#side by side comparison of using gel or injections of testosterone
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What type of testerone hormone replacement therapy is for you? - Article Comparing T-gel,Cream and Injections.
The two of the most debated forms of testerone hormone therapy are the cream ( T gel) and the injection method. This article goes on in depth on these two methods. It compares their positives and negatives to provide a very in depth perspective so you can make an informed decision on the method that is right for you.
THRT gel or creams a topical (rubbed on your skin) application that contains synthesized testosterone. It's typically formulated with carriers that ensure the optimal absorption of the formula through the skin. The exact compounds vary from brand to brand however the primary ingredient is always testosterone. Once applied onto the skin, the testosterone in the cream is gradually absorbed into the bloodstream. This process mimics your body's natural rhythm of testosterone release, also providing a steady level throughout the day.
THRT injections usually contain testosterone cypionate, testosterone enanthate, or testosterone propionate suspended in an oil. These formulations are designed for intramuscular injection, ensuring that the testosterone is slowly released into the bloodstream over a period of time (can range from one to a few weeks apart) These injections require a prescription in Canada and the US, but can also be available at clinics both online and offline. They also may require you to need to make doctor's visits to either do your injection or teach you how (depending on what your health care provider says they want to do). Some people can learn to inject themselves, others may not feel comfortable and can go to their doctor or a clinic to receive your shot. Make sure you have been properly instructed by a professional health care provider prior to doing your own injections.
IS T Gel and T Cream the same?
Differences between the cream and the gel options are the thickness and potency of the actual product . They are both transdermal methods (using the skin to get to the bloodstream) of using testosterone and are very similar in how they are used and function and the are usually a used in a smaller area so less chance of transfer and more equal levels. Creams are becoming a more stable option over the gel. This is a decision you and your doctor should make as to which option is better, side effects can differ slightly from brand to brand.
This is a comparison chart I found to help you make an informed decision on which style of application is best for you.








The images are in order of left to right
Importance of Individualized Treatment: No single THRT method suits everyone. Factors like age, lifestyle, medical history, and personal preferences play a significant role in the best choice.
Factors to Consider: Consider your daily routine, if you are comfortable with injections, the dosage, and potential side effects.
Consulting with Healthcare Professionals: Before deciding on any method, it is very important to discuss options with your/a healthcare provider familiar with testosterone therapies. This can also include an endocrinologist.
Important: remember more is not better! Taking a larger dose than you are instructed to can cause adverse side effects such as irritability, mood swings, changes in libido, and even hair loss.
Here is the source I used for images
Mayo Clinic Source
Source 3
Other sources include my experiences, and advice given to me by my family physician and endocrinologist
#testerone hormone replacement therapy#side by side comparison of using gel or injections of testosterone#t hrt#transgender#trans ftm#transman#trans non binary resources#ftm transition#transgender ftm affirming procedures#information on testosterone therapies#tw needles mentioned#i added more sources are you happy now?
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hi! I've come asking questions about transition (as a trans boy) more specifically, you mentioned that you've used both testosterone cream and injections.
Do you mean the cream/gel kind of HRT that is used once daily? If so, I was wondering whether you noticed any difference in the uptake or changes in the rate of your transition compared to injections. Did changes happen at the same rate as injections or a bit slower, since I've heard there can be problems of the skin not absorbing T as well as injections. Do you have any personal experiences of this?
Also if it's not too personal, which kind of HRT are you on now (injection/cream) and why did you choose to stick with it, if that was your own choice? (ik there can be insurance/supply issues that might affect it)
Howdy! So: this was a ride.
My first provider (not naming names, but she’s a doctor who works in downtown Austin) gave me two choices: find time to take a 1- to 1.5-hour round trip downtown, pay the $20 copay, and have a nurse give me an injection every single week; or use a daily cream from a compounding pharmacy that delivered. For reasons of time and money, I went with the cream.
I was on it for a year; I don’t remember my dosage exactly, but it was something like two clicks of a finicky dispenser. I was on it for a solid year and the only change that occurred was I got a couple more annoying, embarrassing PCOS hairs on my throat. Absolutely nothing else. Meanwhile, every 3 months or so I’d express my frustration with this to my doctor, and she’d just tell me to be patient. Or, you know, come in and pay the copay every week instead.
Now any number of things could have been going on here. She could have had me on a comically-low dose (I really have zero memory of what it was). My biochemistry could have overpowered or resisted it. The compounding pharmacy could have been bullshit. Who knows.
By comparison, right around three months on testosterone cypionate injections, my voice broke and I started sprouting facial and body hair in spades.
Between what my second HR provider (the one who got me onto cypionate) and other trans men I’ve heard from have said, the gel version is a much slower ramp-up usually because you’re adding T to your system in small, daily doses, and the cream version seems to be pretty uncommon; both of them are better if you really want to ease into the changes instead of just getting the whole second puberty thing over with, or if you’ve already been through testosterone-dominant puberty and just need to maintain your levels.
Since July 2017 I’ve been on a weekly 0.4 mL injection of 500 mg/mL testosterone cypionate. It was pretty challenging at first with my phobia of hypodermic syringes, but I’ve inured myself to it over time. My habitual injection site has also acclimated to it so that there’s literally no pain at all if I get myself in just the right spot, so that’s pretty great; and using the bathroom mirror instead of looking directly at myself has proven a great little trick to hoodwink my brain about what’s going on, thus reducing my anxiety about it a great deal.
I’ve stuck with it because it gets results, it’s a lot less messy and aggravating than a topical treatment, getting the right dosage is MUCH easier, it’s become a little ritual of sorts, and I only have to remember it ONCE a week instead of seven times. It’s also lessened my anxiety when I have to get blood drawn or have IVs in (though I still really fuckin’ hate IV lines). YMMV, but for me, it’s been a great experience overall.
We’re not gonna talk about the thinning hair, though. -_- One more crappy thing I inherited from my dad’s side, and wouldn’t you know it, it’s activated by testosterone….
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How Much Does TRT Replacement Therapy Cost?
Understanding TRT Replacement Therapy Costs
Testosterone Replacement Therapy (TRT) has become increasingly popular in recent years as more individuals seek solutions to combat symptoms of low testosterone levels. As with any medical treatment, one of the foremost concerns is the cost. In this article, we delve into the intricacies of TRT replacement therapy costs, exploring various factors that can influence pricing, the most cost-effective treatment options, and essential considerations for those considering TRT.

Factors Affecting TRT Replacement Therapy Costs
Several factors contribute to the overall cost of TRT replacement therapy, including:
1. Treatment Method:
TRT can be administered through various methods, such as injections, patches, gels, or pellets. Each method comes with its own cost considerations, depending on factors like frequency of administration and the type of medication used.
2. Medication:
The type and brand of testosterone medication prescribed can significantly impact treatment costs. Generic options may be more affordable compared to brand-name medications, but efficacy and potential side effects should also be considered.
3. Frequency of Administration:
The frequency at which testosterone is administered can affect overall costs. Some individuals may require weekly injections, while others may opt for less frequent options such as bi-weekly or monthly injections.
4. Clinic Fees:
The fees charged by healthcare providers or TRT clinics for consultations, lab tests, and administration of treatment can vary widely. It's essential to inquire about all associated fees to get a comprehensive understanding of the total cost of treatment.
Cost-Effective TRT Treatment Options
For those seeking cost-effective TRT treatment options, several strategies can help minimize expenses without compromising quality:
1. Generic Medications:
Opting for generic testosterone medications can often result in significant cost savings compared to brand-name alternatives, without sacrificing efficacy.
2. Self-Administration:
Some individuals may choose to self-administer TRT medications, which can eliminate the need for frequent clinic visits and associated fees. However, proper training and supervision are essential to ensure safe and effective administration.
3. Comparison Shopping:
Researching and comparing prices from different TRT clinics or pharmacies can help identify more affordable options. Additionally, inquire about any available discounts or payment plans to further reduce costs.
4. Insurance Coverage:
Check with your health insurance provider to determine if TRT replacement therapy is covered under your plan. While coverage may vary, having insurance can significantly offset the out-of-pocket expenses associated with treatment.
Is Testosterone Replacement Therapy Right for You?
Before embarking on TRT replacement therapy, it's crucial to evaluate whether it's the right option for your individual needs and circumstances. Consider the following:
1. Symptoms:
If you're experiencing symptoms of low testosterone, such as fatigue, decreased libido, or muscle loss, TRT may be beneficial. However, it's essential to consult with a qualified healthcare provider for a proper diagnosis and treatment plan.
2. Risks and Benefits:
Like any medical treatment, TRT comes with potential risks and benefits. Discuss with your healthcare provider to weigh the pros and cons based on your medical history, lifestyle factors, and treatment goals.
3. Monitoring:
Regular monitoring of hormone levels and overall health is essential during TRT to ensure efficacy and minimize potential side effects. Your healthcare provider will work with you to develop a personalized monitoring plan tailored to your needs.
Is Testosterone Therapy Safe?
Testosterone replacement therapy is generally considered safe when prescribed and monitored by a qualified healthcare provider. However, like any medical intervention, it's not without risks. Potential side effects of TRT may include:
Acne
Fluid retention
Increased risk of blood clots
Sleep apnea
Breast enlargement
It's essential to discuss any concerns or potential side effects with your healthcare provider before starting TRT.
Do You Need a Prescription for Testosterone Injections?
Yes, testosterone injections are prescription medications and should only be administered under the supervision of a qualified healthcare provider. Self-administering testosterone injections without a prescription can lead to serious health risks and legal consequences.
How Much Does 1 Shot of Testosterone Cost?
The cost of a single testosterone injection can vary depending on several factors, including the type of medication, dosage, and where the injection is administered. On average, a single testosterone injection can cost anywhere from $30 to $60, but prices may vary based on individual circumstances and provider fees.
In conclusion, the cost of TRT replacement therapy can vary depending on multiple factors, including treatment method, medication, frequency of administration, and clinic fees. By exploring cost-effective treatment options, discussing the risks and benefits with a healthcare provider, and ensuring proper monitoring, individuals can make informed decisions about TRT that align with their needs and budget.
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10 Reasons 1-Testosterone is a stimulating Steroid
AAS Analysis:
10 Reasons 1-Testosterone is a stimulating Steroid
1-testosterone (dihydroboldenone), aka DHB, may be a steroid which has been growing in popularity recently but isn't new the bodybuilding world. DHB isn't a testosterone-based compound; it's merely the 5alpha reduced sort of Equipoise (boldenone). DHB acts during a much different way than standard Testosterone or EQ. DHB is that the dihydrotestosterone (DHT) version of equipoise like DHT is to Testosterone. 1-Test is one among the foremost potent present steroids to be isolated. From 2002-2005, 1-Testosterone was being sold as a supplement until being added as a category III drug in Jan. 2005. During this short 3 yrs, a number of these supplements sold with good success albeit the oral bioavailability isn't very high. Supplement companies were using 1-Testosterone in an oil solubilized softgels attached to an undecanoate ester (think Andriol/ Lymphatic delivery) also as Transdermal solutions/gels at the time. Both of those delivery methods have some positive effects but, the injectable preparations are quite simply, simpler. In most cases, DHB is attached to the cypionate ester. There are not any legit prescription DHB injectable preparations available, therefore the only options are all from underground labs (UGL) sources. Always use caution when using anything from UGLs. UGLs aren't regulated and are available with more risk for contamination. For this text, we are getting to focus mainly on 1-Testosterone Cypionate. Here are ten reasons why 1-testosterone may be a steroid that I find to be very interesting.
1.) DHB has an anabolic to androgenic ratio of 200/100. As compared, testosterone's A: A ratio is strictly 100 (100:100), and Deca Durabolin is rated at 125: 37, so DHB is twice as anabolic as testosterone and almost twice as anabolic as Deca. However, let's not forget that rates given to anabolic androgenic steroids (AAS) are often misleading. DHB is extremely minimally androgenic. Side effects like aggression and vital sign increase are getting to be less likely to occur than with other steroids. Compared to other compounds, DHB is taken into account very mild, but this is often all relative to the dose used. 1-Testosterone doesn't cause significant stress on the kidneys or other organs. 1-Testosterone is understood to yield lean quality tissues gains with little to no bloat with low side effect potential.
2.) DHB is extremely anabolic and doesn't aromatize, which suggests it should yield nice lean muscle gains. DHB is more anabolic than testosterone, equipoise, and Deca Durabolin. Since there's no aromatization to estrogen, there's no got to worry about estrogenic side effects like gynecomastia or water retention. Beat all, DHB are often an excellent pre-contest hormone since it'll offer you minimal water retention. 1-Testosterone Cyp is great for helping to take care of muscle while on a contest diet, might be used for a lean bulk with relative ease by running it at moderate doses, or are often used with aromatizing compounds like Testosterone, Dianabol, or MENT for an all-out bulk when combined with a diet that reflects those goals.
3.) Unfortunately, Injectable DHB is understood to return with prominent post injection pain (PIP). This happens after the injection, and that I believe this might be since 1-Testosterone is an irritating substance on its own. This will even be experienced with a number of the transdermal solutions. The PIP may cause many to avoid DHB and miss out on the potential benefits. From my experience, the PIP seems to vary greatly from person to person. Almost like how some have PIP with steroids attached to the propionate ester. PIP also can vary counting on which underground lab is manufacturing the answer. Most ordinarily you'll find DHB dosed at 100-150mg/ml. The 150mg/ml is typically getting to cause more PIP than the 100mg/ml. to assist reduce the PIP, try diluting the DHB with another steroid or sterile oil like Grapeseed oil (sterilized). Heating the oil with a hot pad before doing the injection can sometimes help also as doing all of your injection slowly. Using less volume with each injection can sometimes help take a number of the snap at also, so rather than doing 2ml on Mon. and Thurs. you'll try doing 1ml Mon., Tues., Thurs., and Friday.
4.) Another potential negative drawback is that the volume of oil needed to offer the user a robust effect. 1-Testosterone is extremely almost like Primobolan when it involves the way they're dosed mg/ml and therefore the volume of oil that has got to be wont to reach the specified effect. Both DHB and Primo are typically dosed at 100mg/ml. Most users notice the simplest results once they recover from 400mg per wk. This suggests you're injecting an honest little bit of this painful oil into your muscles weekly. For many, this may prevent them from using this steroid.
5.) Curiously enough , DHB has some thermogenic properties, almost like trenbolone, mainly regarding sweating and in some cases insomnia. DHB gives very nice strength gains without hurting appetite so it is often a really nice bulker. Although it's going to share its name with equipoise or testosterone, users consider DHB more as trenbolone's baby brother. I personally desire this is often overstating the facility of DHB. Yes, it's an excellent anabolic, and that i desire it's a stronger compound than Primobolan but yet definitely milder than tren. The PIP makes it somewhat difficult to use in most cases, but I even have personally had 1-Test Cyp that had little or no PIP a time or two, and in those cases, it wasn't an inconvenience in the least to use. Meager side effects overall aside from the potential injection site pain and a small increase in blood heat. If you'll find a 1-Testosterone Cyp with little PIP that's from a trusted source, it's worth using both within the offseason and in contest prep counting on your diet and your goals. This compound could easily be implemented in either situation with great success. a bit like all steroids, DHB is suppressive, so a radical post cycle therapy (PCT) should be implemented unless you're on Testosterone replacement.
6.) 1-Testosterone is one among the few steroids which will be taken in oral form, transdermal solution, or in an injectable preparation. As stated above to experience the foremost benefits the injectable preparation is best except for some, the transdermal 1-Testosterone are often a pleasant addition or are often utilized by women in lower doses. Here is what a number of the standard doses were when DHB was being sold as a supplement before being placed on the list as a schedule III drug. When it had been dosed orally and packaged in an oily solution in gel cap form the oral dosing was 100-250mg daily. Transdermally, 75-100mg was applied daily. I personally enjoyed the transdermal version and ran it up to 200mg daily this version is hard to return by nowadays. Starter doses with the injectable cypionate version would be 100-200 mg added to TRT dose of test. Confine mind this is often a really mild dose, and personally, I felt just subtle changes from this dose. If you won’t to running only 1-200mg / wk of Testosterone for TRT then added in 200mg of DHB, you'd probably notice a touch effect, except for a bodybuilder running much higher doses, this is able to probably get to be doubled or tripled to note truth potential positive anabolic effects of this compound. Women have used this steroid at low doses like 25mg daily of the orally. Typically, the oral dosages are prepared much higher per cap. Injectable dosing for ladies is around 10-20mg per wk. Any use of this compound by a female could still very easily because masculinizing effects.
7.) When DHB is combined with moderate to higher doses of testosterone an AI should be used. This is often because 1-Testosterone features a high binding affinity to the androgen receptor which suggests there's an honest chance more testosterone goes to be displaced. This might very likely increase estrogen and free testosterone to above normal levels. For instance, for instance a bodybuilder.
is using around 400-500 milligrams (mg) per week of DHB with long ester testosterone dosed at 4-600mg/wk. Some guys may use 4-600mg of Testosterone by itself with no AI (I wouldn't recommend this, but some people escape with it) but when the 1-Testosterone is employed in conjunction with an equivalent dose of testosterone more of the testosterone are often aromatized which yields a better estrogen level.
8.) DHB does aromatize but only at a really low level. It’s not fully understood how. It’s speculated that the body could also be potentially inserting a covalent bond on its own at carbon-4. Even still estrogen related sides are usually very mild to non-existent with this compound by itself. If employed by itself or stacked with non-aromatizing agents, it shouldn't cause noticeable estrogenic side effects, like lethargy, low libido, or depressed mood. For this reason, it's an honest idea to stack some testosterone with it. Males got to have estrogen to function optimally and by keeping a minimum of a replacement dose of Testosterone in with the DHB cycle should accomplish this. The added testosterone will give the cycle another androgenic kick. The side effects aren't bad in comparison to stronger compounds like trenbolone, and are probably more in line with the side effects which will arise with Equipoise and/or Primobolan. As stated above, support supplements, blood work, and a full post cycle therapy (PCT) should be used in the least times.
9.) 1-Testosterone may be a Dihydrotestosterone (DHT) derived steroid. I even have heard a couple of people say it's not a Testosterone base, DHT base, or 19-Nor base but something different. This is often not correct. 1-Testosterone is what DHT is to Testosterone to Boldenone (EQ). Boldenone may be a Testosterone Derived Steroid and Dihydroboldenone is that the DHT derivative of Boldenone. This is often also why it's the classic DHT type results, Hardening, Strength, little to no water retention, low to no estrogenic side effects.
10.) 1-Testosterone is often an irritating substance to the skin. This has been known to not only cause some irritation within the transdermal formulas but also the PIP which most realize it for. One other thing that I found to be interesting was that some users may experience a small burning during urination from this compound. I personally noticed I felt like I had to urinate more frequently while on 1-Test Cyp once I got over 5-600mg/wk this is often also where I noticed the slight stinging or burning sensation. It had been very mild and honestly had I not been really listening to the small details I’ll have overlooked this.
In closing, my personal opinion on 1-Testosterone is that it is often a superb tool for bodybuilders who don't mind doing frequent, voluminous injections. It works great during a cut phase also as a lean mass building phase. Overall the side effects are relatively mild but to not be taken without any consideration. The anabolic effects are significant if you'll tolerate moderate or higher doses of this anabolic. 400mg+ is where you actually start to ascertain some changes. Do I feel it compares to Tren? No I don’t, but I do desire it works better than both Primobolan and EQ mg per mg, but EQ is simpler to use at higher mgs. The PIP is often severe in some cases and varies from person to person and batch to batch. I hope you guys enjoyed this text to shut I’m getting to offer you a couple of example setups. Here are a couple of hypothetical scenarios, this is often an example of how i might found out differing types of cycles with DHB after having used 1-Test Cypionate quite a couple of times.
Example 1: 1-Test Cyp as a part of a cutting stack would look something like this. For theoretical purposes, here is what a cut stack may appear as if while utilizing 1-Test Cyp for a male bodybuilder : 300mg of Test prop per wk (100mg on Mon, Wed, Fri), 3-450mg of 1-Test Cyp(100+150mg on Mon, Wed, Fri), with 300mg of Tren ace/wk (100mg Mon, Wed, Fri) and perhaps a lower dose of oral Winstrol or Anavar (25-50mg) on training days only. Ancillaries: Exemestane 12.5mg on Mon, Wed, Fri.
Example 2: 1-Test Cyp as a part of a bulking cycle would look something like this. 600mg of 1-Test Cyp (200mg Mon, Wed, Fri), 600mg of Test E or C (200mg Mon, Wed, Fri), 300mg of NPP (150mg Tues and Thurs), 25mg of Dianabol on training days.
GH- 2 IU pre-workout / 2 IU post workout
Ancillaries: Exemestane 12.5mg a day.
LLEWELLYN, W. (2017). ANABOLICS (11th ed.). S.l.: MOLECULAR NUTRITION.
1-Testosterone (dihydroboldenone)
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Oh, so the injection is worse? I was hoping to switch to it.. I'm currently on gel. It was fine till recently, but do you think its because i havent been taking it consistently at the same time? I used to take it always at X. Now I've been taking it +/- 1 hour of when I took it before
I’m assuming this is in relation to the recent question about acne? Do correct me if I’ve guessed wrongly.
Everyone reacts differently to the different forms of testosterone, with some people finding that they get on better with different forms to other people. However, levels do fluctuate slightly more with injections (particularly Sustanon) in comparison to gel so this can contribute to more hormone-related acne. Not everyone finds that this is an issue for them though, so it’s still worth considering and weighing up what you feel are the pros and cons for you against the risk of potentially experiencing more acne at certain times.
Taking it an hour either side of your usual time is unlikely to be causing any dramatic changes to your testosterone levels and contributing to any increased acne; it’s likely that this would have happened now regardless of the times that you apply your gel. If it’s possible to become more regular with your application times again then you could test it out, but I wouldn’t be too concerned about a few hours either way.
~ Alex
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Aytu BioScience Pushes Natesto® Sales to New Record High
Aytu BioScience on Tuesday of last week again reported record prescription sales for Natesto®, its FDA-approved nasally administered testosterone replacement therapy. Sales for October reached 827 total prescriptions, representing a 17% increase over September totals. Additionally, new prescriptions, as well as the number of new prescribers, which provides the most current and accurate gauge of market adoption for Natesto® increased by 495 and 407, respectively. Combined, the October report published by AYTU indicates that the sales and marketing momentum for Natesto® is not slowing down. To the contrary, since March of fiscal year 2017, Natesto® unit sales have risen more than 299%, complemented by an increase in the number of physicians prescribing Natesto® to 407, an increase of 16% for the period and a more than 42% increase since the first quarter of AYTU’s fiscal year 2017. Notably, the reported prescription sales and new prescriber totals for the month represent fresh all-time highs and record growth for both Natesto® pharmacy scripts and prescriber growth.
Impressive Growth For Natesto® Continues
The growth rate for Natesto® is impressive on any scale. Whether investors gauge the momentum by recognizing the spike in product sales or by the growth in new prescribers, AYTU is proving their ability to drive adoption of Natesto® at an accelerated rate and showing its value to a market that is becoming more interested in the product’s benefits.
Side-by-side comparisons demonstrate that Natesto® has significant and differentiating advantages over topically applied competitive products such as AndroGel®, Axiron®, and Fortesta®. Although the inherent difference is apparent, investors need to be somewhat patient while the AYTU sales-force works to persuade physicians that Natesto® is not only as good or better than competing products, but it is a far safer alternative as well. And, from a patient perspective, physicians should pay close attention to the details.
A vital difference, and one that should carry enormous prescribing consideration, is that Natesto® is the only topical TRT product on the market that does not have the FDA’s Black Box warning on the label. For those that don’t know, the Black Box warning is the most severe of warnings that inform users of the potential risks of using a specific product. And, despite the warning getting fixed to all topical TRT products that compete with Natesto®, many physicians still tend to ignore the advice from the FDA, prescribing products that increase the risks of an accidental transmission of the product and minimize suggestions for users to “quarantine” themselves from women and children during product application.
To their benefit, more and more physicians are now prescribing the product based on the clinical data that shows Natesto® to provide as good or better results in treating low testosterone issues in men. And, the known benefits, combined with the Natesto® safety profile, may be factors that drive prescription rates substantially higher.
Natesto® Delivers A Powerful Solution
The cumulative and sequential growth in Natesto® sales is encouraging, and indicators suggest that the momentum will not decrease anytime soon. Based on the fact that Natesto® is the safest and the only nasally-administered TRT product on the market, the growth trend is likely to continue as the differentiated product profile, combined with an increasingly able sales force continue to educate prescribing physicians about the strengths of the product.
The Natesto® nasal dosing application eliminates the risk of accidental transference, and it has also been clinically proven to be both safer and as good or better than its topically-applied competitors. A side-by-side comparison to top-selling AndroGel® exemplifies a few of the critical distinctions. Androgel®, like other available products mentioned, is a TRT treatment that works by releasing a relatively constant amount of testosterone into the user throughout the day. However, the drawbacks to this dosing approach can have detrimental effects on the user.
As the body absorbs this new influx of testosterone, the brain is led to believe that the body’s testosterone levels are adequate and slows the natural production of the necessary hormones LH and FSH. The problem with misleading the brain into thinking that the testosterone flow is normal is that it can cause severe undesired consequences.
In the example, although Androgel® may cause some regulation of testosterone levels, the reduced amounts of LH and FSH have the undesirable effects on the user’s body of dramatically lowering sperm count and in some cases is shown to cause testicular shrinkage. Moreover, a deficit of LH and FSH hormones can cause the brain to slow natural testosterone production as well, often making the patient dependent on artificial treatments in order to maintain proper testosterone levels. And, while these symptoms appear in competing products, Natesto® users have experienced none of these symptoms, a statement supported by data from extensive clinical trials. AYTU released at the beginning of the year, in fact, details of a study in which LH and FSH remained at normal levels after 90 days of continued treatment with Natesto®. Consequently, because with Natesto® treatment LH and FSH levels remain within their normal ranges, it wouldn’t be expected to cause the adverse side effects associated with other treatments. But, although this advantage is significant, there is more to support the switch to Natesto®.
Drawbacks To Competing TRT Products
One of the most severe drawbacks faced by the TRT market is that all long-acting gel preparations and injections are shown to cause increased hematocrit levels in the patient. The increase in the hematocrit levels causes thicker blood within the user’s body, which is clinically associated with a significantly enhanced risk of stroke. To compensate for their higher risk of stroke, patients often are required to lower their prescribed dosage or even quit their TRT medication. Others turn to the undesirable route of donating blood more frequently to thin it out, which is not exactly an easy solution to the problem at hand, especially when FDA-approved Natesto® is available as an alternative. After all, Natesto® has been clinically shown to outperform other TRT products in this area – in fact, Natesto® has been shown to have virtually no effect on hematocrit levels, supporting the case that AYTU’s solution may provide the best option for users of TRT products.
Persuading Physicians To Change
The case for Natesto® being the superior TRT product on the market speaks for itself. Not only is it the only testosterone replacement product on the market that is not Back Box labeled, but Natesto® offers a nasally-administered two to three times daily dosing application. Beyond safety and proven efficacy, Natesto® is discreet and convenient to use, allowing patients to regulate the dosing regimen as part of a daily routine. The strategy getting promoted by AYTU is to educate and inform both users and physicians of the product benefits, and the results are noticeable.
Considering the growth rate of Natesto®, the team at AYTU is making considerable strides to making the product the physicians choice. Taking the current numbers, for instance, Natesto® is set to provide revenue of almost $1,500,000 per quarter based on market pricing, excluding promotional discounts. Then, factoring in that AYTU is successfully broadening its reimbursement coverage from large insurance companies, the likelihood that AYTU will post continued record revenues is likely. Of course, investors need to then factor in the product growth rates, more than 10% per month over the past year, to gain visibility for potential revenue increases in the coming months, a signal which points to continued monthly double-digit growth.
For investors, understanding that the fundamentals and growth of Natesto® are getting established through proven benefit and sales-force market penetration, the recent slump in share price looks to be more of an opportunity than a setback.
It’s always good to know, as well, that AYTU recently raised more than $11 million in a private placement deal with accredited investors, and those investors liked what they saw three months ago. Considering the growth of Natesto®, as well as from the company’s other pipeline and approved for market products, they most certainly must like the numbers getting posted by AYTU now. And, knowing that big money has an active and vested interest in the success of AYTU only provides more confidence to the thesis that Aytu BioScience is a sound investment, even at share prices far higher than current levels.
This article was originally featured on CNA Finance.
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