#LSD1

[pier-carlo-universe]

Glioblastoma: lo studio IEO su Science Advances apre a nuove terapie combinate per superare la resistenza

[thelovebudllc]

Understanding the role of LSD1 in cellular processes and disease

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes and its implications for human diseases. This article sheds light on how post-translational modifications (PTMs) influence LSD1 activity, impacting its function in gene regulation and disease progression. LSD1 is a histone demethylase that plays a significant role in…

[moleculardepot]

KDM1A Protein-GST Fusion

KDM1A Protein-GST Fusion Catalog number: B2024047 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 20 ug Molecular Weight or Concentration: N/A Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: –70°C Keywords: AOF2, BHC110, LSD1, KIAA0601, Lysine-specific histone demethylase 1A,, BRAF35-HDAC complex protein BHC110,…

[leedsomics]

Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer

Neuroendocrine cells have been implicated in therapeutic resistance and worse overall survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EECs), the neuroendocrine cell of the normal colon epithelium, as compared to non-mucinous CRC. Therefore, targeting EEC differentiation may have clinical value in mCRC. Here, single cell multi-omics was used to uncover epigenetic alterations that accompany EEC differentiation, identify STAT3 as a novel regulator of EEC specification, and discover a rare cancer-specific cell type with enteric neuron-like characteristics. Further experiments demonstrated that lysine-specific demethylase 1 (LSD1) and CoREST2 mediate STAT3 demethylation and regulate STAT3 chromatin binding. Knockdown of CoREST2 in an orthotopic xenograft mouse model resulted in decreased primary tumor growth and lung metastases. In culmination, these results provide rationale for new LSD1 inhibitors that target the interaction between LSD1 with STAT3 or CoREST2, which may improve clinical outcomes for patients with mCRC. http://dlvr.it/T2NhrB

[sisiad]

Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion

http://dlvr.it/T1zBZf

[epigen-papers]

LSD1 Regulates Neurogenesis in Human Neural Stem Cells Through the Repression of Human-Enriched Extracellular Matrix and Cell Adhesion Genes

Pubmed: http://dlvr.it/T0hzpk

[tumimmtxpapers]

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer (NSCLC), with elevated T cell infiltration and sensitize tumors to anti-PD-1 therapy. However, the lack of reliable biomarkers limits utilization of LSD1 inhibitors in cancer therapy. Here, we identify an E3 ligase, Trim35, as an effective biomarker for high activity of LSD1 to predict prognosis of LSD1-targeted therapy as well as... http://dlvr.it/Sz1k4z

[eyedao]

#swinknsg #lsdone #brooklyngraffiti #oldschoolgraffiti #graffitistickers #graffiticharacter #lsd1 https://www.instagram.com/p/CYdL-NmMPlh/?utm_medium=tumblr

[neurosciencenews]

New Insight Into How Brain Cells Die in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

The research is in Nature Communications. (full open access)

[scienceinenglish]

LSD1 inhibitor ameliorates autism-associated traits in new mouse model. We need to talk. - https://jlb.qqf.mybluehost.me/?p=358