#LIKE. if synthesizing hormones is something completely possible in universe
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I wanted to know how do you interpret Tanya's gender. After reading chapter 58 of the manga i got the impression that she is definitely trans coded, but maybe thats just me
Very good question.
To be honest, when I think too hard about Tanya’s gender (and sexuality, for that matter) it gives me brain worms. Fun brain worms, but brain worms nonetheless. I can’t explain it. Everything she’s got going on is complicated as shit there’s way too much to think about.
Like, she was a man, but now she's a girl. But at some points she says she still sees herself as a man internally so is this MtFtM? How does that work. And if she accepts she's a woman now, is that just MtF or do we add more letters. More importantly: Was Being X being Transphobic or being the Greatest Trans Ally of All Time with the free divinely issued sex change.
Ok ok, jokes aside. Confession: I actually do not keep up with the manga, so I had to go find the chapter and read it first. Having read it now though, I see what you mean.
The conversation she has with the Salaryman/herself in that chapter really does read as essentially saying “I’ve accepted who I am now.” It’s a far cry from a much earlier part of the manga I remember where she has a breakdown about being a man/people seeing her as a girl.
A friend of mine was actually showing me stuff from more recent chapters of the manga (don’t know which chapter tragically, but I know it’s not currently translated to English) and from what I gathered of it, Being X was showing Tanya a dream of being back in her past life and in response she basically demanded to go back to being Tanya immediately. It is definitely not just you, I 100% see the trans-coding you’re talking about.
As for my personal interpretation of her gender, I touched very briefly on it once before, but I honestly think she wouldn’t want to label herself as anything. At first, this is out of hesitance and not wanting to acknowledge that anything might be ““wrong”” or ““different”” about her. Later on it turns into character growth, more along the lines of, “I don’t need the label to define me, I just am what I am/like what I like. I don’t care about it any more than that.” Yes this is 100% projection on my part. No, I won’t apologize for it lmao.
Of course, that's entirely my own headcanon. I definitely am not saying it’s the only way to interpret her, it’s just my personal thoughts. Especially since my opinion is subject to change on a dime depending on what I’m reading/working on myself. The Tanya gender is, in fact, transient, shifting like water.
Like. A transfem Tanya fic that focuses on her adapting to life in her new world and coming to discover she doesn’t actually hate her new body? I’d totally read that. I’ve seen a few fics that include that as a part of the narrative and those scenes of acceptance were among my favorite parts.
I get the feeling this is the route that the manga is going as well. It’s a bit of a shame that we don't have those aforementioned scenes in the light novel (or at least, I don't remember them), but I don’t think that Carlo Zen really intended that to be the focus/narrative in the first place. And honestly, I also think that’s a good thing because it allows for so much more room for interpretation and headcanon around Tanya’s character.
Anyway, the other direction is also compelling to me. A transmasc Tanya fic where, after feeling uncomfortable and hating how feminine he looks for years and years, he finally goes ‘Fuck this, I’m gonna go back to being a man’? I would read the fuck out of that too.
Could also be paired with him finally choosing to defect, where they think about it like, ‘Well there’s nothing to hold me back now, right? I don’t have to maintain appearances anymore. Also, since I’m defecting this would be a great way to hide myself. They’d all be looking for the wrong person. Two birds with one stone, how efficient.’ …Now we’re getting to fic ideas I won’t ever get to so it’s time to move on I think.
Semi-related to the Trans Tanya Concept, this actually brings me to a bit of a lore/headcanon/idea/question I want to present to the public for opinions. In Norden, during the inciting battle of the war, Tanya uses magic to “dope up” so she could enhance her strength and reaction time and kill pain. I took this to mean she used a formula to synthesize the narcotics/adrenaline hormone/whatever else directly into herself, right?
Can you see where I’m going with this? As long as you know which hormones to make, how they’re made up, and what quantities you need… Well, don’t you think magic HRT is completely possible? Of course, as I'm not sure it makes sense for Salaryman to have known the detailed specifics about it from the modern world, it would require a lot of in-universe research/science advancement for someone to actually do that, but theoretically...
The magic system in this universe has so much potential to be explored, I’m fascinated by what you can theoretically do with it. Although, this is long and off-topic already I think this should be the end, lol.
I think I talked too much? I’m sorry, you were probably not expecting such an answer. I told you, Tanya gives me brain worms (mental illness).
I guess the TL;DR is this: that kid definitely ain’t cishet.
#marathehomosexual#ask#not a daily post#you could ask me a simple yes or no question and i would STILL find a way to make the answer multi-paragraph#i STILL have things to talk about. im just choosing to throw it in the tags now#LIKE. if synthesizing hormones is something completely possible in universe#is birth control possible as well? how about anti-depressants?#how far can we go with this? can you get addicted to these magic-synthetic chemicals/hormones/whatever?#say you need a little pick me up in the day. you give yourself a little boost in the happy-brain-chemicals (dopamine or whatever)#(im not a biologist or knowledgeable about most biology-related things honestly. please just go with it)#would a mages body start to rely on magic to produce it and stop creating it naturally anymore?#could this create a dependency? would you start to need to make more?#its insane. i feel insane#you ask me a simple question and i refuse to stop elaborating#rimu be quiet now
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How aware is cam that pal is synthesizing testosterone in her body in between my teeth?
fic link here
HMMM I actually never thought about that when writing, but I would say if Cam doesn't know for sure that Pal is doing it, she would probably assume it is a possibility.
In-universe, I made up the idea that trans necromancers have something called the "endocrine reflex", where their bodies reflexively attempt to synthesize the correct sex hormone at puberty -- not to the extent of full binary transition, because I don't think non-Lyctor-necromancy allows for such a complete overhaul of ones own physiology (especially without conscious and sustained effort), but it would be noticible to a Lyctor looking in, and without further intentional intervention would result in hormone imbalances that potentially externally have similar results to stuff like PCOS or gynecomastia. maybe more or less extreme depending on the individual.
but back to Cam, I think that this would be a known phenomenon in the Nine Houses, so Cam would probably be able to put together the assumption that when Palamedes is active within her body, his soul may be reflexively attempting to synthesize testosterone. I don't think she would have a problem with it if she did know -- Cam's Whole Issue is that she doesn't consider herself to be her own person, seperate and independent from Palamedes. So like... even though I DO think that Cam deserves a little T, as a treat, I think it's impossible to seperate any personal gender fuckery she might have going on with her fullbody devotion to being Palamedes'.
#ask#anon#fic blogging#THANKS this was fun to dig my teeth into#a bit of a nonasnwer but i actually didnt consdier how much she knows when. writing it. so 😭
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Is The Law of Attraction Scientifically Valid?
The word “manifestation” triggers different responses for different people. For some, it’s a “woo woo” concept based in fantasy. For others, it’s a belief that drives a way of living.
I was introduced to the concept of manifestation as a child, told by my parents that I could visualize whatever I wanted and that would draw it to me. This has worked, in varying degrees, throughout my life.
But it’s not always that simple. Imagining what I want while feeling bad about not having it creates a mixed message—a split focus for both the brain and the Universe—and it never works to give me the outcome I desire. So how do you manifest something you don’t have yet, without focusing on lack?
The Joy Plan
Longing to know the truth about manifestation, I’ve explored the science behind it for years. However, my exploration into the topic took a turn from curiosity to full-on science experiment when I reached a particularly low time in my life.
In desperation, I grabbed onto an idea based on “The Law of Attraction” that I’d heard of, as if it was a life raft. The idea was that 30 days of focusing on your own joy is long enough to completely change your life. Calling on the body of scientific and personal research into hormones, neurotransmitters, mindfulness, and manifestation I had amassed over many years, I calculated a synthesized plan to go after joy from all angles. I called it “The Joy Plan.”
And it worked! Over the next 30 days and in the months that followed, my life and the lives of those around me transformed. I was shocked at how fast it happened. Once I figured out how to harness the neurobiology of joy and apply it in simple ways every day—my life morphed before my very eyes.
I chronicled my experience in a book called The Joy Plan; it’s my 320-page sticky note to refer back to when hard times rock my boat again (which they undoubtedly will). But while The Joy Plan is my story, it’s not just about me. Ultimately, it demonstrates how to find joy in your current life, even when it feels out of reach, and then watch your life transform to match your joy.
Here’s Why I Think It Works:
Numerous studies in the arena of sports have shown that visualizing an outcome daily, such as dunking baskets in basketball, is nearly equal in effectiveness to actually performing the action, such as the daily practice of free throws. Group meditation with a focus on peace in certain urban areas has been correlated with a reduction in crime rate. [source]
So, does manifestation really work?
First of all, I believe science and spirituality are two sides of the same coin, each informing and shaping the other. While there may be a higher power or deep, inner wisdom that answers the call of the desires we wish to manifest, our brains also play an important part in the equation.
Neural networks—clusters of neurons in the brain—grow stronger and larger each time we repeat thoughts and behaviors. Eventually, after they’re activated frequently enough, neural networks clump together to form neural pathways, like favorite highways our brains prefer because they are well-worn and familiar.
Our repeated thoughts eventually shape the way we see and experience the world, and thus inform our actions and reactions. Our minds become pre-disposed to return to repeated thought patterns which activate the neural pathways our brains have become accustomed to. In fact, we unknowingly seek out evidence to confirm those thought patterns because our neural pathways are always hard at work.
As the ancient proverb says, “Watch your thoughts for they become words. Watch your words for they become actions. Watch your actions for they become habits. Watch your habits for they become your character. Watch your character for it becomes your destiny.”
Albert Einstein said, “The world as we have created it is a process of our thinking. It cannot be changed without changing our thinking.” He also explained, when describing his famous equation E=MC2, that “Mass and energy are both but different manifestations of the same thing—a somewhat unfamiliar conception for the average mind.”
So if thoughts create our world and energy is just as real as mass, we can utilize the energy of our thoughts to create tangible results in life. This is not just philosophy; this is physics.
What You Think, You Become
Quantum physics has proven that, at the subatomic level, all matter is made of energy and our thoughts influence the behavior of that energy. Scientists have found in study after study that our observations of reality alter the reality we observe. In fact, quantum physicists claim it is the very act of observing reality that creates it in the first place. Essentially, our thoughts shift subatomic particles and create our physical world.
Our brains have an inbuilt experiential bias, favoring memories with a strong emotional charge. We’re also programmed with a cognitive bias that requires three positive experiences to balance the impact of one negative experience. Stored memories are often played on a feedback loop, activating strong neural pathways and triggering repeated thoughts, behaviors, and thus, experiences—whether negative or positive.
Knowing all of this, I’ve come to the conclusion that positive thoughts really are the key to manifesting what I want in life. By consciously forming new neural networks, and eventually, neural pathways, associated with feelings of joy, abundance, and possibility, I can open up more than my brain—I can open up my world.
When we find joy in spite of the conditions we’re currently experiencing, those conditions morph to match our joy. By intentionally practicing thinking new thoughts, we can create new patterns in our brains, which ultimately translate into a new experience of life.
Buddha said, “What you think, you become.” And I believe neuroscientists would say the same. Our experience of life is shaped by what we think about it, and whether you call that “manifestation,” “The Law of Attraction,” or simply “the power of positive thinking,” if you can do it, you’ll be on track to a joyful life.
By: Kaia Roman
#law of attraction#science#consciousness#subconscious#life#nature#spiritual#spiritualitly#thoughts#emotions#universe#articles
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Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite it slow now concerning dietary supplements featuring CLA Safflower oil. Promising revolutionary changes for those with excess weight, one explicit producer of such supplements have been marred by a rather crass scandal involving dubious selling practices. Even if we have a tendency to could put it out of our minds, the actual fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises within the case of each supplement – does it extremely work? – there are some peculiarities in this case. 1st of all, the designation will be slightly misleading. CLA and safflower oil are connected yet completely different substances and, although they're presented as being a unitary extract, any inquiry and analysis of the compounds are required. Secondly, we should delve a touch deeper into the results of the ingredients that build up these supplements in order to seek out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, facet effects and the like. We have a tendency to will provide you with the required data, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of each), followed by an assessment of the present body of reviews and rounding the article up with our verdict on the likelihood that CLA Safflower oil supplements might help anyone in their quest for a healthier and a lot of appealing silhouette. The CLA – Safflower Oil Connection It slow ago, The American Heart Association released a suggestion concerning the advantages that Omega-half-dozen fatty acids have on the heart health, urging their steady but moderate consumption. Within the wake of this announcement, the quantity of studies undertaken on omega-half dozen acids, and polyunsaturated fats in general, have increased markedly. One such study, conducted at Ohio State University, was involved with the effects of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic ladies who didn't need daily insulin injections. It was long speculated that this type of supplementation would have a positive effect on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They're related, however approximately the same. The 35 girls within the study were divided into 2 groups, individuals in every grouping being administered six.4 grams of fatty acid daily, for sixteen weeks, without any different tampering with medication, or with their routine in general. The results were encouraging, to mention the smallest amount. Subjects within the CLA supplementation cluster exhibited a vital decrease within the Body Mass Index indicator, half a purpose on average, a figure that translated into a drop of three.a pair of percent from the whole body fat. Subjects experiencing safflower oil supplementation, on the other hand, had a considerable reduction in their trunk fat, however with no vital consequences on their overall fat, and a remarkable increase in muscle tissue. Furthermore, the safflower oil supplemented cluster also exhibited a decrease in their blood sugar levels with an average of fifteen points. Within the case of each parties, no alternative alterations in their health were observed, with the notable exception of the increase in the production of the hormone adiponectin, noticed in the cluster supplemented with safflower oil. This hormone is responsible for the pace at which fat is burned within the metabolism. While these results were promising and actually paved the way for a fast introduction on the market of CLA and safflower oil extract supplements, there are some caveats to them. The massive question sign the results of this study raised issues about the surplus fat. Where had it gone? After all, the exercise routine was not modified. The noticeable increase in the adiponectin production raised parallels the dramatic facet effects medicine that tamper with hormone levels have. The surplus fat may be deposited in the liver and/or muscle tissue, therefore increasing the severity of diabetes (or inflicting it to individuals who don't suffer from the condition) or inducing a whole range of liver disorders. This study indeed unearthed exciting advantages that both CLA and safflower oil could bring regarding, nevertheless the possible side effects could not are fathomed throughout the limited amount (16 weeks) the scientists had at their disposal. Currently that we have a tendency to have seen how the underlying principle in the dietary supplements we are discussing came about let us get more acquainted with both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The downside with CLA is not restricted to grammar (i.e., should one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that haven't been sufficiently researched. Nevertheless, there is sufficient knowledge relevant to their use in dietary supplements, and we tend to ought to proceed with the analysis. Conjugated linoleic acids are one amongst 28 isomers of linoleic acids that are made naturally when sure dairy product or meats are attenuated by bacteria within the stomach or intestines. The isomers of a bound substance have the same chemical formula (a single molecule contains the identical elements in precisely the same number), yet they differ in their chemical structure. CLA is classified as trans- fatty acid and conjointly cis- fatty acid, making them something of an oddity, a minimum of in the biochemical realm. This is where we will confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (however, additional than seventy five percent of it is oleic acid, a monosaturated acid) – approximately 0.7 mg/gram. Therefore, CLA and safflower oil are indeed substances that can be placed in the same class, nonetheless they are by no means as alike as to own the identical effect on the human body or to be used interchangeably. From a logical standpoint, that is why the study cited in the previous section used each substances, to find out the outcomes and, as we tend to have seen, the outcomes, though each regard the reduction of body fat, proved indeed to be quite totally different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies haven't slowed their pace since then. But, it was not till 2008 that the Food and Drug Administration (FDA) recognized CLA as being usually safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, although the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the help of the bacteria from the Bifidus strain that reside in the intestine. A host of conditions and dysfunctions – starting from high acidic levels to most digestive diseases and even gluten intolerance – build the synthesis impossible. So, one can conclude that a supplementation of CLA is actually required, especially from a bound age onwards, nonetheless questions of dosage or method of administration stay. At initial, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited on top of (though extrapolating from artificially induced cancer in mice to tumors on humans may be a rather dubious follow). In recent years, and in the sunshine of the study performed at Ohio State University, CLA supplements are half of the supplements that advertise weight loss. According to the WebMD website, CLA is used in dietary supplementation, with doses between fifteen to 175 mg for daily use. The purposes are various – cancer, combating mild food allergies, reducing the effects of chronic disease on weight or atherosclerosis. CLA is presumably effective in fighting obesity and high blood pressure, but, additional analysis on the topic is needed. On the subject of all different claims created by manufacturers, speculation will best characterize them. It's safe for the average healthy adult within the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are gift, one is suggested to avoid CLA. Arriving at the subject of dosage, the results of the Ohio State study are quoted – only 7 grams per day, though there aren't any significant benefits for doses larger than three.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is connected to its interaction with the PPAR receptors. Clinical studies investigating the acid’s impact showed lipogenesis reduction via molecule modulation on in vivo models. The findings also advised that the isomers in conjugated linoleic acid may cut back adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the entire human body, however with a better incidence rate within the adipose tissue. Three types of PPARs[one] are identified and studied: PPAR-alpha, mainly found in the center, liver and adipose tissue, responsible for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, involved within the fatty acid metabolism method PPAR-gamma, within the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They're stimulated by small ligands (purposeful teams of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles in a very series of processes ranging from lipid metabolism in obese models to professional-inflammatory enzyme inhibition. PPARs may have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation in the hippocampus and cortex of folks with neurodegenerative diseases. Normal activity of all 3 receptors maintains homeostasis, that means that the body incorporates a sensible immune system and lower possibilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively concerned in various processes going down inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in both animal and human models. A clinical trial conducted on rodents showed adipogenic method regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
youtube
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Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite it slow currently about dietary supplements that includes CLA Safflower oil. Promising revolutionary changes for those with excess weight, one explicit producer of such supplements are marred by a rather crass scandal involving dubious marketing practices. Even if we tend to could place it out of our minds, the fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises in the case of each supplement – does it very work? – there are some peculiarities in this case. 1st of all, the designation can be slightly misleading. CLA and safflower oil are related nonetheless different substances and, although they're presented as being a unitary extract, any inquiry and analysis of the compounds are needed. Secondly, we have a tendency to should delve a small amount deeper into the results of the ingredients that build up these supplements in order to seek out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, aspect effects and also the like. We tend to can provide you with the necessary info, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of each), followed by an assessment of the existing body of reviews and rounding the article up with our verdict on the probability that CLA Safflower oil supplements might facilitate anyone in their quest for a healthier and a lot of appealing silhouette. The CLA – Safflower Oil Connection A while ago, The American Heart Association released a suggestion concerning the advantages that Omega-six fatty acids have on the heart health, urging their steady however moderate consumption. In the wake of this announcement, the quantity of studies undertaken on omega-half dozen acids, and polyunsaturated fats normally, have increased markedly. One such study, conducted at Ohio State University, was concerned with the results of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic women who didn't need daily insulin injections. It was long speculated that this kind of supplementation would have a positive impact on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They are connected, but more or less the identical. The thirty five women in the study were divided into 2 groups, individuals in each grouping being administered half dozen.4 grams of fatty acid daily, for sixteen weeks, without any alternative tampering with medication, or with their routine normally. The results were encouraging, to say the least. Subjects within the CLA supplementation group exhibited a vital decrease in the Body Mass Index indicator, [*fr1] a point on average, a figure that translated into a drop of three.a pair of percent from the full body fat. Subjects experiencing safflower oil supplementation, on the opposite hand, had a considerable reduction in their trunk fat, however with no vital consequences on their overall fat, and a remarkable increase in muscle tissue. Furthermore, the safflower oil supplemented cluster also exhibited a decrease in their blood sugar levels with a median of fifteen points. Within the case of each parties, no other alterations in their health were observed, with the notable exception of the increase in the assembly of the hormone adiponectin, noticed within the group supplemented with safflower oil. This hormone is responsible for the pace at which fat is burned within the metabolism. Whereas these results were promising and actually paved the approach for a quick introduction on the market of CLA and safflower oil extract supplements, there are a few caveats to them. The big question sign the results of this study raised concerns regarding the surplus fat. Where had it gone? After all, the exercise routine wasn't changed. The noticeable increase within the adiponectin production raised parallels the dramatic aspect effects drugs that tamper with hormone levels have. The excess fat could be deposited within the liver and/or muscle tissue, therefore increasing the severity of diabetes (or inflicting it to people who don't suffer from the condition) or inducing a full range of liver disorders. This study indeed unearthed exciting advantages that each CLA and safflower oil may bring concerning, nonetheless the attainable aspect effects may not have been fathomed throughout the restricted period (16 weeks) the scientists had at their disposal. Now that we have seen how the underlying principle in the dietary supplements we are discussing came about allow us to get additional accustomed to both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The problem with CLA isn't limited to grammar (i.e., should one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that have not been sufficiently researched. Nevertheless, there is sufficient information relevant to their use in dietary supplements, and we tend to ought to proceed with the analysis. Conjugated linoleic acids are one of 28 isomers of linoleic acids that are made naturally when bound dairy products or meats are diminished by bacteria within the stomach or intestines. The isomers of a bound substance have the same chemical formula (a single molecule contains the identical parts in exactly the identical number), yet they differ in their chemical structure. CLA is classed as trans- fatty acid and additionally cis- fatty acid, creating them something of an oddity, a minimum of within the biochemical realm. This is where we have a tendency to can confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (however, additional than seventy five p.c of it is oleic acid, a monosaturated acid) – approximately zero.7 mg/gram. Thus, CLA and safflower oil are indeed substances which will be placed in the identical class, yet they're by no means as alike as to own the same result on the human body or for use interchangeably. From a logical standpoint, that's why the study cited in the previous section used each substances, to search out out the outcomes and, as we have a tendency to have seen, the outcomes, though each regard the reduction of body fat, proved indeed to be quite totally different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies haven't slowed their pace since then. However, it wasn't until 2008 that the Food and Drug Administration (FDA) recognized CLA as being generally safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, although the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the aid of the bacteria from the Bifidus strain that reside within the intestine. A host of conditions and dysfunctions – starting from high acidic levels to most digestive diseases and even gluten intolerance – build the synthesis not possible. Therefore, one can conclude that a supplementation of CLA is truly required, especially from a sure age onwards, yet queries of dosage or methodology of administration stay. At initial, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited above (although extrapolating from artificially induced cancer in mice to tumors on humans is a rather dubious practice). In recent years, and in the sunshine of the study performed at Ohio State University, CLA supplements are half of the supplements that advertise weight loss. According to the WebMD website, CLA is utilized in dietary supplementation, with doses between 15 to 175 mg for daily use. The functions are various – cancer, combating gentle food allergies, reducing the effects of chronic disease on weight or atherosclerosis. CLA is presumably effective in fighting obesity and high blood pressure, however, a lot of research on the topic is required. On the topic of all other claims made by manufacturers, speculation can best characterize them. It is safe for the average healthy adult within the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are present, one is advised to avoid CLA. Arriving at the topic of dosage, the results of the Ohio State study are quoted – no more than 7 grams per day, though there aren't any vital benefits for doses larger than three.4 grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is related to its interaction with the PPAR receptors. Clinical studies investigating the acid’s effect showed lipogenesis reduction via molecule modulation on in vivo models. The findings also urged that the isomers in conjugated linoleic acid might scale back adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the complete human body, but with the next incidence rate within the adipose tissue. Three types of PPARs[1] are identified and studied: PPAR-alpha, mainly found in the heart, liver and adipose tissue, accountable for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, involved within the fatty acid metabolism process PPAR-gamma, in the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They are stimulated by tiny ligands (purposeful groups of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles in an exceedingly series of processes starting from lipid metabolism in obese models to pro-inflammatory enzyme inhibition. PPARs may have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation within the hippocampus and cortex of people with neurodegenerative diseases. Normal activity of all 3 receptors maintains homeostasis, which means that the body features a sensible immune system and lower chances to develop severe medical conditions. By activating the PPAR receptors, CLA is actively involved in numerous processes going down inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in both animal and human models. A clinical trial conducted on rodents showed adipogenic process regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
youtube
0 notes
Text
Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite it slow currently about dietary supplements featuring CLA Safflower oil. Promising revolutionary changes for those with excess weight, one specific producer of such supplements have been marred by a rather crass scandal involving dubious marketing practices. Even if we have a tendency to might place it out of our minds, the actual fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises in the case of each supplement – does it very work? – there are some peculiarities during this case. 1st of all, the designation will be slightly misleading. CLA and safflower oil are related yet completely different substances and, though they're presented as being a unitary extract, additional inquiry and analysis of the compounds are required. Secondly, we ought to delve a touch deeper into the effects of the ingredients that build up these supplements in order to seek out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, facet effects and the like. We can provide you with the necessary data, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of each), followed by an assessment of the prevailing body of reviews and rounding the article up with our verdict on the probability that CLA Safflower oil supplements may facilitate anyone in their quest for a healthier and more appealing silhouette. The CLA – Safflower Oil Connection Some time ago, The American Heart Association released a suggestion regarding the benefits that Omega-6 fatty acids have on the general heart health, urging their steady however moderate consumption. In the wake of this announcement, the amount of studies undertaken on omega-6 acids, and polyunsaturated fats in general, have increased markedly. One such study, conducted at Ohio State University, was involved with the results of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic ladies who didn't require daily insulin injections. It was long speculated that this kind of supplementation would have a positive result on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They're connected, but more or less the identical. The 35 women in the study were divided into two teams, individuals in each grouping being administered half-dozen.four grams of fatty acid daily, for sixteen weeks, without any different tampering with medication, or with their routine generally. The results were encouraging, to mention the least. Subjects in the CLA supplementation cluster exhibited a important decrease within the Body Mass Index indicator, 0.5 a point on average, a figure that translated into a drop of three.2 p.c from the overall body fat. Subjects experiencing safflower oil supplementation, on the opposite hand, had a substantial reduction in their trunk fat, however with no important consequences on their overall fat, and a outstanding increase in muscle tissue. Furthermore, the safflower oil supplemented group conjointly exhibited a decrease in their blood sugar levels with a median of 15 points. Within the case of both parties, no different alterations in their health were observed, with the notable exception of the rise in the production of the hormone adiponectin, noticed in the group supplemented with safflower oil. This hormone is accountable for the pace at that fat is burned within the metabolism. Whereas these results were promising and certainly paved the approach for a quick introduction available of CLA and safflower oil extract supplements, there are some caveats to them. The massive question sign the results of this study raised concerns regarding the excess fat. Where had it gone? After all, the exercise routine was not modified. The noticeable increase in the adiponectin production raised parallels the dramatic side effects drugs that tamper with hormone levels have. The surplus fat might be deposited within the liver and/or muscle tissue, therefore increasing the severity of diabetes (or causing it to people who do not suffer from the condition) or inducing an entire range of liver disorders. This study indeed unearthed exciting benefits that both CLA and safflower oil may bring about, yet the potential aspect effects may not have been fathomed throughout the limited amount (sixteen weeks) the scientists had at their disposal. Now that we have a tendency to have seen how the underlying principle within the dietary supplements we are discussing came regarding allow us to get further conversant in both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The problem with CLA is not restricted to grammar (i.e., ought to one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that haven't been sufficiently researched. Nevertheless, there is sufficient data relevant to their use in dietary supplements, and we should proceed with the analysis. Conjugated linoleic acids are one in all twenty eight isomers of linoleic acids that are produced naturally when bound dairy merchandise or meats are counteracted by bacteria in the abdomen or intestines. The isomers of a sure substance have the identical chemical formula (a single molecule contains the same elements in exactly the same variety), however they differ in their chemical structure. CLA is assessed as trans- fatty acid and also cis- fatty acid, creating them something of an oddity, a minimum of within the biochemical realm. This is where we will confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (however, a lot of than 75 % of it's oleic acid, a monosaturated acid) – approximately zero.7 mg/gram. Therefore, CLA and safflower oil are indeed substances that may be placed in the identical category, however they're by no means that as alike as to have the identical effect on the human body or to be used interchangeably. From a logical standpoint, that is why the study cited in the previous section used each substances, to search out out the outcomes and, as we tend to have seen, the outcomes, though both regard the reduction of body fat, proved indeed to be quite completely different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies haven't slowed their pace since then. But, it was not till 2008 that the Food and Drug Administration (FDA) recognized CLA as being typically safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, although the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the help of the bacteria from the Bifidus strain that reside in the intestine. A host of conditions and dysfunctions – starting from high acidic levels to most digestive diseases and even gluten intolerance – build the synthesis not possible. So, one will conclude that a supplementation of CLA is really required, especially from a sure age onwards, however queries of dosage or methodology of administration stay. At 1st, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited on top of (although extrapolating from artificially induced cancer in mice to tumors on humans could be a rather dubious practice). In recent years, and in the light of the study performed at Ohio State University, CLA supplements are half of the supplements that advertise weight loss. According to the WebMD website, CLA is utilized in dietary supplementation, with doses between fifteen to one hundred seventy five mg for daily use. The purposes are various – cancer, combating delicate food allergies, reducing the results of chronic disease on weight or atherosclerosis. CLA is presumably effective in fighting obesity and high blood pressure, however, more research on the subject is required. On the subject of all different claims made by makers, speculation will best characterize them. It's safe for the common healthy adult in the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are gift, one is suggested to avoid CLA. Arriving at the subject of dosage, the results of the Ohio State study are quoted – no more than 7 grams per day, though there are not any important edges for doses larger than three.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is related to its interaction with the PPAR receptors. Clinical studies investigating the acid’s effect showed lipogenesis reduction via molecule modulation on in vivo models. The findings conjointly suggested that the isomers in conjugated linoleic acid might scale back adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the whole human body, but with a better incidence rate in the adipose tissue. Three types of PPARs[one] are identified and studied: PPAR-alpha, mainly found in the guts, liver and adipose tissue, responsible for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, concerned within the fatty acid metabolism method PPAR-gamma, within the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They are stimulated by little ligands (functional teams of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles in a very series of processes starting from lipid metabolism in obese models to professional-inflammatory enzyme inhibition. PPARs might have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation within the hippocampus and cortex of individuals with neurodegenerative diseases. Normal activity of all three receptors maintains homeostasis, that suggests that the body has a sensible immune system and lower probabilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively involved in varied processes taking place within the body. Various studies indicate that supplementation with CLA has anti-obesity effects in each animal and human models. A clinical trial conducted on rodents showed adipogenic process regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
youtube
0 notes
Text
Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite some time currently regarding dietary supplements featuring CLA Safflower oil. Promising revolutionary changes for those with excess weight, one particular producer of such supplements have been marred by a rather crass scandal involving dubious marketing practices. Even if we have a tendency to could put it out of our minds, the fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises within the case of each supplement – does it extremely work? – there are some peculiarities during this case. First of all, the designation can be slightly misleading. CLA and safflower oil are related however totally different substances and, though they are presented as being a unitary extract, additional inquiry and analysis of the compounds are needed. Secondly, we should delve a touch deeper into the results of the ingredients that create up these supplements in order to search out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, side effects and therefore the like. We can provide you with the necessary information, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of every), followed by an assessment of the present body of reviews and rounding the article up with our verdict on the probability that CLA Safflower oil supplements might facilitate anyone in their quest for a healthier and a lot of appealing silhouette. The CLA – Safflower Oil Connection A while ago, The American Heart Association released a suggestion regarding the advantages that Omega-six fatty acids have on the overall heart health, urging their steady but moderate consumption. In the wake of this announcement, the amount of studies undertaken on omega-half-dozen acids, and polyunsaturated fats generally, have increased markedly. One such study, conducted at Ohio State University, was concerned with the consequences of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic women who didn't need daily insulin injections. It was long speculated that this type of supplementation would have a positive effect on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They're connected, but almost the identical. The 35 ladies in the study were divided into 2 teams, individuals in every grouping being administered six.4 grams of fatty acid daily, for sixteen weeks, without any other tampering with medication, or with their routine normally. The results were encouraging, to mention the smallest amount. Subjects in the CLA supplementation group exhibited a significant decrease within the Body Mass Index indicator, 0.5 a point on average, a figure that translated into a drop of 3.2 percent from the whole body fat. Subjects experiencing safflower oil supplementation, on the opposite hand, had a substantial reduction in their trunk fat, however with no vital consequences on their overall fat, and a outstanding increase in muscle tissue. Furthermore, the safflower oil supplemented group conjointly exhibited a decrease in their blood sugar levels with a mean of 15 points. Within the case of each parties, no other alterations in their health were observed, with the notable exception of the rise in the production of the hormone adiponectin, noticed within the group supplemented with safflower oil. This hormone is responsible for the pace at that fat is burned within the metabolism. While these results were promising and definitely paved the way for a fast introduction on the market of CLA and safflower oil extract supplements, there are some caveats to them. The huge question sign the results of this study raised issues about the surplus fat. Where had it gone? After all, the exercise routine was not changed. The noticeable increase within the adiponectin production raised parallels the dramatic aspect effects medication that tamper with hormone levels have. The excess fat may be deposited within the liver and/or muscle tissue, thus increasing the severity of diabetes (or inflicting it to individuals who don't suffer from the condition) or inducing a whole range of liver disorders. This study indeed unearthed exciting edges that both CLA and safflower oil might bring regarding, nonetheless the possible aspect effects may not have been fathomed during the limited period (16 weeks) the scientists had at their disposal. Now that we have seen how the underlying principle within the dietary supplements we tend to are discussing came concerning allow us to get additional at home with both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The drawback with CLA is not restricted to grammar (i.e., ought to one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that haven't been sufficiently researched. Nevertheless, there's sufficient data relevant to their use in dietary supplements, and we tend to ought to proceed with the analysis. Conjugated linoleic acids are one in every of 28 isomers of linoleic acids that are created naturally when certain dairy product or meats are de-escalated by bacteria in the stomach or intestines. The isomers of a sure substance have the same chemical formula (a single molecule contains the same components in precisely the identical variety), nevertheless they differ in their chemical structure. CLA is classed as trans- fatty acid and additionally cis- fatty acid, creating them something of an oddity, at least in the biochemical realm. This is where we tend to will confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (however, a lot of than seventy five percent of it is oleic acid, a monosaturated acid) – approximately zero.seven mg/gram. So, CLA and safflower oil are indeed substances which will be placed in the same category, nevertheless they're by no means that as alike as to have the identical result on the human body or to be used interchangeably. From a logical standpoint, that is why the study cited in the previous section used each substances, to search out out the outcomes and, as we tend to have seen, the outcomes, though both regard the reduction of body fat, proved indeed to be quite completely different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies have not slowed their pace since then. But, it was not until 2008 that the Food and Drug Administration (FDA) recognized CLA as being usually safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, although the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the aid of the bacteria from the Bifidus strain that reside within the intestine. A host of conditions and dysfunctions – ranging from high acidic levels to most digestive diseases and even gluten intolerance – build the synthesis not possible. Therefore, one can conclude that a supplementation of CLA is really required, especially from a certain age onwards, yet questions of dosage or method of administration remain. At first, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited higher than (although extrapolating from artificially induced cancer in mice to tumors on humans is a rather dubious apply). In recent years, and in the light of the study performed at Ohio State University, CLA supplements are part of the supplements that advertise weight loss. According to the WebMD website, CLA is used in dietary supplementation, with doses between fifteen to one hundred seventy five mg for daily use. The purposes are diverse – cancer, combating mild food allergies, reducing the consequences of chronic disease on weight or atherosclerosis. CLA is possibly effective in fighting obesity and high blood pressure, but, additional research on the topic is required. On the topic of all other claims made by manufacturers, speculation can best characterize them. It is safe for the common healthy adult within the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are present, one is advised to avoid CLA. Arriving at the topic of dosage, the results of the Ohio State study are quoted – only seven grams per day, though there aren't any vital edges for doses larger than three.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is related to its interaction with the PPAR receptors. Clinical studies investigating the acid’s result showed lipogenesis reduction via molecule modulation on in vivo models. The findings additionally urged that the isomers in conjugated linoleic acid might reduce adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the whole human body, however with a better incidence rate within the adipose tissue. 3 sorts of PPARs[one] are identified and studied: PPAR-alpha, mainly found in the heart, liver and adipose tissue, accountable for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, concerned within the fatty acid metabolism process PPAR-gamma, in the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They are stimulated by small ligands (useful groups of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles in an exceedingly series of processes starting from lipid metabolism in obese models to pro-inflammatory enzyme inhibition. PPARs may have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation within the hippocampus and cortex of people with neurodegenerative diseases. Normal activity of all 3 receptors maintains homeostasis, which suggests that the body includes a good immune system and lower probabilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively concerned in varied processes taking place inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in each animal and human models. A clinical trial conducted on rodents showed adipogenic process regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
youtube
0 notes
Text
Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite it slow currently regarding dietary supplements that includes CLA Safflower oil. Promising revolutionary changes for those with excess weight, one explicit producer of such supplements are marred by a rather crass scandal involving dubious marketing practices. Even if we have a tendency to may place it out of our minds, the actual fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises within the case of each supplement – does it extremely work? – there are some peculiarities in this case. Initial of all, the designation will be slightly misleading. CLA and safflower oil are related nevertheless completely different substances and, although they're presented as being a unitary extract, any inquiry and analysis of the compounds are required. Secondly, we have a tendency to ought to delve a small amount deeper into the effects of the ingredients that create up these supplements so as to search out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, side effects and the like. We tend to can provide you with the necessary information, starting with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of every), followed by an assessment of the existing body of reviews and rounding the article up with our verdict on the probability that CLA Safflower oil supplements might help anyone in their quest for a healthier and a lot of appealing silhouette. The CLA – Safflower Oil Connection A while ago, The American Heart Association released a suggestion regarding the benefits that Omega-half dozen fatty acids have on the heart health, urging their steady but moderate consumption. Within the wake of this announcement, the number of studies undertaken on omega-half dozen acids, and polyunsaturated fats in general, have increased markedly. One such study, conducted at Ohio State University, was concerned with the consequences of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic girls who failed to need daily insulin injections. It was long speculated that this sort of supplementation would have a positive result on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They are related, but just about the same. The 35 ladies within the study were divided into two groups, people in every grouping being administered half-dozen.four grams of fatty acid daily, for 16 weeks, while not any alternative tampering with medication, or with their routine in general. The results were encouraging, to say the least. Subjects within the CLA supplementation group exhibited a important decrease in the Body Mass Index indicator, [*fr1] a purpose on average, a figure that translated into a drop of 3.a pair of percent from the total body fat. Subjects experiencing safflower oil supplementation, on the opposite hand, had a considerable reduction in their trunk fat, but with no vital consequences on their overall fat, and a remarkable increase in muscle tissue. Furthermore, the safflower oil supplemented cluster additionally exhibited a decrease in their blood sugar levels with an average of 15 points. Within the case of each parties, no other alterations in their health were observed, with the notable exception of the rise in the assembly of the hormone adiponectin, noticed in the group supplemented with safflower oil. This hormone is responsible for the pace at which fat is burned in the metabolism. While these results were promising and certainly paved the manner for a fast introduction available of CLA and safflower oil extract supplements, there are some caveats to them. The big question sign the results of this study raised issues concerning the excess fat. Where had it gone? After all, the exercise routine was not modified. The noticeable increase in the adiponectin production raised parallels the dramatic aspect effects medication that tamper with hormone levels have. The excess fat might be deposited within the liver and/or muscle tissue, thus increasing the severity of diabetes (or inflicting it to people who do not suffer from the condition) or inducing a whole range of liver disorders. This study indeed unearthed exciting advantages that both CLA and safflower oil could bring about, however the attainable side effects might not are fathomed throughout the restricted period (sixteen weeks) the scientists had at their disposal. Currently that we have a tendency to have seen how the underlying principle in the dietary supplements we tend to are discussing came regarding allow us to get additional aware of both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The drawback with CLA isn't restricted to grammar (i.e., ought to one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that haven't been sufficiently researched. Nevertheless, there's sufficient knowledge relevant to their use in dietary supplements, and we tend to ought to proceed with the analysis. Conjugated linoleic acids are one in all 28 isomers of linoleic acids that are created naturally when certain dairy product or meats are lessened by bacteria within the stomach or intestines. The isomers of a certain substance have the same chemical formula (one molecule contains the identical parts in precisely the identical variety), nonetheless they differ in their chemical structure. CLA is classified as trans- fatty acid and conjointly cis- fatty acid, making them something of an oddity, at least in the biochemical realm. This is where we will confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (but, more than seventy five p.c of it is oleic acid, a monosaturated acid) – approximately 0.7 mg/gram. So, CLA and safflower oil are indeed substances that can be placed in the same class, yet they are by no means that as alike as to possess the identical effect on the human body or for use interchangeably. From a logical standpoint, that is why the study cited within the previous section used both substances, to seek out out the outcomes and, as we have seen, the outcomes, though each regard the reduction of body fat, proved indeed to be quite completely different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies have not slowed their pace since then. However, it wasn't until 2008 that the Food and Drug Administration (FDA) recognized CLA as being typically safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, though the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the aid of the bacteria from the Bifidus strain that reside within the intestine. A host of conditions and dysfunctions – starting from high acidic levels to most digestive diseases and even gluten intolerance – build the synthesis not possible. Thus, one can conclude that a supplementation of CLA is actually required, especially from a bound age onwards, nonetheless queries of dosage or method of administration remain. At first, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited higher than (although extrapolating from artificially induced cancer in mice to tumors on humans is a rather dubious observe). In recent years, and in the light of the study performed at Ohio State University, CLA supplements are part of the supplements that advertise weight loss. According to the WebMD website, CLA is utilized in dietary supplementation, with doses between 15 to 175 mg for daily use. The functions are various – cancer, combating gentle food allergies, reducing the effects of chronic disease on weight or atherosclerosis. CLA is probably effective in fighting obesity and high blood pressure, however, more research on the subject is required. On the subject of all alternative claims made by manufacturers, speculation can best characterize them. It is safe for the typical healthy adult within the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are gift, one is suggested to avoid CLA. Arriving at the topic of dosage, the results of the Ohio State study are quoted – only seven grams per day, though there are not any significant edges for doses larger than 3.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is related to its interaction with the PPAR receptors. Clinical studies investigating the acid’s impact showed lipogenesis reduction via molecule modulation on in vivo models. The findings also suggested that the isomers in conjugated linoleic acid would possibly reduce adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins spread throughout the complete human body, however with a better incidence rate in the adipose tissue. Three sorts of PPARs[one] have been identified and studied: PPAR-alpha, mainly found in the heart, liver and adipose tissue, accountable for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, involved in the fatty acid metabolism method PPAR-gamma, in the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They're stimulated by tiny ligands (practical teams of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles during a series of processes starting from lipid metabolism in obese models to professional-inflammatory enzyme inhibition. PPARs would possibly have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation in the hippocampus and cortex of people with neurodegenerative diseases. Normal activity of all 3 receptors maintains homeostasis, which suggests that the body includes a smart immune system and lower possibilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively concerned in various processes going down inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in each animal and human models. A clinical trial conducted on rodents showed adipogenic process regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
youtube
0 notes
Text
Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite some time currently regarding dietary supplements that includes CLA Safflower oil. Promising revolutionary changes for those with excess weight, one explicit producer of such supplements are marred by a rather crass scandal involving dubious selling practices. Even if we may place it out of our minds, the actual fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the obvious question that arises within the case of each supplement – does it very work? – there are some peculiarities during this case. First of all, the designation will be slightly misleading. CLA and safflower oil are connected nevertheless completely different substances and, though they're presented as being a unitary extract, more inquiry and analysis of the compounds are needed. Secondly, we tend to should delve a bit deeper into the effects of the ingredients that build up these supplements in order to search out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, facet effects and therefore the like. We have a tendency to can provide you with the necessary information, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of every), followed by an assessment of the existing body of reviews and rounding the article up with our verdict on the chance that CLA Safflower oil supplements might facilitate anyone in their quest for a healthier and additional appealing silhouette. The CLA – Safflower Oil Connection Some time ago, The American Heart Association released a suggestion regarding the advantages that Omega-six fatty acids have on the heart health, urging their steady however moderate consumption. In the wake of this announcement, the number of studies undertaken on omega-6 acids, and polyunsaturated fats in general, have increased markedly. One such study, conducted at Ohio State University, was concerned with the consequences of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic ladies who failed to require daily insulin injections. It was long speculated that this sort of supplementation would have a positive effect on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. But, their chemical structure differs slightly. They're connected, but roughly the same. The 35 women in the study were divided into 2 groups, people in every grouping being administered half-dozen.4 grams of fatty acid daily, for sixteen weeks, while not any different tampering with medication, or with their routine generally. The results were encouraging, to mention the smallest amount. Subjects in the CLA supplementation group exhibited a important decrease within the Body Mass Index indicator, [*fr1] a point on average, a figure that translated into a drop of three.2 p.c from the full body fat. Subjects experiencing safflower oil supplementation, on the opposite hand, had a substantial reduction in their trunk fat, however with no significant consequences on their overall fat, and a outstanding increase in muscle tissue. Furthermore, the safflower oil supplemented cluster conjointly exhibited a decrease in their blood sugar levels with a median of fifteen points. In the case of both parties, no other alterations in their health were observed, with the notable exception of the rise in the production of the hormone adiponectin, noticed within the group supplemented with safflower oil. This hormone is responsible for the pace at that fat is burned within the metabolism. While these results were promising and definitely paved the means for a quick introduction on the market of CLA and safflower oil extract supplements, there are a few caveats to them. The big question sign the results of this study raised issues regarding the excess fat. Where had it gone? After all, the exercise routine was not modified. The noticeable increase in the adiponectin production raised parallels the dramatic side effects medication that tamper with hormone levels have. The surplus fat might be deposited within the liver and/or muscle tissue, so increasing the severity of diabetes (or inflicting it to people who do not suffer from the condition) or inducing an entire range of liver disorders. This study indeed unearthed exciting edges that each CLA and safflower oil may bring regarding, yet the doable side effects might not have been fathomed during the limited amount (16 weeks) the scientists had at their disposal. Currently that we have seen how the underlying principle within the dietary supplements we tend to are discussing came regarding let us get additional aware of both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The problem with CLA is not restricted to grammar (i.e., ought to one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that have not been sufficiently researched. Nevertheless, there is sufficient information relevant to their use in dietary supplements, and we tend to should proceed with the analysis. Conjugated linoleic acids are one in every of twenty eight isomers of linoleic acids that are created naturally when bound dairy products or meats are weakened by bacteria in the abdomen or intestines. The isomers of a sure substance have the identical chemical formula (one molecule contains the identical components in exactly the identical number), however they differ in their chemical structure. CLA is assessed as trans- fatty acid and conjointly cis- fatty acid, making them something of an oddity, a minimum of within the biochemical realm. This is where we have a tendency to can confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (however, more than 75 p.c of it is oleic acid, a monosaturated acid) – approximately 0.7 mg/gram. Therefore, CLA and safflower oil are indeed substances which will be placed in the identical category, nonetheless they are by no suggests that as alike as to possess the same effect on the human body or for use interchangeably. From a logical standpoint, that's why the study cited in the previous section used each substances, to search out out the outcomes and, as we have a tendency to have seen, the outcomes, though each regard the reduction of body fat, proved indeed to be quite different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies haven't slowed their pace since then. However, it wasn't until 2008 that the Food and Drug Administration (FDA) recognized CLA as being typically safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, although the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the aid of the bacteria from the Bifidus strain that reside in the intestine. A host of conditions and dysfunctions – ranging from high acidic levels to most digestive diseases and even gluten intolerance – make the synthesis impossible. So, one will conclude that a supplementation of CLA is actually required, especially from a bound age onwards, nonetheless queries of dosage or method of administration remain. At first, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited above (although extrapolating from artificially induced cancer in mice to tumors on humans is a rather dubious follow). In recent years, and in the light of the study performed at Ohio State University, CLA supplements are part of the supplements that publicize weight loss. According to the WebMD website, CLA is utilized in dietary supplementation, with doses between 15 to a hundred seventy five mg for daily use. The purposes are diverse – cancer, combating gentle food allergies, reducing the effects of chronic disease on weight or atherosclerosis. CLA is possibly effective in fighting obesity and high blood pressure, but, more analysis on the topic is needed. On the subject of all other claims made by manufacturers, speculation will best characterize them. It's safe for the common healthy adult in the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are present, one is advised to avoid CLA. Arriving at the subject of dosage, the results of the Ohio State study are quoted – no more than 7 grams per day, though there aren't any vital edges for doses larger than three.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is related to its interaction with the PPAR receptors. Clinical studies investigating the acid’s impact showed lipogenesis reduction via molecule modulation on in vivo models. The findings conjointly suggested that the isomers in conjugated linoleic acid would possibly reduce adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the entire human body, however with the next incidence rate within the adipose tissue. 3 varieties of PPARs[1] are identified and studied: PPAR-alpha, mainly found in the heart, liver and adipose tissue, responsible for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, involved within the fatty acid metabolism method PPAR-gamma, in the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They're stimulated by tiny ligands (purposeful groups of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles in a very series of processes ranging from lipid metabolism in obese models to pro-inflammatory enzyme inhibition. PPARs might have an antitumorigenic effect in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation in the hippocampus and cortex of individuals with neurodegenerative diseases. Normal activity of all three receptors maintains homeostasis, which suggests that the body includes a sensible immune system and lower probabilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively concerned in varied processes happening inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in both animal and human models. A clinical trial conducted on rodents showed adipogenic method regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
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Cla Safflower Oil Review
Cla Safflower Oil Review There has been a hype for quite a while currently regarding dietary supplements that includes CLA Safflower oil. Promising revolutionary changes for those with excess weight, one particular producer of such supplements are marred by a rather crass scandal involving dubious marketing practices. Even if we have a tendency to may put it out of our minds, the actual fact that CLA Safflower oil supplements are still being manufactured and commercialized warrants an in-depth analysis. Besides the plain question that arises in the case of every supplement – will it very work? – there are some peculiarities during this case. Initial of all, the designation will be slightly misleading. CLA and safflower oil are related nevertheless completely different substances and, although they're presented as being a unitary extract, additional inquiry and analysis of the compounds are needed. Secondly, we should delve a bit deeper into the results of the ingredients that create up these supplements so as to seek out out if they work towards achieving the goal of weight loss. Then there are technicalities – dosage, aspect effects and therefore the like. We tend to can offer you with the required info, beginning with a separate discussion of CLA and then safflower oil (with arguments for and against the consumption of each), followed by an assessment of the prevailing body of reviews and rounding the article up with our verdict on the probability that CLA Safflower oil supplements might facilitate anyone in their quest for a healthier and a lot of appealing silhouette. The CLA – Safflower Oil Connection Some time ago, The American Heart Association released a suggestion regarding the advantages that Omega-half-dozen fatty acids have on the general heart health, urging their steady but moderate consumption. Within the wake of this announcement, the amount of studies undertaken on omega-6 acids, and polyunsaturated fats generally, have increased markedly. One such study, conducted at Ohio State University, was involved with the results of supplementation with safflower oil and conjugated linoleic acid (CLA) in menopausal, obese, diabetic girls who did not require daily insulin injections. It was long speculated that this type of supplementation would have a positive impact on weight loss efforts. Safflower oil (or rather a linoleic acid it contains) and conjugated linoleic acid share a chemical formula. However, their chemical structure differs slightly. They are connected, however almost the identical. The 35 ladies in the study were divided into two teams, people in every grouping being administered half dozen.4 grams of fatty acid daily, for sixteen weeks, without any different tampering with medication, or with their routine normally. The results were encouraging, to mention the smallest amount. Subjects within the CLA supplementation group exhibited a important decrease in the Body Mass Index indicator, [*fr1] a purpose on average, a figure that translated into a drop of three.2 % from the full body fat. Subjects experiencing safflower oil supplementation, on the other hand, had a substantial reduction in their trunk fat, however with no important consequences on their overall fat, and a remarkable increase in muscle tissue. Furthermore, the safflower oil supplemented cluster also exhibited a decrease in their blood sugar levels with a mean of 15 points. In the case of both parties, no different alterations in their health were observed, with the notable exception of the increase in the production of the hormone adiponectin, noticed in the cluster supplemented with safflower oil. This hormone is accountable for the pace at which fat is burned within the metabolism. Whereas these results were promising and actually paved the method for a quick introduction on the market of CLA and safflower oil extract supplements, there are some caveats to them. The big question sign the results of this study raised concerns regarding the excess fat. Where had it gone? After all, the exercise routine wasn't changed. The noticeable increase in the adiponectin production raised parallels the dramatic aspect effects drugs that tamper with hormone levels have. The excess fat may be deposited in the liver and/or muscle tissue, therefore increasing the severity of diabetes (or inflicting it to people who don't suffer from the condition) or inducing an entire range of liver disorders. This study indeed unearthed exciting advantages that each CLA and safflower oil might bring about, nonetheless the attainable facet effects could not are fathomed during the restricted amount (16 weeks) the scientists had at their disposal. Now that we have seen how the underlying principle within the dietary supplements we have a tendency to are discussing came concerning let us get additional conversant in both CLA and safflower oil. CLA (Conjugated Linoleic Acids) The problem with CLA isn't restricted to grammar (i.e., ought to one use “CLA is” or “CLA are”, as some reviewers use them interchangeably), rather CLA are compounds that have not been sufficiently researched. Nevertheless, there is sufficient knowledge relevant to their use in dietary supplements, and we have a tendency to should proceed with the analysis. Conjugated linoleic acids are one of 28 isomers of linoleic acids that are produced naturally when certain dairy product or meats are countermined by bacteria in the stomach or intestines. The isomers of a sure substance have the identical chemical formula (a single molecule contains the identical parts in specifically the same number), yet they differ in their chemical structure. CLA is classified as trans- fatty acid and also cis- fatty acid, making them something of an oddity, a minimum of in the biochemical realm. This is where we will confront the “CLA – safflower oil” confusion and convolution of terms. Safflower oil contains traces of linoleic acid (but, a lot of than 75 % of it's oleic acid, a monosaturated acid) – approximately 0.7 mg/gram. So, CLA and safflower oil are indeed substances that may be placed in the same category, yet they're by no means as alike as to own the same effect on the human body or for use interchangeably. From a logical standpoint, that is why the study cited within the previous section used each substances, to seek out out the outcomes and, as we have a tendency to have seen, the outcomes, though both regard the reduction of body fat, proved indeed to be quite totally different. CLA sprang into the spotlight as early as 1979, when a study performed on mice showed that the fatty acids had properties of visibly shrinking chemically induced tumors in mice. The studies have not slowed their pace since then. But, it was not until 2008 that the Food and Drug Administration (FDA) recognized CLA as being generally safe. Nevertheless, supplements containing CLA had been manufactured and marketed before, though the hype around CLA has magnified since that moment. The human body naturally synthesizes CLA from linoleic acid through the help of the bacteria from the Bifidus strain that reside within the intestine. A host of conditions and dysfunctions – ranging from high acidic levels to most digestive diseases and even gluten intolerance – create the synthesis not possible. So, one can conclude that a supplementation of CLA is actually needed, particularly from a bound age onwards, nevertheless queries of dosage or methodology of administration stay. At first, CLA supplements were mainly marketed as natural anti-cancer solutions, with their scientific basis being the rodent study cited higher than (though extrapolating from artificially induced cancer in mice to tumors on humans is a rather dubious follow). In recent years, and in the sunshine of the study performed at Ohio State University, CLA supplements are half of the supplements that advertise weight loss. According to the WebMD website, CLA is used in dietary supplementation, with doses between 15 to a hundred seventy five mg for daily use. The functions are various – cancer, combating delicate food allergies, reducing the consequences of chronic disease on weight or atherosclerosis. CLA is presumably effective in fighting obesity and high blood pressure, but, more research on the subject is needed. On the subject of all different claims made by manufacturers, speculation can best characterize them. It's safe for the average healthy adult within the doses found in food and in most supplements, though in cases where surgery, bleeding disorders, and diabetes are gift, one is suggested to avoid CLA. Arriving at the subject of dosage, the results of the Ohio State study are quoted – not more than seven grams per day, though there aren't any vital edges for doses larger than 3.four grams per day. What is CLA’s Mechanism of Action? CLA’S biochemical mechanism of action is connected to its interaction with the PPAR receptors. Clinical studies investigating the acid’s effect showed lipogenesis reduction via molecule modulation on in vivo models. The findings also suggested that the isomers in conjugated linoleic acid may cut back adiposity by influencing energy metabolism. The PPARs are a family of nuclear receptor proteins unfold throughout the whole human body, however with a better incidence rate within the adipose tissue. 3 sorts of PPARs[one] have been identified and studied: PPAR-alpha, mainly found in the guts, liver and adipose tissue, responsible for triglyceride reduction and homeostasis PPAR-beta, expressed in brain and adipose tissue, involved in the fatty acid metabolism process PPAR-gamma, within the white adipose tissue and intestines, with role in glucose metabolism and insulin sensitization The receptors are transcription factors, similar relations a ip to the thyroid hormones. They're stimulated by tiny ligands (purposeful teams of molecules with biological purpose) derived from the body’s lipid substrates. Evidence shows of roles during a series of processes starting from lipid metabolism in obese models to pro-inflammatory enzyme inhibition. PPARs would possibly have an antitumorigenic impact in patients who have colon cancer. In vivo studies indicate a decrease in plaque accumulation within the hippocampus and cortex of people with neurodegenerative diseases. Normal activity of all three receptors maintains homeostasis, that means that the body contains a good immune system and lower probabilities to develop severe medical conditions. By activating the PPAR receptors, CLA is actively concerned in numerous processes taking place inside the body. Various studies indicate that supplementation with CLA has anti-obesity effects in both animal and human models. A clinical trial conducted on rodents showed adipogenic process regression following the acid’s action on the PPAR-gamma receptor (a regulator of adipocyte differentiation).
https://www.youtube.com/watch?v=9EYSd8oFDHM
https://www.youtube.com/watch?v=ZeID54r5MBQ
https://www.youtube.com/watch?v=fyOyAjLcK-w
https://www.youtube.com/watch?v=c2pmkOeLcyE
https://www.youtube.com/watch?v=cNlQLp_iRAY
https://www.youtube.com/watch?v=27yMQxKSO5o
https://www.youtube.com/watch?v=Ly_FjhJWt5k
https://www.youtube.com/watch?v=8T7rJ4ofpTA
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Why Do Onions Make Us Cry? Dr. Mercola By Dr. Mercola If you plan on making a salad, some kind of soup or a savory stir-fry, onions will most likely be part of the equation. You might also slice them into rings to place on sandwiches, or sauté them gently in coconut oil or grass fed butter until they're soft, translucent and absolutely delicious. But something else may be likely as well: When you're cutting or chopping them, before you get very far into the first onion, you're very likely to find your nose twitching and tears making your eyes smart. Medical News Today suggests onions make your eyes spring a leak when you cut into them (or, to a lesser degree, other potent-smelling members of the allium family, such as garlic, chives, scallions and leeks) to discourage greedy predators from eating them. Whatever the reason, you can blame — or thank — specific volatile chemicals for giving onions their characteristic bold flavor and fragrance. A perennial vegetable, onions form a bulb the first year, which happens to be quite flavorful and functions as the plant’s energy store. The next year, they produce flowers and seeds, which keep the fragrance and cause the onion itself to keep reproducing. Researchers have recently determined how it actually works. The eye-irritating factor released by chopping onions was once thought to be “cut loose,” so to speak, by the enzyme alliinase, which breaks down into flavor molecules, and in the process, some are converted to lachrymatory factor (LF) by LF synthase.1 The journal Nature published the study, in which the researchers explained: "Here we show that this factor is not formed as a by-product of this reaction, but that it is specifically synthesized by a previously undiscovered enzyme, lachrymatory-factor synthase. It may be possible to develop a non-lachrymatory onion that still retains its characteristic flavour and high nutritional value by downregulating the activity of this synthase enzyme."2 The Science Behind the Smell Marcin Golczak, an assistant professor in the department of pharmacology at Case Western Reserve University in Cleveland, headed up the team that tackled the exact structure of the enzyme, known as lachrymatory factor synthase, or LF synthase, which shows that the enzyme responsible for the crying phenomenon is simply doing its job to create the heady fragrance and intensify the onion's flavor. When the eau de parfum of onion reaches your nose and eyes (specifically your cornea), the nerve endings there are alerted that an irritant is in the vicinity. Your brain activates your tear ducts to send the sniffles and tears, which help wash away the offending irritation. Blinking helps, too. How LF synthase enzymes work is somewhat complex, which is why, since being identified in 2002, scientists haven't actually demonstrated how it works. In order to do that, Golczak and company turned solutions of the onion-derived enzyme into microscopic crystals, after which they were detectable under X-ray, which revealed the enzyme's 3-D structure, as well as the tiny pocket where the LF conversion occurs. Medical News Today notes: "Detailed knowledge of this chemical process fills a fundamental gap in knowledge and gives scientists a better understanding of the biochemical potential of onions." Onions Offer a Unique Set of Nutrients for Health Some of the most potent vitamins and minerals contained in onions include vitamin C, pantothenic acid and vitamin B6 (pyridoxine), which helps augment levels of the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, assure a good night’s sleep and combat depression and anxiety. They also provide quite a lot of fiber. Iron, folate, thiamin and potassium are additional minerals. Along with the vitamin C, manganese helps fight colds and flu because it also strongly discourages inflammation. But several valuable antioxidant compounds in onions, including flavonoids, polyphenols and quercetin, help enhance your health. Research shows that the same compounds that initiate the tears — allium and allyl disulphide — change to allicin when they're cut or chopped and have the ability to fight diabetes and cancer, specifically stomach and ovarian cancers.3 This is significant, as other serious diseases and disorders, most being related, are also positively impacted, according to Nutrition and You,4 including: High blood pressure Platelet clot formation Coronary artery disease Peripheral vascular diseases Stroke Being antidiabetic, anticarcinogenic and anti-inflammatory, onions and the compounds they hold: Have been used in ancient traditional medical treatments for millennia Help optimize cholesterol production by inhibiting the HMG-CoAreductase enzyme in liver cells Exert antibacterial, antiviral and antifungal activity Inhibit atherosclerosis by reducing stiffness in your blood vessels Help decrease in overall risk of coronary artery disease and peripheral vascular diseases Something about the compounds in onions that can bring about healing also brings about tears, but the tears are for protection, Medical News Today explains: "The chemical at the heart of our discomfort is called propanethial S-oxide, which is also known as lachrymatory factor (LF). The technical term for our tear glands is 'lacrimal glands,' and LF is a chemical that causes tears."5 Not All Tears Are the Same, Especially if You're Chopping Onions In 2010, a photographer specializing in microscopic views, Rose-Lynn Fisher, found that depending on the emotion or cause of peoples’ tears, when they’ve dried, they look different up close. Using powerful scanning electron microscopes, she was able to produce in pictures how different dried human tears appear. According to Smithsonian Magazine, when Fisher caught one of her own tears on a slide and examined it under a microscope, she noted: "It was really interesting. It looked like an aerial view, almost as if I was looking down at a landscape from a plane … Eventually, I started wondering — would a tear of grief look any different than a tear of joy? And how would they compare to, say, an onion tear?"6 Her query spawned an interesting photographic undertaking, and a quite abstract one at that — literally, as each photograph has all the elements of a topographical map — hence the name of her project, “Topography of Tears.” It entailed collecting, examining and photographing more than 100 tears, essentially crystalized salt, from several subjects, including a newborn baby. Some appear similar to a wall treatment known as Spanish Lace — flat, pale and abstract in spots, and dark, rounded and almost geometric in others. Those associated with grief or regret seemed paler and less complex that those evoked by so-called "happy" or "laughing" tears, Fisher noted. Basal tears are usually small and sparse for the purpose of lubrication of the cornea, while reflex tears are in response to an irritant, such as sawdust or tear gas. The third type is from crying due to an emotion such as stress or pain. The article noted: "All tears contain a variety of biological substances (including oils, antibodies and enzymes) suspended in salt water, but as Fisher saw, tears from each of the different categories include distinct molecules as well. Emotional tears, for instance, have been found to contain protein-based hormones including the neurotransmitter leucine encephalin, a natural painkiller that is released when the body is under stress."7 Interestingly, the slides with tears collected from someone crushing or cutting onions were beautifully patterned and completely unique, almost like a series of snowflakes packed on a windowpane. However, Fisher concedes that the way the tear dries can make all the difference in its final appearance, including variables such as "the chemistry, the viscosity, the setting, the evaporation rate and the settings of the microscope."8 Another Reason Why Tears Are Useful Believe it or not, if you find chopping onions to be so bothersome you'd rather just buy the chopped and dried variety, you might be interested in knowing that at least two groups of scientists have been trying to produce an onion devoid of the tearjerking response most people are affected by. One of the new "tearless" onion varieties inhibits platelet aggregation, which is linked to cardiovascular disease,9 but one has to wonder if, by silencing LF synthase, the nutritional value of the onion is compromised. Tears are an interesting phenomenon, nonetheless, that have been studied or at least wondered about for thousands of years. Not so long ago, scientists found that tears can be used just as effectively to monitor glucose levels in diabetic patients. The research,10 conducted by scientists from the University of Michigan, would provide a painless way to accurately measure such levels, even in animals, using an electrochemical sensor device. According to the study: "A strong correlation between tear and blood glucose levels was found, suggesting that measurement of tear glucose is a potential noninvasive substitute for blood glucose measurements, and the new sensor configuration could aid in conducting further research in this direction. It may be possible to measure tear glucose levels multiple times per day to monitor blood glucose changes without the potential pain from the repeated invasive blood drawing method."11 Another thing this research proved is that tears aren't always a bad thing, especially if they're produced by chopping onions. Buying organic onions is always best, and you may be interested in knowing that red onions have particularly beneficial properties for your health, although each variety has tremendous potential depending on your needs. In past articles, I've discussed different onion types and the best ways to cook and store them.
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