#StemCellResearch

[viezec]

What Are Stem Cells Sourced From?

Stem cells can come from several places in the body, and the source often depends on the condition being treated. Common sources include:

Bone marrow – a rich source of hematopoietic and mesenchymal stem cells, often used for orthopedic and autoimmune treatments.

Adipose (fat) tissue – easily accessible and abundant in mesenchymal stem cells.

Umbilical cord blood – collected at birth and stored in cord blood banks, these cells are young, potent, and carry low risk of immune rejection.

https://www.viezec.com/science/stem-c...

[globalstemcellcare]

Restoring Vision: Advantages of Using Stem Cell Treatment for Glaucoma

Glaucoma is an eye disorder which affects the optic nerve, found on the back of your eye, which causes vision loss and blindness. There are several ways to treat this condition, but stem cell therapy is becoming the preferable one because of its regenerative potential to recover the damaged tissues. We provide you with the best stem cell therapy, which promises a positive success rate.

https://www.globalstemcellcare.com/eye-disorder/stem-cell-treatment-for-glaucoma/

[joelekm]

Understanding Stem Cell Therapy for Cancer Treatment and Health Improvement | Dr. Jamal A. Khan

In this video, Dr. Jamal A. Khan discusses the significance of stem cell therapy in treating cancer and improving overall health. He shares his observations and experiences, contrasting cultural differences in perceptions of social interactions and highlighting the importance of new generations adopting progressive mindsets.

[beeswire]

Human Organoids Market Forecast to Reach USD 6,267.09 Million by 2034 | CAGR: 22.8%

Human Organoids Market Analysis: Opportunities, Innovations, and Growth Potential Through 2034 Global Human Organoids Market size and share is currently valued at USD 805.32 million by 2024 and is anticipated to generate an estimated revenue of USD 6,267.09 million by 2034, according to the latest study by Polaris Market Research. Besides, the report notes that the market exhibits a robust 22.8%…

[prateekcmi]

Global Induced Pluripotent Stem Cells Market Trends and Growth Prospects

The Global Induced Pluripotent Stem Cells Market is witnessing robust growth as breakthroughs in regenerative medicine and personalized therapies gain momentum. Driven by advancements in biotechnology, this industry size expansion reflects the increasing adoption of stem cell technologies across research, clinical, and pharmaceutical sectors worldwide.  

Global Induced Pluripotent Stem Cells Market –   https://www.coherentmarketinsights.com/industry-reports/global-induced-pluripotent-stem-cells-market  

[lifesciencesmagazine]

Acne Drug Sparks Breakthrough in Limb Regeneration Research

Source: popsci

Axolotls, the endangered Mexican salamanders known for regrowing entire limbs, are at the center of a groundbreaking discovery. Scientists have long been fascinated by these aquatic creatures’ ability to reconstruct bones, muscles, skin, and nerves with remarkable precision. While the phenomenon has been documented since Aristotle’s time, modern biologists are getting closer to understanding the underlying mechanisms and possibly translating them into human medicine.

A recent study led by James Monaghan, a developmental biologist at Northeastern University, has revealed a critical link between limb regeneration and retinoic acid, a compound better known as the active ingredient in the acne medication Accutane. The research shows how retinoic acid plays a central role in guiding the growth and structure of new limbs, offering new hope for future medical treatments.

Retinoic Acid as the Blueprint KLimb Regenerationeeper

Using genetically modified, glow-in-the-dark axolotls, Monaghan’s team traced how retinoic acid helps determine the layout of a regenerating limb. Varying levels of this compound act as a biological map, guiding cells on where to grow joints, bones, and digits. Too much of the chemical causes malformed limbs; too little, and development stalls. The key regulator of this chemical gradient is a single enzyme, CYP26b1, which helps break down excess retinoic acid.

Disrupting this enzyme leads to abnormal limb growth, proving that tightly controlled levels of retinoic acid are essential. The team also identified at least three other genes that are directly influenced by retinoic acid and are vital for forming bones and structuring limbs. These findings underscore how even low, naturally occurring levels of this chemical can have a significant effect, a breakthrough compared to earlier studies that relied on artificially high dosages.

“These results get us closer to answering a long-standing question in biology: How does regenerating tissue know exactly what to rebuild?” said Catherine McCusker, a developmental biologist at the University of Massachusetts Boston, who was not involved in the study.

A Future of Human Regeneration

Retinoic acid is produced across many animal species, including humans, where it plays an essential role during embryonic development. Its involvement in limb regeneration raises hopes that similar mechanisms in humans could eventually be reactivated. According to Monaghan, the potential to induce regeneration in human limbs may not be as far-fetched as it once seemed.

“The ability might already be there,” Monaghan said, suggesting it could be a matter of reprogramming adult cells to behave like embryonic ones. He emphasized that while this discovery is a big step forward, full human limb regeneration is likely decades away.

Other researchers are also making strides. McCusker’s lab recently discovered how the top and bottom parts of limbs differentiate, while a separate Austrian team identified genetic feedback loops that help tissues remember limb structure. These foundational studies are crucial for long-term success, McCusker noted.

With sustained investment in basic biological research, scientists are optimistic that future therapies could help regenerate not just limbs, but also treat burns, spinal injuries, and even cancer. The once science-fiction dream of human regeneration may soon become a reality.

[globalgenerex]

The Future of Medicine: Unlocking Stem Cell Power |

Stem cell therapy holds vast promise with benefits that revolutionize clinical treatment. Its regenerative capability allows for:

Tissue Repair: Stem cells contribute to the restoration and regeneration of diseased or damaged tissues.

Disease Treatment: They offer novel approaches to deal with a myriad of diseases, from neurodegenerative problems to cardiovascular conditions.

For more details about the treatment, kindly visit

https://globalregenex.com/stem-cell-therapy/

[researchatory]

Lab-Grown Spine! Amazing New Model Grown from Stem Cells | @researchatory

This is a major step forward in understanding the human spine! Researchers have grown a lab-based model that mirrors early spinal development, potentially leading to breakthroughs in treating spinal conditions and birth defects.

#LabGrown #Spine #research #SpineResearch #StemCells #Organoids #humandevelopment #regenerativemedicine #SpinalHealth #medicalbreakthrough #ScienceNews #labgrown #Research #Innovation #sportsmedicine #biology #stemcellresearch #notochord #developmentalbiology

It's important to note: This is a simplified model and not a fully formed human spine. It develops for only a few days and cannot form an embryo. However, it represents a significant step forward in our ability to study human development and spinal disorders using lab-grown models, also known as organoids. This falls under the exciting field of regenerative medicine, which aims to understand, repair, replace, or regenerate human cells, tissues, or organs to restore or establish normal function.

By @imaakashkhurana For more details join our medium page. (https://medium.com/@researchatory)

[habithub]

Breakthrough Hydrogel Reprograms Cancer Cells in 24 Hours

Japanese scientists have developed an innovative hydrogel capable of transforming cancer cells back into cancer stem cells within just 24 hours. This groundbreaking discovery opens new possibilities for cancer research, offering a potential pathway to better understand cancer development and resistance, and paving the way for more targeted and effective treatments in the future.

[churchofgladtidingsyubacity]

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Don't miss this life-changing experience!

🎟 Use promo code: AHS50 for $50 OFF your in-person ticket. 📍 Register now: https://giveb.co/m/E0zLNG before time runs out!

[viezec]

Parkinson’s Disease? Explore Advanced Stem Cell Therapy in Delhi |

Stem Cell Treatment for Parkinson’s Disease in India has emerged as a promising avenue for patients seeking innovative therapeutic options. Parkinson’s Disease is a progressive neurodegenerative disorder, and conventional treatments may only manage symptoms to some extent. However, stem cell therapy offers a potential breakthrough by targeting the root cause of the disease.

https://www.viezec.com/diseases/neuro/parkinsons-disease-stem-cell-treatment-india/

[globalstemcellcare]

What is Glaucoma and Its Symptoms? Know the Signs Before It’s Too Late |

A complex and progressive eye condition called glaucoma affects the optic nerve and, if left untreated, can cause irreversible vision loss. It is frequently brought on by increased intraocular pressure, also known as intraocular pressure, which gradually weakens the optic nerve. Regular eye checkups are essential for early detection of glaucoma because it often develops without symptoms in its early stages.

https://www.globalstemcellcare.com/important-advice-to-consider-for-newly-diagnosed-glaucoma-patients/

[thesisphd]

Transforming Regenerative Medicine: AI's Role in Stem Cell Therapy

🌟 Regenerative Medicine: AI's Role in Stem Cell Therapy 🌟 🔬 Explore how Artificial Intelligence is revolutionizing regenerative medicine by advancing stem cell research and therapy. From predictive modeling to personalized treatment, AI is paving the way for breakthroughs in healthcare!

[lifesciencesmagazine]

An Overview of Bone Marrow Mononuclear Cells: Structure, Function, and Applications

https://thelifesciencesmagazine.com/wp-content/uploads/2025/01/1-An-Overview-of-Bone-Marrow-Mononuclear-Cells_-Structure-Function-and-Applications-Source-precisionformedicine.com_.jpg

Source: precisionformedicine.com

Bone marrow mononuclear cells (BM-MNCs) are the most fascinating factor of the body’s cellular system. It plays a vital role in terms of immunity and tissue regeneration. The bone marrow mononuclear cells are a diverse mixture of stem cells such as lymphocytes, monocytes, and hematopoietic progenitor cells.

They have contributed to the medical and research field in various ways, from combatting infections to repairing tissues. These cells gave a new direction to the research and development of many therapies for many diseases and injuries. The bone marrow mononuclear cells are helping advance and change the way healthcare assistance works by becoming a key player in stem cell therapy. The BM-MNCs help in various bodily functions, mainly related to our immune system and blood cell production.

In this article, we will dive into the world of these distinct cells and study their function and application in the research field. 

What are Bone Marrow Mononuclear cells?

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1. Hematopoietic Stem Cells (HSCs)

They are known as master cells in blood production, and they have the ability to self-renewal and differentiate between all types of blood cells, such as red blood cells, white blood cells, and platelets.

2. Lymphocytes

These cells are important components of the immune system. They consist of T cells, B cells, and killer cells. They are responsible for fighting against infection and targeting abnormal cells.

3. Monocytes

They have Precursors to macrophages that are vital for Ingesting and destroying foreign particles, tissue repair, and wound healing. It also helps in initiating and regulating immune responses.

4. Mesenchymal Stem Cells (MSCs)

These cells are known for their potential to differentiate into various cell types, such as bone, cartilage, and fat cells. It also plays a crucial role in tissue repair and regeneration.

Function and Application of Bone marrow mononuclear cells:

Function of BM-MNCs:

As mentioned, these cells are important and contribute to various bodily functions, as well as the production of blood cells. Their functions can be broken down in this way:

1. Hematopoiesis

This is the main function of BM-MNCs; they have the hematopoietic stem and progenitor cells (HSPCs). They are used for generating all types of blood cells, such as red blood cells (help in transporting oxygen through the body), white blood cells (fight any kind of infection and are vital for the immune system), and platelets (help in blood clotting).

2. Immune Response

The BM-MNCs contain various immune cells like lymphocytes and monocytes. These cells work together to eliminate foreign invaders and develop future immunity to fight against bacteria. It also helps regulate immune responses to prevent excessive inflammation or autoimmune reactions.

3. Tissue Repair and Regeneration

The Bone marrow mononuclear cells help in tissue repair and also in the regeneration of many organs and tissues. They can secrete the growth factors and signaling molecules that contribute to cell growth and differentiation. They are capable of differentiating into specific cell types needed for tissue repair, such as endothelial cells (lining blood vessels) or muscle cells.

Application:

1. Regenerative Medicine

They help in cardiac repair, as the bone marrow mononuclear cells consist of cardiac progenitor cells that help in treating heart damage. They also help in improving heart function by promoting new blood vessel growth. These cells have also shown promising outcomes when it comes to treating neurological disorders such as stroke, spinal cord injury, Parkinson’s, and Alzheimer’s. They are also boosting bone healing in fractures and treating cartilage damage in joints.

2. Hematopoietic Disorders

The BM-MNCs are vital for bone marrow transplants, as they are used to treat blood cancers like leukemia and lymphoma, along with other blood-related disorders. These cells are also used to restore the immune function in patients with immunodeficiency disorders by replenishing depleted immune cell populations.

3. Drug Discovery and Development

BM-MNCs are used for screening and testing new drugs for their efficacy and safety. It can also be used to develop personalized therapies for individual patients, taking into account their unique genetic and immunological profiles.

4. Research

It is considered a valuable tool in studying and understanding basic biological processes like hematopoiesis (blood cell formation), immune function, and stem cell biology.

Conclusion

Bone marrow mononuclear cells have brought various changes in the stem cell therapy field. And gave birth to phenomenal experiences that led to many discoveries. The world of cells is mysterious, but if you are willing to look inside, they can give answers to many questions that could help in the medical field to save lives. It can be used as a powerful tool to enhance the genetic makeup of someone’s body. It can help in curing many diseases. BM-MNC study takes a lot of patience, but if we understand the concept and how to use it, we can make wonders out of it. Tissue repair and regeneration to treating many Hematopoietic disorders.

FAQ:

How many mononuclear cells are in bone marrow?

The average BMMNC per mL in patients of age group 0–20 years was 4.71 million; in 21–40 years it was 4.03 million; in 41–60 years it was 3.67 million; in 61–80 it was 3.02 million. The average BMMNC per mL in all the 332 patients ranged from a minimum of 1.47 million to a maximum of 15.36 million.

What are mononuclear cells of bone?

Mononuclear cells are a mixture of cells isolated after Ficoll density gradient separation of the bone marrow aspirate. This procedure removes most of the erythrocytes and polymorphonuclear cells. The resulting mononuclear cell fraction is a mixture of lymphoid, myeloid, erythroid, and stem cell populations.

What are examples of mononuclear cells?

A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.

[globalgenerex]

Exosome Therapy Benefits: How It Works with Stem Cell Treatment |

Exosomes are found in various body fluids, including blood, urine, saliva, and cerebrospinal fluid. They are involved in processes such as immune response, inflammation, and tumor growth. Their ability to transfer bioactive molecules makes them potential therapeutic agents for a range of diseases.

https://globalregenex.com/what-is-exosome-treatment-and-its-benefits/

Email id- info@globalregenex.com Ph no- +91 7827791242

[stemcellcareindia]

Hope After Parkinson's: Indian Patient's Experience with Stem Cell Therapy |