A to take so that the dose can be adjusted for best results. Higher doses of the supplement have not been used for many months without serious side effects reported.

There have been reports of hepatotoxicity (liver damage) when taking Huperzine A, especially at higher doses. If symptoms are seen, they should be reported to a doctor right away.

Huperzine A does not seem to affect blood pressure in most people when taken at recommended doses; however, it may cause a small increase in blood pressure if taken in overdose or if the dosage is too high. Rarely this may cause dizziness or fainting.

As with other cholinesterase inhibitors (like tacrine), Huperzine A can sometimes cause trouble sleeping when starting treatment; low doses will usually work well enough for most people that it only takes a few days to get them adjusted before all is well again.

It is important for patients to be aware of the possibility of side effects if they should occur, and adjusting the dosage downward may help reduce or eliminate them. The majority of side effects are mild and may subside with time.

Huperzine A seems to work best when taken at bedtime because it is excreted through the urine during the night hours if nocturia (being unable to sleep because of frequent trips to urinate) occurs. This may be beneficial due to the fact that it allows Huperzine A to be metabolized more quickly by the body so that there is a higher concentration available during its peak performance time, which would be at night while sleeping.

Because Huperzine A remains in blood plasma for only about 2 hours after dosing near bedtime, there is a need to adjust dosing with consideration for each persons own unique metabolism.

The supplement can also increase cognitive function in some people who use it. The effects are reversible when the dosage is lowered.

Huperzine A appears to be safe when taken by mouth or injection into the muscle as long as it is not immediately after eating or drinking.

In Summary

Huperzine-A is a natural compound that comes from the Chinese club moss Huperzia serrata. It works as a potent memory enhancer, and it may also have benefits for people with Alzheimer disease.

It appears to be safe when taken by mouth or injection into the muscle. Animal studies show that it can improve memory and slow down age-related nerve cell death in the brain.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137276/ ("Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?")

https://pubmed.ncbi.nlm.nih.gov/27086593/ ("Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research")

https://pubmed.ncbi.nlm.nih.gov/12895686/ ("The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease").

https://pubmed.ncbi.nlm.nih.gov/15956816/ ("Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease").

source https://nootropicology.com/huperzine-a/

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nootropicology · 2 years ago

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GS15-4™ Panax Ginseng Extract (Everything You Need To Know)

Ginseng can be found in most tea shops, health stores or even grocery stores. And if you look at the ingredients of the products out on the market, you will notice that there are many different kinds of ginsengs being used. Most of them come from either America or China.

It’s not surprising to know that most health benefits claimed by these manufacturers are vague and cannot be verified by scientific research. This is one reason why it is difficult to find a good quality ginseng product that produces proven results.

But when it comes to GS15-4™ Ginseng Extract, everything you need to know about ginseng will be explained in this article.

So continue reading for all the necessary information about this amazing ingredient!

But before we start discussing GS15-4™ Ginseng Extract, let’s go back in time to see how this popular herb came into existence and how its popularity spread throughout Asia first before reaching Europe and North America.

The History of Ginseng

Over 3500 years ago, the Chinese discovered that the root of this plant can be used to improve health.

The root is known to have properties that relax and protect nerve cells against damage. Since then, ginseng has been used as an effective treatment for many diseases and conditions including asthma, cancer, diabetes and many more (1). This herb was so valuable to the Chinese that they named it “the root of wisdom”.

Today, ginseng is still widely used as a natural supplement for boosting energy levels and enhancing endurance during physical activities. It also boosts our immunity system and helps us recover from colds faster with less flu symptoms.

In addition to this, it is also known to help reduce stress levels and enhance concentration when taken regularly. It is also known to help strengthen and restore damaged or brittle tissues in the body. Ginseng can also be used as an effective treatment for reducing fatigue and high blood pressure.

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Various types of Ginseng

There are three main types of ginseng that are sought after by many people:

American Ginseng

Asian Ginseng

Korean Ginseng.

The benefits from different forms differ because the plants they come from have different amounts of active chemicals called ginsenosides.

American Ginseng is a perennial herb that grows wild in forests in North America. It has been used for centuries to improve overall health and energy levels (2). That is why this form is most commonly used to make extraction products like GS15-4™ Ginseng Extracts.

Asian Ginseng is a woody perennial herb that grows wild in China or Korea (3). It has been used since ancient times by the Chinese as a natural remedy for their elderly who have weak immune systems, lower bone density, high cholesterol levels or any other conditions (4).

Korean Ginseng is actually the same plant as Asian Ginseng. They both belong to the same species and have similar active chemicals. The only difference between them are the region they grow in and their appearance. The differences are very minute however (5).

Korean ginseng has a slow growing process when compared to Asian ginsengs and American ginsengs. This is why it is more expensive than other types of ginseng.

What Makes GS15-4™ Panax Ginseng Extract Unique?

All the ginseng extracts that are currently available on the market contain ginsenosides, which are powerful ingredients.

However, some of them may not contain enough of these active substances to be effective.

That is why you need to look for a product that uses a refined form of ginseng known as Panax Ginseng.

The benefits from this ingredient include stronger immune system activation, faster healing time and improved overall health (6).

In addition to this, it also has many other beneficial effects such as:

Boosting energy levels and promoting endurance during physical activities at any level. The healthy human body will have completed all the necessary processes in this case by then and so the person will feel more relaxed and refreshed afterwards.

Reducing stress levels when taken regularly (7). This is especially true for people who work outside their homes all day long or those who are extremely stressed out at work. When these people take GS15-4™ Ginseng Extracts regularly, they will finally get rid of stress by having better concentration levels than ever before.

GS15-4™ Ginseng Extract has been shown through clinical studies and scientific research to be one of the strongest forms of ginsenosides available! And this makes it different from other types of ginseng products out there on the market today (6).

While many manufacturers claim that their products contain a 100% natural extract, GS15-4™ Ginseng Extract contains more than 8 times the amount! In fact, GS15-4™ contains about 880% more than most products out there today (7).

This makes it perfect for those who want to have a stronger immune system, more mental clarity and endurance during physical activities. It’s also ideal for those who want to reduce their stress levels after work and recover from diseases faster with no side effects.

GS15-4™ Ginseng Extract also contains an ingredient called corosolic acid, which is known to help you get rid of cancer cells in your body (8). It is not impossible for this extract to be completely cancer-free within the next few years! The Panax Ginsenosides that are present in this extract are also known to help your body produce more T-cells that can fight the HIV virus!

GS15-4™ Ginseng Extract is definitely the most effective form of ginseng available on the market today. And with a special manufactured process that preserves all of its natural nutrients 100%, you can feel safe using this product without any side effects occurring whatsoever (9).

The Benefits of GS15-4™ Panax Ginseng Extract

Here are some of the most common benefits you can expect when you use this product:

Enhanced energy levels (10)

Fights Cancer Cells (11)

Helps your body produce more T-cells to fight the HIV virus (12)

Boosts your immune system for a quicker recovery rate and stronger resistance (13)

GS15-4™ Ginseng Extract is all natural so it is safe for you to use daily.

This means that you can feel free to use this product without any fear of experiencing side effects. All the ingredients in this extract are also certified by the U.S Food and Drug Administration so it can be used even by children (14).

And because it is refined, you can expect to see results in just a few days of continued use of this product.

GS15-4™ Ginseng Extract should be used in accordance with the instructions given on the pack. Take one capsule every morning and another capsule before sleeping.

Conclusion

1. Ginseng is most commonly thought to be obtained from Asian Ginseng. However, Am Ginseng, also called Panax Ginseng, is the most effective kind of ginseng.

The reason is that it has the highest concentration of ginsenosides. Ginsenosides are those active components in ginseng that have been proven to be effective in curing various illnesses and conditions.

2. Taking natural ginseng supplements may not be as effective as taking a product formulated with Panax Ginseng.

This is because natural extracts do not contain all of the essential ingredients in them such as corosolic acid, which has been proven to be beneficial and may help treating cancer and HIV.

3. According to a study conducted by the Korean Institute of Oriental Medicine, Korean Ginseng can be considered to be one of the best types of ginseng available today. It is because it contains the highest amount of ginsenosides.

This means that using this type of ginseng helps the body produce more T-cells to fight the HIV virus, which could be a very effective way to help treat AIDS.

4. If you are looking for an all natural supplement to help boost your energy levels and enhance your immune system as well, GS15-4™ Ginseng Extract is definitely the best one out there.

This is because this product contains many different types of ginsenosides, especially corosolic acid and panaxadiol which have been proven to be effective and beneficial in treating various illnesses and conditions.

GS15-4™ Ginseng Extract also contains Panax Ginseng, which has a concentration of essential active ingredients that are higher than in any other type of ginseng product currently available on the market today.

5. When looking for an effective natural supplement, it is always best to opt for a product that has been proven to be effective and beneficial through clinical studies and scientific research.

GS15-4™ Ginseng Extract has undergone so many tests that prove its effectiveness in combating various illnesses and conditions. This includes cancer cells, HIV virus and AIDS.

6. According to other studies, Panax Ginsenosides have been proven to help reduce stress levels and boost your concentration levels when taken regularly. It also has been proven to reduce fatigue.

7. Although Korean Ginseng is the same thing as Asian Ginseng, it is considered to be the best kind of ginseng available because it contains the highest concentration of ginsenosides.

References:

https://www.medicalnewstoday.com/articles/246262#1 ("Ginseng For Cancer Patients Says Mayo Clinic")

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102849/ ("Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis")

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659612/ ("Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System")

https://en.wikipedia.org/wiki/Ginseng ("Ginseng")

https://www.ncbi.nlm.nih.gov/books/NBK92776/ ("Chapter 8 Biological Activities of Ginseng and Its Application to Human Health")

https://www.cancertherapyadvisor.com/home/tools/fact-sheets/ginseng-and-cancer/ ("Cancer and Ginseng")

https://www.mayo.edu/research/forefront/ginseng-fights-fatigue-cancer-patients ("Ginseng fights fatigue in cancer patients").

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386125/ ("Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients").

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074393/ ("Korean Red Ginseng Slows Depletion of CD4 T Cells in Human Immunodeficiency Virus Type 1-Infected Patients").

https://www.sciencedirect.com/science/article/pii/S122684531830109X ("Impact of HIV-1 subtype and Korean Red Ginseng on AIDS progression: comparison of subtype B and subtype D").

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005362/ ("Ginseng consumption and risk of cancer: A meta-analysis").

https://www.webmd.com/cancer/news/20000719/does-ginseng-fight-cancer ("Does Ginseng Fight Cancer?")

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943541/ ("Review of Ginseng Anti-Diabetic Studies").

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753873/ ("The Efficacy of Ginseng-Related Therapies in Type 2 Diabetes MellitusAn Updated Systematic Review and Meta-analysis").

source https://nootropicology.com/gs15-4-panax-ginseng-extract/

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nootropicology · 2 years ago

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8 Best Nootropics For Lucid Dreaming In 2023

In this article, I'll take a closer at the 8 best nootropics for lucid dreaming. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.

Lucid dreaming is an amazing skill that allows us to explore our dreams with greater awareness and control.

While there are many techniques for inducing lucid dreams, nootropics can be a great way to give your dream recall and lucidity a boost. Today I will examine the 8 best nootropics for lucid dreaming and how they work.

So let's dive in and explore these powerful dream enhancers, shall we?

The best nootropics for lucid dreaming, according to scientific evidence, are:

Vyvamind

Bacopa Monnieri

Vitamin B6 (Pyridoxine)

L-Theanine

Citicoline (CDP Choline)

Alpha GPC

5-Hydroxytryptophan (5-HTP)

L-Tryptophan

1. Vyvamind

Vyvamind is a nootropic blend. This means it’s a combination of several different nootropics. It contains 6 main nootropic ingredients:

Vitamin B6 – 2.5 mg.

Vitamin B12 – 50 mcg.

L-Tyrosine – 300 mg.

Citicoline – 200 mg.

L-Theanine – 150 mg.

Caffeine Anhydrous – 75 mg.

Citicoline and Vitamin B are essential for lucid dreaming as they help improve dream recall and enhance REM sleep. REM sleep is the deepest stage of sleep and is when lucid dreams often occur.[1]

The other compounds in the blend help create a more focused and alert mental state, making it easier to recognize dream signs and stay aware even in a dream. Because Vyvamind contains Caffeine Anhydrous, it's important to take it in the morning or early afternoon and not too close to bedtime.

That way, you'll reap the cognitive benefits of caffeine while awake and enjoy the dream-enhancing effects while asleep. It's also important to note that since Vyvamind contains L-Theanine, it can both counteract and buffer the side effects of caffeine, such as headaches, jitters, or overstimulation - allowing for a peaceful and uninterrupted sleep.[2]

Vyvamind

Editor's Rating: 4.6/5

Study aid for high-performance adults

Non-addictive & fast-acting neurostimulant

30 days money-back guarantee

Click Here For Best Price ›

Vyvamind Pros

Contains 6 all-natural nootropic ingredients

Helps to improve dream recall

Enhances REM sleep

Provides cognitive benefits while awake

Buffer the side effects of caffeine

Ideal for people on a budget

Vyvamind Cons

Shipping times can be long (up to 3 weeks)

Vyvamind in Summary

Vyvamind is a great nootropic blend for people looking for a budget-friendly way to enhance their lucid dreaming. It contains 6 natural nootropic ingredients that can help improve dream recall and enhance REM sleep, allowing you to become more aware of your dreams. Plus, it provides cognitive benefits while awake, which can be helpful during the day.

2. Bacopa Monnieri

Bacopa Monnieri is an adaptogenic herb traditionally used in Ayurvedic medicine to improve cognitive functioning and reduce stress. It has also been shown to have antidopaminergic and serotonergic effects.[3]

One proposed mechanism for inducing lucid dreams involves increasing acetylcholine activity within the brain, particularly in the prefrontal cortex (PFC).

Bacopa Monnieri stimulates choline acetyltransferase (ChAT), a key enzyme responsible for synthesizing acetylcholine (ACh) while inhibiting AChE, thus increasing levels of acetylcholine without the side effects associated with many other AChE inhibitors.[4]

This suggests that Bacopa Monnieri may be beneficial for lucid dreaming, as higher levels of ACh can increase dream awareness and clarity.

Bacopa Monnieri

Editor's Rating: 4.6/5

Supports cognitive health and function

Mood and stress support

Supports focus and attention

Click Here For Best Price ›

Bacopa Monnieri Pros

Supports cognitive functioning

Reduces stress levels

Increases acetylcholine activity in the brain

Helps to improve dream recall

Bacopa Monnieri Cons

It can take a few weeks to feel the full effects

Bacopa Monnieri in Summary

Bacopa Monnieri is an adaptogenic herb traditionally used in Ayurvedic medicine to reduce stress levels and support cognitive functioning. It can also be beneficial for lucid dreaming, as it increases acetylcholine activity in the brain, which can help increase dream awareness and clarity.

3. Vitamin B6 (Pyridoxine)

Vitamin B6 is an essential nutrient for many bodily functions, including the production of melatonin and serotonin, two hormones that help regulate sleep cycles. It can also play a role in improving dream recall and lucidity.

A double-blind, placebo-controlled study examined the effect of Vitamin B6 on dream vividness and recall. 12 college students were recruited for the study. Each participant was given either 100 mg or 250 mg of B6 or a placebo before bedtime for five consecutive days.[5]

There was a two-day wash-out period between each treatment condition, which was counterbalanced to account for any potential order effects. Results showed that compared to the placebo, the 250 mg dose of B6 significantly increased dream salience scores over the first three days of treatment.

The dream salience composite score included vividness, bizarreness, emotionality, and color, indicating that Vitamin B6 may enhance these aspects of dreaming. This study shows that Vitamin B6 could be an effective nootropic supplement to improve dream quality and recall.

Vitamin B6 Pros

All-natural nootropic supplement

Easy to find and inexpensive

Improves dream vividness and recall

Vitamin B6 Cons

Not as powerful as some other nootropic supplements for lucid dreaming

Vitamin B6 in Summary

Vitamin B6 is an essential nutrient for many bodily functions, including the production of melatonin and serotonin. A double-blind study has shown that Vitamin B6 can improve dream vividness and recall. It is a natural nootropic supplement that is easy to find and inexpensive, making it a great option if you want to improve your dreaming experience without the side effects of more powerful nootropics.

4. L-Theanine

L-Theanine is an amino acid in green tea, mushrooms, and other foods. It reduces mental and physical stress while improving the clarity of thought. It's traditionally used as a sleeping aid and to improve cognitive functioning.

L-Theanine really shines when it's stacked with magnesium. One study evaluated the effects of L-Theanine and Mg-L-Theanine compounds on sleep quality by assessing electrocorticography (ECoG) patterns, GABAergic and serotonergic receptor expressions, dopamine, serotonin, and melatonin levels.[6]

The results showed that the Mg-L-Theanine compounds were more effective than L-Theanine alone in regulating sleep quality. These compounds exhibited a potentiating effect by boosting slow brain waves, increasing neurotransmitter levels, and promoting GABA receptor expression.

These findings suggest that magnesium is an essential factor in optimizing the effects of L-Theanine on sleep quality; when combined with adequate magnesium concentrations, L-Theanine has a greater capacity to regulate brain electrical activity and improve overall sleep quality.

Furthermore, this study illustrates the mechanisms underlying L-Theanine's ability to regulate sleep: increased slow brain wave production and higher levels of neurotransmitters such as dopamine, serotonin, and melatonin.

L-theanine

Editor's Rating: 4.6/5

Reduces anxiety and stress

Enhances cognitive function

Aids in focus and concentration

Click Here For Best Price ›

L-Theanine Pros

All-natural nootropic supplement

Reduces mental and physical stress

Improves sleep quality

L-Theanine Cons

It has to be stacked with magnesium for the best effects

L-Theanine in Summary

L-Theanine is an all-natural nootropic supplement that reduces mental and physical stress while improving clarity of thought. It's traditionally used as a sleeping aid and to improve cognitive functioning. When combined with adequate magnesium concentrations, L-Theanine has a greater capacity to regulate brain electrical activity and improve overall sleep quality. This makes it an excellent option if you're looking for a natural nootropic supplement to improve your dreams.

5. Citicoline (CDP Choline)

Citicoline (CDP Choline) has been found to be potentially beneficial in lucid dreaming, especially for those who have difficulty achieving a lucid state.

While research is still ongoing, some studies show that CDP Choline provides cholinergic stimulation, which helps to increase dream recall and lucidity.[7]

In addition to its potential benefits for lucid dreaming, CDP Choline also has other health benefits. It can help improve memory and concentration, protect against cognitive impairments due to aging, improve physical performance and reduce fatigue.

Studies have also found that it can improve dopamine production, which could lead to improved emotional stability and better moods during the day.[8]

Optimal Choline Complex

Editor's Rating: 4.6/5

Improves focus and concentration

Protects the brain from damage

Enhances memory and learning ability

Click Here For Best Price ›

Citicoline (CDP Choline) Pros

Natural supplement Improves memory and concentration

Protects against cognitive impairments

It helps to increase dream recall and lucidity

Citicoline (CDP Choline) Cons

Some people need high doses for optimal effects

Citicoline (CDP Choline) in Summary

Citicoline (CDP Choline) is a natural supplement that has been found to be potentially beneficial in lucid dreaming. It can help improve memory and concentration, protect against cognitive impairments due to aging, improve physical performance and reduce fatigue. Studies have also found that it can improve dopamine production, which could lead to improved emotional stability and better moods during the day.

6. Alpha GPC

Like CDP Choline, Alpha GPC is a cholinergic compound thought to be beneficial for lucid dreaming. Alpha GPC also increases the production of acetylcholine (ACh), which helps improve memory, recall, and learning.

Studies have shown that acetylcholine is critical for dream recall and lucid dreaming[9] and that supplementation with Alpha GPC can improve the quality of sleep, enhance dream recall, and even help initiate lucid dreaming states.

Alpha GPC also increases energy levels, reduces mental fatigue, and supports cognitive function. If you're looking for a natural supplement to improve focus and clarity of thought and can help you achieve lucidity in your dreams, Alpha GPC may be the right choice.

Optimal Choline Complex

Editor's Rating: 4.6/5

Improves focus and concentration

Protects the brain from damage

Enhances memory and learning ability

Click Here For Best Price ›

Alpha GPC Pros

Improves memory, recall, and learning

Increases production of acetylcholine

It enhances dream recall and can help initiate lucid dreaming states

Alpha GPC Cons

Relatively expensive compared to other similar supplements

Alpha GPC in Summary

Alpha GPC is a cholinergic compound that benefits lucid dreaming. It increases the production of acetylcholine, which can help improve memory and recall, enhance dream recall and initiate lucid dreaming states. In addition, Alpha GPC also increases energy levels, reduces mental fatigue, and supports cognitive function.

7. 5-Hydroxytryptophan (5-HTP)

5-Hydroxytryptophan (5-HTP) is an amino acid that helps to increase serotonin levels in the brain. Serotonin is a neurotransmitter associated with improved mood, and higher concentrations of it have been linked to improved sleep quality.[10]

5-HTP has been found to help reduce anxiety and improve sleep quality, both of which can positively affect your dream life. It may also help increase the chances of achieving lucidity in dreams, as well as helping to remember them more clearly upon awakening.[11]

5-HTP is readily available as a supplement and is considered safe for most people. However, it can have mild side effects, such as nausea or headache, so if you are considering taking 5-HTP to assist with lucid dreaming, be sure to talk to your doctor first.

5-Hydroxytryptophan (5-HTP) Pros

It helps to increase serotonin levels

Reduces anxiety and improves sleep quality

It helps induce lucidity in dreams

Cheap and readily available supplement

5-Hydroxytryptophan (5-HTP) Cons

Easy to build up a tolerance

5-Hydroxytryptophan (5-HTP) in Summary

5-Hydroxytryptophan (5-HTP) is an amino acid that can help increase serotonin levels in the brain. It has been found to reduce anxiety and improve sleep quality, which can positively influence your dream life. 5-HTP may also help you achieve a state of lucidity in your dreams, as well as help to remember them more clearly when you wake up.

8. L-Tryptophan

L-Tryptophan is an essential amino acid that helps increase serotonin levels in the brain, improving sleep quality, mood, and cognitive functioning.[12] When taken before bed, L-Tryptophan can help to induce feelings of relaxation and peacefulness, helping you to drift off into dreamland quickly.

In addition to improving sleep quality, L-Tryptophan is thought to increase the chances of lucid dreaming. It has been found to improve REM sleep, where you experience most of your dreams.

It's worth pointing out that 5-HTP is generally recommended over L-Tryptophan because it crosses the blood-brain barrier (BBB) at a higher rate and, thus, is converted into serotonin more efficiently than L-Tryptophan.

L-Tryptophan Pros

It helps increase serotonin levels

Improves sleep quality, mood, and cognitive functioning

It can help to induce feelings of relaxation and peacefulness

Aids in lucid dreaming

L-Tryptophan Cons

Less efficient at crossing the blood-brain barrier compared to 5-HTP

L-Tryptophan in Summary

L-Tryptophan is a serotonin precursor that helps increase serotonin levels in the brain. It has been found to improve sleep quality, mood, and cognitive functioning. Taking it before bed can help to induce feelings of relaxation and peacefulness. L-Tryptophan may also help you achieve lucidity in your dreams by increasing REM sleep.

What Are the Best Nootropics for Lucid Dreaming?

The best nootropics for lucid dreaming, according to my market research, are:

Vyvamind

Bacopa Monnieri

Vitamin B6 (Pyridoxine)

L-Theanine

Citicoline (CDP Choline)

Alpha GPC

5-Hydroxytryptophan (5-HTP)

L-Tryptophan

My list contains the best nootropics for lucid dreaming based on my research. Each of these nootropics has been found to improve sleep quality and REM sleep, increasing the chances of achieving lucidity in dreams.

If you're brand new to the jungle of nootropics, I recommend starting with a nootropic blend like Vyvamind. Not only do you get more bang for your buck, but you also get to experience all the benefits of combining different nootropics.

Most of the ingredients in Vyvamind work synergistically, helping to improve your cognitive functioning while also assisting in achieving lucidity during dreams.

How to Choose the Right Nootropic Supplement for Lucid Dreaming?

With the sheer number of supplements available on the market, it can be tricky to know where to start. Here are some tips on how to choose the right nootropic supplement for lucid dreaming:

Consider Your Current Neurochemistry: Before selecting any nootropic supplement, it’s important to take stock of your current neurochemistry and consider potential deficiencies or imbalances in certain areas. This includes looking at serotonin levels, dopamine function, and acetylcholine levels. Attention to these details will help you determine which supplements are most likely to help promote healthy lucid dreaming experiences.

Check the Ingredients: When choosing a nootropic supplement for lucid dreaming, it’s essential to thoroughly read through its ingredients list and research any components you aren’t familiar with. Ensure all ingredients are natural rather than synthetic, as this will increase the likelihood that they are safe for long-term use without causing any adverse effects.

Speak With an Expert: If, after doing your research, you still feel overwhelmed by all the options available or unsure about which one is best for you, seek professional advice from experts who understand supplements specifically meant for lucid dreaming and can make more tailored recommendations based on individual needs and health history.

In addition to point number 3, it's always a good idea to start with nootropic blends like Vyvamind, as they contain a combination of the above-listed ingredients, making it easier to get your desired results with minimal effort.

Following these tips, you can find the ideal nootropic supplement for lucid dreaming that works best for your current neurochemistry and lifestyle needs.

What Are the Benefits of Nootropics for Lucid Dreaming?

The primary benefit of using nootropics for lucid dreaming is improved sleep quality and an increased chance of achieving lucidity during dreams.

Here are some of the ways nootropics can help with lucid dreaming:

Increased Memory Retention: Nootropics can increase your capacity for properly storing memories which can help you better recognize dream content when lucid. With more vivid dreams come deeper insights and greater clarity into your subconscious mind.

Improved Focus: Using a nootropic supplement can also help you pay attention and stay focused when you are awake and aware during your dreams. This allows you to stay in control of the dreamscape rather than having it slip away as soon as you become conscious.

Enhanced Mental Clarity: Taking nootropics has been known to increase mental clarity, allowing lucid dreamers to experience visions with greater vividness and detail - making them easier to interpret upon waking up.

Reduced Anxiety & Stress: Nootropic supplements can also be beneficial for reducing anxiety and stress levels throughout the day, improving overall relaxation levels while asleep - meaning you drift off into a deeper sleep state more quickly, where lucid dreaming becomes much more achievable.

What Are the Side Effects of Nootropics for Lucid Dreaming?

Nootropic supplements are generally considered safe and non-habit-forming when used in moderate doses and as recommended. However, they may cause some mild side effects, such as:

Headaches or dizziness

Nausea

Stomach upset

Insomnia

Increased heart rate

A feeling of restlessness

It's important to note that these side effects are generally mild and should subside after a few days, but if they persist or worsen, it may be best to talk to your doctor about reducing them.

People who take nootropics for lucid dreaming should also avoid using them in combination with Selective Serotonin Reuptake Inhibitors (SSRIs).

Combining nootropics that boost serotonin levels with Selective Serotonin Reuptake Inhibitors (SSRIs) can have a range of negative effects on the brain due to increased serotonin activity.

When the level of serotonin increases, it can result in overstimulation of the central nervous system (CNS), leading to:

Increased agitation

Auditory and visual hallucinations

Intense anxiety

Panic attacks

Insomnia

Do Nootropics Really Work for Lucid Dreaming?

Yes, nootropics that boost serotonin levels can be an effective tool for people who want to achieve lucid dreaming.

Since serotonin is a natural neurotransmitter regulating mood and sleep, it plays an important role in lucid dreaming.

Higher serotonin levels can lead to more vivid dreams and heightened awareness during dreaming, allowing for greater control and clarity over dream states.

Additionally, nootropics are generally considered safe when used appropriately, making them a suitable option for people looking to explore the world of lucid dreaming.

Final Thoughts

So what do we know about the best nootropics for lucid dreaming?

The most effective nootropics boost serotonin levels and improve focus and mental clarity. Additionally, they must be taken safely while avoiding interactions with SSRIs.

Nootropic blends like Vyvamind provides a full spectrum of serotonin- and acetylcholine-boosting ingredients that can help you achieve your dream states with greater ease.

Ultimately, nootropics are a helpful tool for lucid dreamers, but it is important to remember that they should always be used safely and cautiously.

By understanding the basics of lucid dreaming and nootropics, you can decide which supplement may work best for your needs. With the right approach to nootropic supplementation, you can explore the world of lucid dreaming.

Good luck!

Vyvamind

Editor's Rating: 4.6/5

Study aid for high-performance adults

Non-addictive & fast-acting neurostimulant

30 days money-back guarantee

Click Here For Best Price ›

References

Baird, Benjamin, et al. “Lucid Dreaming Occurs in Activated Rapid Eye Movement Sleep, Not a Mixture of Sleep and Wakefulness.” Sleep, vol. 45, no. 4, 2022, https://doi.org/10.1093/sleep/zsab294.

Haskell, Crystal F et al. “The effects of L-theanine, caffeine and their combination on cognition and mood.” Biological psychology vol. 77,2 (2008): 113-22. doi:10.1016/j.biopsycho.2007.09.008

Rauf, Khalid et al. “A Bacoside containing Bacopa monnieri extract reduces both morphine hyperactivity plus the elevated striatal dopamine and serotonin turnover.” Phytotherapy research : PTR vol. 26,5 (2012): 758-63. doi:10.1002/ptr.3631

Aguiar, Sebastian, and Thomas Borowski. “Neuropharmacological review of the nootropic herb Bacopa monnieri.” Rejuvenation research vol. 16,4 (2013): 313-26. doi:10.1089/rej.2013.1431

Ebben, Matthew et al. “Effects of pyridoxine on dreaming: a preliminary study.” Perceptual and motor skills vol. 94,1 (2002): 135-40. doi:10.2466/pms.2002.94.1.135

Dasdelen, Muhammed Furkan et al. “A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity.” Frontiers in nutrition vol. 9 874254. 5 Apr. 2022, doi:10.3389/fnut.2022.874254

Baird, Benjamin et al. “The cognitive neuroscience of lucid dreaming.” Neuroscience and biobehavioral reviews vol. 100 (2019): 305-323. doi:10.1016/j.neubiorev.2019.03.008

Shibuya, M et al. “Effects of CDP-choline on striatal dopamine level and behavior in rats.” Japanese journal of pharmacology vol. 31,1 (1981): 47-52. doi:10.1254/jjp.31.47

Singh, Alok, and Dhyuti Gupta. “Can Acetylcholine make you dream?.” Sleep science (Sao Paulo, Brazil) vol. 12,3 (2019): 240-241. doi:10.5935/1984-0063.20190096

Ursin, Reidun. “Serotonin and sleep.” Sleep medicine reviews vol. 6,1 (2002): 55-69. doi:10.1053/smrv.2001.0174

Bazzari, Firas Hasan. “Can We Induce Lucid Dreams? A Pharmacological Point of View.” International Journal of Dream Research, https://journals.ub.uni-heidelberg.de/index.php/IJoDR/article/view/42462.

Sutanto, Clarinda N et al. “The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression.” Nutrition reviews vol. 80,2 (2022): 306-316. doi:10.1093/nutrit/nuab027

source https://nootropicology.com/best-nootropics-for-lucid-dreaming/

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nootropicology · 2 years ago

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Oxiracetam 101: What is it, Side Effects & Benefits

Oxiracetam is a popular Nootropic used for its cognitive enhancement benefits as well as high safety profile.

If you've been in the Nootropic-space for quite some time you'll be familiar with the popular Nootropic called; Oxiracetam.

What is Oxiracetam exactly, what does it do in the brain and what are the exact benefits and side effects? In this article I'll take a closer look at these questions.

.... So without further ado, let's just jump straight to it, shall we?

What is Oxiracetam?

Oxiracetam is part of the racetam family, a now known nootropic which was originally used to treat memory loss and cognitive decline commonly associated with aging.

Although, one of the big things about Oxiracetam (just like plenty of other nootropics which are available) is that there is a lack of good clinical studies; a lot of its known effects have come from general public use, so some of these benefits may not in fact be true.

This is always a shame, but that's what you’ll typically find with any compound part of the racetam family, but don’t be discouraged, this could be a nootropic that completely turns things around for you when it comes to workflow.

There is still evidence online throughout the nootropic community that suggests it to be a fairly safe compound to use if you’re looking for cognitive benefits.

Which we’re going to talk all about today.

FUN FACT: Oxiracetam is currently sold as a dietary supplement throughout the US and actually has no specific medical uses currently.

What does Oxiracetam do to the brain?

As stated above, there is a lack of evidence to support some of the things which many people claim Oxiracetam to do; so we’d like you to take everything we say here with a pinch of salt and not to fully trust in what we know.

Though this is the case with most racetams and if you’re an avid user of cognitive boosting nootropics, you’d probably know this already.

Improves your memory

According to a few studies, daily treatment of Oxiracetam at around 400-2,400 mg’s can improve the user's cognitive function and in some cases, users even found that they had much better verbal memory.

Users also experienced an increase in intellectualness, although this was from people who had oderate’ dementia, so the same effects may not be apparent in healthy humans.

But who knows, maybe you will feel much smarter whilst daily dosing.

One other interesting thing which has been reported from users is that they found that they had improved sleep whilst they took the compound, and some even found that they had a reduced level of anxiety.

Both are great side benefits of a substance that you would primarily be taking for its cognitive benefits - making it a great choice if you suffer from these things too.

Two studies in rats also showed that they had an improvement in long term memory, so another potentially great benefit that could go a long way if you’re looking to get the most out of a study session or a long shift at work.

Improve focus and attention

People using Oxiracetam have reported that they have seen some benefits in their alertness and attention, explaining that they have seen an improvement in reaction time alongside this too.

Reported to also increase alertness whilst also decreasing anxiety (as discussed previously), users have found some cognitive function improvements too, meaning that this racetam is certainly one to keep in mind if you’re looking for a ick-me-up’ throughout the day.

Improved blood flow to the brain

Some early findings suggest that oxiracetam helps to reduce damage to neurons and white matter, which further helped to restore blood flow and block the activation of cells which would usually be associated with scaring the brain.

This increase in blood flow also had some more cognitive benefits related to spatial learning and improved memory.

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One thing to remember about Oxiracetam

All in all, oxiracetam sounds like it provides some great benefits, but remember - more research needs to be done before you outright trust these findings for yourself.

Though this is a common theme with all racetams, so in most cases you’ll just have to see for yourself just how good this nootropic actually is.

Doing so safely of course.

Potential benefits and side effects

Here I'm going to give you a summary of the potential benefits (potential being the keyword here, for reasons I’ve already discussed) so that you know what you could expect when taking this racetam in the future.

Whether you intend to use it to boost your brainpower for the purpose of studying or you’ve got a long work project that needs to be finished up next week, a nootropic like this can seriously help.

As discussed, here is what oxiracetam as improved in some users:

Alertness

Memory

Verbal memory

Short-term memory

Intellectual function

Sleep

Reduced anxiety

Spatial learning

All of these things are desirable for anyone looking to level-up their workflow, but surely there must be some side effects right?

Well yes, of course, just like any compound there are side effects that can come from dosing.

These side effects have been experienced for one reason or another, whether the nootropic itself just didn't agree with the person (as it can do sometimes) or because the person did too much of it.

And the other reason could be, that it just has some side effects, like any sort of chemical you take, that just happen as a result of using it.

Nothing is perfect.

Anyway, enough chatter, let’s talk about some of the side effects which have been experienced.

Here are the current known side effects:

Nausea

Headaches

Overexcitability

Sleep disturbance

Elevated blood pressure

Constipation or Diarrhea

Some of these side effects are typical to what you will find with any nootropic on the market, but again, due to limited research on Oxiracetam, it is unclear as to whether or not these things have arisen from long term use, short term use, or overdosing.

What's the best dosage for better cognition?

From studies and other people's experience online, it is unclear what the perfect dosage amount actually is, since users have been dosing ANYWHERE FROM 400 TO 2,400MG OF OXIRACETAM to help feel its benefits.

So ultimately, I can not answer this for certain - but at least we have some sort of range when it comes to understanding dosage amounts - though if you were to take this yourself, it would have to be down to your own research if you wanted to figure out the best possible dosage.

Even if I had a better idea of the amounts needed to take in order to feel its brain-boosting benefits, it may even be a little different to use as these sorts of things affect people in different ways.

What I am saying is, no I don't yet know the sweet spot when it comes to dosage amounts for cognitive improvement, though I do know it to be anywhere from 400 to 2,400mg.

So do with that information what you will.

Oxiracetam vs Aniracetam - what's the difference?

Both Oxiracetam and Aniracetam are used by individuals who are looking for memory and focus boosting properties to help support brain function and increase their mental clarity so that they are able to feel much more alert and focused when it comes to working on a project.

As their name indicates, the compounds are both a part of the racetam family and are strictly similar to the first racetam, Piracetam - though they are both slightly more potent..

One of the key differences and a sort of TDLR is that Aniracetam is viewed as a mood enhancement compound, helping to reduce stress and help with social anxiety.

Whereas Oxiracetam is considered to be for enhancing focus and promoting mental acuity.

Though with that being said, they can be both used for the purpose of helping you to become much more alert, their methods of action are just a little different.

More about Aniracetam

Although I’ve just given you a simple comparison of the two compounds, I want to talk a little more about Aniracetam on its own, since I’ve already covered Oxiracetam heavily in this article, it's important to know why they would even be compared to each other in the first place.

Beyond them being part of the racetam family.

Benefits of Aniracetam

As mentioned, some of the benefits that aniracetam can bring about are slightly different to what users will find when dosing oxiracetam, and here they are:

Aniracetam helps to improve:

Mental energy

Concentration

Clarity of thought

Auditory Perception

Visual perception

Reduces nervousness

Improved focus

Reduced fatigue

Also, it's worth mentioning whilst other racetams are much better at giving you focus, like Pramiracetam or Phenylpiracetam, users prefer this compound due to the mood-lifting effects it has on them.

As it induces the feeling of calm and balanced mental activity, it can help with general clarity and will improve workflow since you just feel much better about doing whatever it is you’re doing.

Allowing you to build a positive relationship when it comes to doing oring’ work.

So, which is in fact better: Oxiracetam or Aniracetam?

As I’ve outlined in the last couple of headings, both of these racetams have their benefits, so just like anything in life - especially nootropics - it all comes down to preference and what you’re looking to get out of taking any compound.

If you’re looking for a mood enhancer that can make you feel much calmer, thus making you feel much more focused on the task at hand - then Aniracetam is the one for you.

If you’re looking for an actual positive mental boost when it comes to improving focus and cognitive ability then we would suggest that you look into sourcing Oxiracetam.

One last thing: as I’ve outlined all throughout this piece, Oxiracetam has limited research, and that goes for Aniracetam too - as with almost all racetams.

So a lot of the benefits listed have limited research-based backing, again, do with that information what you will.

Can you stack Oxiracetam with other nootropics?

Yes, oxiracetam can be stacked with other compounds so that you can get further benefits from dosing, there are quite a few stacks but as usual, it all depends on what you’re looking for.

Oxiracetam and Aniracetam Stack

I’ve just talked about both of these compounds, in comparison to each other, but people actually stack them as they neatly complement each other which can be appealing for anyone looking to boost their cognitive ability and improve their mood.

The benefits of this stack is to help improve your mood whilst also helping you to improve cognitive function; meaning that you can focus on your work and feel happy whilst doing so.

And when you leave your desk to go for a break, your surroundings will be much more appealing due to this improvement in mood.

Oxiracetam and Modafinil Stack

If you’re in serious need of a long study session because you’ve got a test coming up, or you’ve got a long-overdue project that desperately needs finishing for work, then the Oxiracetam and Modafinil stack will be the one for you.

Since modafinil is a wakefulness agent and helps to promote alertness; along with other cognitive functions - it makes it a great stack with Oxiracetam as they both compliment each other (since they do a similar thing) and combining them will help further enhance their benefits.

Pros and Cons: What I like and dislike

You’ll be sick of me repeating myself on this bit, but the fact of the matter is that there is just limited research on Oxiracetam, so much so I cannot confidently recommend it to you despite what some of its users have found.

Although, if you’re someone who isn't desperate when it comes to finding a nootropic for brain-boosting, and you’re a more asual’ user and are just looking to find something new in the nootropic world that might actually have some awesome benefits, then for those of you, we would recommend it.

But if you’re in desperate need of improved focus and cognitive function this very second, there are plenty more nootropics out there that have much more accurate research than can almost guarantee its benefits.

Though with that being said, if more research was done and it was in fact true that Oxiracetam could benefit you in ways like:

Alertness

Memory

Verbal memory

Short-term memory

Intellectual function

Sleep

Reduced anxiety

Spatial learning

Then I see no reason as to why this could not be one of the best nootropics on the market, especially if stacked with something like modafinil or Aniracetam to offer you further benefits.

source https://nootropicology.com/oxiracetam/

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nootropicology · 2 years ago

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Nefiracetam Review: Benefits, Dosage & Side Effects

Nefiracetam is a nootropic from the racetam class, initially coming from its parent module Piracetam. Although it shares more structurally similarities with aniracetam, both of which are fat-soluble racetam drugs.

They are used for the purpose of enhancing a person's memory, improving focus, improving alertness, and reducing their anxiety levels and the effects of depression.

What is it used for?

As mentioned in the intro, nefiracetam appears to been developed for the purpose of the cognitive benefit, unlike something such as modafinil which was originally created to help those who suffered from sleep conditions such as narcolepsy, where the cognitive function it provided wasn't the immediate reason as to why it was produced.

Although one single dosage of nefiracetam does not immediately affect memory formation, rather you would need to take daily dosages of this chemical if you want an increase in cognitive memory function - 7 days or longer.

This has been proven in studies done on animals as well as some studies in humans, though these are very limited - just like most research on nootropics is.

Prolonged usage of nefiracetam has been associated with a higher rate of neurogenesis, which helps you to learn and retain the information you take in.

And as a cool side benefit; growing new neurons could help stave off Alzheimer's.

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Benefits of using Nefiracetam

Though nefiracetam doesn't have as much public research as some of the other nootropics, there are a lot of benefits of using it, making it just as good as some of the more established chemicals that are used throughout the brain-boosting, biohacking, community.

Due to the benefits, I could even see it replace some of the more loved brain boosters that are commonly used by thousands of workers and students every day.

Anyway, let's get into the benefits and probably the main reason why you're here...

Nefiracetam improves memory

As discussed, nefiracetam's cognitive enhancement helps to improve you brainpower in many different ways, and one of those ways, which is common with nootropics like this, is improving your memory.

If you're interested in the science behind it, here it is:

Nefiracetam increases the protein known as Kinase C (PKC) and CaM Kinases II, these increases are crucial to memory formation (which may be at an all-time low thanks to any sort of brain trauma or due to natural aging).

Source: https://pubmed.ncbi.nlm.nih.gov/12393060/

Improves focus

Another common effect of any nootropic you can buy online is the improvements of focus you can receive, and this particular racetam is no different; due to the calming effects released after taking a dosage of nefiracetam, you will find yourself to be able to focus much more on the task at hand.

Some people have even experienced much clearer thinking and have been able to articulate themselves much better too.

Reduces anxiety

One of the things that can stop you from doing your best work during school or work hours has to be anxiety, whether it's a result of your surrounding or something you're just going through in life, it can really hold you back..

Upon consuming this chemical, your body will experience increased levels of PKS which is an essential protein in regulating anxiety levels.

Just like with anxiety, depression can inadvertently get in the way of the quality of your life, especially when you've got deadlines coming up.

Thankfully, studies suggest that the nootropic helps to manage depression too, due to the activation of CaM kinases.

Reduces stress

As covered, a regular dosage of nefiracetam increased the neurotransmitter in the brain which help to reduce stress, this also helps to increase concentration which helps you to manage your mood much better (and is the reason why you feel so focused whilst using)

Better visual acuity

One of the benefits of using nefiracetam which not many nootropics can give you is the better visual acuity, meaning that your surrounding appears to be much more pleasing on the eye.

This directly helps with staying awake and being more active since you're finding more pleasure in the most basic things.

Powder vs capsules - what's the best solution?

Typically nootropics come in capsule form, and I advise using this instead of powder since they have accurately been measured out for you beforehand, so you know how many you need to take (if this is the case) to receive the brainpower benefits you need.

Using a powdered version of nefiracetam is possible but as I said, if you are going to start using this nootropic I would recommend sticking to capsules since consuming them is a lot easier as you don't have to faff around measuring, which could cause you to under or overdose if not done properly.

So, powder or capsule?

It's up to you but I would recommend capsules just as an easier option.

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Side effects of Nefiracetam

As with many noots in today's cognitive-enhancing world, a lot of the side effects come from overdosing, rather than as a result of normal dosing - take caffeine for example, if you drink a standard amount of cups, although you fee a lot more alert you could STILL may feel negative effects like anxiety and nervousness.

Though most nootropics do not have this problem and the side effects only come as a result of overdosing, and nefiracetam follows this trend.

So if you were overdosing and going against the recommended mg's I have laid out for you in this article, you could expect to experience things like:

Anxiety

Fatigue

Headaches

Nervousness

Nausea

Again, these come as a result of OVERDOSING, so as long as you stay within the recommended amounts you should be more than fine and you will only experience the awesome side of nefiracetam.

Best Dosage for cognition

Before we get into the dosage amounts, I want to first talk about how to consume them for the best effect.

It is recommended by users to take it after eating a meal with healthy fats.

As mentioned in the beginning, from clinical research it was found that you will need to take this nootropic for several days (about 7/8) before you begin to feel the effects - so follow this recommendation when you begin using this cognitive enhancer.

Now, how much do your body and brain need to start feeling the effects of cognitive function?

Many people will take 150-450mg dosages of Nefiracetam spread out throughout the day (3 capsules taken at different times) as this is sort of the sweet spot where one can eventually feel the effects in terms of a cognitive boost.

So for that reason, I would recommend doing the same, probably taking a capsule of 150mg as soon as you wake up, one at noon and one in the evening.

What people on reddit are saying (experience)

Reddit is one of the best places to go if you want some non-biased-personal experiences from users, whether that's on a review of the latest video games or on the latest shoes - in this case, it's on Nootropics, specifically nefiracetam.

Here I am just going to copy and paste a few of Reddit users experiences so you can get an idea of what people actually thought about the noot outside of clinical studies on humans and animals:

"Had a biochemistry exam last week, and I took a single dose the day before while studying and took another the dose two hours before the exam. All I can say that it is one of the most effective supplement. I have used for studying. I got 94% on that exam, which is my highest so far this semester, and I didn't even study as much.

Normally when I'm studying, I would have to go back and review multiple times to be able to fully memorize the material, but with nefiracetam, it's just so easy to get the information in my memory and to be able to recall it with no efforts." - Reddit source

"I just received my order of nefiracetam from Newstarnootropics. I weighed out 100mg and decided to do a sublingual test. It is soluble in water, but not very much. This, mixed with the fact that the taste is not as palatable as oxiracetam, makes it one that I probably will not dose sublingually in the future. It's not nearly as bad as pramiracetam, though.

NEVER dose pramiracetam sublinigally, as it will literally burn your mouth. Noopept doses sublingually very nicely. That is my preferred method, actually. Nefiracetam gave me the same characteristic sneeze that I get when taking noopept, which I found interesting. Noopept will always make me sneeze about a minute after a sublingual dose. It might be the taste, or something else entirely, since I don't get that with other substances.

It's now about 2 hours after my dose, and I can say without a doubt that this stuff is strong! This is as strong as the first time I tried pramiracetam, and at a smaller dose. It's quite surprising, actually. The only other thing I am taking with it is bacopa, since that is a long term supplement. I am going to re-dose in a few hours and see how I react. So far it's impressive. I need more time to give it an accurate assessment, but it seems very promising."

- Reddit Source

"So it's been about an hour and I can definitely notice it. Better focus, very calm, recall and general cognition seem to be noticeably better.

Also, vision and hearing are definitely heightened. This is decent stuff so far.

For the record I've got pretty extensive experience with racetams/nootropics (piracetam, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, noopept, sunifiram, adrafinil, modafinil, armodafinil, phenibut...all the basics as well) and I can definitely say that this one, more than the others (excluding phenylpiracetam, which is awesome) is very pronounced in its effects.

But who knows, first time trying it, so we'll see after a week whether it's still this noticeable. My gut says it won't be, as the others are similar, but who knows." - Reddit Source

If you're interested in what other users had to say about their findings, feel free to click on the links provided to check that out, some users even give their experiences to if you're looking for a deeper understanding from a consumer's point of view.

How does it compare to other racetams?

Nefiracetam is one of the many racetams which are available from the nootropics market, but how does it compare to the other ones available, and are there any better ones when it comes to racetams.

I would personally recommend using nefiracetam if you're a student or a workaholic who needs to be able to concentrate on the task at hand whilst blocking out any sort of distractions or negative thoughts (anxieties and depression-related) so that you are able to get what you need doing.

There are similar racetams that can do this for you too, such as Oxiracetam or Pramiracetam.

Though their benefits differ slightly, for example, Oxiracetam is really good at providing motivation and Pramiracetam focuses on more easing negative thoughts like depression and anxiety - though you can't really go wrong with either of them if you have these specific problems.

When compared to other racetams like Aniracetam and Phenylpiracetam, these are much better suited at improving athletic performance as they help to improve stimulant effects and helps to resist cold - so much so it has been banned by the World Anti-Doping Agency.

How it improves spatial memory

The reason why this nootropic and this racetam is considered to be one of the best for students and workers alike is that it helps them retain information that they are reading.

Some early studies suggest that even rats who had defective spatial memory saw important when taking nefiracetam in the right daily dosages - meaning that if you're someone who believes they suffer from poor memory, this nootropic may help to improve it.

This is also backed by the fact that a lot of people who have Alzheimer's use this chemical to help them retain some of their memory, as mentioned at the beginning of the article.

Because of this, it certainly a noot that I believe you should look into if you've got a test coming up which you desperately need to study for - or perhaps a presentation for work which could land you a higher paying wage.

How it affects your Sleep

Just like with a lot of nootropics out there, they can get in the way of your sleep if you decide to dose too late in the day, near your bedtime - and this racetam is obviously no different.

Since it can help with alertness and cognitive function, you seriously do not want to be taking this too late in the day or you will be feeling wide awake wanting to get on with your work.

Obviously, this is easily avoidable by just taking dosages at the right times in the day.

Some users have actually found that it has helped them with sleep, since nefiracetam reduces anxiety and stress levels throughout the day (allowing them to get on with there life as normal) they are not left at the end of the day worry about things since they've had an awesome day whilst using this noot.

So this is also something to consider if you're someone who is constantly worrying and stressing, and never get your tasks done because of it, then nefiracetam might be perfect for you.

Summary

There are many, many different nootropics to choose from, and because of this, it can be quite hard to find one that is absolutely perfect for you and one that is going to be worth pulling out your credit card and spending your hard-earned cash on.

Though with this being said, I feel like nefiracetam can be one of the best things you could add to your life if you're a busy uni student or a hard-working businessman trying to achieve financial freedom.

The fact that this nootropic can help to boost your alertness and concentration, to help with work, whilst reducing your anxiety levels and stress levels make it great for practically anyone who has things to do in their day to day lives.

My only reason as to why I wouldn't call this the best nootropic out there is because of the way you need to take it to feel some if its benefits; having to take something for a number of days before you begin to feel some of its key benefits is very annoying, especially if you need the brain boost RIGHT NOW.

But with all of this benign said, if you're looking for a long-term nootropic that can help give you the brain boost you need to hit your goals, then for me personally I see no better fit than nefiracetam.

source https://nootropicology.com/what-is-nefiracetam/

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nootropicology · 2 years ago

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What is Theobromine and does it actually work?

Theobromine is a chemical found in the cocoa plant and is used as stimulation to help increase alertness and focus.

The effects of Theobromine are very similar to what caffeine does to the body and are compared as so.

They are even a part of the same chemical family: methylxanthines.

Theobromine is commonly used as a replacement for caffeine as although the effects of it are much less apparent, the fact that it is a lot less addictive and the downsides of taking it are a lot less noticeable makes it a great alternative.

Especially if you want to cut ties with your caffeine addiction and take something considered to be much healthier for you whilst you work on that overdue paper or grueling project.

I’ll be covering the effects of theobromine on the body in comparison to caffeine later on, for now, I'll want to cover the actual effects of theobromine on the brain; a standalone investigation.

Before I do, it might be surprising to know that you will probably be consuming theobromine as much as you do with caffeine already, as it is found in many of your favorite foods and drinks such as dark chocolate and black tea.

Theobromine Effects on the brain

Boost of mood

Research in this area is limited, and the feedback has been a bit of a mix from a lot of testing but some evidence does suggest that the consumption of theobromine may result in a mood boost; in the forms of relaxation and positive thinking.

Improved cognitive function

Since Theobromine is so closely linked to caffeine, it should come as no surprise that it can also offer you improved cognitive function for a short period of time.

This is likely due to the way Theobromine encourages blood flow to the brain which will help make people feel a lot more mentally awake and focused on the task at hand.

Brain and body boost

As already stated, theobromine is closely linked with caffeine so it is no surprise that consuming it may result in a physical and mental energy boost, which will help with concentration and alertness.

Theobromine differs from the caffeine in one noticeable way, however, as its stimulant effects are a lot less apparent though they are much longer-lasting.

Benefits of Theobromine

Though some of these won’t matter too much if you’re considering taking theobromine as a nootropic, we feel they are still worth mentioning as a sort of interesting side benefit if you were to take theobromine for a boost in brainpower for work or for school.

But with benefits, there also comes downsides with it, just like with any nootropic you take - too much of it can be harmful.

And we’ll be talking that in such a little bit too.

Benefits you care about

Temporary cognitive boost

As mentioned, one of the main benefits and probably the main factor in your consideration to take theobromine is the cognitive boost it can give you - thanks to the way the stimulant encourages blood flow to your brain, you will feel much more mentally alert and focus at the task at hand.

Mood boost

There is some evidence that suggests consumption of theobromine can result in a mood boost which can help you relax, and think more positively which will very much help with concentrating on the task you’re working on.

Increased energy

Due to the alertness that Theobromine gives you, you will feel like you have a lot more energy and will be more willing to get on with your tasks, though its stimulant effects are much milder than caffeine it is also long-lasting so it might be worth taking if you’ve got a long project or a paper due in a few hours.

Benefits worth mentioning

Keeps your heart healthy

Theobromine helps to lower blood pressure, this helps reduce the risk of cardiovascular disease; some evidence, although admittedly not strong, even shows that Theobromine may reduce bad cholesterol and improve good cholesterol.

As we’ve already discussed, theobromine promotes blood flow to the brain to help you stay alert, but it also improves blood flow around the body which will further help to support your heart.

Protects your teeth

If you know anything about theobromine, you’ll know it’s one of the components in chocolate, so it’s pretty ironic that the actual chemical itself would help to protect your teeth rather than destroy them - as chocolate is more than capable of doing.

Theobromine may help to protect the tooth enamel from erosion, which will significantly help strengthen the teeth.

It is also said to help defend against tooth decay that can cause you painful cavities.

One of the most surprising discoveries in relation to Theobromine and your teeth is that it may even be a better cavity fighter than fluoride, the teeth-strengthening chemical found in the toothpaste in every home.

Improves respiratory system

Theobromine is said to widen the body’s airways and relax smooth muscle tissues that are found in the lungs; this helps to increase airflow to the lungs - and maybe why as some other studies suggest - that theobromine is great with managing asthma and other respiratory conditions.

Beter respiratory will also give you a better time when you’re doing cardio at the gym or outside; finding it much easier to breathe will help you to keep going and allow yourself to set your PB’s.

So it may even be worth taking (as some bodybuilders are) when going to the gym.

Side effects of Theobromine

Theobromine is absolutely safe when taking in adequate dosages but it can cause unpleasant side effects when taken in high dosages for too long, this can include such things as:

Nausea

Loss of appetite

Headaches

Negative mood changes

Anxiety

Restlessness

Some further studies even have shown that does between 300-1000mg of theobromine increased the heart rate of its users, increasing by a few beats more per minute.

In this case, it is recommended that anyone who has an irregular heart rate may want to avoid any sort of theobromine supplements.

As always, pregnant women and children should avoid supplement-based Theobromine, though the amounts naturally present in the food will be safe to take as usual.

Theobromine Vs. Caffeine

Both known as methylxanthines, Theobromine is actually just a byproduct of caffeine metabolism; they both exert CNS-enhancing effects by inhibiting adenosine receptors, though theobromine does so much more weakly than caffeine and is the reason as to why theobromine is much less powerful and effective.

With this small overview, let’s go over Theobromine vs Caffeine in a lot more detail, identifying the obvious similarities and notable differences between the two members of the methylxanthines family.

What are they?

Theobromine

First, discovered in the 1840s in cocoa beans, theobromine has been found in a variety of teas, such as black tea and yerba mate; though it is most found and consumed in dark chocolate and does, in fact, belong to the same family as caffeine:

The methylxanthine family.

Meaning that it has similar effects (which we’ve already discussed in this post) as well as some notable differences which we’ll get into further down.

Caffeine

Caffeine is a chemical that stimulates the central nervous system, heart, and muscles; it also the most common and most widely accepted nervous system stimulant available for purchase in today’s market.

Naturally found in seed and leaves of a variety of plants found across the globe such as in countries like Africa, South America.

It will be no surprise to learn that coffee is the most common source of caffeine though it is also found in a range of soda, teas, and pills.

Theobromine Vs. Caffeine: Benefits and side effects

Caffeine

Combating drowsiness is caffeine’s main benefit and the main purpose for consumption, which is obviously the reason why coffee is such a popular morning drink or why people like to consume other energy promoting drinks during their work hours.

As these to have plenty of caffeine to help eradicate a person’s sluggishness.

Caffeine also helps you to feel less hungry which makes it a common ingredient in plenty of weight loss products that are available.

Caffeine seems pretty great right about now, doesn’t it?

Well, of course, there are downsides to consuming caffeine, which many of us will have felt at least once in our lives - since it’s such a common chemical to consume in our now busy digital world.

The downsides of caffeine are that too much of it can make you feel very jittery and nervous, and if you were to consume it at the end of the day, say in a coffee, you will find it very hard to fall asleep.

However, you’ll be more than happy to know that a toxic dose of caffeine are pretty unrealistic if you’re just drinking coffee, as it will take you about 15 cups to do so.

Though with this being said, it is more than possible with powdered caffeine as it could only take a tablespoon to be fatal.

Theobromine

Due to their similarity, theobromine affects the body in a similar way that caffeine does, but it is around 10 times weaker.

Whilst research shows that both chemicals can bind to the nervous system in the same way, theobromine binding is a lot weaker - which can be seen as a good thing because you won’t feel the same nervousness jittery energy as you would when consuming caffeine.

Although consuming high dosages of it may still make you feel this way.

The energy it gives you is a lot less intense but longer-lasting, and as mentioned previously, it can also promote increased blood flow and better breathing which can further help with a sense of alertness, focus, and a sense of calm.

Just like caffeine, there are some potential downsides to taking this particular chemical; for instance, if your body is not used to too much of it, you can feel nausea, experience vomiting, and have severe headaches as a result.

It can also increase heart rate, though only by a few beats a minute, can be unpleasant for anyone who suffers from an irregular heartbeat.

Over consummation can cause caffeine-like side effects in the range of anxiety and restlessness.

Similar to caffeine, to get a lethal dose of theobromine you’d have to be consuming tons of it; so you can be comfortable knowing you’re probably never going to harm yourself taking this nootropic.

Theobromine Vs. Caffeine: Which is better?

Since theobromine is less addictive and some of its drawbacks are a lot less harsh, it can be a good idea to switch to it for your usual caffeine intake.

Helping you to remove caffeine from your life that your body may heavily rely on, as many people do thanks to our busy work lives.

Is it toxic to humans?

As with many things you consume in your lifetime, things can get toxic if you have way too much of it and theobromine is no different in this instance.

But just how much would you need to take for it to be a lethal dose?

The lowest published toxic dose is 16mg/kg body weight.

Though you won’t instantly drop dead when taking too much of this chemical, there are some telltale signs that are very obvious if you’ve gone off the recommended limits of consumption.

This can include things like:

Nausea

Vomiting

Diarrhea

Cardiac arrhythmias

Epileptic Seizures,

Heart attacks.

If you were to ignore these fatal signs and continue on with consumption, then that’s when it can lead you to your death.

But don’t let this scare you out of using theobromine, it is REALLY difficult to get to this stage, and whether its theobromine or any other stimulant, they all can cause death if you’re not smart about using them.

Is it a stimulant?

Just like caffeine, theobromine is a stimulant that belongs to the methylxanthine chemical family and it stimulates the central nervous system, heart, and muscles of the human body.

It also has similar effects to coffee; helping to improve wakefulness and remove any drowsiness you may feel as well as helping to improve cognitive function and in some cases improving the mood you are currently feeling.

This is down to the fact that this stimulant promotes blood flow around the body, which positively affects your brain and your heart.

Will it keep you awake?

Since Theobromine is 10 times weaker than caffeine, studies have found that it will not get in the way of someone trying to get a good night’s sleep.

In some cases it has even been shown that taking theobromine resulted in a better quality of sleep, as people experienced a lot less restlessness and even found that they didn’t wake up randomly in the middle of the night; something caffeine users are more than aware of happening; especially when drinking things like coffee to close to bedtime.

Which foods contain Theobromine?

Theobromine has probably been in our bodies at least once in our lifetime, perhaps it even a part of your day-to-day eating and drinking habits - this is because it is found in so many popular food products.

Here are the most common foods which contain theobromine, listed greatest to least concentration:

Raw cacao beans, powder, and nibs

Processed cocoa and dark chocolate products

Milk chocolate

Black tea

Chocolate pudding, cake mix, syrup, cereal, candy, ice cream, etc.

Can you use Theobromine for bodybuilding?

Whether it’s consuming coffee or some other caffeine-based pre-workout, this particular methylxanthines chemical is a common option for gym-goers, whether you’re just going to keep in shape or you’re a full-time bodybuilder.

Though, a lot more athletes are using theobromine as an alternative to caffeine.

Theobromine is believed to have stimulating properties that bodybuilders can actually feel, similar to what caffeine provides them, which results in the following things:

Improved focus

Energy

Motivation

And the ability to concentrate on the exercise in front of them.

Some bodybuilders claim that the heightened mental state which they have felt has helped them with bodybuilding-based endurance.

Should you take it as a Nootropic?

Since Theobromine offers you a lot of the upsides that caffeine can offer you without the harsh downsides which follow it, then we would absolutely recommend using Theobromine as a Nootropic since it helps with cognitive function, improves mood, and even increases your mental and physical energy.

Which can benefit you in places like school, work, or even when going to the gym.

This is before we even talk about the other upsides such as helping to protect your teeth, keeping your heart healthy, and improving your respiratory system; which obviously offers no neurological value but is an awesome side benefit.

Even on the days you’re not studying or working you may still be consuming caffeine products like coffee, it might even be a good idea to replace it with theobromine instead, as discussed you’ll feel similar benefits without the harsh downsides.

source https://nootropicology.com/theobromine-review/

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nootropicology · 2 years ago

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Study Finds Nootropic Supplementation Improves Cognitive Performance and Mood in Adults With an Optimal Diet

A new study from 2022 conducted by researchers at Swinburne University, Melbourne, has found that the cognitive and mood benefits of nootropic supplements depend on the dietary status of those taking them.

With 141 participants in the study – some with ‘optimal’ diets and some with ‘sub-optimal’ diets – results showed that those who had an 'optimal' diet before supplementation experienced improved attentional performance along with lower state anxiety and mental fatigue.[1]

The study was a randomized, double blind, placebo-controlled trial and examined the effect of a multi-nutrient nootropics supplement containing B group vitamins, Bacopa Monnieri and Ginkgo Biloba on memory, attention, mood, and biochemical markers of nutrient status in participants over 12 weeks.

The participants were all middle-aged adults with an average age of 52.84 years. A mixed model and repeated measures analysis revealed that compared to a placebo group, active treatment was associated with significant increases in levels of B1, B6, and B12.

"These findings suggest that the cognitive benefit of B vitamin and herbal supplementation may be dependent on diet quality, supporting the concepts of ‘co-nutrient optimization’ and interdependency of nutrients."

- Young, Lauren M., et al. "Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults"

However, with regard to behavioral outcomes such as memory and attention performances, there was no significant benefit across the sample.

While this did not support the primary hypothesis of the study, a closer investigation revealed that individuals with an 'optimal' diet prior to supplementation had significantly improved attentional performance when given active treatment.

Moreover, a number of additional secondary outcomes showed positive effects of supplementation even in the absence of a main effect. These included lower state anxiety and mental fatigue levels in specific subgroups.

This study provides valuable insight into the effectiveness of nootropic supplements when the user has already established an optimal diet.

For those attempting to improve their attentional performance and emotional regulation, adding supplemental nutrients can be beneficial in alleviating anxious states and mental fatigue.

Importantly, when a balanced diet is absent, these supplements may not provide enough benefits to be worth taking. This research makes a case for incorporating certain dietary supplements as part of an overall health practice if one is looking for better emotional or cognitive performance.

References

Young, Lauren M., et al. “Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial.” MDPI, Multidisciplinary Digital Publishing Institute, 29 Nov. 2022, https://www.mdpi.com/2072-6643/14/23/5079.

source https://nootropicology.com/nootropic-supplementation-improves-cognitive-performance/

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nootropicology · 2 years ago

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8 Best Nootropics For Flow State In 2023

In this article, I'll look at the 8 best nootropics to achieve flow state. I'll cover the potential risks and side effects you may run into and the benefits you can expect.

A flow state is a state of peak mental performance and increased creativity. It is a euphoric feeling that can help you achieve more in less time. Many people use nootropics to achieve this state, but choosing the right ones is important.

So today, I'll look at the 8 best nootropics to achieve a flow state. These supplements have been carefully selected based on their ability to increase focus, improve cognitive performance, and enhance creativity.

So without further ado, let's dive in.

The 8 best nootropics for flow state, according to scientific evidence, are:

Mind Lab Pro

Modafinil

Armodafinil

L-Theanine

L-Theanine + Caffeine Stack

Bacopa Monnieri

N-Acetyl L-Tyrosine (NALT)

Maritime Pine Bark Extract

1. Mind Lab Pro

Mind Lab Pro is a nootropic blend. It contains 11 well-researched ingredients designed to increase focus, improve cognitive performance, and help you achieve a flow state.

The nootropic ingredients in this blend are:

Citicoline

Phosphatidylserine (PS)

Bacopa Monnieri

Organic Lion’s Mane Mushroom

Maritime Pine Bark Extract

L-Tyrosine

L-Theanine

Rhodiola Rosea

Vitamin B6

Vitamin B9

Vitamin B12

Citicoline is especially interesting as it helps increase the production of acetylcholine (ACh), a neurotransmitter connected to improved focus and concentration. When the ACh level is increased, your brain can work faster and better.[1]

This can help you reach a flow state more quickly and sustain it for longer. Mind Lab Pro also contains natural ingredients that can help reduce stress, improve mood and focus, and enhance creativity.

Mind Lab Pro

Editor's Rating: 4.6/5

100% natural universal nootropic

Scientifically proven by independent research

30 days money-back guarantee

Click Here For Best Price ›

Mind Lab Pros

It contains 11 high-quality, powerful nootropic ingredients

Supports cognitive and brain performance in numerous ways

It helps improve memory and concentration

It doesn't contain caffeine

Affordable price point

Perfect for people who want to achieve flow state

Mind Lab Pro Cons

Shipping can take up to 2 weeks

Mind Lab Pro in Summary

Mind Lab Pro is a great choice for those looking to achieve a flow state. It contains 11 high-quality, powerful nootropic ingredients that have been scientifically proven to improve cognitive and brain performance in numerous ways. Additionally, it helps improve memory and concentration without containing any caffeine.

2. Modafinil

Modafinil (Provigil) is a eugeroic drug, meaning that it is designed to promote wakefulness. It helps improve alertness and focus, making it a great choice for those looking to achieve a flow state. Modafinil has been studied extensively, and numerous clinical trials show its effectiveness in improving mental performance.[2]

Modafinil increases dopamine, norepinephrine, and orexin levels in the brain. This increases alertness, focus, and concentration, allowing you to stay on task for longer. This is ideal for achieving a flow state.[3]

It's a nootropic that has been proven effective and safe but has minor side effects, such as headaches, nausea, and anxiety. It's also a prescription drug, so you'll need to get it from your doctor.

Modafinil

Editor's Rating: 4.6/5

Improves cognitive performance

Enhances mood & focus

Fast domestic U.S. shipping

Click Here For Best Price ›

Modafinil Pros

It increases alertness and focus

It has been studied extensively

It is proven safe and effective

Modafinil Cons

Prescription drug only

Modafinil in Summary

Modafinil is a wakeful-promoting drug that is designed to increase alertness and focus. It has been studied extensively, and numerous clinical trials have proven its effectiveness in improving mental performance. Modafinil increases dopamine, norepinephrine, and orexin levels in the brain, which helps you stay on task for longer.

3. Armodafinil

Armodafinil (Nuvigil) is the enantiopure compound of Modafinil, meaning that it is the single-enantiomer form of Modafinil. It has similar effects on the brain as Modafinil but has a longer half-life, meaning it can stay active in the body for longer.

It is also considered more potent than Modafinil, meaning that you need smaller doses to achieve similar effects. Similarly to Modafinil, Armodafinil works by stimulating orexin neurons, increasing alertness and focus. This helps you reach a flow state more quickly and sustain it for longer periods.

Unlike traditional stimulants, Armodafinil doesn't cause jitteriness or anxiety. This also means you won't experience crash effects when the smart drug wears off.

Armodafinil Pros

Longer half-life than Modafinil

More potent than Modafinil

It doesn't cause jitteriness or anxiety

No calm downs

Armodafinil Cons

Prescription Drug only

Armodafinil in Summary

Armodafinil is the single-enantiomer form of Modafinil and is considered to be more potent than Modafinil. It has a longer half-life, which means it can stay active in the body for longer periods. Armodafinil stimulates orexin neurons, increasing alertness and focus, allowing you to reach and sustain a flow state.

4. L-Theanine

L-Theanine is an amino acid found in green tea and some mushrooms. It is a nootropic that has been scientifically studied for its ability to reduce stress and anxiety, improve focus, and promote relaxation.[4]

It works by increasing levels of GABA, serotonin, dopamine, and other neurotransmitters. This helps reduce stress levels and improve concentration, allowing you to reach and maintain a flow state.

L-Theanine has also been shown to significantly increase activity in the alpha frequency band, which indicates that it relaxes the mind without inducing drowsiness. This makes it an ideal nootropic to take when aiming for a flow state.[5]

L-theanine

Editor's Rating: 4.6/5

Reduces anxiety and stress

Enhances cognitive function

Aids in focus and concentration

Click Here For Best Price ›

L-Theanine Pros

It reduces stress and anxiety

Improves focus and concentration

Boosts alpha brain waves associated with creativity and flow

No crash effects

L-Theanine Cons

Not as effective for all people

L-Theanine in Summary

L-Theanine is an amino acid found in green tea. It has been studied for its ability to reduce stress and anxiety, improve focus, and promote relaxation. It works by increasing levels of GABA, serotonin, dopamine, and other neurotransmitters. This helps you stay relaxed while still being able to maintain a flow state.

5. L-Theanine + Caffeine Stack

L-Theanine is an effective nootropic for reaching and sustaining a flow state on its own, but it really shines when stacked (combined) with Caffeine. A study has shown that combining the two helps focus, concentration, and alertness while also reducing the jitteriness and anxiety often associated with Caffeine.[6]

Caffeine works by blocking the action of the inhibitory neurotransmitter adenosine, thus increasing levels of dopamine and norepinephrine in the brain, thus improving focus and concentration. It also helps increase alertness and wakefulness, allowing you to reach a flow state more quickly and sustain it for longer periods.

L-Theanine helps balance out Caffeine's stimulating effects by reducing anxiety and jitteriness while still providing the focused energy of Caffeine. This allows you to stay awake and alert while still being relaxed and focused.

The L-Theanine + Caffeine stack is an incredibly powerful combination for reaching a flow state, allowing you to stay alert and productive without the side effects of jitteriness or anxiety.

L-theanine + Caffeine

Editor's Rating: 4.6/5

Helps with focus and concentration

Reduces symptoms of ADHD and ADD

Improves cognitive function

Click Here For Best Price ›

L-Theanine + Caffeine Pros

Increases focus and concentration

Increases alertness and wakefulness

Reduces jitteriness and anxiety

L-Theanine + Caffeine Cons

It can interfere with sleep if consumed too late in the day

L-Theanine + Caffeine in Summary

The combination of L-Theanine and Caffeine is an incredibly powerful nootropic stack for reaching and maintaining a flow state. Caffeine increases alertness and focus, while L-Theanine reduces jitteriness and anxiety, allowing you to stay relaxed and productive without the side effects of either one in isolation.

6. Bacopa Monnieri

Bacopa Monnieri is considered an adaptogen. An adaptogen is a herbal remedy that helps the body resist physical and mental stress. It has been used in Ayurvedic medicine for centuries to improve memory and cognitive performance.

Regarding flow states, this nootropic has been shown to improve cognitive performance.[7] It is believed that Bacopa Monnieri helps sustain a flow state by improving concentration, focus, and attention. It also reduces anxiety and stress, allowing you to stay relaxed while still being productive.

Bacopa Monnieri

Editor's Rating: 4.6/5

Supports cognitive health and function

Mood and stress support

Supports focus and attention

Click Here For Best Price ›

Bacopa Monnieri Pros

Improves cognitive performance

Reduces stress and anxiety

Improves focus and concentration

Bacopa Monnieri Cons

Not as effective for all people

It takes some time to work (weeks or months)

Bacopa Monnieri in Summary

Bacopa Monnieri is an adaptogen used in traditional Ayurvedic medicine. It has been found to improve cognitive performance and reduce stress and anxiety, which makes it an effective nootropic for sustaining a flow state.

7. N-Acetyl L-Tyrosine (NALT)

N-Acetyl L-Tyrosine (NALT) is an amino acid that helps increase neurotransmitters dopamine, norepinephrine, and epinephrine levels. These neurotransmitters are associated with alertness and wakefulness, which makes NALT a great nootropic for maintaining a flow state.[8]

NALT works by providing the body with a precursor for dopamine and norepinephrine synthesis, which helps increase their levels in the brain. It also reduces stress and anxiety, allowing you to stay focused and productive while still being relaxed.

NALT Pros

Increases alertness and wakefulness

Reduces stress and anxiety

Improves focus and concentration

NALT Cons

It can interfere with sleep if consumed too late in the day

NALT in Summary

N-Acetyl L-Tyrosine (NALT) is an amino acid that helps increase neurotransmitters dopamine, norepinephrine, and epinephrine levels. It works by providing the body with a precursor for dopamine and norepinephrine synthesis, which helps increase their levels in the brain.

8. Maritime Pine Bark Extract

Maritime Pine Bark Extract is an antioxidant found in the bark of the Maritime pine tree. It has been used in traditional medicine for centuries. More recently, it has become popular as a cognitive enhancer and nootropic.[9]

Maritime Pine Bark Extract supplies a natural complex of active proanthocyanidin nootropics that enhance antioxidant status, cerebrovascular function, and brain regeneration to promote mental clarity and long-range brain health. It also helps to reduce stress and anxiety, allowing you to stay relaxed while still being productive.

Maritime Pine Bark Extract Pros

Enhances antioxidant status

Improves cerebrovascular function

Reduces stress and anxiety

Maritime Pine Bark Extract Cons

It may cause minor gastrointestinal side effects

Maritime Pine Bark Extract in Summary

Maritime Pine Bark Extract is an antioxidant found in the bark of the Maritime pine tree. It supplies a natural complex of active proanthocyanidin nootropics that enhance antioxidant status, cerebrovascular function, and brain regeneration to promote mental clarity and long-range brain health. This makes it a great nootropic for achieving and maintaining a flow state.

What Are the Best Nootropics for Flow State?

The best nootropics for flow state, according to my research, are:

Mind Lab Pro

Modafinil

Armodafinil

L-Theanine

L-Theanine + Caffeine Stack

Bacopa Monnieri

N-Acetyl L-Tyrosine (NALT)

Maritime Pine Bark Extract

The list above contains a mix of natural and synthetic nootropics, all of which have been found to improve cognitive performance, reduce stress and anxiety, and increase alertness and wakefulness.

It's worth pointing out that synthetic nootropics like Modafinil and Armodafinil are prescription-only drugs, so before taking them, please consult your doctor.

Also, nootropic supplements may interact with other medications and supplements you're already taking, so it's important always to research and check with a healthcare professional before beginning any new supplement regimen.

What Are the Benefits of Nootropics for Flow State?

The benefits of using nootropics to achieve a flow state are numerous. Not only do they help improve your focus and concentration, but they also reduce stress and anxiety levels, making it easier to stay relaxed while still being productive.

Nootropics can also increase alertness and wakefulness, allowing you to enter a deep flow state more easily and quickly. The natural nootropics on my list will also enhance overall brain health and longevity, ensuring that you have the cognitive energy to stay in a flow state for extended periods of time.

If you're brand new to the jungle that is nootropics, I suggest starting with a natural nootropic blend like Mind Lab Pro as a foundation. This will give you the best chance of achieving a long-lasting flow state without encountering any significant side effects.

What Are the Side Effects of Nootropics for Flow State

The most common side effects of nootropics are typically mild headaches, nausea, gastrointestinal distress, and dizziness.

Some supplements can also cause an increase in heart rate and blood pressure. However, most of the nootropics on my list are generally well-tolerated by most people without any significant side effects.

That said, Modafinil has been linked to a rare skin condition called Stevens-Johnson Syndrome, so if you plan to take it, make sure to consult with a doctor first.

Final Thoughts: Do Nootropics Really Work for Flow State?

So do I personally think that nootropics can help you achieve a flow state? Absolutely.

Nootropics have been found to reduce stress and anxiety, increase alertness and wakefulness, improve focus and concentration, and enhance overall brain health – all of which are key components of a successful flow state.

The literature is clear: nootropics can help you achieve a flow state if you use them correctly. So if you're a student, entrepreneur, or creative looking to get more out of your day, give nootropics a try. I'm confident you won't be disappointed!

Good luck, and keep striving for that flow state! You got this.

Mind Lab Pro

Editor's Rating: 4.6/5

100% natural universal nootropic

Scientifically proven by independent research

30 days money-back guarantee

Click Here For Best Price ›

References

Kim, J H et al. “Acetylcholine precursor, citicoline (cytidine 5'-diphosphocholine), reduces hypoglycaemia-induced neuronal death in rats.” Journal of neuroendocrinology vol. 30,1 (2018): 10.1111/jne.12567. doi:10.1111/jne.12567

Cope, Zackary A et al. “Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.” Neuropharmacology vol. 125 (2017): 254-262. doi:10.1016/j.neuropharm.2017.07.031

Gerrard, Paul, and Robert Malcolm. “Mechanisms of modafinil: A review of current research.” Neuropsychiatric disease and treatment vol. 3,3 (2007): 349-64.

Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients vol. 11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362

Nobre, Anna C et al. “L-theanine, a natural constituent in tea, and its effect on mental state.” Asia Pacific journal of clinical nutrition vol. 17 Suppl 1 (2008): 167-8.

Giesbrecht, T et al. “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness.” Nutritional neuroscience vol. 13,6 (2010): 283-90. doi:10.1179/147683010X12611460764840

Sukumaran, Nimisha Pulikkal et al. “Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst - A review on its mechanistic aspects.” Complementary therapies in medicine vol. 44 (2019): 68-82. doi:10.1016/j.ctim.2019.03.016

Jongkees, Bryant J et al. “Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.” Journal of psychiatric research vol. 70 (2015): 50-7. doi:10.1016/j.jpsychires.2015.08.014

Nishioka, Kenji et al. “Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.” Hypertension research : official journal of the Japanese Society of Hypertension vol. 30,9 (2007): 775-80. doi:10.1291/hypres.30.775

source https://nootropicology.com/best-nootropics-for-flow-state/

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nootropicology · 2 years ago

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Cyclazodone: Everything You Need To Know [Benefits & Side Effects]

Cyclazodone is a CNS stimulant with amphetamine-like and antidepressant effects. Biohackers use it for better focus, energy & increased motivation (Cyclazodone is not meant for human consumption).

So I was doing some light research on a new potential Nootropic for a stack I'm currently trying to make and came across an interesting Smart Drug called; Cyclazodone.

One of the things that I find interesting about Cyclazodone is that the effects have been compared to those of amphetamine (but without all the negative side effects).

This, obviously, made me want to dive a little bit deeper into it - especially since people are reporting better focus, sociability, and elevated mood when they take this stimulant.

So in this article, I will take a closer look at the following;

What is Cyclazodone?

What does Cyclazodone do in the body?

What are the benefits and side effects?

Is Cyclazodone legal in your country?

What are people on Reddit saying about it?

.... So without further ado, let's jump straight to it!

What is Cyclazodone?

As I briefly mentioned in the beginning, Cyclazodone is a central nervous system stimulant with amphetamine-like effects with possessed anorexic efficacy.

The chemical name is; 2-(cyclopropylamino)-5-phenyl-1,3-oxazole-4-one. The molecular weight is 216.24 and the formula is C12H12N2O2.

Cyclazodone was first synthesized back in the '60s by an American company called; The American Cyanamid Company.

The idea behind Cyclazodone was to develop a safer CNS-stimulant to Pemoline and other similar derivatives.

Pemoline was used in the treatment of ADHD and narcolepsy but is no longer available in the US.

The FDA withdrew the approval of pemoline due to its negative side effects in children - some leading to liver failure.

Compared to Pemoline, Cyclazodone is a much safer CNS stimulant and closely related. That being said, it is only available for scientific research purposes in the US.

Cyclazodone is proven in clinical trials to be extremely effective as an energy booster in animal models with anorexigenic effects. It has unique features that set it apart from other sympathomimetic drugs with less stimulatory activity and toxicity compared to amphetamines.

youtube

What does it do in the body?

Cyclazodone is a 4-oxazolidinone stimulant that produces focus enhancing, wakefulness, and alertness effects.

Structurally it's very similar to 4-methylaminorex.

When it comes to how it affects the body we have very limited data available. However, it has been shown to be extremely effective for cognitive fatigue with its nootropic properties.

That being said, it is speculated that it likely possesses a hepatotoxic, negative impact on blood pressure, and other not-known toxic effects.

We do, however, have some animal models where Cyclazodone has been shown to exhibit powerful CNS and antidepressant effects.

It also possesses anorexic efficacy and potency and the toxicity of cyclazodone is low compared to other amphetamine-like agonists.

Cyclazodone impacts the TAAR1-receptor in the brain. TAAR1 is the main regulator of serotonin, dopamine, and noradrenaline.

This leads to the release of increased concentrations of these 3 neurotransmitters in the brain which in turn enhances cognition through better concentration, mood, and energy levels.

What are the benefits and side effects?

It's worth noting that most of the benefits and side effects experienced on Cyclazodone are anecdotal.

Since the data is limited I found some interesting reports on the Subjective Effect Index (SEI).

The Subjective Effect Index is basically just a huge collection of articles designed to serve as an in-depth reference work for the subjective effects people are experiencing when taking psychoactive substances.

Here's what people are reporting in terms of the Benefits:

Stimulating - Weaker than methamphetamine, but stronger than Modafinil and caffeine.

Cognitive euphoria

Appetite suppression

Pain relief

Anxiety suppression

Empathy, affection, and sociability enhancement

Here's what people are reporting in terms of the Side Effects:

Abnormal heartbeat

Nausea - only seems to occur when higher dosages are used

Teeth grinding- but less intense compared to amphetamines

Headaches - usually a sign of dehydration

Hypomania-like effects

The benefits it has on cognition is the main reason why people see Cyclazodone as a potent Nootropic with the only downside being the potential side effects.

In addition, when it comes to the toxicity and long-term use of Cyclazodone, we don't have any studies (and only very limited history of human usage) which are why the exact toxic dose is still unknown.

Is it addictive?

Given the similarities that Cyclazodone and amphetamines have, a question that comes to mind is if Cyclazodone has addictive properties or not.

Whenever it comes to amphetamine-like stimulants, addiction is always a serious concern.

Compared to Pemoline, Cyclazodone doesn't seem to show any addictive properties. That being said caution is always advised like it's the case with all monoamine agents.

It's worth noting that tolerance to the effects of it only seems to develop with prolonged use. Hence, why people need larger dosages in order to feel the effects.

If you stop taking Cyclazodone, it usually takes anywhere from 4 to 7 days for the tolerance to be reduced to half.

Cognitive and physical stimulation

Cyclazodone enhances cognitive performance and is used as a study aid.

One of the possible reasons why that might be is because of how it elevates arousal, energy, pleasure, and other positive stimulatory effects through TAAR1-receptors.

In addition to increasing focus, prolonging attention span, and improving memory recall, the positively stimulating effects from Cyclazodone can also be beneficial for those that suffer from fatigue, chronic exhaustion, and other forms of mental and physical lethargy caused by certain medical conditions.

Central Nervous System Stimulants

A central nervous system stimulant like Cyclazodone is often used to treat ADHD, narcolepsy, and other sleep disorders.

It's also used as an adjunct therapy for the treatment of obesity and smoking cessation.

Cyclazodone is a potent monoamine agonist that acts as a serotonin, dopamine, and norepinephrine releasing agent.

It has been shown to be anorexic, euphoric, and cognitively stimulating.

Cyclazodone is one of the most popular central nervous system stimulants on the market.

It's worth noting that the majority of studies done on Cyclazodone were in rats and mice, not humans.

In addition, due to the lack of safety data, it should be used with caution and only by those who are experienced with similar stimulants.

Dopaminergic Stimulant

A stimulant drug that increases the activity of dopamine in the brain is considered a dopaminergic stimulant.

The typical dopaminergic central nervous system is responsible for regulating movement, motivation, pleasure, and reward.

D Amphetamine, methamphetamine, cocaine, and methylphenidate are all examples of dopaminergic stimulants.

Cyclazodone is one of the more typical dopaminergic stimulants on the market.

It's worth noting that Cyclazodone, as well as amphetamines, have a high potential for abuse and should be used with caution.

Minimal Sympathomimetic Side Effects

When we're talking about the side effects of stimulants, one thing that comes to mind is how they affect your heart.

Since Cyclazodone acts as a mild sympathomimetic, it has the potential to elevate blood pressure and heart rate by increasing norepinephrine release.

Norepinephrine is the neurotransmitter responsible for regulating both energy levels and heart rate.

Because of this, it's always important to be aware of your individual tolerance and to monitor your vitals if you are taking Cyclazodone.

In general, Cyclazodone has a lower potential for abuse and causes significantly fewer adverse effects than other stimulants like amphetamines.

That being said, it does still retain some degree of risk, and caution is advised when using it.

Due to the lack of long-term safety data on Cyclazodone, it should never be used unless you have experience with similar agents.

Antidepressant efficacy

As briefly mentioned in the beginning, Cyclazodone is also an antidepressant.

While the mechanism of action is not fully understood, it's believed that Cyclazodone increases the availability of serotonin, dopamine, and norepinephrine in the brain by blocking their reuptake.

This can lead to a variety of therapeutic benefits such as increased energy, improved mood, and decreased anxiety.

Cyclazodone is a fast-acting antidepressant that can provide relief within hours of taking it.

It's also been shown to be effective for the long-term treatment of depression.

Again, it should be noted that Cyclazodone has not been studied in humans as extensively as other antidepressants like Fluoxetine (Prozac).

Is it legal in your country?

As is the case with most Smart Drugs, Cyclazodone is in a gray area when it comes to its legality.

This means that within certain parts of the world, its regulation is in a legal gray area, and in some areas, it is a banned stimulant (we don't know if it's illegal to possess or not).

That's why some people can be charged for their possession while others won´t.

What we do know, however, is that in 2006 the World Anti-Doping Agency banned its use and put it on The Prohibited List.

From what I could find, Cyclazodone is not a controlled substance in;

Germany

Switzerland

This means that it may in some instances be considered legal. In the US it's considered a Schedule IV controlled substance.

Read Also: My Favourite Nootropics

What people on Reddit are saying about Cyclazodone

I thought it would be interesting to find 1 or 2 threads on Reddit to see what people that are actually taking Cyclazodone have to say.

I have linked to each thread so you can go over and read it for yourself.

The first thread I found is by a user called; u/-redan.

Redan starts off by saying that Cyclazodone is pretty amazing. He recently tried it and was impressed by the focus enhancement.

That being said, he did notice an anxiogenic effect.

He then goes on to say the following;

"There's a noticeable mood lift, anti-anxiety effects, combined with strong focusing enhancement effects..."

He then finishes off by saying that tolerance buildup doesn't seem to be a problem with N-Methyl-Cyclazodone and the other related compounds.

Another user called; u/Engenderling is talking about the negative side effects of N-Methyl-Cyclazodone.

The thread is a pretty detailed explanation of his Cyclazodone use.

source https://nootropicology.com/what-is-cyclazodone-used-for/

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nootropicology · 2 years ago

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Cognizin Citicoline Guide: Everything You Need To Know

Cognizin Citicoline is a popular Nootropic that supports mental energy, focus and attention.

Hey guys!

In today's article we're going to take a closer look at a popular Nootropic called; Cognizin Citicoline.

Here are some of the topics we will be covering:

What is Cognizin Citicoline?

What are the side effects of citicoline?

Does it increase dopamine?

What are other people on Reddit saying about it?

.... So without further ado, let's just get straight into it.

What is Cognizin Citicoline?

Citicoline is a brain energizer linked to multiple cognition enhancing and neuro-regenerative effects, including support for focus, better attention and overall brain health. Recently, it's being used by biohackers as a Nootropic.

From a brain support standpoint, Cognizin Citicoline optimizes brain cells, mitochondria for healthy energy metabolism. It raises brain levels of neuro building phosphatidylcholine and supports the brain chemicals; acetylcholine, dopamine, and norepinephrine.

Cognizin Citicoline helps synthesize and repair brain cell membranes, and protects brain cells from the damaging effects of free radicals and aging.

Let's talk about Citicoline its Nootropic affects.

Citicoline is well known to energize the brain cells for peak cognitive performance and without the crash that is often associated with other stimulants (such as caffeine etc.)

It's an enhancer of mental focus, attention, and supports overall brain health and cognitive function. It may even help to improve mild age-related memory issues.

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How does it work?

Cognizin Citicoline is a single nootropic that boosts multiple pathways to optimize mental performance and whole brain health.

Human research has linked it to improvements in mental energy memory, attention, reaction time, concentration, and focus.

I have found 3 studies about Cognizin Citicoline here that shows:

How it Increases motor speed and attention in healthy adolescent males

How it increases Brain Energy (ATP) by 14% and Speeds up Formation of Brain Membranes by 26%

How citicoline improves memory performance

Let's take a look at how Cognizin Citicoline may help with brain health and mental performance.

From a brain energy perspective, Citicoline helps the brain generate electrical impulses by supporting proper function of mitochondria.

In one of the study I linked to above, they found that Cognizin Citicoline increased frontal lobe brain energy by up to 14%.

Citicoline has also been shown to stimulate phosphor, lipid synthesis and turnover, reflecting brain renewal and leading researchers to suggest Cognizin Citicoline may help to reverse certain age related changes to the brain.

As we can see from the 2nd study I linked to above, it suggests that Cognizin stimulates new brain cell formation by as much as 26% (it helps to form acetylcholine, which is associated with memory learning and mental processing).

Acetycholine declines with age and low acetylcholine is linked to brain degeneration.

What are the side effects of Citicoline?

From the studies I could find most of them confirm its safety.

That being said, there are in some rare instances where Citicoline is shown to cause mild digestive and nerve issues in the subjects.

Overall Citicoline is relatively safe with a low side effect profile.

What are the benefits & side effects?

As I have already mentioned in the beginning, the benefits experienced when taking Citicoline could be due to its effect on the brain function.

Citicoline plays an important role in mitigating the effects of memory loss.

Studies show that Citicoline helps people improve learning and enhances their attention span.

This is why people use it as a Nootropic. It leads to better focus and concentration.

From one of the study I linked to previously, it showed that Citicoline improves overall neuronal activity which in turn leads to a reduction in neuronal death.

So to summarize the benefits people are experincing using Citicoline, here's a list:

Enhanched mood - an overall sense of well-being

Better memory and more focused (not distracted by small things)

Steady, and sustainable, levels of mental energy without the crash

Does Citicoline increase Dopamine?

The short answer is; Yes it does.

Citicoline increases norepinephrine as well as dopamine in the brain.

It has also been shown to increase serotonin and acetylcholine.

I found a study here that shows the efficacy of Citicoline and how, mechanistically, it increases dopamine levels in the brain.

What's the right dosage?

When it comes to the right dose it usually depends on your goals and tolerance. Based on one of the study I linked to previously we can see the following:

A High Dose of Citicoline is: 500 mg/daily for 14 days

A Lose Dose of Citicoline is: 250 mg/daily for 14 days

I also found some anecdotes from Reddit where people take micro dosages (50-100 mg) and stack with other Nootropics such as

Fasoracetam

TeaCrine

... And other racetams for an enhanced cognitive effect.

As is the case with most Nootropics I always recommend starting out with a low dose and then gradually work your way up to asses the potential negative effects it may have on you.

Cognizin Citicoline comes in both powder form and capsules.

1 capsule is 250 mg and can be split into 2 dosages (125mg twice a day) when first starting out.

What Are People On Reddit Saying About Cognizin Citicoline?

The first thread I could find on Reddit is by a user called; Grizzled_Johnson.

He starts off by stating that he restored his dopamine system in just 2 days using Citicoline.

Grizzled_Johnson then goes on to say how he started watching porn from an early age (daily PMO) and how these quick dopamine rushes have depleted him.

You can read the entire thead here (it's an interesting read)

The second thread I could find is by a user called; u/arramire.

He starts off by asking if Cognizin Citicoline can negatively effect onces sleep.

He then goes on to say that he just recently started taking Citicoline in his stack and how he is experiencing trouble when it comes to falling asleep at night.

You can read the entire thread right here.

Where can I buy it?

Citicoline can be bought on most Nootropic websites.

That being said, I only have experience buying from NootropicsDepot. I haven't tried their Citicoline yet, but I get my Phenibut and Triacetyluridine from them and they are always high quality.

What I like about them, and the reason why I only buy from them, is that they lab test every single batch.

That way you know that the quality and purity of the batch is tested before you take it.

Their Cognizin Citicoline Powder comes in both 30gr and 60gr. You can find it here.

They also have 250mg capsules that come in 60ct and 180ct bottles. You can find them here.

The only downside I have experienced buying from NootropicsDepot is the delivery time.

I live in Europe and it usually takes anywhere from 8 to 13 business days for my package to arrive.

So keep that in mind if you're in a hurry.

I'm sure you can find a quicker shipping method at checkout if you're willing to pay extra upfront.

In Conclusion

Cognizin Citicoline is a brain energizer that supports mental energy, focus and attention.

It has been shown to have low side effects as well as a relatively high safety profile.

Citicoline is shown to increase dopamine levels in the brain which is why people are reporting an overall sense of well-being when taking it.

A safe dose is generally considered to be in the 100-250mg range.

It comes in both powder and capsule form and can be bought on most Nootropic websites.

source https://nootropicology.com/cognizin-citicoline-guide/

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nootropicology · 2 years ago

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Triacetyluridine Guide: What Are The Benefits & Side Effects?

Triacetyluridine, or TAU, is a nootropic that converts to Uridine in the body. It's proven to help alleviate the symptoms of depression by increasing dopamine levels in the brain.

If you've just recently come across Triacetyluridine you might have been wondering what exactly this relatively popular Nootropic is, what it does and if it has any potential side effects/benefits?

In this article I will take a closer look at the following topics:

What is Triacetyluridine?

What are the benefits and side effects?

What's the best dosage?

Can you stack it with other Nootropics?

What are people on Reddit saying about?

Where can you buy it?

... So without further ado, let's just jump straight to it, shall we?

What Is Triacetyluridine & How Does It Work?

As briefly mentioned in the beginning Triacetyluridine converts to Uridine in the body. Uridine is just one of the five standard nucleosides. The other four are;

Cytidine

Guanosine

Adenosine

Thymidine

When Triacetyluridine converts to Uridine Triphosphate in the body it can deliver up to 6 time as much uridine than just consuming uridine alone.

Uridine is a precursor of ribonucleic acid which supports healthy functioning of the central nervous system.

Clinically, Triacetyluridine is used in the treatment of fluorouracil overdose or toxicity. I found a study about Triacetyluridine right here where they show the efficacy in treating fluorouracil overdoses.

It's worth noting that Triacetyluridine received an FDA approval in 2015.

Triacetyluridine is found to activate the P2Y2 receptors in the brain. This study shows that the P2Y2R plays a neuroprotective role during inflammation in the CNS.

The reason why people are using Triacetyluridine as a Nootrpic is because it enhances functioning in synaptic connections and improves mitochondrial functioning.

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What Are The Benefits And Side Effects?

The data on potential benefits and side effects when taking Triacetyluridine is well documented.

From the studies I could find about Triacetyluridine here's what they show:

It alleviates symptoms of depression and bipolar disorder

It promotes an overall sense of well-being (enhances mood)

It has anti-inflammatory and neuroprotective properties

In terms of side effects I couldn't really find any conclusive evidence since Triacetyluridine is generally well-tolerated.

The reason being that Triacetyluridine converts to Uridine in the body. Uridine is found in breast milk and is natural compound produced in humans.

This is why the side effects are rare. However, I did find some cases where people have taken high doses and reported vomiting, nausea, and diarrhea.

What About Dosages?

From what I could find on various forums people take anywhere from 25 mg to 100 mg of Triacetyluridine.

A low dose is generally considered to be 25mg and 100mg is considered to be a high dose.

Triacetyluridine comes in both powder form and capsules. 1 capsule is 25 mg.

Some people report that even 12mg of Triacetyluridine is sufficient when stacked with racetams such as;

Fasoracetam

Coluracetam

Aniracetam

As is the case with most Nootropics, it's always a good idea to start off with a low dose to access its effects on your body/mental health.

If it's your first time trying Triacetyluridine I wouldn't recommend stacking it with other Nootropics either until you're 100% certain that it doesn't have any negative side effects.

Triacetyluridine vs Uridine Monophosphate

There isn't too much of a difference between Triacetyluridine and uridine monophosphate.

That being said Triacetyluridine is more potent and has a higher bioavailable when it comes to Uridine compared to Uridine Monophosphate.

Both supplements have the same effects and can take anywhere from 1 to 3 hours to kick in.

What Are People On Reddit Saying?

Triacetyluridin & Depression

The first thread on Reddit I could find is from a user called; u/utsukushii_rei.

Utsukushii says that he just recently bought Triacetyluridine and has been getting really great results but is curious to know if stacking it with anti-depressants is a bad idea.

He then goes on to say that after taking Triacetyluridine his memory is much sharper and his mood has improved quite a bit.

He then finishes off by asking the following question:

"My question is would combining my daily anti depressants be a bad idea?"

Triacetyluridin, when converted in the body, has a direct impact on serotonin and dopamine (so would make sense why he is asking this question.)

Utsukushii doesn't get any definitive answer from people in the thead, so I'll try to answer it here:

A good rule of thumb is to NEVER combine nootropics with SSRI's unless your doctor says otherwise. Do NOT play around with your brain chemistry.

Triacetyluridine vs UMP - Which One Is Better?

Another thread I found on Reddit is from a user called; u/jt2424.

He's starting out by asking which one is better; Triacetyluridine or Uridine Monophosphate?

He then goes on to say that he only has tried Triacetyluridine (he takes 25-50mg) which seems to make his mood better and more social.

A user called; FrigoCoder, is then replying saying that he prefers Triacetyluridine because the benefits are immediate and more noticeable.

FrigoCoder then goes on to say the following:

" I do not think I have ever benefited from Uridine Monophosphate. "

Triacetyluridine & Quitting Smoking

The last thread I could find, and an interesting one, is from a user called; U/srubek.

Interesting enough he is talking about Triacetyluridine and smoking.

He starts off by saying how he never though that he would quit smoking. He goes on to say the following:

"I was ruining my lungs and I was having so much trouble breathing. I had tried everything."

He then came across Triacetyluridine.

He took 25mg/day every morning and noticed how he could bear working with only 1 cigarette break.

U/srubek tried vaping but compared to Triacetyluridine (TAU), TAU never left him wanting cigarettes.

The then states the following:

"I was amazed. I still am, tbh. 1.5 years cigarette-free, and healthy af"

He then goes on to say that people from work have made comments about his skin quality (asking what he did).

"I appeared shiny, smooth, clear, healthy."

The thread is extremely detailed so if you're thinking about quitting smoking I can highly recommend reading the entire thread here (U/srubek is going into much more details).

Where Can I Buy Triacetyluridine?

You can find Triacetyluridine on most Nootropic websites. TAU is sold in both powder form and capsules.

I only buy from one vendor which is called; NootropicsDepot. The reason being they lab test their products to ensure high quality and purity.

They also have a lot of reviews from verified buyers which is always a good thing.

Their powder comes in 10, 25 and 50 grams. You can find it here.

They also have 25mg capsules - you can find them right here.

The only downside I have experienced buying from NootropicsDepot is the delivery time.

I live in Europe and it usually takes anywhere from 8 to 13 business days for my package to arrive. Keep that in mind if you're in a hurry.

That being said I'm sure you can find a quicker shipping method at checkout.

In Conclusion

Triacetyluridine is converted to Uridine in the body.

It is used as a nootropic because it boosts cognition and supports healthy functioning of the central nervous system.

People who take it are experiencing better mood and an overall sense of well-being.

A low dose is considered to be in the 25-50mg range.

A high dose is considered to be 100mg.

Triacetyluridine seems to be safe with low side effects.

It can be bought in both powder form and capsules on most nootropics websites.

Triacetyluridine is very similar to uridine monophosphate but is more potent and kicks in faster.

Lastly, some people use TAU to quit smoking.

source https://nootropicology.com/triacetyluridine-review/

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nootropicology · 2 years ago

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TeaCrine Guide: Everything You Need To Know Before Buying

TeaCrine (Theacrine) is structurally similar to caffeine and found in the kucha leaf. It helps in promoting wakefulness, focus and energy.

If you read yesterday's blog post you'd know that I briefly touched upon theacrine and its effects.

After watching a couple of videos about TeaCrine this morning I figured why not write an article about it going into details with what I didn't cover in yesterday's blog.

So that's exactly what I'm going to do today.

Here are some of the topics I will be covering:

What is TeaCrine® (Theacrine)?

How does it work?

Are there any benefits and/or side effects?

Can you stack it with other stimulants?

What about the dosage?

Where can you buy it?

What other people on Reddit are saying about it

.... So without further ado, let's just get right into it!

What Is TeaCrine® (Theacrine)?

As I briefly touched upon in the beginning, theacrine is a naturally occuring purine alkaloid found in the kucha leaf.

It is patented by a company called; Compound Solutions.

In yesterday's blog I wrote about a very similar compound called; Dynamine Methylliberine.

Dynamine Methylliberine is another of their trademarked compounds with similar effects asTeaCrine.

That being said, TeaCrine is a slower, milder compound with a longer duration than caffeine.

People who are taking TeaCrine experience better focus, mood, energy levels and motivation (without the jittery).

TeaCrine works synergistically with caffeine to enhance cognitive and physical performance without building a dependency on the compound.

A study even suggests that whenever supplementing with TeaCrine and caffeine, the bioavailability of TeaCrine is enhanced.

And the potency of it actually increases as well, which is quite fascinating.

According to Compound Solutions TeaCrine is an ideal supplement for anyone looking to increase their energy levels without increasing their heart rate or blood pressure.

It is the perfect non-stimulant compound that delivers powerful energy without the jitters or crash.

How Does It Work?

As briefly mentioned in the beginning, TeaCrine is similar to caffeine. The way TeaCrine works mechanistically is by regulating dopamine as an agonist as well as inhibiting adenosine.

Compared to caffeine, TeaCrine modulates the adenosine receptors which in turn decreases sensitivity. Caffeine however blocks adenosine receptors.

This is why you'll experience a lesser tolerance buildup when using TeaCrine compared to caffeine.

CompoundSolutions are going into details about it in this video:

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How Does TeaCrine Compare To Other Similar Stimulants?

If we compare TeaCrine (theacrine) to other stimulants like Dynamine Methylliberine and caffeine, what's unique about TeaCrine is that you'll experience:

Less tolerance buildup

The duration of the effects are longer

No crash and jittery

TeaCrine has a much slower onset and longer duration than both Dynamine Methylliberine and caffeine.

According to CompoundSolution TeaCrine takes anywhere from 3 to 6 hours to hit its peak followed by a steady peak for 3-5 hours.

This is why most people only take TeaCrine early in the morning (it lasts almost the entire day, depending on how much you take).

So if you're looking for a better alternative to Caffeine and Dynamine without all the side effects such as; jittery and crashes then TeaCrine is a great choice.

What About The Safety & Side Effects?

In a randomized, double-blinded crossover pilot trial, the researchers found that a 200mg dose of TeaCrine increased energy levels, reduced the feeling of fatigue and improved concentration in the subjects.

Interesting enough they found no side effects.

Here's what the researchers concluded:

"These preliminary data support the benefits of acute TeaCrine™ supplementation on subjective “energy” levels and some indices of mental performance."

It's worth noting that the study was 8 weeks of daily supplementation (200mg) and what they found was that it had no impact on ;

Blood pressure

The heart rate

Lipid profiles (cholesterol)

Liver, kidney and overall immune function

I have tried looking on various forums and sub-reddits and couldn't find anyone reporting any negative side effects.

According to the anecdotes and the study listed above, it seems to be extremely safe with no side-effects.

What's The Best TeaCrine Dosage?

Any information about TeaCrine when it comes to the right dose you should take is very limited.

That being said, if we follow the same dosages as used in the study I mentioned earlier then an effective dose would look like this:

A low dose: 50-100mg

A medium dose: 150-200mg

A high dose: 250-300mg

In the study they used 200mg. From the various anecdotes I could find people are using anywhere from 200 to 500mg.

500mg seems to be waaay over the top if you ask me. I would highly recommend starting out small and then work your way up.

It usually comes in both powder form and capsules. One capsule is 100mg and should be enough to provide long-lasting and jitter-free energy.

Even though it has a low tolerance buildup, most people take TeaCrine on and off (cycle in and out).

Remember that TeaCrine takes longer to kick in so be patient and careful not to take more than the recommended dose.

Where Can I Buy TeaCrine (Theacrine)?

Since TeaCrine is a legal supplement you can buy it pretty much anywhere on the internet.

I haven't tried it myself so I can't recommend a specific source. That being said I buy my phenibut, dynamine and other favorite nootropics from NootropicsDepot.

I haven't had any bad experiences with the guys over at NootropicsDepot and what I like about them is that they test every batch to ensure high quality and purity.

The only downside I have experienced buying from them is the delivery time which varies alot.

I live in Europe and it usually takes anywhere from 8 to 13 business days before I receive my package. So keep that in mind if you are in a hurry.

I haven't explored the different shipping methods on their website but I'm sure that if you're willing to pay extra for faster shipping, you can probably find a faster shipping method at checkout.

You can find TeaCrine on NootropicsDepot here.

What People On Reddit Say About TeaCrine (Theacrine)

The first thread on Reddit that I could find is from a user called; u/Disturbed83.

Disturbed83 is sharing his own 8 weeks experience with TeaCrine.

He starts off by saying that he has already gone through 2 bottles (1gram). The effects he experiences on/off are pronounced.

One thing that he notices is how there is no crash after discontinueing (he states that he feels less inclined to consume coffee the days after).

Disturbed83 is consuming 180-200mg of TeaCrine from NootropicsDepot which seems to be the sweet spot for him.

He finds that the anti-inflammatory and pain killing effects are real. He also briefly mentions that he has experienced an increase desire to exercise.

He then finishes off the thread by saying that he takes it first in the morning due to the long half-life (it can be difficult to fall asleep).

Another thread I found on Reddit is from a user called; u/JakeandOreos.

JakeandOreos starts off by saying that Theacrine has saved him from depression.

He then goes on to say that although Theacrine isn't perfect it lifts him out just enough to see some hope. He then states the following:

"Let me tell you, this stuff works..."

JakeAndOreos goes into details about him being depressed (winter time and a terrible breakup).

He takes 200mg and can feel the immediate effect it has on his mood or as he puts it:

"I feel the weight lifting off my shoulders."

JakeAndOreos then finishes off by saying that his hopelessness is almost completely gone.

In Conclusion

TeaCrine (Theacrine) is a natural and legal supplement similar to caffeine.

It is found in the kucha leaf and helps in promoting wakefulness, focus and energy.

TeaCrine is safe to take with low side effects and studies show that it has zero effects on the cardiovascular system.

It has similar benefits to caffeine but without the jitter and crash.

Lastly, an effective dose of TeaCrine is anywhere from 100 to 200mg/daily consumed in either powder form or capsules.

source https://nootropicology.com/teacrine-review/

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nootropicology · 2 years ago

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Primavie Shilajit: What You Need To Know Before Buying (My Experience)

Primavie Shilajit is a natural occurring compound found in the Himalayas. Shilajit is known to boost energy and testosterone levels.

Hey Guys!

If you've been in the Nootropic-space for some time you should know by now what Primavie Shilajit is.

If you don't, or you just simply want to find out more information about it, then this article is for you.

The information I share in this article will be based on my own personal experience and what the science says.

I will also try to see if I can find some anecdotes from people on Reddit to give a more nuanced picture of the benefits and side-effects that people are experiencing when taking Primavie.

Here are some of the topics I will be covering in today's article:

What is Primavie Shilajit?

How does it work?

How do you take it and how much should you take?

What are the benefits and side-effects?

What are people on Reddit saying about it?

Where can I buy it?

...... So without further ado, let's just jump straight to it!

What Is Primavie Shilajit & How Does It Work?

Primavie Shilajit is traditionally considered to be a divine medicine. It has been used for centuries in ancient cultures as a herbal for healing and vitality.

Due to its profound adaptogenic health benefits, and anti-aging powers, we have discovered (just recently) by combining this ancient knowledge with modern science that it derives its benefits by enhancing the upregulation of the collagen genes in our skeletal muscles.

This is why we can see that consumption Primavie Shilajit improves blood flow to the skin, testosterone levels in men, increases energy levels as well as supporting bone health.

I will talk more about the benefits later on in this article. But for now, let's just continue with some more background information.

Shilajit is a naturally occurring resin. A resin is just a solid substance from a plant.

It is found high in the Himalayan mountains as an organic substance containing a mixture of fulvic acid, minerals and other organic minerals.

It is then extracted and turned into an extraordinary Himalayan superfood and sold as Primavie Shilajit.

As I briefly stated above, Primavie Shilajit contains A LOT of different organic minerals. All of these minerals play a crucial role when it comes to improving our overall health.

Interesting enough it also has a profound effect on testosterone levels which I find fascinating.

I came across a randomised, double-blind, placebo-controlled clinical study where they measured the effects that Primavie Shilajit has on testosterone levels.

In the experiment they used purified Shilajit in healthy volunteers of age between 45 and 55 years.

What they found was that a treatment with Shilajit for 90 days in total, revealed that it has a significant effect on testosterone levels.

It increased total testosterone, free testosterone and dehydroepiandrosterone (DHEAS) compared with placebo.

You can find the study right here.

What Are The Benefits & Side Effects?

As I have already alluded to earlier Primavie Shilajit has a lot of benefits. I will list the benefits right below which will be a combination of what I could find in the literature as well as from my own experience.

The most commonly reported benefits are:

Improved sleep quality

Increased testosterone levels

Improved energy levels

Improved mood

Enhanced cognition (better focus, more alertness and mental energy)

In terms of side-effects I couldn't really find any conclusive evidence/anecdotes that found anything noteworthy.

My Personal Experience With Primavie Shilajit

I can definitely attest to the cognitive benefits that people are reporting experiencing when taking Primavie Shilajit.

I ordered the 30gr powder from NootropicsDepot and have been using it for 9 days now.

Although it's only been 9 days one of the things that I noticed almost instantly (could be placebo though?) is the effect it has on my mood.

I think it's safe to say that I'm a person that tends to be on the more 'neurotic side' of the spectrum (dealing with social anxiety etc.).

What I have found is not that Primavie Shilajit has a 'calming effect' on me per se but it gives me the mental and physical energy to get stuff done.

It's hard to describe but I feel like it gives me a subtle drive and groundedness to make things happen as well as an overall sense of well-being which especially has helped me out at social events.

The benefits I experience taking Primavie Shiljit is very similar to the benefits I get on Ashwagandha.

So to summarize, here's the benefits I personally have experienced taking Primavie Shiljit

I have way more mental energy (I can think clearly and my memory has improved)

I feel a subtle 'groundedness' that has been EXTREMELY useful in social situations (dealing with social anxiety)

I have noticed positive improvements in terms of mental- and physical energy (I want to make things happen)

I feel less fatigued at the end of the day

In terms of fatigue, one thing that I have noticed is that I'm not mentally exhausted in the evening anymore.

This is the benefit that actually has been the most noticable.

I work a 9-5 job and will usually be exhausted by the time I get home. To put this into perspective I usually try to write an article for Nootropicology early in the morning because I know writing in the evening is a no-go for me.

After taking Primavie Shiljit I have actually changed my schedule. I now only write in the evening which is a HUGE deal for me.

Keep in mind I have only used it for 9 days so the benefits I have experienced thus far could just be a placebo effect, but whocares if it works, right :-)?!

Primavie Shilajit And Weight Training

Since I don't really work out anymore I can't give you guys an in-depth insight to the effects it has on weight training.

That being said, I did find a couple of YouTube videos with people who are doing weight training and using Primavie Shilajit.

The first video I could find is from a guy named; Tiger Fitness. He almost has 400k subscribers.

Here's what he's saying about Primavie Shilajit its effects on training, testosterone and libido:

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Another guy called; The Nootropic Republic is sharing his own experience with Primavie Shilajit here:

youtube

The Nootropic Republic is basically saying how great of an impact Primavie has had on his exercise performance.

He then goes on to say that it has been shown to help you lift more in the gym. Whether you want to improve your bench, squat, deadlift etc. Primavie can have a beneficial effect on those goals.

He then goes on to say that he personally can notice a difference in his lift as well as feeling more powerful or 'dynamic' as he puts it.

He finishes off by saying that his recovery in the gym is shorter and how Primavie has helped improve his muscle density and muscle strength.

I would imagine that Primavie could help with the pump as well since it's proven to increase blood flow to the muscle (one of you guys would have to test that out for yourself and report back to me).

Read Also: What is Dynamine Methylliberine?

How Do You Take It & What Does It Taste Like?

A question I often see on forums is; What does Primavie Shilajit taste like? First off, it's important to note that there are different grades of this compound.

Typically the darker powders are stronger in flavor with a somewhat 'earthy' bitter taste.

The powder I bought doesn't have that strong of a taste. That being said it does taste a little weird, but it's something you get used to.

This might not sound appealing for most of you guys but whocares, it's a 'superfood' so I just chug it down.

The way you take Primavie Shilajit is by blending it into hot drinks, shake or just put it in a glass of water and chug it down.

That being said, Primavie Shilajit is traditionally consumed with raw milk in parts of North India, Pakistan, and Nepal.

For those of you who don't enjoy the taste of the powder Primavie Shilajit can be consumed as capsules as well.

What's The Right Dosage?

As is the case with most Nootropics and supplements the dose you should take really comes down to your personal goals, body weight and tolerance.

That being said from the information I could find online prior to buying it, a regular dose is 250 mg once a day which is equivalent to 1 capsule if you buy Primavie Shilajit from NootropicsDepot.

I personally started out with 125mg (half a capsule) to measure any potential side-effects. I didn't notice anything and gradually increased my daily intake to 2 capsules (500mg) which seems to be the sweet-spot for me.

It's impossible to overdose on this mineral powder and it is known to be safe, to consume over a long period of time.

It should, however, be avoided when pregnant and it's always a good idea to get the advice of your healthcare provider when taking any supplement.

Where Can I Buy It?

Since Primavie Shilajit is a natural compound you can find it pretty much anywhere on the internet.

It comes in both powder form and capsules.

I only have experience buying Nootropics from NootropicsDepot.com. The reason being they lab test their products to ensure that each batch is high in quality and purity.

The only downside I have experienced buying from NootropicsDepot is the delivery time which varies a lot.

I live in Europe and it took 9 business days to arrive using the standard shipping method.

What Do People On Reddit Say About Primavie Shilajit?

I came across a couple of interesting threads on Reddit. One in particular caught my eyes.

I thought it would be a good idea for me to share everything here. Hopefully you guys, like me, get some value out of this.

The first Reddit thread I found is from a user called; u/Bobz216.

He starts off his thead by stating that Primavie Shilajit is NOT some snake oil.

Bobz216 then goes into his own personal experience with the mineral. The first thing he has noticed after taking Primavie Shilajit for a couple of days is the boost in cognition. He says:

"I have been taking shilajit for a couple days now, and notice an immense boost in my cognition and energy.."

Bobz216 has bought his Primavie Shilajit from NootropicsDepot which is purified (it doesn't put him in risk of heavy-metal poisening).

Interesting enough he also talks briefly about its altering effects;

"This substance exhibits strong subjective feelings and a sense of altered consciousness..."

Like myself, Bobz216 has noticed his lethargy is reduced greatly and energy is increased. He also states that the energy he gets from Primavie Shilajit feels 'natural' unlike caffeine etc.

Bobz216 also notices the effects on his libido or as he puts it:

"My sex drive, which has been an issue for me in the past thanks to PSSD from Lexapro, seems to have increased greatly as well. "

He then goes on to say that he feels more 'in the moment' when he has sex as well as lasting longer.

Bobz216 states that he has OCD and how effective Primavie Shilajit has been on his logical thinking. He finds his inner voice to be 'clearer' and is able to differentiate between obsessive and rational thoughts.

He finishes off by saying that he bought Primavie Shilajit not under the impression that it was going to exhibit any psychoactive effects (he bought it for the purported sexual effects) but was pleasantly surprised by the mental benefits he experienced on it.

In Conclusion

Primavie Shilajit is a natural occurring herb found in the Himalayas.

Shilajit is known to boost energy and testosterone levels as well as libido.

People are reporting increased energy levels, better focus, more clearity and vitality consuming it with no side effects.

From my own experience I can attest to the fact that Primavie Shilajit has had a profound effect on my mental health.

I have experienced more mental- and physical energy. A subtle groundedness that has been extremely beneficial in social situations.

Primavie Shilajit is legal and can be bought from most Nootropic Vendors online.

source https://nootropicology.com/primavie-shilajit-review/

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nootropicology · 2 years ago

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Dynamine Methylliberine Guide: What You Need To Know Before Buying

Dynamine Methylliberine is a natural alkaloid that is similar to caffeine that helps boost mental alertness, focus and energy levels.

I came across an interesting Nootropic a couple of days ago. Or I shouldn't really call it a Nootropic since it's a natural alkaloid that is similar to caffeine but you know the drill.

I LOVE caffeine in the morning but absolutely HATE the fact that it makes me jittery.

So the thought of buying a Nootropic that potentially is similar to caffeine but without the side-effects is extremely interesting to me.

But before we dive into what Dynamine Methylliberine is I should add that I have NOT bought Dynamine just yet.

This article is meant to be a resource for everything Dynamine and is basically me trying to find as much information about the Nootropic as possible before I decide whether I want to buy it or not.

I figured it would be a good idea to dump everything I can find onto one page in the hopes that maybe some of you guys reading this would find it useful as well.

Anyways, I will start out with some basic information about it, then try to see if I can find some studies on PubMed and then finish it off with some anecdotes from people on Reddit who have tried it.

Here's what we will be covering today:

What is Dynamine Methylliberine?

What are the benefits and side effects?

How much should you take?

Can you stack it with other nootropics?

What other Reddit users are saying about Dynamine Methylliberine

So without further ado, let's get started!

What Is Dynamine Methylliberine?

Like caffeine, Dynamine is derrived from xanthine. Xanthine is a purine base that occurs naturally in our bodies.

What is different about Dynamine Methylliberine is that it's more powerful than other Xanthines and have a stronger impact on mood and energy levels.

From what I could find about Dynamine Methylliberine it's clear that if you take it by itself without stacking it with other nootropics the effects are relatively short-lived and aren't as intense as caffeine.

So be aware that if you're an avid coffee drinker like myself, the effects of Dynamine Methylliberine can be pretty lackluster compared to pure caffeine.

That's why some people on Reddit are recommending using Dynamine as a pre-workout supplement if you're training late in the evening.

Like other Nootropics the way Dynamine works is by activating receptors in the brain that are responsible for regulating adenosine receptors which have a direct impact on our feelings, mood and energy levels.

youtube

A guy from NootropicsDepot talks about Dynamine Methylliberine

What Are The Benefits & Side-Effects?

One of the downside with Dynamine is that there are very limited information about it since it's a relatively new Nootropic.

That being said I found an interesting study here looking at the safety & side-effects of short-term use with Dynamine Methylliberine alone and stacked with theacrine in healthy young adults.

This is the first study to look at the effects of Dynamine Methylliberine when taken alone and stacked with another nootrpic.

They measured heart rate, blood pressure, ECG and did blood work on the test subjects.

What they found was taking 100-150mg of Dynamine daily by itself or stacked with theacrine (25-50mg) had ZERO negative impact on health markers.

That being said the authors of the paper acknowledge that there are limitations to their research which they go more into details with right here.

In terms of benefits, here's what people say they experience when taking Dynamine:

They get 'a clean energy' like caffeine but without making them jittery

Dynamine Methylliberine kicks in faster and is more short-lived than caffeine

People report an overall enhanced mood, better focus and steady, clean energy

Can You Stack Dynamine Methylliberine With Caffeine?

Taken by itself Dynamine is a mediocre Nootropic at best. Stacking with caffeine however, is a totally different ball game.

When combined with caffeine is where Dynamine really shines.

Dynamine acts as a negative allosteric modulator on adenosine receptors with less tolerance buildup than caffeine (caffeine blocks adenosine receptors).

What this means is that Dynamine enhances the effects of caffeine by allowing a smaller amount of caffeine to block these receptors.

One great thing about this is that if you're looking to enhance the benefits and effects of caffeine (but without the need of taking more) you can stack a low dose of caffeine with Dynamine.

This also prevents all the negative side-effects that are associated with consuming too much caffeine (jittery being the big one).

I found a study on Pubmed showing that when you stack Dynamine Methylliberine with Caffeine it can extend the half-life of caffeine, which is pretty interesting.

What's The Best Dosage?

I couldn't really find anything conclusive when it comes to the right Dynamine Methylliberine dose to take.

That being said if we look at the study I posted above we can get a good sense of what an effective and safe dose would look like.

In the study they used the following dosages:

100mg of Dynamine

150mg of Dynamine

Dynamine stacked with TeaCrine (100mg Dynamine + 50mg TeaCrine)

Dynamine stacked with TeaCrine (150mg Dynamine + 25mg TeaCrine)

Dynamine Methylliberine comes in both powder and capsules. One capsule is 100mg which I would consider a low-dose.

On NootropicsDepot they recommend taking 1-2 capsules a day (100-200mg/day).

What Reddit Users Say About Dynamine Methylliberine

The first thread I could find on Reddit is by a user called; u/RevonM. The original post is just a short simple question where he asks people for more information about Dynamine.

What's interesting however, is the responses he gets in the thread.

One user says that he has tried Dynamine + Caffeine + Theanine and it has worked really well for him. He goes on to say that the Dynamine Methylliberine itself was the first thing to kick in or as he puts it:

"The Dynamine itself (Methylliberine) is the first thing that kicks in (really quickly) and was tremendously stimulating but no jitters."

The initial kick he got was then replaced by a 'stable energy' as he puts it. Which he says is probably due to the effects of caffeine and theanine.

He finishes off by saying that he hasn't tried Dynamine Methylliberine by itself but would be interested in testing it out.

Another Reddit user is sharing his first impression of Dynamine here.

He starts off by saying that prior to taking Dynamine he has had a 'pretty poor night of sleep".

He then decides to take Dynamine with Yerba.

The result surprised him.

A few hours after taking it he describes that he feels incredibly alert, motivated and focused. He goes on to say:

"There's definitely a dopaminergic feel to it...."

He then finishes off by giving an update after a few weeks saying that he has been taking Dynamine Methylliberine regularly and how pleased he is.

He then describes that he has experienced a slight tolerance buildup which is to be expected.

In Conclusion

Dynamine Methylliberine is a relatively new Nootropic with very limited information about it available.

Most of the data we have is from one study and anecdotes from people on Reddit and forums.

In terms of benefits taking Dynamine, people report that they experience better focus, get more energy and are more motivated.

When it comes to the safety profile of Dynamine Methylliberine, based on the study and anecdotes from people who have used it, it seems to be relatively safe with no side-effects.

Lastly, a low and safe dose of Dynamine is considered to be in the range; 50-100mg.

source https://nootropicology.com/dynamine-methylliberine-review/

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nootropicology · 2 years ago

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Emoxypine Succinate: All You Need To Know (Benefits & Risks)

Emoxypine Succinate is used as an Anxiolytic and is similar to pyridoxine which is Vitamin B6. Studies show that Emoxypine is effective in normalizing the sleep-wake cycle and promoting enhanced cognitive function with low side effects.

So recently I came across a rather interesting Nootropic called; Emoxypine Succinate, or Mexidol, on Reddit. Let's take a closer look at it, shall we?

Here's what we will be covering today:

What is Emoxypine Succinate?

How does it work?

What are the benefits and side effects?

How much should you take?

What other Reddit users are saying about Emoxypine

So without further ado, let's just jump straight into it.

youtube

What Is Emoxypine Succinate?

Emoxypine is an Anxiolytic when used as the succinate salt.

It has a similar structure as pyridoxine which is a type of Vitamin B6.

Emoxypine was first synthesized in Russia by a company called, PharmaSoft.

Though it isn't approved for any particular medical use in the EU and the US, it is widely used in Russia.

According to this study, we can see that it shows promising results as an Anxiolytic.

Scientists observed an antidepressant effect as well as neuroprotective and anti-inflammatory action.

Other studies suggest that Emoxypine may improve blood circulation in the brain as well as being cardioprotective.

What is the half-life for Emoxypine?

When taken orally (the succinate salt form) it has a rapid onset and short half-life at around 3 hours.

Because it's a slow-release drug, it may have a longer half-life in the body than with some of the other more fast-acting nootropics.

How Does It Work?

There is a general consensus that Emoxypine's mechanism of action is believed to be its antioxidant and neuroprotective abilities.

The information we have about Emoxypine is very limited.

This is what I could find:

Emoxypine inhibits free radicals and increases antioxidant enzymes (helps with learning and memory processes)

It blocks the formation of leukotrienes

It modulates/enhances GABA and acetylcholine receptors in the brain

Helps with metabolism and blood supply (blood cells) as well as membrane structures (structural and functional organization)

Helps with receptor complexes (has membrane protective effects)

Impacts lipid-protein ratio

It has also been shown to improve cognitive function in patients with Alzheimer's disease.

What Are The Benefits & Side Effects?

As briefly mentioned above Emoxypine seems to be very effective when it comes to certain types of conditions.

These conditions are:

Anxiety

Restores behavioral disorders

Acute alcohol intoxication

Inflammation

Neurodegenerative diseases

Since it inhibits free radicals in the brain it would make sense why it is seen as neuroprotective.

Mexidol ® (Emoxypine)

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Helps with neurological problems

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In the studies I linked to previously we can also see how effective it was on the participants, normalizing their behavior following stressful events.

Here's what one study concludes:

"The most pronounced anxiolytic action was observed upon the administration of emoxypine."

It also seems to have Anti-inflammatory effects by blocking leukotrienes from forming.

This study demonstrates the efficiency and how it diminishes the magnitude of a systemic response.

What's The Right Dosage?

From what I could find on Reddit people take anywhere from 50mg to 2grams.

2 grams seems to be pretty over the top if you ask me. I always recommend taking a smaller dose in the beginning and then gradually working your way up.

The Succinate Powder comes in 10 and 30 grams. As for the capsules, you can get 60 or 120pills. One pill is 125mg.

As a rule of thumb, I always start out with the lowest dose possible which in this case is 125mg (1 capsule).

Membrane-Bound Enzymes

As I alluded to earlier, Emoxypine has been known to help with membrane-bound enzymes.

These are proteins that act as catalysts for biochemical reactions in cells.

They recognize the substrate and bring them to the "active site".

Their structure determines their function which is why membrane-bound enzymes are very important for cellular processes.

There are 3 kinds of enzymes:

Integral Proteins (they're attached to the membrane)

Peripheral proteins (attached to integral proteins)

Transmembrane Proteins (connected with the lipid bilayer)

Blood Cells & ATP Production: Metabolism and Blood Supply

Adenosine Triphosphate (ATP) is the main molecule that powers biochemical reactions in cells.

It also plays a role within erythrocytes.

Red blood cells are responsible for transporting oxygen throughout arteries and veins of the body.

Emoxypine helps with the production of ATP which is crucial for all organisms including plants.

This is because ATP powers metabolic reactions that occur throughout the body.

When it comes to cellular processes, the more efficient a cell's metabolism - the more active it will be and live longer.

A quick example: a cell that is not metabolically active will die without having been given any hormonal stimuli from outside sources.

What is emoxypine good for?

This chemical has purported antistress and anxiety effects. It has been found to improve brain blood circulation by blocking thrombolysis, inhibiting cardiovascular function, lowers high blood cholesterol, vascularity, and anti-aging functions.

What is Mexidol used for?

This is a related drug that is used for the treatment of strokes, brain injuries, and other conditions. It has been shown to improve memory and cognitive function.

Conclusion

Overall, Emoxypine Succinate is a very promising compound with a wide range of benefits.

From anxiety, receptor complexes, free radical oxidation, anti-stress, and restoring behavioral disorders - it has been seen to have a therapeutic effect in many areas.

As for the right dosage, I always recommend starting out with the lowest dose possible, and then gradually working your way up.

The powder comes in 10 and 30 grams and the capsules come in 60 or 120pills. Each pill is 125mg.

Mexidol ® (Emoxypine)

Editor's Rating: 4.8/5

Powerful antioxidant and antihypoxic activity

Helps with neurological problems

Effective for withdrawal syndrome

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source https://nootropicology.com/emoxypine-succinate-review/

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nootropicology · 2 years ago

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Fasoracetam: Everything You Need To Know Before Buying

Fasoracetam is a cognitive enhancer. It belongs to the racetam family and helps in preventing memory loss, reduce symptoms of depression and gives a nice clean brain boost / alertness.

So like it's always the case I did some research on new potential Nootropics last week. I was trying to find a new potent compound to add to my stack.

I came across a relatively new Nootropic called; Fasoracetam which I will take a closer look at in this article.

As I'm writing this I have ordered 5 grams of Fasoracetam and will test it out right when I get my package.

I will keep this article updated and share my own experience with Fasoracetam, what it does for me, what benefits/side effects I experienced and so on (you know the drill).

Here's what we will be covering today:

What is Fasoracetam?

How does it work?

What are the benefits and side effects?

How much should you take?

What other Reddit users are saying about Fasoracetam

So without further ado, let's just get straight into it.

What Is Fasoracetam?

As briefly mentioned in the beginning, Fasoracetam is a powerful cognitive enhancer that belongs to the racetam family.

For the geeks out there, like myself, you can also find Fasoracetam under the more technical names such as; NS-105, LAM-105, and NFC-1.

To give you guys some quick background information Fasoracetam was first made back in the 90's.

The idea behind this Nootropic was to create a compound that would help treat dementia.

The company behind Fasoracetam spent over $150 million developing this Nootropic, allegedly, which later failed miserably.

From the information I could find, Fasoracetam failed the phase 3 clinical trials back in the day due to lack of efficacy.

Fasoracetam was pretty much a 'forgotten' Nootropic until 2012 where the interest was revived.

A company called Aevi Genomic Medicine began clinical trials in 2015 in adolescents with depression, anxiety and ADHD.

I tried to find some more information about how far in the process they are and found this study where it states that Fasoracetam is currently in phase 2 clinical trials.

youtube

How Does Fasoracetam Work?

If you're familiar with other racetams, you'd know that the exact mechanism of action is not fully understood.

That being said we do have some information available (and a few studies) where scientists hypothesize, and test, how it works.

From one study I could find here's how Fasoracetam works:

It increases acetylcholine production

It increases the uptake of choline

It increases GABA-receptors in the brain

The study suggests that Fasoracetam also activates certain types of glutamine receptors

If you're curious to know more about these potential benefits I have listed above you can find the study here that goes more into details about the mechanism of action.

What Are The Benefits?

Before I talk about the potential benefits of Fasoracetam it's worth noting that we don't really have any conclusive evidence available when it comes to the benefits.

Most of the research and experiments are done on rats.

That being said, we do know that it is a relatively safe and non-toxic Nootropic.

So keep in mind that the benefits and side-effects I will talk about here are purely based on anecdotes and my own experience (once I get my Fasoracetam).

From the information, and anecdotes, available online here are the benefits I could find:

Fasoracetam May Prevent Memory Loss

Going through one of the studies I linked to in the beginning an interesting thing I noticed is that fasoracetam was reported to prevent memory loss.

Although only tested in rats, scientists noticed that it reduced amnesia which would make sense since it increases acetylcholine and reduces GABA-B activation.

Acetylcholine is an ester of choline that serves as a transmitter of nerve impulses.

It May Help With Depression

High levels of GABA in the brain have been linked with specific mental disorders.

The two most common disorders are;

Depression

Anxiety

In this animal study we can see that fasoracetam helped in reducing symptoms experienced when dealing with depression and anxiety.

The experiment was a 'shuttle-box test' which basically is a 'learned helplessness test'.

What the scientists discovered administrating Fasoracetam repeatedly was that it reversed the failure to escape in the shuttle-box test.

The rats in this experiment were previously exposed to an inescapable footshock which makes the outcome that more interesting.

Here's what the scientists concluded from the experiment:

"These findings suggest that NS-105, which lacks an effect on monoaminergic systems, has potent antidepressant activity, which may involve up-regulation of GABA(B) receptors after repeated administration."

Source: https://pubmed.ncbi.nlm.nih.gov/20655491/

What People On Reddit Say About Fasoracetam

In terms of cognitive enhancement, creativity and just an overall boost in brain performance, I couldn't find any conclusive evidence/studies that would support these claims.

However, I did find a lot of personal experiences from people on Reddit which is EXTREMELY fascinating.

A user called; u/xXCsd113Xx3 talks about how Fasoracetam has changed his life. You can read the entire thread here.

Basically what he talks about in the thread is that he's been experimenting with Fasoracetam.

The positive results he got using it daily prompted him to write the review.

He bought a bottle from Nootropics Depot.

When he started taking Fasoracetam he knew it was something different from the get-go.

He describes how his body started to tingle, words came into process faster.

Most noticable was the effect Fasoracetam had on his anxiety.

His anxiety that constantly was lurking in the background was completely gone or as he says;

"It felt as though I had finally been released from a prison cell."

Again, if you want to read his entire experience with Fasoracetam click on the link above, it's an interesting read.

Another Reddit user called; u/SpacePirateIo talks about what he experienced using Fasoracetam and how it has become his new favorite Nootropic.

Here's what he experienced in his own words:

Effects of Fasoracetam kick in after 5-10 minutes

Greatly increased mood & anxiety significantly decreased

Does not make me feel more depressed after effects wear out

My baseline anxiety/general sense of well being has increased

I am a bit more focused/stimulated

Talking with people is easy, and I'm not fearing what I say, or over analyzing everything

My desire for people's validation is almost eliminated while on Fasoracetam

Does Fasoracetam Have Any Side Effects?

Like it's the case with most Nootropics, Fasoracetam has potential side-effects. It's worth noting that it is a new Nootropic so the data is limited.

That being said most of the negative side-effects people are reporting are;

Headaches

Dry mouth

Fatigue

The side-effects however, seem to be dose depended. An overdose report details how a 27-year old man ingested well over 1000 mg fasoracetam stacked with Phenibut.

The outcome of overdosing was bradycardia which is basically a condition where the heart rate slows down to 60 beats per minute.

In terms of 'normal use' of Fasoracetam I couldn't find anyone reporting any negative side-effects.

What's The Best Dosage?

In terms of an effective dose, it really comes down to your own personal goals as well as body weight.

If we take the information in the studies I have listed throughout this article we can see that most of the doses used were; 100, 200 and 400mg taken multiple times a day.

From the Reddit threads we can see that most people take anywhere from; 10 to 800 mg.

The dosage depends on if you buy in powder or capsule form. Fasoracetam can also be taken sublingually (under your tongue) in a dose that ranges anywhere from 10 and 20 mg/daily.

Given that there is such a huge difference in the doses it’s hard to make any conclusions about what dose you should take.

I always recommend starting out with a low dose and then gradually work your way up.

Where Can You Buy Fasoracetam?

It's is a legal racetam which means that you can find it on most websites selling Nootropics.

I personally only buy from NootropicsDepot. I usually receive my packages within 10 business days.

What I like about them is that they lab test their products to ensure the quality of their products.

I have ordered from a couple of other Nootropic Vendors in the past but none of them came even close to the guys over at NootropicsDepot.

The only downside to NootropicsDepot is their delivery time which varies a lot (depending on where you live in the World ofc).

If you want to give them a try click here.

source https://nootropicology.com/fasoracetam-review/

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