#thepraticolab

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Mechanism Underlying Alzheimer- Like Damage in the Brain of Patients with Down Syndrome Elucidated by

Life expectancy for individuals with Down syndrome has grown in recent decades, thanks in large part to progress in patient care and treatment. But with survival into the fifth and sixth decades of life now possible, increasing numbers of these individuals are affected by conditions linked to aging, among them impairments in thinking that are associated with the accumulation in the brain of atypical proteins better known for their involvement in Alzheimer’s disease.

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Alzheimer's Center at Temple Awarded $3.8 Million from Pennsylvania Department of Health to Lead Col

Alzheimer’s disease is the most common form of dementia in the elderly. Memory loss and difficulty thinking worsen progressively, with some patients eventually becoming delusional, disoriented, and vulnerable to mood swings and depression. Finding ways to slow or reverse this progression, or even prevent symptoms from developing in the first place, are major goals in Alzheimer’s research.

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Medications to avoid for a patient with Alzheimer’s disease ~ Domenico Pratico, MD, FCPP

The risk of side effects can rise if drugs are taken for conditions other than Alzheimer’s disease (AD) treatment. Some sedatives and antidepressants can deteriorate cognitive function, make people drowsy and confused, and worsen cognitive impairment, which increases the risk of falls.

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Cognitive Changes in Normal Aging ~ Domenico Pratico, MD, FCPP

People may endure cognitive changes as they get older, including forgetfulness and a loss of their capacity for multitasking or concentration. Although these changes are typical, they can be upsetting for elderly people. Writing down vital information, utilising a daily calendar, and putting easily misplaced items in specified places are some methods to help healthy older persons with forgetfulness.

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Common Myths about Alzheimer’s disease ~ Domenico Pratico, MD, FCPP

Alzheimer’s disease is a debilitating condition that affects millions of people around the world, but there is also a lot of misinformation about it. One of the most common myths is that memory loss is a natural part of aging.

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Can Music Help Patients with Alzheimer's Disease? ~ Domenico Pratico, MD, FCPP

Did you know that music might be able to connect you with your family members affected by Alzheimer’s disease (AD) in a way that words cannot? Many studies have shown that music can evoke a response or a memory in people with Alzheimer’s Disease. 

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Diagnosing Alzheimer's Disease: Neuro-psychological and Memory Testing ~ Domenico Pratico, MD, FCPP

Diagnosing Alzheimer’s disease (AD) is a complex process that doesn’t rely on a single test. When someone seeks medical attention for memory and thinking impairments, doctors first aim to rule out other potential causes like medication side effects, vitamin deficiencies, or brain tumors.

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The Power of the Mediterranean Diet: Preventing Alzheimer's Disease ~ Domenico Pratico, MD, FCPP

“Can Alzheimer’s disease be prevented?” While definitive answers are still elusive, there is promising research underway. Today, I will share with you evidence suggesting that we can take simple steps to delay and potentially keep Alzheimer’s disease and other chronic illnesses at bay.

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What Is Alpha-Synuclein? ~ Domenico Pratico, MD, FCPP

In the field of neurodegenerative diseases, one protein has garnered significant attention: alpha-synuclein. It plays a crucial role in regulating synaptic vesicle trafficking and neurotransmitter release within neuronal cells. While alpha-synuclein is primarily found in the brain, it is also present in smaller amounts in other tissues, including the heart.

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What If I have a parent with Alzheimer’s disease? ~ Domenico Pratico, MD, FCPP

When a parent is diagnosed with Alzheimer’s disease, it’s natural for concern to arise about the possibility of inheriting the condition. However, it’s important to dispel the misconception that having a parent with Alzheimer’s automatically predisposes an individual to develop the disease.

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AI Study Uncovers Olive Oil's Potential in Combating Alzheimer's Disease, Domenico Pratico, MD, FCPP

A recent study has used Artificial Intelligence (AI) to reveal the remarkable potential of extra virgin olive oil (EVOO) in the fight against Alzheimer’s disease (AD). Researchers combined AI technology, chemistry, and omics research to identify specific bioactive compounds in EVOO that show promising effects in treating and preventing AD.

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What is a Transient Ischemic Attack (TIA)? ~ Domenico Pratico, MD, FCPP

A transient ischemic attack (TIA) refers to a temporary blockage of blood flow to the brain. Typically, this blockage is caused by a blood clot that either dissolves on its own or becomes dislodged, resulting in the restoration of blood flow. The symptoms experienced during a TIA are usually brief, lasting less than five minutes.

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Is Alzheimer's the most expensive disease in the country? ~ Domenico Pratico, MD, FCPP

Alzheimer’s disease continues to be a profoundly significant public health concern in the United States and other developed nations. In fact, it is estimated that taxpayers bear a staggering cost of approximately $20 million per hour to address this disease. Within the USA, the total national expenditure for providing care to individuals with Alzheimer’s and other dementias exceeds a staggering $300 billion annually.

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What is Cerebral Amyloid Angiopathy? - Domenico Pratico, MD, FCPP

Cerebral Amyloid Angiopathy (CAA) might not be a term that rolls off the tongue easily, but its impact on brain health is far from subtle. Cerebral Amyloid Angiopathy (CAA) is a condition characterized by the progressive accumulation of amyloid-beta proteins, the same material that forms the amyloid plaques in Alzheimer’s disease, in the wall of the brain blood vessels.

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World Alzheimer’s Month 2023: Shining a Light on Alzheimer's – Domenico Pratico, MD, FCPP

I am so pleased to share that this year’s theme for Alzheimer’s Month is very dear to my heart: “Never too early, never too late.” We all know that the disease often starts years before symptoms appear and how important it is to make lifelong choices that favor healthy living and healthy aging.

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Learning from Down Syndrome: Understanding Connection with AD ~ Domenico Pratico, MD, FCPP

Down’s syndrome (DS), the most common genetic disability worldwide, offers a unique insight into Alzheimer’s disease due to a shared genetic link. This article explores the intriguing connection between these two conditions and the potential it hold for advancing our understanding of Alzheimer’s disease.