#ewing sarcoma

[crossborderscare]

The diagnosis of Ewing sarcoma in starts with the detection of various symptoms, such as pain at the tumor site and swelling.

[healthcareporium]

Exploring Bone Sarcoma: Variants, Therapeutic Approaches, and Future Prospects

Bone sarcoma, a rare type of cancer, affects the bones and surrounding tissues. The condition comprises various types, including chondrosarcoma, Ewing sarcoma, and osteosarcoma, each presenting unique challenges in treatment. However, recent advancements in therapies offer hope for improved outcomes in managing bone sarcoma. Challenges Associated with Bone Sarcoma Treatment: Bone sarcoma…

[barringtonishigh]

Adding to this, actually, a little about me. Hi, I'm Barrett. I'm about to turn 17 years old. I'm a completely normal teenager. Well, uh, autism aside/hj. I spent most of my childhood completely average and healthy. When I was fifteen, though, I started getting pain in my left foot, in the space between my big toe and second toe. It started fairly normal, so I just assumed it was from walking a bit too much. But throughout that year it just kept getting worse. I went to the doctor, who shook me off and told me to get new shoes. I tried so many different new shoes but the pain just kept getting worse. By the time I was almost sixteen it was completely debilitating. I couldn't make it through a day of school without having to come home early due to how badly I hurt. I was on pain medicine and even with the fairly high dose the doctor put me on, I still was in so much pain. It had started to hurt in my shoulder as well. We went back to the doctor, and he tried to diagnose me with plantar fasciitis, but I had already researched that and told him that it couldn't possibly be that. I begged for an x-ray, and he finally ordered one. I had it done, and was told that there was a mass in my foot. I was sent for a ct scan, before being sent to an orthopedic surgeon for examination. While waiting for that doctors appointment, I was on crutches from how bad my foot was hurting. I fell while using those crutches and ended up breaking my left shoulder, the one that had been hurting. It was an insanely awful break according to the ER doctor. After that I was also given a PET scan. We finally went up for the surgeon to biopsy my foot, and a few days later, we were told the worst news I have ever heard, I had a rare pediatric cancer called Ewings Sarcoma. At this point, it had spread to my left shoulder (causing the break), my thighs, and my lungs. I went through 14 rounds of chemo which caused so many awful symptoms such as sores in my G.I tract (which is some of the worst pain I have ever felt in my life, and I have a pretty high pain tolerance), nausea, fatigue, and of course, hair loss. I went through radiation twice, once to my shoulder/foot, and thigh, and once for my lungs. I was then given another bone marrow biopsy (which they had also done around the time of the pet scan), and was declared to be in remission. I am insanely lucky to be in remission, but that doesn't mean my journey is over. I try to spread awareness as much as I can, because every child deserves to live cancer free. Only four percent of funding from the NCI goes to pediatric cancer patients. Four percent. We are worth so much more than four. Please donate if you can.

Childhood cancer awareness is incredibly important to me!! A very close friend has recently gone into remission!! This experience has drawn my attention to how little funding and recognition childhood cancer receives!! (Especially for rare cancer types like Sarcoma)

1 in every 285 children will develop cancer before the age of 20, 47 of those children will be diagnosed today, those 47 families will spend over 40% of their annual income on supporting their child. Tomorrow another 47 children will need your help and funding.

According to the Children’s Cancer Research Fund:

Childhood cancer remains the most common cause of death by disease among children in the U.S.

The amount of funding that goes to childhood cancer research continues to pale in comparison to the funds available for research into adult cancers. Current cancer research funding from the federal government, dedicates funding to childhood cancer research that is in the single digits.

I believe that these numbers can and should change. And that you can help! In the notes have I will be providing links to resources for helping children with cancer in your community, as well as links to donate directly to funding childhood cancer research and relief. Remember that you can have positive change in your community and in this world.

Ways To Aid:

Remember that you have the power to reach out and help your community! Organize. Support. Reach out and find opportunities to volunteer! Make the world a better place!!

[somosprojetoamigos]

Menina de 12 anos morre de câncer raro após sinal inesperado

Noite comum virou pesadelo para a família Phelps. Enquanto escovava os dentes, Beth, de apenas 12 anos, notou um caroço em seu ombro. O que parecia algo simples revelou-se um diagnóstico devastador: sarcoma de Ewing, um câncer ósseo raro e agressivo. Moradora da ilha de Jersey, no Reino Unido, Beth iniciou uma luta intensa e dolorosa contra a doença. Ela foi encaminhada para tratamento em…

[ustechbog]

A total of 434 Ewing Sarcoma clinical trials were conducted as of February 2024. The Ewing Sarcoma clinical trial report provides a comprehensive understanding of the Ewing Sarcoma clinical trial scenario across regions, and countries

[bommagoni]

Ewing Sarcoma Drugs Market Size, Share, Analysis and overview

[thescoopess]

Leah Smith, TikToker Who Documented Rare Cancer Passed Away March 11

PHOTO: Leah Smith/TikTok The 22-year-old celebrity on TikTok, who documented her uncommon cancer diagnosis on the internet, passed away. Leah Smith, a resident of Woolton, Merseyside, passed away on Monday due to Ewing’s Sarcoma, a condition that typically affects youth. Over 500,000 individuals tracked Ms. Smith’s journey on TikTok, where she shared daily updates on her illness. Her partner…

[drpedi07]

Toronto Childhood Cancer Staging criteria for Ewing sarcoma Calculator

Ewing sarcoma treatment usually begins with chemotherapy and/or radiation followed by surgery to remove any remaining cancer. Treatment options for recurrent sarcoma include targeted therapy and high-dose chemotherapy with stem cell transplant.

[letterstotommy]

There's a lighthouse.

Falling asleep during your cancer treatment has been more difficult than usual for me. Last night I struggled, even though I find myself in a more calm space these days, the anxiety still creeps back in at times. I’ve been trying to put myself into a more meditative state when it happens, and sometimes, when I'm successful, I go into such deep sleep I can’t recall my dreams. But last night, I saw a lighthouse.

We’ve been sailing new, uncharted waters for almost half a year. It’s not a very long time that we’ve been out here, but I’m struggling to remember the place we came from before this. I've felt unsafe and disoriented for the entire journey until just a few weeks ago, after your surgery. I began to feel some sense of direction and the slightest bit of confidence about where we're going.

The lighthouse spun slowly, with a beam of light flashing in and out of my focus. It symbolizes how I feel these days—often focused and moving forward, but never too far from a moment of darkness. Sometimes, I can feel the fortitude leave my body, replaced with mild shaking and a sense of dread or panic. Just yesterday, I felt it at the hospital on our way to an ultrasound to check your lymph nodes. For weeks, I’ve felt my intuition say, "There's nothing to worry about." And yet with cancer, there is almost always some cause for concern, or at least diligence. This disease is rare and not well understood. Even at this point, when you have a map of sorts, there are still plenty of times when you feel like you are floating in the dark.

I can’t help but feel that I’m a highly inexperienced captain who is not qualified for this journey, but we've been forced out to sea.

Between the three of us, we can see the lighthouse more clearly at different times and take turns guiding this ship forward. The light hits us in distinct ways. I can see it emanating between us.

Yesterday, you told your nurse you feel like you are experiencing a sort of rebirth in your life, open to new possibilities and where this all might take you. You’re recognizing challenges that don’t serve you and articulating the support you need in a moment. I can see your instincts in action, no longer looking to me or your dad for direction as often, exhibiting a calm confidence about where you want to go. You’re fit for duty to keep us moving in the right direction, and we’re pretty thrilled to follow.

There’s a lighthouse somewhere, and it’s easy to feel lost when we can’t see it, but we know it’s there somewhere. It begins to guide you to a harbor, a place of arrival. We may never know how long we’ll stay there—maybe we’ll be forced out to sea again. But at least we know the next beam of light will be out there. We will get to it.

[lazarro]

[tragicallyuncreative]

Chapter five soon queen? Hope all is well!

Consider this my T-minus 12 hours or sooner announcement!!! I WILL be posting Chapter 5 tonight. Whether it be before or after midnight, I can't tell you, but I have tomorrow off and nothing due in the next 24 hours so I'm determined not to sleep before it's posted.

Thank y'all SO much for being so patient. All is well, just been so insanely busy that I haven't had a time to breath, let alone finish editing the chapter. I have learned so much in the last few weeks during my ICU rotations. Spent today managing hemorrhagic shock in a GI bleed patient (original bleed had been repaired and was about to be discharged when it was suddenly like a massacre 😬) and we gave 2 units of blood over the span of 1 minutes through a line in his internal jugular, then watched as they did a bedside emergent colonoscopy and put in 2 endoclips. Coolest shit I've seen in a while (well, not for him, poor guy). @fangirl-docintraining have you had your ICU rotations yet? As my fellow medical nerd who gets so excited/ enthusiastic about new stuff, you will love it!

The biggest reason this chapter has taken so long is my balance between keeping it completely accurate to 1960s medicine vs. incorporating modern elements in a realistic way because it's just hard not to and I really want to keep my plot/ outline intact. If anyone wants clarification about what elements are modern or not that I don't specify in my chapter notes, don't hesitate to ask. There are two articles that I would really love everyone to read before or after reading my chapter. For years, I have been so passionate about St. Jude Hospital and several specific doctors and the work they did/ continue to do to treat pediatric cancer. Dr. Emil Freireich essentially eliminated bleeding as a cause of death in leukemia patients after experimenting with his own platelets and finding the correct way to infuse them. He then proposed that the method of treating tuberculosis (using multiple drugs at once) could also cure leukemia. In 1962, pediatric leukemia was a death sentence. People thought it was crazy that Danny Thomas and these doctors were stating that they would find a way to cure it. Kids diagnosed would die within weeks of diagnosis from infection or bleeding to death. Their experimental treatment of combining two or more chemotherapeutic agents was seen as inhumane by many doctors, who thought that would make these children sicker and it was better to let them die peacefully. To everyone's shock, they saw success. This treatment was trialed in the early 60s, but didn't become something doctors would refer patients to St. Jude to until 1968ish. In 1970, the man behind this extraordinary discovery, Dr. Don Pinkel, was able to officially proclaim that childhood leukemia was no longer a fatal disease, with the cure rate at 50%. Today, ALL has a 94% cure rate, but the treatment remains harsh and lasts approximately 2.5 years. And despite all the hard work of researchers, other pediatric cancers such as Wilm's tumor, Ewing's sarcoma, osteosarcoma, rhabdomyosarcoma, medulloblastoma, DIPG, and more have high relapse rates and higher fatality rates (DIPG is something I encourage everyone to research and support higher funding for- a pediatric brain cancer with 0% survival rate). I actually went to a conference at St. Jude when I was 19 for childhood cancer advocates as I was a top fundraiser that year and interested in a future career there. I cannot say enough positive things about it!

So obviously, my story will deviate the timeline a little and the fictional Children's Hospital of Oklahoma (which in reality was not established until the 21st century) will be offering this experimental treatment in '65. Some of the medications and medical devices I include were not available until after '65 (for example, ports/ central lines in this particular model were not a thing), but I also make a point to use meds that were more common during the time, not include certain devices such as heart monitors, pulse ox, etc.

This has turned into a really long ramble. The point is, I hope everyone is ready to learn a lot this chapter and I encourage you to let this motivate you to learn more about childhood cancer, the fact that it is not as rare as many think, and that it is severely underfunded.

So far, this chapter is 15K words. My last few hours of edits may result in more or a little less. So get comfy and settle in when it's time to read- it's a big one with a lot going on!!

[pedripics]

After arriving at their hotel in Madrid yesterday, Pedri, Ferran, Iñigo, Oriol Romeu and Marcos Alonso spent over one and a half hours talking to the wonderful Maria Caamaño Múñez, a little football fan who has been fighting Ewing Sarcoma (a rare type of bone and tissue cancer) for the past four years ❤️

vía mariacmfutbolera and __luuciacm

[copperbadge]

Radio Free Monday

Good morning everyone, and welcome to Radio Free Monday!

(Quick message to Anon who submitted an item for their friend who is fundraising for food and meds -- the post was deleted and I couldn't find another one on a quick skim, so I'm guessing they took down their fundraising, that's the reason they aren't included!)

Ways to Give:

doctorscienceknowsfandom linked to a fundraiser for larjb3; they met when Larjb3 contacted them thinking they were a medical doctor, to ask about a lump on her neck. After a long diagnostic journey, it was diagnosed as Ewing Sarcoma, rare in adults, and she is looking at possibly having to quit her job to focus on survival. She's raising funds for medical bills, household bills, and against the months of treatment ahead, and you can read more and support the fundraiser here.

Anon linked to a fundraiser for Eddie, a hard-working LGBTQ artist in the rural South, trying to move himself and his pets to the west coast to build a new life; he's been dealing with a string of escalating issues where he is, and the move will help open up opportunities and keep him safe. You can read more and support the fundraiser here.

forlorn-kumquat is raising funds to get seating and storage for their third-grade classroom, to help their students learn comfortably. You can read more and support the fundraiser here.

Recurring Needs:

Anon linked to a fundraiser for a friend whose family has not had a working furnace since November; they've been using space heaters to keep warm but January in Chicago has been brutal and the space heaters aren't sufficient. With vulnerable family members including elderly relatives and children in the home, they need to raise $6K to get the furnace replaced. You can read more and support the fundraiser here.

Anon linked to karla-hoshi or Hoshi on TikTok, who is raising funds for cancer treatment for her cat Naku; they caught the cancer early and hope that he can survive it. You can read more and support the fundraiser here.

chingaderita's partner's family house recently caught fire and completely burned, killing his grandmother and causing extensive property loss; he has also recently lost his job due to the fire, and a number of family members have since become ill. They're raising funds to keep food on the table, and get their partner mental health aid, and now are looking at doctor's bills for medical treatment. You can read more, reblog, and support the fundraiser here.

nivchara-yahel and rivalconga are raising funds to cover January and now February's rent and fees; their synagogue had agreed to help, but backed out after the deadline had passed for payment. They're trying to raise what they need before the landlord files for eviction; you can read more and support the fundraiser here.

thelastpyler is raising funds for food and medication for them and their family, and for transportation costs to medical appointments; you can read more, reblog, and find giving information here.

And this has been Radio Free Monday! Thank you for your time. You can post items for my attention at the Radio Free Monday submissions form. If you're new to fundraising, you may want to check out my guide to fundraising here.

[barringtonishigh]

𝙰𝚋𝚘𝚞𝚝 𝙼𝚎 <𝟹

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Hi! I'm Barrett. Welcome to my account! It's primarily a fan account/fanfiction page for: The Academy Is..., Fall Out Boy, iDKHOW, This Is Ivy League, and The Young Veins. HOWEVER, I have a lot of other interests that I post about, such as Ultra Q My Chemical Romance, Ben Schwartz, Wendigoon, and Pink Floyd. My fanfiction masterlist will be linked at the bottom of this post!

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Some info about me: My name's Barrett, but I often go by Bear or Barrington. I use he/they pronouns, and I have relapsed metastatic Ewing Sarcoma. I love music, drawing, writing, the sims 4, making kandi, going to concerts, and my friends. My dms are always open for new friends, and my inbox is open for anything, especially requests (though I suck at doing them in a timely manner). I'm pro-palestine! I'm bi/ace and trans masc.

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Some random fun facts about me: Before I went to WWWY, I'd only seen big artists above the age of 70. I met my best friends of four years on instagram/wattpad (ik) because of Ultra Q (Hello Beni and Emilio!). I'm a Make-A-Wish alumni! As of 11-13-2024 I have the most listens on FMbot for Grantchester Meadows by Pink Floyd by over a thousand plays.

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My main tags: #bear's faves - my favorite things/people! #barrett speaks and speaks and speaks - my og posts (I forget to tag this one a lot.)

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My fanfiction info

My masterlist

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[justkidneying]

Neoplasms of Bone

Just like when I talked about tumors of the CNS, this list is not all-encompassing. This convers what I'm pretty sure board exams are concerned with, but don't quote me on that.

Alright, so you have two broad categories of tumors: primary and metastatic (spreading from somewhere else). Primary bone tumors are rarer and are found in the long bones of the extremities. Most are asymptomatic, slow-growing, and benign. The benign ones we'll talk about are osteoid osteoma, osteoblastoma, osteochondroma, chondroma, and giant cell tumors. The malignant ones are osteosarcoma, Ewing sarcoma, and chondrosarcoma. The metastatic bone tumors don't have fancy names because they're really lung cancer or whatever.

Osteoid Osteoma

These tumors have no malignant potential, and are less than 2 cm in size. They're more common in males less than 25 years old, and in the long bones, face, and skull. An interesting syndrome is called Gardner's Syndrome, which causes adenomatous polyposis, osteomas, and soft tissue tumors.

Osteomas are slow growing and show a thick rim of reactive cortical bone on x-ray. They also cause nocturnal bone pain that is relieved by Aspirin and NSAIDs.

These and osteoblastoma have similar histological features, which is a trabeculae of woven bone with a single layer of prominent osteoblasts forming a rim. There will also be loose connective tissue with dilated and congested arteries. Reactive bone will encircle the actual tumor. The two also have similar gross features, which is a roundish, well-circumscribed mass of hemorrhagic, gritty tan tissue.

You treat osteoid osteoma with radiofrequency ablation.

Osteoblastoma

These are greater than 2 cm in size and are also common in males less than 25 years old. They arise in the spine, and cause pain that is all day and not relieved by Aspirin or NSAIDs. That's how you tell the two apart clinically. To treat, you just cut that bitch out.

Osteochondroma

These are fairly common and 85% of them are sporadic. The other 15% are part of multiple hereditary exostosis syndrome. You're going to see these near the growth plate on the metaphysis of long bones. They will be palpable and are basically a little knot attached to the skeleton via a bony stalk and capped with cartilage. They can cause pain if they impinge on a nerve.

Histologically, you'll see a disorganized growth plate, which undergoes endochondral ossification, and a cartilage cap lined by perichondrium (continuous with mature bones).

Chondroma (Enchondroma)

This is a benign tumor of hyaline cartilage. They're usually well-circumscribed nodules less than 3 cm in diameter. The cut surface will be gray-blue and kinda see-through. On x-ray, you'll see irregular calcifications, sclerotic rims, and an intact cortex.

Two conditions are associated with these. Ollier disease causes enchondromas that are on one side of the body and limited to the limbs. It also causes an increased risk of gliomas and ovarian tumors. Maffucci syndrome also causes spindle cell hemangiomas and gliomas.

Giant Cell Tumors (Osteoclastoma)

This is a rare benign tumor of multinucleated osteoclast-type giant cells. Locally, it is aggressive. 4% of cases metastasize to the lungs, but may regress spontaneously. These are rarely fatal.

You're most likely to see these at the knee, and observe arthritis-like symptoms. They may cause fractures and destroy the overlying cortex, resulting in a bulging mass of soft tissue. Grossly, these are large, red-brown masses that frequently cystically degenerate. Histologically, you'll see uniform oval tumor cells and a bunch of osteoclast-type giant cells with over 100 nuclei. Necrosis and mitotic activity can be prominent. X-ray shows a characteristic soap bubble (shown below).

To treat, cut the bitch out. 40-60% reoccur locally.

Osteosarcoma

This is the most common primary malignant bone tumor. These are more likely in people younger than 20, those with Paget disease, bone infarcts, and prior radiation. Half of cases are in the distal femur or proximal tibia (so the fucking knee).

The peak incidence is at the growth spurt of youth, and at the growth plates of rapidly growing bones (your fucking legs). These are painful and cause bone fractures. X-ray may show infiltrative margins, lifting of the periosteum, and reactive periosteal bone formation. This includes patterns like the Codman triangle (aggressive), or a Sunburst pattern. These are due to the fact that the bone cannot grow fast enough to cover the tumor.

These are bulky, gritty, gray-white tumors. Typically with hemorrhage and cystic degeneration. It will destroy the surrounding cortices to make soft tissue masses and spread into the medullary canal, replacing hematopoietic marrow (so less RBCs are gonna be made). Histologically, you're gonna see pleomorphism, large hyperchromatic nuclei, bizarre tumor giant cells, and mitosis. It can be described as "lace-like."

To diagnose, you need the presence of malignant tumor cells making unmineralized osteoid or mineralized bone. All cases are assumed to have occult metastases, such as those to the lung, bones, brain, etc. The 5-year survival rate is less than 20% for those with metastases.

Ewing Sarcoma

This is another malignant one, and common in the femur, pelvis, humerus, and ribs. 80% of cases are in those under 20. These are painful, enlarging masse that cause the affected site to be tender, warm, and swollen. Systemic findings will show elevated EST, anemia, and leukocytosis. X-ray will show a lytic tumor with moth eaten margins and reactive bone with onion-skin layering (seen below). Grossly, these are soft, tan-white tumors with hemorrhage and necrosis. Histologically, you can see a uniform sheet of small, round cells and scant cytoplasm. You'll also see Homer-Wright rosettes.

Treatment is chemotherapy plus excision, which yields a 75% 5-year survival rate.

Chondrosarcoma

These are painful, progressively enlarging masses that produce cartilage. They are classified as conventional, clear cell, dedifferentiated, or mesenchymal. They're typically found in the axial skeleton.

These are bulky tumors that grossly appear as gray-white nodules of see-thru cartilage. The matrix is usually gelatinous and they'll ooze from a cut surface. There may be spotty calcifications and cystic spaces. Histologically, there is cytologic atypia and mitotic activity.

Treatment is wide excision (conventional) or excision and chemotherapy (mesenchymal and dedifferentiated).

Metastatic Bone Tumors

Not a lot to say on these, as they appear histologically as whatever cancer they came from. But 75% of them are going to come from the prostate, breast, kidney, or lung (in adults, anyway). X-ray may show lytic or blastic (destroying or forming) lesions. Sometimes it's mixed. Bidirectional interactions between the cancer cells and the bone cells cause changes in the bone matrix. Tumor cells stimulate osteoclast activity (bone destroying).

Treatment is symptomatic pain relief, radiotherapy, and use of bisphosphonates zoledronic acid to prevent further metastases. The prognosis is poor.

[sharkkweak]

Putting this out here, Alex goes to my school and he recently got diagnosed with Stage IV cancer, so we’ve set up a gofundme to help him pay for his chemo and other bills.

Please share this around! Anything helps, even if it’s just giving this post reach!