#TDBT

[jusagi91]

I keep moving forward… 😤

[sugarpsalms]

since I'm not gonna have my laptop or anything for like 6 days (like I'll have my phone but um,,, writing long form on that is crazy) I'm probably gonna use the opportunity to bang out a BUNCH of little shit in my notebook...looking at YOU, For Whom The Skee Ball Rolls 👀

[communicom]

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[slycecaik]

can we bring back those faces from the flipnote era

[doc-pickles]

i saw mommy kissin’ santa claus

Hello! And welcome to “Festive Fridays with Two Dumb Bitches So Dumb They Can’t Stick to the Schedule They Make for Themselves” featuring me and @odd-birds-and-booksellers We wanted to find a day of the week for December to post our Christmas fics on and decided on Thursdays (this was originally titled ‘Two Dumb Bitches Thursday’ but we are both terrible procrastinators so now we have that fancy new title up there)

Will you get posts on Thursdays? Fridays? Who knows! But we’ve both committed to posting once a week every week of December with a fun festive fic! (Please don’t come to our inboxes and hound us about them, we yell at each other enough as it is and Lay is mean.....)

Anyways this is my first fluffy fic entry of the month and it’s definitely not inspired by real life events. Hope you enjoy! :) 

(also this is not my best work because i’m sleep deprived and also my pregnancy brain is not letting me write how i normally do soooo cut me some slack please and thanks)

“Karev!”

Both Jo and Alex turned at the sound of Bailey’s voice behind them, the woman looking expectantly at Alex. Now that he wasn’t a young resident, Bailey rarely evoked a feeling of fear in him but today her stern voice had him racking his brain for anything he’d done wrong recently.

“What can I do for you, Chief?”

“Doctor Peterson retired earlier this year,” Bailey waited for either Jo or Alex to make a connection from her words, but both stared blankly at her instead. “Doctor Peterson used to dress up as Santa every year for the Peds Ward Christmas party. Since he’s no longer available, I need a replacement.” 

Jo’s eyes lit up in delight as she turned to Alex who wore an unamused expression, “Absolutely not, I am not putting on that ridiculous costume.”

“Oh c’mon! It’s for sick kids Alex,” Jo settled a hand onto her husband's arm as she batted her eyelashes at him. “It’ll be fun! You should do it!”

Alex looked between his wife and his boss, Jo smiling excitedly at him while Bailey fixed him with a glare. A groan left him as he realized he didn’t have a say in the matter, “Fine I'll do it. But I’m not happy about it.” 

Jo let out an excited squeal as Bailey thanked him, walking away with a satisfied smirk. Turning to his giddy wife, Alex wrapped his arm around her waist and leaned down to whisper in her ear, “You better make this worth my damn while.”

“What, do you want me to come and sit on Santa’s lap and tell him what I want for Christmas,” Jo rolled her eyes, but Alex kept his gaze fixed on her. “You’re serious? You really are a pervy old man sometimes I swear.” Alex swatted at Jo’s ass playfully as she walked away from him. If she hadn’t happened to be standing next to him when Bailey asked he wouldn’t have caved so easily. His eyes narrowed at the thought, knowing that at least one of the women had planned that out. 

“Stupid freakin’ Santa costume…” 

+

There was a reason that he’d avoided the Christmas party for the Peds ward all these years and he finally realized why. Alex was surrounded by dozens of sugar high children who hadn’t seen outside of the hospital walls in weeks. He loved his job and working with kids, but he rarely had to deal with them when they were running around and screaming at the top of their lungs.

“Well you look like you’re having a great time,” Meredith sidled up to Alex, chuckling as she pulled on his fake beard. “The white doesn’t look so bad on you, maybe by next Christmas you won’t even need the fake beard.” “Oh shut up, I’m only here because Jo made me come. And she hasn’t even bothered to show up and make things around here more enjoyable,” Alex grumbled as he swatted away Meredith’s hand. He’d been sitting with kids on his lap for almost an hour and a half now, asking them what they wanted for Christmas and listening to their lists. “I’ve got fifteen minutes left before I can go home and drink beer and I can’t wait.”

“I’ve gotta go find my kids in this madness, but it looks like you have another visitor,” Meredith gestured to the little girl patiently waiting to meet Santa, bright blue eyes staring up at Alex in awe. “Have fun Santa!”

As soon as she was gone, the little girl bounded up to Alex and settled herself onto his lap, a gap toothed grin appearing on her face. Alex recognized her as one of his own patients, five year old Lauren who had a gastrointestinal problem that kept her in the hospital for weeks at a time, “Hi Santa!”

“Hi Lauren,” Alex almost chuckled at Lauren’s wide eyed expression when she realized that ‘Santa’ knew her name. “What do you want for Christmas?”

“I want a Barbie dream house and a pink glitter ballerina Barbie too,” Lauren was full of giggles as she relayed her wish list to Alex. Her expression softened however and she leaned in close to him, whispering her next words. “And I want my tummy to feel all better so I can go home and have a real Christmas. Christmas in the hospital is no fun.” Alex’s heart broke at the little girls words, realizing just how much of a toll being here was taking on such a young girl, “You know what, I think your doctors will do their very best to get you home for Christmas so you can play with all your new Barbies. How does that sound?” Lauren’s face lit up at Alex’s words, her arms wrapping around his neck as she giggled in delight. A string of thank yous left her as she hopped off Alex’s lap and reunited with her mother, who sent an appreciative wave in his direction. 

“Well aren’t you the best Santa in the world,” Alex turned at the sound of Jo’s voice, holding back an eye roll as she lifted her camera to snap a photo of him. “See, I told you it wouldn’t be that bad! Your mom is going to love that photo, I hope she puts it on the mantle.” “Did you come here for any reason besides to mock me,” Alex grumbled. “I’m almost done with this and then I’m never doing it again no matter how much you beg.” Alex couldn’t help but smirk at Jo’s amused expression. She looked so happy that he was doing this, like it had made her whole year. If nothing else, Jo’s excitement made the stupid gig worth it.

“Well I came here to tell Santa what I want for Christmas but if he’s too grumpy…,” Alex reached for Jo’s hand, pulling her into his lap as she laughed at his antics. 

“Now what do you want for Christmas,” Alex pressed his face into Jo’s neck, more laughter coming from her at the feel of the fake beard against her skin. “I’m sure Santa would be more than happy to oblige.”

“You realize you’re trying to talk dirty to me at a children’s party right,” Alex pinched Jo’s leg at her remark, a squeal leaving her as she jumped. “Okay okay, what I want for Christmas is… a baby.”

“A baby?”

“Yes a baby,” Jo grinned widely, leaning in close to Alex with a twinkle in her eyes. “I want you to knock me up. Preferably not wearing the Santa costume.” 

Alex stared dumbly up at his wife for a moment, her grin never fading as she watched him process what she’d said. A baby… Jo wanted to have kids. Kids with him.

“You know there’s easier ways to say that you want to try for a baby,” Alex chuckled as he leaned up to kiss Jo, his fake beard getting in the way of his attempt. “C’mon let’s go home, I finished my duty for the day. Maybe if you’ve make it on the nice list I’ll put in a good word for you with Santa.” A string of giggles left Jo as she watched Alex try and sneak out of the room, instead getting ambushed by almost all of the kids that were running around. After a quick goodbye and a promise to work hard on their wishes, the pair finally made it out of the room, Alex turning to Jo with a grin, “You want one of those? You sure?”

“More than anything. Now kiss me,” Jo pointed upwards to the doorway where a sprig of mistletoe hung. “It’s tradition.”

+

“I can’t believe you volunteered to do this this year,” Meredith stared dumbfoundedly at Alex, who sat in his chair with a smirk peeking through his fake beard. “Seriously, are you feeling okay? You couldn’t stop complaining last year.” “Would you pipe down, it’s different this year,” Alex shrugged, waving at one of the kids that ran by. “I wanted to spread some Christmas cheer to sick kids, is that so wrong?” “Don’t listen to him, he didn’t want some ‘germy mall Santa’ to hold Peyton for photos,” Meredith turned at the sound of Jo’s voice, a grin lighting up her face as she took in the sight of the small baby cradled in the baby sling across Jo’s chest. “Although the peds ward of a hospital can’t be much better.”

“Stop whining and come over here,” Alex held his arms out, expecting Jo to hand the baby to him but instead having her sit across his lap. “Really? You’re gonna sit on my lap again?”

Jo shrugged, pressing a kiss against his cheek as Alex reached up to uncover the baby’s face, “I figured my Christmas wish came true last year, might as well go again.” “Listen I love you but this one barely sleeps through the night as it is,” Alex gestured to Meredith, who was smiling at the happy family with her phone in hand. “Now would you smile so we can have a semi decent first Christmas photo for our daughter.” Jo and Alex both wore bright smiles as they looked at Meredith, the two month old between them not even batting an eyelash as she slept soundly on her mom’s chest. The warm feeling in Jo’s chest almost made her tear up, thinking to just the year before when her husband had begrudgingly put on a Santa costume to please her. This year he had eagerly gone through the motions, excited to create memories with their daughter without a care about all of the patients that came with the deal.

“What’s on your mind? You have that blissed out look on your face,” Alex’s fingers on her cheek snapped Jo out of her daze, her lips coming down to press against his briefly.

“Nothing, just thinking about how lucky I am and how much I love you.” “I love you too, but you can’t just kiss me like that,” Jo’s brows furrowed as she took in Alex’s serious expression. “The kids are watching! What are they gonna think when they see you kissing Santa like that? I’ll get a bunch of angry letters.” “You’re the worst, Karev.”

[yoonminist]

✨✨✨✨

[thebestdamnthing]

The Best Damn Thing: Booklet - 2007

[doc-pickles]

the only reason i’m reblogging this is because i’m contractually obligated to do so

also lay I hate you

I’ll be home for Christmas if only in my dreams…

It’s time for another very late “Tis the Damn Season for Two Dumb Bitches” TW; Major character death read at you own risk.

Keep reading

[aforestofworlds]

Hi, I’m Forest, a book lover who’s been writing since I could hold a pencil. My motivation to write dropped off in the last few years, but I’ve really been missing it lately so I’m hoping to rekindle the spark!

My main wip at the moment is a space fantasy straddling the line between YA and adult, inspired in parts by Star Wars and eldritch horror. It features fierce girls finding their strength, world-weary boys searching for peace, the complicated bonds between siblings, and the terrifying prospect of trusting another person with your heart. Its tentative working title is The Dark Beyond the Stars - posts related to it will be tagged TDBTS.

I also write fanfic - as of right now I don’t have any made public, but I’m in the process of digging into my archives and polishing up some old favorites to publish. When I do so, I’ll link my AO3 here as well. You can find a list of fandoms I’m involved in at my main blog, @lavenderlemonrose, which is also the blog I’ll be following from.

A note: My writing, both original and fanfic, contains mature themes and explicit (nsfw) scenes. All such content will be tagged properly, but for my own comfort, I respectfully ask minors under 16 DNI. I was reading smutty fanfic at your age too, there’s nothing wrong with it - I’d just rather not talk to you about it by accident. 

That’s all the housekeeping for now - welcome! 

[sugarpsalms]

WIP TAG GAME!

Rules: make a new post with the names of all the files in your wip folder, regardless of how non-descriptive or ridiculous. Tag as many people as you have wips. People send you an ask with the title that most intrigues them, then post a little snippet or tell them something about it! 

wheeee thanks @physics-of-one-piece this is cute! okie time to clown 🤡 working titles indicated by (wt). Otherwise, they're final. Spicing it up and adding my original WIPs too qjdwjd

FANFIC

(wt) Not As Bad As It Looks — shuggy, rated T

(wt) Really, Rosi? In Church? — dq bros, rated T (ch. 2 of TDBT)

To Azazel, With Love — doflaw, rated M

(wt) Nice Rock! — chopperlaw, rated T

ORIGINALS

What Winter Takes — YA arthurian fantasy (in final editing hell, will perhaps kill me)

Blood, Bitch! — horrorotica

Fallon Hall — gothic romance 

uuuuh tags ummmm @dytabytes @allmightskitten @tideswept @heirofdragons @withercrown @flamboyant-vampire

[vanderdeer]

flipnote hatena faces:

tdBt (to show trickery, for “teh lols”)

oFTo (generic smile. to show friendliness) 

e3e (annoyance or suspicion) 

owo (to show joy, pleasant and friendly)

TT-TT (sadness, crying)

;=; (???)

[doc-pickles]

make my wish come true

Hello! And welcome to your weekly edition of “Tis the Damn Season for Two Dumb Bitches” (thank you taylor swift for our new title) I’m super excited about this post because my brain power is coming back and this is like the first real thing I’ve written in awhile. Enjoy! 

PS: @odd-birds-and-booksellers hurry up the people are waiting

“I’m sorry babe, there’s a storm and there’s no flights going to Seattle at least until the 27th.” 

“You were supposed to be home two days ago Alex,” Jo tried to contain her frustration as she settled onto the couch in the empty living room. She stares at the Christmas tree in the corner, the boxes of lights and ornaments spread out on the floor around it.  “The house isn’t even decorated and now I’m going to have to spend Christmas alone.”

“You can go to Meredith’s, I’m sure the kids would love to see you. I’m sorry, you know I'd be home if I could.”

“That doesn’t change the fact that you’re not here! I’m just… this is exhausting. I don’t know how much longer I can keep this up,” Jo swiped at her eyes as tears began to well up in them. “Just text me when you have a flight.”

“Jo, I-”

“I have to go,” Jo let a shaky breath out, running one hand through her hair. “I love you.”

“I love you too.”

Ending the call, Jo threw her phone onto the cushion next to her as she let her tears freely fall. It had been six months since Alex had come home from Kansas for the first time, sitting across from her and telling her about Izzie and their kids and everything that had happened in the two weeks he had been gone. There had been screaming and crying and a lot of fighting, but they had both decided that their marriage was worth saving. Alex had been splitting his time between Kansas and Seattle as much as he could which unfortunately left Jo alone more than she would care for. She loved that Alex had stepped up to his new role as a father, she even loved Eli and Alexis like they were her own, but recently her and Alex’s relationship had been strained. 

Alex's absence from Seattle wouldn’t be an issue if he and Jo hadn’t just moved into a new home. The two story home was supposed to house the twins on their visits to Seattle as well as any other tiny Karev’s that might come along. The thought made Jo laugh now, she’d spent more nights alone in their new bedroom then she had with Alex despite the fact that she’d gone off her birth control two months ago. 

They’d decided that they wanted kids of their own, that they were ready to start their family. Jo was regretting that decision now, she barely saw Alex and when she did their time was split between work and arguing. The only times they’d even had sex since deciding to try had been out of anger and frustration, meeting in on call rooms late at night and muttering curses as they set a quick and desperate pace while they both had a moment to spare. Between on call rooms and the one time in their new bedroom that Alex had lavished her body for hours on end, there hadn’t even been a chance to try for a baby.

Somewhere deep down, Jo was grateful for that. It wasn’t that she didn’t want a baby with Alex, she really did, but she didn’t think that their practically long distance marriage wouldn’t handle the stresses of a pregnancy and a baby, the thought nauseating her as she sat with the thought. The sudden wave of nausea got her brain turning, calculating how long it had been since she’d been to the store for tampons…. 

Cursing under her breath Jo ran upstairs and began to dig under the bathroom sink for the pregnancy tests she kept stashed there. Leave it to Alex to get her pregnant when they were barely having sex. She missed him, she wished so badly that he was sitting on the other side of the bathroom door making fun of her as she peed on the four pregnancy tests. As she sat on the closed lid of the toilet waiting for an answer to appear on the four pieces of plastic, her phone lit up with a text. 

I’m sorry I can’t be there tomorrow. I promise your Christmas gift will more than make up for it. I love you so much Jo. 

Before she typed out a response, her eyes flitted to the tests waiting for her, all of them reading the same exact thing. A heavy sigh left her then, eyes closing for a moment as she took a steadying breath. 

Love you too. See you soon.

Jo barely sleeps that night, in fact when she does fall asleep it’s on the floor of the bathroom because she can’t seem to keep her dinner down. She’s hurt and upset and kinda pissed that her morning sickness seems to have cropped up late at night. She almost calls Alex, when she’s half asleep and crying on the bathroom floor she almost reaches for her phone and dials his number because she misses him so much. But she knows in the end it’ll only make her feel worse because he can’t be there.

When she wakes the next morning her back is aching and her face is cold from the tile of the bathroom, but her stomach turns uncomfortably and sends her back to the toilet bowl. She’s shocked that there’s anything left for her to throw up, but she’s heaving and gasping for air just like she’d done all night. The twisting feeling in her stomach intensifies when she realizes that she’s home alone in a huge house on Christmas and will probably spend her whole day in the bathroom. A round of sobs accompanies her next bout of nausea, hot tears streaming down her face as a feeling of loneliness encompasses her, reminding her of her solitary days spent in her car.

“Jo?”

Jo looks up in surprise at the voice sounding from the doorway, her eyes meeting her husbands for just a moment before the urge to vomit overwhelms her exhausted body once more. This time Alex’s hands are on her back rubbing circles as she continues to cry between heaves. She’s barely registered her shock at his presence, just grateful to have him close to her. 

“Geez, you look awful,” Alex’s remark barely phases Jo as she flushes the toilet and leans heavily against him. His fingers find their way to her forehead, feeling for any sign of a fever even though she knows he won’t find one. “You probably just have a bug, why don’t you go lay in bed?” She doesn’t have time to ask how he’s home, her body barely makes it to their bed where she promptly tucks herself under the covers. She thinks Alex says something to her, but she’s asleep before she can register it. Her mind drifts off more peacefully than it had the night before knowing Alex is here now. Even if she has a million questions, she’s just glad she doesn’t have to spend the holiday alone. 

When she wakes up again, the sun is filtering through the curtains brightly and the other side of the bed is occupied. Jo turns around to look at Alex, who’s sitting against the headboard looking down at her, “You know staring at people is creepy. And rude.”

“I think I get an exception since you’re my wife,” Alex smirked, running one hand through Jo’s hair as she snuggled back into her pillow. “You feeling better?”

“A little bit now that I’ve gotten some sleep,” Jo paused before moving her gaze away from Alex. “What’re you doing here? You said you wouldn’t be home.”

“I had to fib a little bit, I wanted to surprise you. I didn’t think you’d be lying in the bathroom throwing up when I got home, but now I’m glad I’m back because I’m not leaving this time.” 

Jo’s brows furrowed as she tried to make sense of Alex’s words. Of course he was going to leave again, his kids lived in another state, “You're going back after the new year Alex, you already booked your flight.”

“No I’m staying here and so are the kids.”

She took a moment to soak in Alex’s words, head spinning as she tried to wrap her mind around it. Finally she sat up, propping her head on her hand as she stared at her husband in confusion. Alex wore a smirk as he watched her slowly put together what he was saying, “Alex Karev what the hell did you do?” “I didn’t do anything, Izzie decided to move back to Washington for her mom and that means the kids are 30 minutes away instead of almost halfway across the country,” Alex shrugged as Jo gawked at him, her shock clearly evident on her face. “That’s why I’ve been out there so much, because I’ve been helping Iz pack up her house and get the kids ready.” Jo’s eyes are wide as she registers everything that Alex is saying to her. She almost doesn’t believe him, but his behavior the past few weeks all makes sense now. She wants to cry in relief, for her marriage and her exhausted husband and their new baby. In fact she almost does as she meets his eyes again, realizing that he probably feels just the same as she does.

“I’m sorry about that, being gone so much and leaving you here, but I promise that I’m not gonna be gone from here on out,” Alex lets his hand trail down to Jo’s stomach, a smirk on his face as he does so. “I wouldn’t want to anyways, someone’s gonna have to hold your hair back if you’re gonna be puking for the next few weeks.”

The satisfied look on Alex’s face tells Jo that somehow her husband has figured out she’s pregnant without her telling him. A small grin lights up her face as she blushes, “I just figured it out myself but I’m sure the constant vomiting would’ve given it away sooner or later.” “Yeah and the tests you left on the bathroom counter were also a pretty big indicator,” Alex let out a laugh as he leaned down and kissed Jo sweetly. “Merry Christmas.”

“I know you said your Christmas gift was good but I think mine is better,” Jo grinned up at Alex, a laugh escaping her as she sat up and straddled his lap. “Merry Christmas.”

[pharmaphorumuk]

Orchard raises $150m to develop gene therapies

Biotech Orchard Therapeutics has raised $150m to further develop its three most advanced rare disease gene therapies.

Earlier this year GlaxoSmithKline handed over its rare disease gene therapy pipeline to Orchard, along with the already approved Strimvelis, for adenosine deaminase severe combined immunodeficiency (ADA-SCID) – the immune disorder known as “bubble boy syndrome”.

GSK also took a 20% stake in the company and Orchard is looking to progress development of its three most promising pipeline drugs – gene therapies OTL-101 for ADA-SCID, OTL-200 for metachromatic leukodystrophy (MLD) and OTL-103 for Wiskott Aldrich syndrome.

Funding will also support clinical and preclinical development of other rare disease drugs in Orchard’s pipeline.

Orchard also has a drug for X-linked chronic granulomatous disease (X-CGD) and transfusion dependent beta-thalassemia (TDBT) in the clinic.

Deerfield Management led the Series C financing, with significant cash from new investors including RA Capital Management, Perceptive Advisors,  and Ghost Tree Capital Group.

Existing investors also participated including Temasek, Baillie Gifford, RTW Investments, LP, Cowen Healthcare Investments and Agent Capital.

Mark Rothera

Mark Rothera, president and CEO of Orchard, said: “We are thrilled to have such strong support from both new and existing investors in this financing round.”

“The quality of this investor syndicate is a testament to the confidence we have built among our stakeholders, based on the substantial progress of Orchard’s clinical and preclinical programs since our Series B round last year.”

Elise Wang, Principal at Deerfield Management, said: “Orchard has made an impressive transition from a start-up company to an emerging leader in gene therapy for rare diseases by building a comprehensive, industry-leading portfolio of ex vivo gene therapies and assembling a highly experienced team.  We are pleased to have led this round of financing. We believe the company has generated compelling clinical data on products which have the potential to become breakthrough treatments for patients.”

The post Orchard raises $150m to develop gene therapies appeared first on Pharmaphorum.

from Pharmaphorum https://pharmaphorum.com/news/orchard-raises-150m-to-develop-gene-therapies/

[weirdmageddon]

tdBt

oFTo

[jculture-ja]

旭有機材工業 ボールバルブ21型エア式TA型 ＜A21AGUVF5＞ 【型式 ...

#歌舞伎 #中山百蔵 [MentePost]瀬戸酒造は2018年3月に復活した、新進気鋭の蔵です。40年ほど自主醸造ができずにいました … 無料（一部地域除く）】 【10日限定☆カード利用でP14倍】トラスコ中山 アルミパレット片面二方差型 1100X1100X140 TDBT-1111 [A130803] 2輪 カヤバ/KYB …

[kabukiinfo]

旭有機材工業 ボールバルブ21型エア式TA型 ＜A21AGUVF5＞ 【型式 ...

#歌舞伎 #中山百蔵 [MentePost]瀬戸酒造は2018年3月に復活した、新進気鋭の蔵です。40年ほど自主醸造ができずにいました ... 無料（一部地域除く）】 【10日限定☆カード利用でP14倍】トラスコ中山 アルミパレット片面二方差型 1100X1100X140 TDBT-1111 [A130803] 2輪 カヤバ/KYB ...