#peg1

[hello-bellasmith]

Bromo-PEG-CH2CO2H (PEG1-PEGn)

[midiemporium]

peg, originally by steely dan

this marks the start of a new era of midis.

[neurogenpapers]

Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset.

PubMed: Related Articles Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset. Front Mol Neurosci. 2016;9:166 Authors: Mesman S, van Hooft JA, Smidt MP Abstract Mesodiencephalic dopaminergic (mdDA) neurons originate at the floor plate and floor plate-basal plate boundary of the midbrain ventricular zone. During development mdDA neurons are specified by a unique set of transcription factors and signaling cascades, to form the different molecular subsets of the mdDA neuronal population. In a time series micro-array study performed previously, mesoderm specific transcript (Mest) was found to be one of the most upregulated genes during early mdDA neuronal development. Here, we show that Mest transcript is expressed in the midbrain throughout development and becomes restricted to the substantia nigra (SNc) at late stages. In Mest KO animals mdDA neurons are progressively lost in the adult, mostly affecting the SNc, reflected by a 50% decrease of TH protein and DA release in the striatum and a reduction of climbing behavior. Analysis of Lrp6 KO embryos suggest a subtle opposite phenotype to the Mest KO, hinting toward the possibility that specific loss of mdDA neurons in Mest ablated animals could be due to affected WNT-signaling. Interestingly, the mdDA neuronal region affected by the loss of Mest remains relatively unaffected in Pitx3 mutants, suggesting that both genes are essential for the development and/or maintenance of different mdDA neuronal subsets within the SNc. Overall, the neuroanatomical and phenotypical consequences detected upon the loss of Mest, resemble the loss of SNc neurons and loss of movement control as seen in Parkinson's Disease (PD), suggesting that the Mest mouse model may be used as a model-system for PD. PMID: 28133444 [PubMed - in process] http://dlvr.it/NFmHQW

[blessedby-puberty]

Peg Leg || Open

Hiccup had secluded himself from the rest of the carnival for the past few weeks. He had been so wrapped up in the new born cubs, he forgot completely about social interaction. But he didn't need that, he didn't need people..So he always reminded himself. 

He sat now in the cage where the cubs were, and smiled to himself. They had opened their eyes by now, and each of them had developed their own personality. The fact that Hiccup could be so close to them, bond with them, blew his mind. He knew that everyone thought he was nuts, he could tell just by the way they watched him with the animals. He didn't know why, but he had always had a special gift with the animals. One that no one else in the entire carnival had.  He never worried about an incident happening, or him getting hurt..Simply because he trusted the animals. All of them. Even his biggest cat, Trixie.

He leaned back, resting on the cage, and watched as the fattest cub wabbled towards him. He let out a chuckle and watched as it started sniffing his leg..Well..The fake one. The chunky cat began to paw at it, and Hiccup knew it wouldn't be good. "Please don't bite that." He mumbled, readjusting himself. He was sure that no one was around, beings he hadn't seen any body in about a week. He pulled his pant leg up, reveling his fake leg,  and slowly removed it. "Not today, bud." He whispered to the cat, setting the leg down beside him.

This was the only time he had taken the leg off outside of his car. Normally he was so self conscious about it, he didn't want anyone to know that it wasn't real. But here with the cubs, that didn't matter. He smiled softly as the chunk laid its head on his stump, closing it's eyes slowly and yawning. He was beginning to think that maybe he could take a nap, as well. That was until he heard rustling behind him. 

"Who's there?!" He called out frantically, torn between waking the cub up to fix his leg, or to let it sleep. Exposing himself. 

[hello-bellasmith]

N3-PEG-Boc-PEG-NHS ester (PEG1-PEGn)