#Angiogenesis

[bpod-bpod]

Sugar and Sprouts

Love sugar? Too much can damage your blood vessels, increasing your risk of diabetes and cardiovascular disease. Love artificial sweeteners? Unfortunately, they too may increase your risk of cardiovascular disease. Researchers investigated in zebrafish embryos. Fluorescence microscopy revealed exposing embryos to lots of sugar or artificial sweeteners caused excessive blood vessel sprouting (angiogenesis) along the length of the body (pictured) – a process linked to diabetic complications in humans, including cardiovascular disease. Looking closer at embryos exposed to artificial sweeteners, they found cells lining their blood vessels (endothelial cells) developed into cells that promote sprouting. Analysing the RNA of these cells revealed changes in gene activity, notably reduction of one, Foxo1a (highlighted in red in the vessels along the fish embryo), was underlying the increase in sprouting when the embryos were exposed to sugar. Further experiments confirmed activity of this gene played the same role in embryos exposed to artificial sweeteners, uncovering how these sugar alternatives can negatively affect blood vessels.

Written by Lux Fatimathas

Image from work by Xiaoning Wang, Jinxiang Zhao and Jiehuan Xu, and colleagues

Affiliated Hospital of Nantong University, Nantong Laboratory of Development and Diseases, School of Life Science; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

Image contributed by the authors under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence

Published in eLife, October 2024

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[cardiologyucg]

Track 4 : Vascular Biology CALL FOR ABSTRACTS: - " Join us as a Speaker/Poster/Listener submit your abstract now at the CME/CPD accredited 5th world cardiology and cardiovascular diseases conference from October 15-17, 2025|Dubai,UAE  Submit Now: https://cardiology.utilitarianconferences.com/submit-abstract The abstract submission deadline is January 31st, 2025 #Cardiology #InterventionalCardiology #VascularBiology #Angiogenesis #EndothelialCells #VascularRemodeling #BloodVessels #VascularHealth #CardiovascularResearch #VascularInflammation #EndothelialDysfunction #SmoothMuscleCells #VascularDisease #MolecularCardiology #VascularTherapeutics #VascularRegulation

[austin-kai-12]

Call For Abstract Track 4: Vascular Biology Join us as a Speaker/Poster/Listener submit your abstract now at the CME/CPD accredited 5th world cardiology and cardiovascular diseases conference from October 15-17, 2025|Abu Dhabi, UAE  Submit Now: https://cardiology.utilitarianconferences.com/submit-abstract The second round submission is April 16, 2025.

[globalstemcellcare]

HOW DOES STEM CELL THERAPY SLOW DOWN THE SYMPTOMS OF LUNG DISEASE?

https://shorturl.at/ivPRW

Stem cell therapy has emerged as a promising avenue for slowing down the symptoms of lung diseases, offering innovative solutions beyond traditional treatments. This groundbreaking approach taps into the regenerative potential of stem cells to address various aspects of lung diseases, providing a multifaceted impact on the progression of symptoms. 

The combination of regenerative, anti-inflammatory, and immunomodulatory effects of stem cell therapy contributes to an improvement in respiratory function. This can result in a reduction of symptoms such as shortness of breath, coughing, and fatigue, ultimately slowing down the progression of lung diseases.

[budandtender]

Endocannabinoids can potentially modulate the formation and progression of cavernomas, as they affect cell proliferation, migration, survival, and VEGF expression. They can exert anti-inflammatory effects, making them a potential target for cavernoma treatment. 🤔

[bpod-bpod]

More or Less

After a heart attack, growing new blood vessels (angiogenesis) is essential to repair the damage. In cancer patients, preventing blood vessel growth can starve a tumour and prevent expansion. To investigate the effectiveness of potential new treatments to boost or block angiogenesis, researchers have developed a platform for testing the impact of various interventions on sprouting – the formation of new vessels from existing ones. They confirmed that cells lining the aorta – the body’s largest artery – sprout more in low oxygen conditions (pictured, right) than normal (left), showing the platform can support normal blood vessel growth patterns. They then screened 105 molecules and identified two enzymes that alter gene expression to regulate this vessel sprouting – one promoting growth and the other restricting it. This both provides promising information about these potential stop and go interventions, and provides a green light to screen future drugs.

Written by Anthony Lewis

Image from work by M. Beter and colleagues

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Scientific Reports, January 2025

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[soul-of-rei]

i just began playing memory from undertale and it started Raining heavily .i am god

[liuisi]

okay so it's 7 pm and i've done. the first point. hm

okay things i have to do today:

finish reading and taking notes on the article for our comms presentation

watch last week's (lol) toxico class

read the articles for my internship + start writing a summary

do at LEAST two chapters of psychopharmaco

[covid-safer-hotties]

Reference archived on our website

Another study showing what we call recovery from covid may not actually be recovery. Mask up. Stop covid in its tracks.

Background: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome.

Methods: PCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis of the plasma proteome. A prospective cohort of 66 unvaccinated and 24 vaccinated persons with different degrees of infection severity were evaluated acutely (within 40 days of symptom onset), and at three and ten months. Comparisons based on vaccination status alone and unsupervised hierarchical clustering were performed. A second cohort of vaccinated Omicron patients were evaluated acutely and at ten months.

Results: Acutely, unvaccinated patients manifested overexpression of proteins involved in immune and inflammatory responses, while vaccinated patients exhibited adaptive immune responses without significant inflammation. At three and ten months, only unvaccinated patients had diminished but sustained inflammatory (C3b, CCL15, IL17RE) and immune responses (DEFA5,TREM1). Both groups had underexpression of pathways essential for cellular function, signaling, and angiogenesis (AKT1, MAPK14, HSPB1) across phases. Unsupervised clustering, based on protein expression, identified four groups of patients with variable vaccination rates demonstrating that additional clinical factors influence the plasma proteome. The proteome of vaccinated Omicron patients did not differ from vaccinated pre-Omicron patients.

Conclusions: Vaccination attenuates the inflammatory response to SARS-CoV-2 infection across phases. However, at ten months after symptom onset, changes in the plasma proteome persist in both vaccinated and unvaccinated individuals, which may be relevant to post-acute sequelae of SARS-CoV-2 and other viral infections associated with post-acute infection syndromes.

[darkmaga-returns]

Raise your hand if you think sunlight causes skin cancer. For decades, doctors and the “cancer industry” have warned us to stay out of the “dangerous” sunlight and/or use plenty of sunscreen. But is this good advice?

Did you know Vitamin D deficiency has been linked to cancer, diabetes, osteoporosis, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and autism? Vitamin D isn’t really a “true” vitamin, as we don’t need food to attain it. Natural sunlight allows our body to create vitamin D and even destroys excessive amounts. How does that happen? When the sun’s ultraviolet B (“UVB”) rays hit your skin, they trigger a precholesterol molecule (7-dehydrocholesterol), which is then turned into vitamin D3 (aka “cholecalciferol”).

The mechanisms by which vitamin D reduces the risk of cancer are fairly well understood. They include enhancing calcium absorption, inducing cell differentiation, increasing apoptosis (programmed cell death), reducing metastasis and proliferation, and reducing angiogenesis (formation of new blood vessels).

[bpod-bpod]

Pressure Vessel

New blood vessels arise from endothelial tip cells sprouting. This study in zebrafish reveals that along with polymerisation of the cell scaffold protein actin, hydrostatic pressure resulting from water intake though channels called aquaporins, underlies the push of tip cells into new territory

Read the published research article here

Video from work by Igor Kondrychyn and colleagues

Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, February 2025

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[pro-birth]

While cabergoline (and other dopamine agonists) are not the only drugs that can inhibit angiogenesis, the Boston and Brigham researchers believe that cabergoline has a better safety profile compared to other drugs with the same effect. They are currently enrolling more women in a new clinical trial to attempt to increase their sample size and glean more information about the potential benefits of cabergoline for endometriosis-related pain (this time, compared to a placebo). 

With a larger sample size, the researchers can also measure how (or if) cabergoline helps reduce other symptoms of endometriosis, like infertility or irregular bleeding, plus whether cabergoline shrinks endometriosis lesions or prevents or slows existing lesion growth. A tiny 2011 study of just nine women found that another dopamine agonist, quinagolide, decreased endo lesions by 69.5% over the course of 20 weeks [7]. Might cabergoline do the same? 

[universalsatan]

im reading up on breast cancer metastasis for a paper i need to write and my stupid hilson brain cant stop going “this is so wilson-coded” 🙄 shut UPPPPP