#GeneEditing

[techaivisionx]

Unraveling Personality: How CRISPR Sheds Light on Our Genetic Code

CRISPR’s precision “molecular scissors” are transforming our understanding of how DNA shapes traits like anxiety, confidence and novelty-seeking. By editing specific genes and non-coding regulators—such as deleting the BE5.1 enhancer of the BDNF gene in mice—researchers have shown that these “dark matter” regions play a crucial role in emotional regulation.

Personality emerges from the interplay of dozens (or even hundreds) of genetic variants—MAOA for impulse control, DRD4 for novelty-seeking, 5-HTTLPR for emotional sensitivity—and life experiences. A supportive environment can often temper strong genetic predispositions, illustrating that genes influence but do not dictate our destiny.

Today, CRISPR drives breakthroughs in mental-health research: editing DISC1 to decode schizophrenia pathways or tweaking CACNA1C to study mood disorders in animal models. While “designer personalities” remain science fiction, CRISPR’s true promise lies in personalized mental-health care—early risk detection, preventative strategies and treatments tailored to your unique genetic profile.

[healthdivine]

Rewriting life, molecule by molecule. Revolutionizing pharma, agriculture, and diagnostics with synthetic DNA breakthroughs.

[techbiotrends]

Uso de tijeras moleculares para mejorar la terapia con células CAR-T

 Científicos de Mayo Clinic usan tijeras moleculares para mejorar la terapia CAR-T y ayudar a pacientes que no responden. Avance clave contra el cáncer. | Mayo Clinic researchers use molecular scissors to boost CAR-T therapy.

[lifesciencesmagazine]

Scientists Use CRISPR to Eradicate HIV from Human Immune Cells in Groundbreaking Study

Source: news-medical.net

In a scientific breakthrough that could reshape the future of HIV treatment, researchers have successfully eliminated HIV from infected human immune cells using CRISPR HIV gene-editing technology, and the virus did not return. The study marks a significant advancement in the decades-long search for a permanent cure for HIV/AIDS. Conducted in controlled lab conditions, the gene-editing procedure targeted and removed the virus from T-cells, which are critical to the body’s immune defense.

The international research team, composed of virologists, geneticists, and immunologists, used a highly specialized CRISPR HIV method to cut out the integrated viral DNA from the host genome. The procedure was successful in completely eradicating the virus from the cells, with no detectable reactivation over time. The experiment builds on years of earlier CRISPR research, but is the first to demonstrate complete viral clearance in human immune cells without recurrence.

How CRISPR Achieved the Unthinkable

The researchers utilized an optimized CRISPR HIV Cas9 system to seek out and excise HIV’s proviral DNA embedded within the chromosomes of infected T-cells. Once HIV infects a person, it integrates its genetic code into the host’s genome, making it extremely difficult to remove without harming the cell itself. Traditional antiretroviral therapy (ART) only suppresses viral replication but does not eliminate the virus, requiring lifelong treatment.

In this study, scientists were able to achieve complete excision with high precision, minimizing off-target effects, a common concern with CRISPR. The immune cells remained functional and viable post-editing, which is a critical factor if the technique is to be applied in clinical settings. “The absence of viral rebound in our results is a major milestone,” the lead researcher stated, adding that this demonstrates the potential of gene-editing tools to deliver a functional cure for HIV.

What This Means for the Future

Though the research is still in preclinical stages and limited to laboratory environments, experts are optimistic about its implications. The next steps include testing CRISPR HIV therapies in animal models, followed by human clinical trials. If successful, CRISPR-based therapies could one day offer a one-time, curative treatment for HIV patients, eliminating the need for lifelong medication and dramatically reducing transmission rates.

Public health organizations and advocacy groups have lauded the CRISPR HIV breakthrough as a game-changer in the fight against HIV research. However, scientists also caution that there are numerous regulatory, ethical, and technical hurdles to overcome before this treatment can be rolled out on a global scale. Questions about safety, delivery methods, and access in low-income regions remain central to the discussion.

Still, the idea that HIV can be not just managed, but truly cured at the genetic level, brings renewed hope to the estimated 39 million people living with the virus worldwide. As researchers prepare for the next phase of trials, the scientific community watches closely, united in the belief that with CRISPR HIV breakthroughs, the end of the HIV epidemic may finally be within reach.

[usascripthelpersofficial]

🌟 Groundbreaking Discovery! Scientists use CRISPR/Cas9 gene editing to remove HIV-1 DNA from human T-cells in the lab. Unlike current treatments that only suppress the virus, this method eliminates HIV’s genetic blueprint, offering hope for a permanent cure. 🧬✨ 👉 Still in lab testing – human trials next!

[bio-basic-inc]

Beyond Synthesis: Comprehensive Molecular Biology Services

At Bio Basic, we go far beyond basic synthesis, offering a full suite of molecular biology services designed to support the diverse needs of today’s life science researchers. From custom oligo synthesis, plasmid prep, and cloning, to DNA sequencing, mutagenesis, and gene editing, our expert-driven solutions deliver speed, accuracy, and consistency every step of the way. Whether you're building constructs, verifying sequences, or scaling up for complex projects, Bio Basic is your trusted scientific partner from start to finish.

Explore our services: https://www.biobasic.com/services

[amanabioinfo]

Genetic engineering involves directly modifying an organism's DNA to achieve desired traits, using techniques like CRISPR, gene insertion, or deletion. It’s applied in agriculture (e.g., GMO crops like Bt corn), medicine (e.g., gene therapies for diseases like sickle cell anemia), and research (e.g., creating model organisms). Benefits include increased crop yields, disease resistance, and targeted treatments, with examples like insulin production via engineered bacteria. Risks involve ecological imbalances, ethical concerns (e.g., designer babies), and unintended mutations—studies suggest CRISPR can cause off-target effects in 1-40% of cases depending on the method. Public debate centers on safety, regulation, and moral implications, with some advocating bans on human germline editing.

[computationalbiologistsawards]

!! Computational Biologists Awards !!!

🏆Quantitative Biology Prize – Nominate Now! 🚀

📅 30-31 May 2025

📍 Paris, France

advancement of quantitative approaches in biological research. This prestigious award honors researchers who have demonstrated innovative applications of mathematics, physics, and computational techniques to address complex biological questions.

🔹 Nominate Now!

Quantitative Biology Prize

[underthewingsofthblackeagle]

A baby born with a rare and dangerous genetic disease is thriving after receiving an experimental, tailor-made gene editing treatment. KJ Muldoon was diagnosed shortly after birth with severe CPS1 deficiency, estimated to affect one in a million babies. Affected infants lack an enzyme needed to remove ammonia from the body, meaning it can build up and become toxic. Researchers say KJ is among the first to be successfully treated with such a bespoke therapy, and hope the technology can help many more in the future.

00:00 A US infant with a rare illness treated with gene editing 00:47 Fyodor Urnov, University of California, Berkeley 05:30 Julian Grünewald, Technical University of Munich

[newstech24]

A bespoke gene-editing remedy for a child born with a life-threatening dysfunction : Pictures

KJ Muldoon, who was born at Youngsters’s Hospital of Philadelphia in August, reaches out to docs after being handled for a uncommon genetic dysfunction utilizing CRISPR know-how. CHLOE DAWSON/Youngsters’s Hospital of Philadelphia disguise caption toggle caption CHLOE DAWSON/Youngsters’s Hospital of Philadelphia For the primary time, docs have handled a child born with a uncommon,…

[joelekm]

CRISPR: The Genetic Revolution That Will Change Humanity Forever

CRISPR is a revolutionary gene-editing technology that is reshaping the future of medicine. 🧬✨ By using molecular scissors to precisely cut DNA, CRISPR holds the potential to eliminate genetic diseases, fight cancer, and even extend human lifespan. From its use in treating sickle cell disease to offering hope for genetic blindness, CRISPR's applications are vast, powerful, and game-changing.

[market-insider]

Cell and Gene Therapy Manufacturing: Overcoming Challenges for Market Expansion

The global cell and gene therapy manufacturing market size is expected to reach USD 47.1 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to register a CAGR of 26.6% from 2023 to 2030 owing to the exponential progress of the clinical pipeline, coupled with a rising number of regulatory approvals for advanced therapies, which has majorly driven the growth of the market.

Cell And Gene Therapy Manufacturing Market Report Highlights

The cell therapy manufacturing segment dominated the 2022 market in terms of revenue. A growing number of ongoing clinical trials and increasing research in this space has resulted in the segment dominance

A high number of candidate molecules in the pre-commercial scale stage has contributed to the largest revenue share for the pre-commercial scale manufacturing market segment in 2022

With an increasing number of regulatory approvals for gene and cell therapy products, the demand for commercial production of these therapies is increasing rapidly, thereby increasing the share of the commercial-scale manufacturing segment

The contract manufacturing segment is expected to witness lucrative growth during the forecast period, as a substantial number of biomanufacturers are turning to CMOs for efficient and rapid product development

Moreover, the constantly growing clinical pipeline is another contributing factor expected to accelerate contract manufacturing segment growth

North America dominated the global market in terms of revenue owing to advancements in research and development pertaining to gene therapy and the increasing number of investments by the regional governments

The Asia Pacific region is anticipated to grow at the fastest rate throughout the forecast period

This can be attributed to the establishment of accelerated approval pathways, growing private and government investments, and increasing healthcare needs

For More Details or Sample Copy please visit link @: Cell And Gene Therapy Manufacturing Market Report

Significant investments by government authorities and key market players are other factors fueling the growth of cell and gene therapy manufacturing. Around USD 2.3 billion was invested in gene therapies by companies over the last decade. Major service providers, including CDMOs/CMOs and in-house manufacturers, consider these therapies as an active area of investment. For instance, in May 2020, Thermo Fisher Scientific also invested USD 180 million to scale up its viral vector manufacturing capacity twofold. These players are investing significant amounts either in building and/or expanding manufacturing capabilities or forming strategic alliances with competitors to boost their market presence. Thus, these factors are anticipated to act as primary driving factors for this market.

The number of cell and gene therapies entering clinical trials and later gaining marketing authorization from regulatory bodies is increasing every year. By the end of 2019, 17 cell and gene therapy products were approved by the U.S. FDA for commercial use. The U.S. FDA is expecting to receive over 200 gene and cell treatment INDs annually from the beginning of 2020. The regulatory body is also planning to approve up to 20 products per year from 2025. Such supportive government initiatives are expected to increase the demand for cell and gene therapy manufacturing services in the near future.

Following an article published in March 2020, in the U.S., the number of cell and gene therapies in the pipeline (phase III trials) was 289 at the beginning of 2019, which reached 362 in early 2020. The number is expected to increase twofold if the preclinical pipeline is considered. This growing number indicates the high demand for manufacturing services for cell and gene therapies. According to a report by America’s Biopharmaceutical Companies, gene and cell therapies range from early to late stages of clinical development with a focus on a wide spectrum of diseases, including neurologic conditions, genetic disorders, and cancer.

List of Key players in the Cell And Gene Therapy Manufacturing Market

Lonza

Bluebird Bio Inc.

Catalent Inc.

F. Hoffmann-La Roche Ltd.

Samsung Biologics

Boehringer Ingelheim

Cellular Therapeutics

Hitachi Chemical Co., Ltd.

Bluebird Bio Inc.

Takara Bio Inc.

We have segmented the global cell and gene therapy manufacturing market on the basis of therapy type, scale, mode, workflow, and region.

[techbiotrends]

Innovación en la huerta: una lechuga que cambia las reglas del juego

Nueva lechuga de INTA duplica el rendimiento y mejora la resistencia con edición génica. Más hojas, más valor. INTA's new gene-edited lettuce doubles yield and boosts resilience.

[biopractify]

Top Biotech Startups Changing the World Right Now 🌍🧬

The biotech industry is making groundbreaking advancements in medicine, AI-driven drug discovery, gene editing, and sustainability. From mRNA vaccines to CRISPR gene editing, these startups are changing the future of healthcare and bioengineering.

Let’s take a look at some of the most innovative biotech startups today! 🚀

🔹 1. Moderna – Revolutionizing mRNA Technology

What They Do: Moderna pioneered mRNA vaccines, playing a critical role in the COVID-19 response and is now working on cancer, rare disease, and flu vaccines.

💡 Why It Matters: Their mRNA technology is the foundation for future personalized medicine.

🔗 Learn more about biotech breakthroughs at BioPractify

🔹 2. Ginkgo Bioworks – Synthetic Biology Powerhouse

What They Do: Ginkgo Bioworks uses synthetic biology to engineer microbes for pharma, agriculture, and bio-manufacturing.

💡 Why It Matters: They’re developing sustainable biofuels, biodegradable plastics, and bioengineered bacteria to reduce environmental impact.

🔗 Discover how synthetic biology is shaping the future at BioPractify

🔹 3. Recursion Pharmaceuticals – AI in Drug Discovery

What They Do: Using AI and machine learning, Recursion analyzes massive biological datasets to speed up drug discovery and identify new treatments.

💡 Why It Matters: AI-powered research could reduce drug development time from years to months!

🔗 Explore AI-driven biotech innovations at BioPractify

🔹 4. CRISPR Therapeutics – Gene Editing for a Cure

What They Do: CRISPR Therapeutics is using gene-editing to treat sickle cell anemia, beta-thalassemia, and cancer.

💡 Why It Matters: We are now able to edit faulty genes and potentially cure genetic disorders permanently!

🔗 Stay updated on gene-editing breakthroughs at BioPractify

🔹 5. Zymergen – The Future of Bio-Based Materials

What They Do: Zymergen develops bio-based materials for industries like electronics, textiles, and pharmaceuticals using synthetic biology.

💡 Why It Matters: Instead of relying on petroleum-based plastics, they are creating sustainable alternatives.

🔗 Find out how biotech is making sustainability possible at BioPractify

🔹 6. Mammoth Biosciences – CRISPR Diagnostics

What They Do: Co-founded by Jennifer Doudna (Nobel Prize Winner), Mammoth Biosciences is developing CRISPR-based disease detection tests.

💡 Why It Matters: Faster, cheaper, and more accurate disease detection could transform global healthcare.

🔗 Discover how biotech is changing diagnostics at BioPractify

🔹 7. Twist Bioscience – DNA Data Storage

What They Do: Twist Bioscience is exploring DNA-based data storage, which can store huge amounts of digital information in a tiny strand of DNA.

💡 Why It Matters: Imagine storing libraries of knowledge inside a single DNA molecule!

🔗 Explore DNA sequencing innovations at BioPractify

🚀 Final Thoughts: Biotech is the Future!

These biotech startups are shaping the future of medicine, sustainability, and technology. From AI-powered drug discovery to gene editing and bio-manufacturing, the future is here!

💡 Which biotech startup do you think will have the biggest impact? Let’s discuss in the comments! 👇

📌 Want to stay ahead in biotech? Explore the latest trends at BioPractify