#gct

[jcsmicasereports]

Giant Cell Tumor of the Infrapatellar Fat Pad of the Knee: A Case Report by Ahmad Jiblawi in Journal of Clinical Case Reports Medical Images and Health Sciences

Abstract

Giant Cell Tumor is a rare benign soft tissue tumor occurring in two forms: localized and diffuse. The two subtypes differ in their location at presentation, shape, recurrence after treatment and prognosis. MRI is still essential in the diagnosis, however pathology remains the gold standard for the final diagnosis. In this article, we report a case of Giant Cell Tumor involving a very rare location with very few reports in the literature; the infrapatellar (Hoffa’s) fat pad of the knee. We discuss its keen clinical and radiological features. The tumor was managed with arthroscopic resection. Confirmation of the diagnosis was done by pathology. Our case is the first to be reported in Lebanon.

Keywords: GCT; Hoffa’s fat pad; STIR

Introduction

First described by Chassaignac in 1852, Giant Cell Tumor (GCT) is a benign soft tissue tumor [1]. It is a rare disease, associated with synovial inflammation due to hemosiderin deposition. GCT occurs in two forms: localized GCT and diffuse formerly known as pigmented villonodular synovitis. The former typically consists of small well circumscribed, nodule or pedunculated mass that might be intra- or extra-articular, most commonly (85%) in the small joints (ex: hands and feet) while the latter is typically intra-articular with an infiltrative growth pattern commonly occurring in large joints (ex: ankles and knees) [2–4]. Both share similar histologic features; however they have different biological behavior, treatment outcome and prognosis. Thus the importance of differentiating between the two entities [5,6].

MRI is considered essential for the diagnosis, staging, preoperative planning and clinical follow-up of GCT. The mass appears of iso/low signal intensity on T1 and T2 weighted images. In addition to joint effusion and synovial proliferation. Some “blooming” artifact of low signal might be noted on echo-gradient because of the magnetic susceptibility from hemosiderin deposition [1,2].

In this article, we report the first case in Lebanon (to our best knowledge) of a rare, localized Giant Cell Tumor originating in the infrapatellar (Hoffa’s) fat pad, emphasizing on its radiologic manifestation.

Case report

We report a case of a 35-year-old gentleman, previously healthy, complaining of a 4-month history of recurrent and painful left knee locking. The patient denies any trauma, any recent surgery, no accompanying systemic symptoms as of fever, rash, diffuse arthralgia, or myopathy. His presentation was mimicking that of a meniscal tear injury.

An MRI of the left knee was performed using 1.5 Tesla Philips Ingenia Unit, manufactured in the Netherlands. The following planes and sequences: A sagittal T1 weighted (T1W), proton density (PD) and STIR image, a coronal STIR and an axial STIR image. Result showed the presence of a soft tissue-like lesion arising directly anterior to the anterior cruciate ligament in between both femoral condyles estimated to be 3 cm in its transverse diameter, 2.7 cm in its antero-posterior diameter and 1.2 cm in its supero-inferior diameter. The lesion showed iso-intensity to the cartilage on T1W as well as on PD but showed an increase signal intensity on STIR weighted images. The lesion relaxes directly on the ACL posteriorly which is of adequate continuity and signal. Minimal associated excess of joint fluid filling the supra-patellar bursa. Both menisci, anterior cruciate ligament, posterior cruciate ligament and  medial and lateral collateral were normal. No capsule-meniscal separation is seen. The overall radiologic impression was for a Cyclops lesion or a soft tissue tumor such as Giant Cell Tumor.

The patient underwent an arthroscopic excision of the soft tissue tumor. Procedure went uneventful. The tissue was sent to pathology. Microscopic examination showed fragments of fibrous tissue involved by sheets of fibro-elastic to epithelioid cells with band nuclei and moderately abundant cytoplasm. They are intermixed with osteoclast-like giant cells and foamy histiocytes. There was no evidence of malignancy. Findings suggestive of Giant Cell Tumor of the Tendon Sheath. Unfortunately, the patient was lost to follow up, thus recurrence could not be reassessed.

AT1 weighted image, sagittal plane: showing a soft tissue-like lesion iso-intense to the cartilage measuring 2.7 cm in its antero-posterior diameter relaxing directly on the anterior cruciate ligament posteriorly which is of adequate continuity and signal B: Proton density weighted image, sagittal plane: showing a soft tissue-like lesion iso-intense to the cartilage measuring 2.7 cm in its antero-posterior diameter relaxing directly on the anterior cruciate ligament posteriorly which is of adequate continuity and signal.

C: Short T1-Inversion Recovery weighted image, sagittal plane: showing a hyperintense soft tissue-like lesion measuring 2.7 cm in its antero-posterior diameter. D: Short T1-Inversion Recovery weighted image, coronal plane: showing a hyperintense soft tissue-like lesion measuring 1.2 cm in its supero-inferior diameter. E: Short T1-Inversion Recovery weighted image, transverse plane: showing a hyperintense soft tissue-like lesion measuring 3 cm in its transverse plane.

Discussion

Giant Cell Tumor is a rare benign soft tissue tumor arising from the synovial tissue of the joints, tendon sheath, mucosal bursas, and fibrous tissues adjacent to tendons. Multiple terms are found in the literature to describe this entity; pigmented nodular tenosynovitis, fibrous xanthoma of synovium, benign synovioma, xanthogranuloma and tenosynovial giant cell tumor [1]. Etiology and histiogenesis of which is not completely understood, but many risk factors were mentioned in the literature such as trauma, infection, vascular abnormalities, lipid metabolism disorders, osteoclastic proliferation, and immune system disorders. It can present in two forms: localized and diffuse [3,7]. Localized GCT presents mainly in small joints (85 % observed in fingers while 12% is observed in large joints, GCT in the knee is rare) [4], either intra-articular or extra-articular. Diffuse form occurs mainly in the extra-articular space [8]. However, extra synovial soft tissue forms of localized GCT are very rare and mainly concern the knee joint. Around 50% of patients with a localized GCT arising primarily within the infrapatellar fat pad have a history of trauma but the exact etiology is still unknown [9]. The onset age of localized GCT is older than that of the diffuse type (i.e. localized type usually occurs above 40 years of age)[10]. When affected, patient presents clinically with mechanical derangements, progressively worsening over time. Meniscal symptoms and locking are often present within the knee joint. The main symptoms are swelling (86%), pain (82%), stiffness (73%), limited range of motion (64%) and joint instability (64%) [7,10].

MRI is an effective and highly sensitive diagnostic tool; however pathology is still the gold standard of final diagnosis. On T1 and T2 weighted images, dense collagen and hemosiderin presents with homogenous low or intermediate signal. The most typical feature of a localized GCT is a well circumscribed, nodular mass with low signal intensity on T1, T2 and proton weighted images and high signal intensity on STIR images [4,6,9,10]. Microscopically, GCT is characterized by multinucleated giant cell, lipid-laden macrophages, hemosiderin deposition and fibroblast proliferation [5].

Various pathological conditions should be considered in the differential diagnosis, for example: Synovial Chondromatosis, Cyclops lesion, Rhabdomyosarcoma, Fibroma of tendon sheath, Synovial Sarcoma, Amyloid Arthropathy, Haemophilic Arthropathy, Lipoma Arborescens and Rheumatoid Arthritis [6,9].

The ability to differentiate between the diffuse and localized forms of GCT is paramount to give patients a realistic outlook on future prognosis, chance of recurrence and optimal treatment course [5]. Several treatment options are present: surgery, radiotherapy, pharmacology or a combined solution of the listed methods. Important to note, local recurrence after treatment was reported in 18-46% of cases. However, this might be linked to incomplete resection of satellite nodules in the area of initial change. Other risk factors for recurrence are the location of the disease (more common in the knee), history of previous surgeries and positive surgical margins.

Conclusion

To the best of our knowledge, our case is the first to be reported in Lebanon. It is very rare to have a localized GCT in the extra-synovial infrapatellar (Hoffa’s) fat pad of the knee. The rarity of the presented case suggests that GCT should be considered in the differential diagnosis of a painful knee locking in a young patient. Accurate diagnosis will lead to successful treatment associated with low recurrence rate resulting in a better patient outcome.

Conflict of Interest:

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article

[cosmogenous]

who wants to play cults with me?

[starrinlem]

[newsk112]

Carlsen wins GCT 2025 Zagreb; Gukesh finishes third, Praggnanandhaa ends in ninth

World No. 1 Magnus Carlsen of Norway emerged as the winner of the Grand Chess Tour 2025 Rapid & Blitz in Zagreb while reigning world champion D. Gukesh finished third in the standings. Carlsen defeated local player Ivan Saric in the final match in blitz to top the overall standings with 22.5 points to take his sixth straight GCT R&B win. After clinching 10 points in the rapid stage, Carlsen was…

[future1205]

USB type C: Explore GCT's 6, 16, and 24 pin connector range

https://www.futureelectronics.com/m/global-connector-technology GCT’s USB connectors feature 6, 16 and 24-pin ranges, we highlight the capabilities that set these connectors apart. From IP67 rated to advanced 240W power delivery options. Discover the unique features of each pin configuration and how they cater to different device requirements. https://youtu.be/NIBOPKBIbc4

[futureelectronic1527]

USB type C: Explore GCT's 6, 16, and 24 pin connector range

https://www.futureelectronics.com/m/global-connector-technology GCT’s USB connectors feature 6, 16 and 24-pin ranges, we highlight the capabilities that set these connectors apart. From IP67 rated to advanced 240W power delivery options. Discover the unique features of each pin configuration and how they cater to different device requirements. https://youtu.be/NIBOPKBIbc4

[stochastique-blog]

Im Human

2023.02.11: Grand Central Terminal - New York City, NY #grandcentralterminal #afternoonlight #lightandshadow #newyorkcity #gct #blackandwhitephotography #cityscape (at Grand Central Terminal) https://www.instagram.com/p/ColKuNaO4kD/?igshid=NGJjMDIxMWI=

[ghst-kng]

*after finishing a book that changed me on so many levels* how the fuck am i supposed to live my life now?

[gabrielferaud]

im happy that gukesh beat magnus but to be honest i wasn’t even paying attention to what tournament they’re playing

[swampythesweetsketch]

Racing Through The Night is a Kiyotaka song and Ghost City Tokyo is a Mondo song and they go together because the vibes are there and I will chew through your door if you tell me I'm wrong.

[jiangchengsjawline]

and now for the knives (tw miscarriage)

fem jc! is pregnant when she’s captured by the wens, but it’s early on and wwx doesn’t know. and she miscarries during her torture becoming another thing that makes her miserable that she intends to keep from wwx so he won’t be hurt or pity her or stay with her out of obligation. maybe jc can’t get pregnant anymore and that was their only possible baby

wwx stays by her bedside wracked with worry and guilt, falls asleep crouched next to jc and holding her hand. core transfer doesn’t happen, they get married instead (wwx attempt at protecting his shimei) but ofc they don’t communicate and wwx thinks jc isn’t interested anymore, and jc thinks wwx pities her

so wwx takes revenge for his darling wife, and brings her wen chao’s and wen zhuliu’s heads

HIS DARLING WIIFFEEE STOP IT. wei wuxian doing the cat thing and bringing jiang cheng sweet little dead things as a symbol of devotion...THAT'S romance <3

jiang cheng with no core and no baby :( she must have agonized over how to tell him, how he’d react. must have let herself dream just once of a sunlit future where he's thrilled and he wants her and the baby and they stay together forever. and then the worst thing in the world happens and lotus pier burns and her parents are murdered and her core and baby are stolen from her. all possible futures gone, just like that. so maybe it's a good thing, in the end, that she kept her mouth shut, if it was just going to end like this. she'll never know how wei wuxian would have felt about the baby and wei wuxian never has to know what he lost. this, too, is a sacrifice.

[watchingyoufromthestars]

Merry Glenn Close day y’all

[suplexenjoyer]

And Magnus Carlsen wins the gct rapid and blitz Croatia 2025

Not a super dominant preformance but the man simply cant stop winning tournaments.

Other notable stories from the last day

Nordibek has had an incredible blitz portion and after struggling all event Alireza got into a groove today and performed well. Gukesh also managed to stabilize today had has maintained a strong overall tournament.

[s-ccaam-era-crepe]

Getting ready for school tomorrow? No you’re mistaken. Making my ren faire outfit <33

[ritualvirtuality]

got a text from my boss saying i dont have to come in after i already got to midtown… way to unravel my entire day

[ahavaas]

#chengxian#re: the gct. a supreme act of devotion and also a complete denial of agency#wwx somehow forced them core-first into TPE noncon. and then we find out he has a gege kink and a rape kink#i still retain that wwx is deep deep down aware of the power he holds over jc and that scares the shit outta him#chengxian noncon where jc is crying and begging wwx to stop and wwx smiles and coos and kisses jc’s tears away before fucking him harder?#perfection. to love is to own and to love is to hurt and where are our limits where do i end and you begin? it’s pure symbiosis#anyway all this to say wwx is sooo proud of himself and he should be! and jc should be grateful and he isn’t! no wonder wwx left him so fast#wwx gave him sooo much and ruined himself for the sake of this boy he didn’t even respect and then jc had the audacity to become even more#nagging and demanding. cut wwx some slack jc! let him drink his wine in peace! nothing warms him up now jc! read the room!#one day i’ll finish my gct noncon porn with drugged jc i pinky-promise - @gardensofthemoon

sadistic rapist this. guilty rapist that. everyone knows the best kind of rapeplay is when your rapist really truly believes that what they're doing is the best thing for you. it might be scary and overwhelming at first but it's going to be okay, they're going to make sure you're okay. this is what you need and they love you enough to give it to you even if you're being difficult about it.