#src unknown

[kojakus]

2023-12-28

[metamorphesque]

on trees

J. R. R. Tolkien ("The Fellowship of the Ring"), Parte de todo (src), Faiz Ahmed Faiz/tr. Naomi Lazard ("When Autumn Came"), Marina Tsvetaeva, a photo by me (src), Margaret Atwood ("War Photo 2"), photo (src), Tony Hoagland (“Peaceful Transition”), Slope Point, New Zealand (src), Tara Bray ("Listen"), Max Dupain ("Banksias by the Sea"), Mary Oliver ("When I am Among the Trees"), source unknown, Ted Kooser ("Trees")

[florealegiardini]

Me as a cat mom squishing my kitty's faces ~ src unknown

[bynineb]

What pieces of media are your biggest creature design inspirations?

ooh how fun! let's see...

Pokemon Crystal (Ken Sugimori)

(src: Bulbapedia)

I had a Pokemon Crystal strategy guide with all 251 Pokemon in it that I studied religiously when it came to making monsters of my own. I love Ken Sugimori's illustrations so much - the dappled paint makes it so soft, gives everything the feeling of being struck by light dancing down from foliage above. The subtle implied detailing with line strokes and shadow allows the imagination to run wild. They, truly, feel like creatures to have adventures with. And of course, Pokemon is a juggernaut of an RPG, facilitating those childhood fantasies, and then there's a TV show showing them playing and shouting their name and fighting... No wonder so many people got hooked on it!

Dragon Warrior Monsters 2 (Akira Toriyama)

(src: Dragon's Den)

Since they're designed as enemies foremost, Dragon Quest's monsters can get a lot kookier & scarier than Pokemon can. And Toriyama gives his monster designs so much charm and personality! You feel like he always has fun coming up with them, and it makes every Dragon Quest game more delightful for having them be your foes (and sometimes friends). Also, all the English names are puns and portmanteaus and other fun word things!

After Armageddon Gaiden (artist unknown - dev is PandoraBox)

(src: Bogleech, who also wrote a wonderful article on these critters: https://bogleech.com/halloween/hall18-aagolem)

Uniquely grotesque beasts from a deeply obscure Japanese RPG named After Armageddon Gaiden, the second in a duology about player-controlled demons fighting alien invaders. Some of the designs get quite gory or disturbing, fair warning. But in a cool way!! The sheer strangeness of these designs are something to behold!... And they have the best names ever, like "Barabumblebo"...

YU-GI-OH early card art (Kazuki Takahashi)

(src: Yugioh fandom page)

Yu-Gi-Oh's early monster designs are something I think about a lot. I don't know what that says about me, but I do know they're unbelievably cool, a blend of genuinely scary Egyptian-flavored horror and wacky, tropey, cartoony fantasy. The fact that these ridiculous designs are frequently art for a card that's completely worthless in terms of winning duels, combined with their randomly specific descriptions about how unbelievably powerful they are, gives them a certain mystique. It's as if the creature you see depicted truly exists as a part of some greater fantasy world...

Legend of Zelda: Ocarina of Time

(src: me, many moons ago)

Seeing properly scary monsters inside a strange virtual world in Ocarina of Time was quite the experience for my young self. For example, I had nightmares about the Stalchildren who used to burst, endlessly, from the ground of the strangely empty Hyrule Field. But that also made it feel like such an adventure! The thrill added to the experience. And even many of the game's races are quite monsterlike; Gorons, Zora, Deku, and so forth. This had me imagine turning a "bad" creature into a friend, a concept I cherish to this day... hence Love-Love here.

Well that's that! Thanks for asking, this was fun to write : )

[gael-garcia]

Free Palestine chants at the premiere of the only Palestinian film screening @ 2024 Cannes (Director's Fortnight) "To a Land Unknown" by Mahdi Fleifel starring the 4th Bakri brother Mahmood & Greek icon Angeliki Papoulia (src)

[werehounded]

ON OATHS AND DEVOTION - AZIRAPHALE TO CROWLEY

SRC: Red and Black, Les Miserables // Much Ado About Nothing, William Shakespeare // Unknown // ???, Mahmoud Darwish // Punisher, Phoebe Bridgers // Orestes, Euripides, trans. Anne Carson

less a webweave this one, more a collection of quotes, but heigh ho (said anthony crowley)

Reminder that these webweaves and aesthetic posts etc. are for my Good Omens Dark Fantasy AU fic, Oath!

[qalbtalk]

This or That

coffee or tea | early bird or night owl | chocolate or vanilla | spring or fall | silver or gold | pop or alternative | freckles or dimples | snakes or sharks | mountains or fields | thunder or lightning | egyptian mythology or greek mythology | ivory or scarlet | flute or lyre | opal or diamond | butterflies or honeybees | macarons or eclairs | typewritten or handwritten | secret garden or secret library | rooftop or balcony | spicy or mild | opera or ballet | london or paris | vincent van gogh or claude monet | denim or leather | potions or spells | ocean or desert | mermaids or sirens | masquerade ball or cocktail party

src: unknown

[longhaulerbear]

ABSTRACT

Mast cells (MCs) are strategically located at the interface between host and environment. The non-allergic functions of MCs in immunosurveillance against pathogens have been recently underscored. However, the activation of MCs by pathogens may beneficially or detrimentally regulate immune inflammation to combat or promote pathogen invasion. We and others have conclusively demonstrated that MCs serve as a crucial mediator in the induction of hyperinflammation initiated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to substantial tissue damage across multiple organs in murine and nonhuman primate models. Whereas the precise mechanism underlying virus-induced MC activation and degranulation remains largely elusive, our previous findings have indicated that the binding of the Spike proteins to cellular receptors is sufficient to elicit MC activation for rapid degranulation. This study aims to corroborate the ubiquity of coronavirus-induced MC degranulation and elucidate the intracellular signaling pathways that mediate the activation of MCs upon Spike protein binding to the cellular receptors. Our transcriptome analysis revealed MC activation upon the stimulations with a range of Spike/RBD proteins and viral particles of coronavirus. Notably, the interaction between these Spike/RBD proteins and cellular receptors triggered the activation of src kinase, a member of Src Family Kinases (SFKs). This activation, in turn, stimulated the PI3K/AKT signaling pathway, resulting in an accumulation of intracellular calcium ions. These calcium ions subsequently facilitated microtubule-dependent granule transport, ultimately promoting MC degranulation. In summary, this study elucidates the mechanism underlying virus-triggered activation of MCs and has the potential to aid in the development of MC-targeted antiviral therapeutic strategies.

IMPORTANCE

The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. In this study, we demonstrate the ubiquity of coronavirus-induced MC degranulation and investigate the intracellular signaling pathways that mediate this process. We reveal that the binding of Spike proteins and cellular receptors is sufficient to elicit MC activation for rapid degranulation. This binding triggers the activation of src kinase and the downstream PI3K/AKT cellular signaling pathway, resulting in an accumulation of intracellular calcium ions. These calcium ions subsequently facilitate microtubule-dependent granule transport, ultimately promoting MC degranulation. This study elucidates the mechanism underlying virus-triggered activation of MCs and has the potential to aid in the development of MC-targeted antiviral therapeutic strategies

[anonymocha]

“I’m an untitled folder with unknown contents.”

New gender dropped.

src: Normality and Monsters / フツーと化け物

[kojakus]

[pbskidsnews]

We now have an official press release for Season 4 of Odd Squad! Includes a teaser image of our two new main characters.

Key points:

Will be known as "Odd Squad UK" the same way Season 3 was referred to as "Odd Squad Mobile Unit"

A joint production between Sinking Ship Entertainment and BBC Studios Kids and Family, along with PBS Kids, TVO Kids, CBBC and SRC

Unknown if Netflix still has involvement in the season

12 half-hour episodes (24 11-minute ones)

Premiering sometime in 2024

Created due to Odd Squad being extremely popular in the UK

Billed as a "new format" but it's quite clear that this article views it as a spinoff; whether it actually is one depends on the prodco or network

Will be distributed in the US by FRP and distributed elsewhere by SSE

Big thanks to @tumblydove for finding this article!

[shefightslikeagirl]

Key: Unknown

VIII Interlinked Circles, an 8, or an Infinity Circle A key

Cipher Type: Unknown

Y AEF U IUM C YRY TSZP F ZEC F EFY D SRC O MZD

Answer: Unknown

[werehounded]

ON OATHS AND DEVOTION - CROWLEY TO AZIRAPHALE

SRC: Unsplash // Shauna Barbosa, Cape Verdean Blues // Alfonsina Storni, The Siren // Franz Kafka, Letters to Milena // Unsplash // Hélène Cixous, Stigmata: Escaping Texts // Unsplash // Unknown // Fatima Aamer Bilal, from ‘I am your mould, but the shape of you is true absence, leaving me purposeless.’

If no one else is gonna make web weaves for my fic then I gues I'll make my own /lh

[qalbtalk]

src: unknown

[itsgerges]

Best Greetings

Physics Nobel Prize For Imaginary Ideas! (Fourth Question)

THE PLANET DIAMETER IS CREATED BY A MATHEMATICAL EQUATION.

Can Anyone please tell The Physics Nobel Prize Community that-

The planet diameter is created by A Mathematical Equation and by A Geometrical Rule. 

The physics book tells (Planet diameter and creation data are created by random process, initial conditions and historical unknown factors) 

The physics book is wrong –

I have 5 equations define the planets data theoretically– and my 4th equation (Planet Diameter Equation) defines Each planet diameter theoretically – and proves that the planet diameter is created as a function in its rotation period and velocity.

For example, Uranus diameter = 51118 km because A Geometrical Rule caused to create it and this diameter is not changed since its creation through the history-

The paper tests and analyzes my planet diameter equation and answers the question (How's The Matter Created?) 

(Notice, if the space is similar to the sea of water, the matter is similar to a whirlpool found on the sea page- the matter and space are created from the same energy - but the matter has a distinguished picture from the space as the whirlpool is distinguished from the sea waves), Planet Diameter Equation proves this fact in my paper (Points No. 6)     

Thanks a lot – please read

Physics Nobel Prize For Imaginary Ideas!

or

Gerges Francis Tawdrous +201022532292

Physics Department-  Physics & Mathematics  Faculty 

Peoples' Friendship university of Russia – Moscow   (2010-2013)

Curriculum Vitae                 https://www.academia.edu/s/b88b0ecb7c

E-mail                            mrwaheid@gmail.com, mrwaheid1@yahoo.com

                                      gergesgerges@yandex.ru                   

ORCID                          https://orcid.org/0000-0002-1041-7147

Facebook                       https://www.facebook.com/gergis.tawadrous

VK                                 https://vk.com/id696655587

Tumblr                           https://www.tumblr.com/blog/itsgerges 

Researcherid                   https://publons.com/researcher/3510834/gerges-tawadrous/

Google                                https://scholar.google.com/citations?user=2Y4ZdTUAAAAJ&hl=en

Livejournal                     https://gerges2022.livejournal.com/profile

Pocket                                                                     https://getpocket.com/@646g8dZ0p3aX5Ad1bsTr4d9THjA5p6a5b2fX99zd54g221E4bs76eBdtf6aJw5d0?src=navbar

PUBLICATIONS

box                                https://app.box.com/s/47fwd0gshir636xt0i3wpso8lvvl8vnv

Academia                       https://rudn.academia.edu/GergesTawadrous

List of publications         http://vixra.org/author/gerges_francis_tawdrous

Slideshare                             https://www.slideshare.net/Gergesfrancis