#but that's nothing new >>;;

[rovermcfly]

I think a lot of people are forgetting that on tumblr fandom used to be practiced very differently. now everyone fucks off to their discords or tumblr groups to discuss everything with a select few, making tags be nearly only used for posting some finished fanworks or not at all

a decade ago people didn't have tumblr groups. people didn't even have dms. if you wanted to talk to anyone about anything you had to make a post, or send an ask (which more often than not would get published and thereby become a post in the end too)

so next time you think "I have a fandom thought but I have to find a small group of hyperspecifically like-minded people to share it with in private" remember all the freaks you could be missing out on meeting by keeping the tags dead. use tags, make friends. fuck discord.

[remynisce]

Love to see the evolution of their dynamic in the latest chapters

[eddiegayass]

Greatest day on twitter since the billionaire sub

[chloesimaginationthings]

Poppy playtime chapter 4 post credit scene

[reasonsforhope]

"Tim Friede’s YouTube channel is home to a collection of videos depicting the Wisconsin-native truck mechanic subjecting himself to purposeful snake bites, blood slowly dripping down his arms.

For the past 20 years, Friede has been one of the most notorious “unconventional” medical researchers, undergoing over 200 bites from the world’s deadliest snakes — and more than four times as many — 850 — venomous injections. 

He did it all in the name of science.

According to the World Health Organization, an estimated 100,000 people are killed by snake bites each year, with countless more being disabled by the venom of the deadly reptiles. 

While life-saving anti-venom is available, very few countries actually have the capacity to produce it properly, given that most bites occur in remote and rural areas, and anti-venom requires arduous sourcing and accuracy. 

But Friede’s blood is now full of antibodies, following decades of strategic exposure to the neurotoxins of mambas, cobras, and other lethal slithering critters.

His blood is now the source material researchers are using to develop an anti-venom capable of neutralizing a broad spectrum of snake bites...

Friede started this hobby — which he is indeed adamant no one else tries at home — out of sheer curiosity in childhood. After playing with harmless garter snakes in his youth, he began keeping more dangerous species of snakes as pets. At one point, he had 60 of them in his home basement.

In 1999, he began extracting venom from his snakes, drying it, diluting it, and injecting himself with tiny doses — keeping meticulous records as he went.

He had one major hospitalization in 2001, when he was paralyzed and in a coma for four days. But instead of giving up, he doubled down. 

“In hindsight, I’m glad it happened,” Friede told The Times. “I never made another mistake.”

Jacob Glanville, an immunologist and founder of biotech company Centivax, stumbled on Friede’s videos.

Now, Friede is the director of herpetology at Centivax and serves as something of a “human lab” to Glanville.

“For a period of nearly 18 years, [Tim] had undertaken hundreds of bites and self-immunizations with escalating doses from 16 species of very lethal snakes that would normally a kill a horse,” Glanville told The Guardian.

“It blew my mind. I contacted him because I thought if anyone in the world has these properly neutralizing antibodies, it’s him.”

To develop the new anti-venom, Glanville and his fellow researchers identified 19 of the world’s deadliest snakes — in the elapid family — which kill their prey by injecting neurotoxins into their bloodstream, paralyzing muscles (including the big, important ones, like the heart and lungs).

The trouble is, each species in the elapid family has a slightly different toxin, meaning they would each require their own anti-venom.

But Friede’s blood contains certain fragments of each of these toxins; protein molecules seen across the various species. Because of his decades of service to science, his blood also contains the antibodies required to neutralize these toxins, preventing them from sticking to human cells and causing harm.

Combining the antibodies LNX-D09, SNX-B03, and a small molecule called varespladib that inhibits venom toxins, Centivax has successfully created a treatment effective against the entire range of 19 species’ toxins.

Their work, which was recently published in the journal Cell, will soon be tested outside of the lab. 

Trials will start with using the serum to treat dogs admitted to Australian veterinary clinics for snake bites. Assuming that goes well, the next step will be to administer human tests.

Researchers also believe that because the serum stems from a human, this should also lower the risk of allergic reactions when being administered to other people. 

“The final product would be a single, pan-anti-venom cocktail,” Professor Peter Kwong of Columbia University, a senior author of the study, told The Times.

Or, he added, they could make two: “One that is for the elapids, and another that is for the viperids, because some areas of the world only have one or the other.”

As for Friede, he maintains his affinity for snakes, though his last bite was in November 2018, when he said “enough is enough,” according to The New York Times.

By then, he had certainly done enough. His pursuit of immunity could feasibly save countless lives.

“I’m really proud that I can do something in life for humanity,” Friede told The New York Times, “to make a difference for people that are 8,000 miles away, that I’m never going to meet, never going to talk to, never going to see, probably.”

-via GoodGoodGood, May 2, 2025

[poorly-drawn-mdzs]

Dog Meshi.

[arrgh-whatever]

no fun buttons for april fools' day?....

[blessyouhawkeye]

i love that every time magneto loses his helmet in the x men movies he immediately starts going charles you could make me do ANYTHING YOU WANTED right now......... i'd be POWERLESS TO STOP YOU........ you could GET IN MY MIND and HAVE ME AT YOUR MERCY..... i think a lot of their problems could have been solved if charles just took him up on what was a very blatant proposition

[editoress]

It's very possible that the only way to ensure you don't become a conservative old person is to keep checking whether you're wrong. Every time. Genuinely mull over the opposing viewpoint even and especially when it's uncomfortable. You absolutely cannot a) consider yourself safely incapable of terrible principles because you're a good person, or b) treat a your disgust reaction to something as a moral truth. You can't get comfortable. Tiring! But you'd rather be tired and choose the right path, you know?

[werepires]

Happy 2025 everyone 🥂

[hellenhighwater]

If you enjoy random videos people doing their craft really well as background noise, then may I suggest this dressmaker I just stumbled across, because I want everything she's ever made and holy crap, the SKILL.

[kensatou]

the h in nhl stands for homoerotic

bonus intricate rituals:

[notlemoncello]

[laneichy]

GIRL WHAT?!

[citrispace]

Let's go together!