#Extracellular Matrix

[bpod-bpod]

Rhobo Meets Matrix

Close-up on the extracellular matrix (ECM) – the molecules and minerals that are outside cells but involved with their biochemical and mechanical signalling – made possible using a fluorophore called Rhobo6 that binds the sugar chain glycans abundant in ECM

Read the published research article here

Video from work by Antonio Fiore and colleagues

Janelia Research Campus, Howard Hughes Medical Institute (HHMI), Ashburn, VA, USA

Video contributed by the authors under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence

Published in Nature Methods, February 2025

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[ghostoflostsplendor]

Yes I strongly suspect it's related to the extracellular matrix and cytoskeleton! Very important in connective tissues as well as in synapse formation. While working on my Bachelor's degree I actually came across a research paper linking a cytoskeleton protein to troubles with behavioral flexibility and autism risk genes. It's on fruit flies tho, so we will see if it translates to humans. That same protein activates an enzyme which breaks down collagen.

Alternatively/additionally, I wonder if it could be related to mast cells. MCAS is a common comorbidity with hypermobility, and mast cells are in our brains as well as in connective tissues. They could definitely explain the GI issues, those are common in allergies and MCAS after all.

comorbid disorders are either like "yeah ok, makes sense" or "what the fuck"

adhd and autism having a high comorbidity rate? yeah checks out

adhd and autism both having high rates of comorbidity with hypermobility and GI issues? thats an evil curse

[medicomunicare]

No pain, no gain: not true for ion flows regulating cartilage loss in osteoarthritis

Osteoarthritis (OAS) is characterized by cartilage degeneration with the loss of the extracellular matrix that allows the joint to compress without damage. The chondrocytes in OAS show multiple alterations in their metabolism. These occur as part of the chondrocyte response to both external mechanical and internal biochemical stimuli. Chondrocytes also produce multiple inflammatory and enzymatic…

[brucekee135711]

Dental Implants are like people: They May Never Get A Second Chance To Make A Good First Impression.

It sounds strange. Doesn’t it? But it is true. If you find this interesting, read on. The process of bone integration has yet to be fully understood, but it involves a sequence of protein adsorption, cell migration, proliferation, and bone deposition. According to the Vroman effect [1], smaller proteins with higher concentrations tend to adsorb the surface first and are later replaced by larger…

[poonamcmi]

Extracellular Matrix Market Is Estimated To Witness High Growth Owing To Increasing Demand for Regenerative Medicine

The global Extracellular Matrix Market is estimated to be valued at US$ 46.12 billion in 2023 and is expected to exhibit a CAGR of 9.8% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: Extracellular matrix (ECM) is a network of extracellular molecules such as proteins, glycoproteins, and proteoglycans, which provides structural and biochemical support to the surrounding cells. ECM is widely used in regenerative medicine to promote tissue repair and regeneration. The demand for ECM is increasing due to the growing prevalence of chronic diseases, such as cardiovascular diseases and diabetes, which require tissue engineering and regenerative medicine solutions. Furthermore, advancements in ECM technology and the development of innovative ECM-based products are also driving market growth. Market Key Trends: One key trend in the extracellular matrix market is the increasing adoption of three-dimensional (3D) cell culture systems. 3D cell culture systems mimic the in vivo environment more accurately compared to traditional two-dimensional (2D) cell culture systems. They enable more physiologically relevant cell behaviors and provide better predictive models for drug discovery and toxicity testing. ECM plays a crucial role in supporting 3D cell culture systems by providing a natural and biocompatible scaffold for cellular growth and organization. The adoption of 3D cell culture systems is expected to increase in the coming years, driving the demand for ECM. The extracellular matrix market is projected to witness significant growth in the coming years due to the increasing demand for regenerative medicine and the adoption of 3D cell culture systems. This market offers lucrative opportunities for key players such as Thermo Fisher Scientific, DSM, Acelity (KCI Concepts), and others to develop innovative ECM-based products and expand their market presence. PEST Analysis: Political: The political factors in the extracellular matrix market involve regulations and policies set by government bodies. These regulations can influence the development and distribution of extracellular matrix products. For example, changes in regulations related to the approval and licensing of medical devices can impact the market. Economic: Economic factors affecting the extracellular matrix market include factors such as GDP growth, healthcare expenditure, and disposable income. The growth of the market can be influenced by economic conditions, as well as the affordability and accessibility of extracellular matrix products. Social: Social factors include demographic trends, cultural preferences, and patient awareness. Increasing awareness of the benefits of extracellular matrix in tissue regeneration and wound healing among patients and healthcare professionals can drive market growth. Technological: Technological factors include advancements in technology that impact the production and application of extracellular matrix products. Technological advancements in tissue engineering and regenerative medicine can drive innovation in the market. Key Takeaways: Market size: The global Extracellular Matrix Market Share is expected to witness high growth, exhibiting a CAGR of 9.8% over the forecast period (2023-2030). This growth can be attributed to the increasing prevalence of chronic diseases and the growing demand for regenerative medicine. The market size is projected to reach US$ 46.12 billion by 2023. Regional analysis: North America is expected to be the fastest-growing and dominating region in the extracellular matrix market. Factors such as advanced healthcare infrastructure, high healthcare expenditure, and a large patient pool

[animystsoul]

MATRIX

The layers of the body

Like roots of forest trees

Are interwoven into one

The matrix, the deep underworld

Speaks as images, vision & dream—

As our feelings & thoughts

There is a forest under the skin—

— with interconnected root systems,

— the cellular matrix,

— the deep underworld,

— in which information flows,

— as electromagnetic & molecular currents

The underworld currents,

Are felt-sensations of aliveness,

Presenting to Consciousness,

As dreams & thoughts

There is two-way transduction

Between mind & matrix—

DNA reveals itself to mind—

And mind feeds back onto DNA

Layers are woven

Into one whole

In which sacred balance

Is delicately kept

#ecm #extracelularmatrix #ecosystem #spiritualecology #ecospirituality #roots #forest #animism #witch #wholeness

[time-sponges]

The more I learn about colony animals the more I am convinced that the ocean really is just some kind of creature forge that reflects the development of our own bodies

Maybe I’m misunderstanding but siphonophores are a third level of creature organization?

Humans go cells->tissues -> organs-> human body.

Siphonophores and colony animals go

cells->creature->tissues->colony animal?

Like if to make a giant person it took one small person cloning and gluing themselves together until a giant person was built

Or maybe not a giant person. Maybe a giant car made of people holding onto and gluing themselves together that was faster and stronger than all the people-parts individually.

Are we not also a colony of sorts?

siphonophores will never not freak me out. stop doing that its SCARY but also please don't ever stop doing that you ethereal marine cryptid

[generalmarketresearch-blog]

https://www.htfmarketintelligence.com/report/global-extracellular-matrix-ecm-patches-market

[bpod-bpod]

Excise and Customise

This study uses human mesenchymal (the embryonic origin of connective tissue) cell lines (immortal and unlimited lab-grown cells) as a surrogate supply of extracellular matrix – the molecules outside cells but influential in their functions and behaviour. Customising these cells by CRISPR/Cas9 gene editing reveals biochemical components of the matrix that are important in bone tissue repair

Read the published research article here

Image from work by Sujeethkumar Prithiviraj and colleagues

Cell, Tissue & Organ Engineering Laboratory, Department of Clinical Sciences, Lund Stem Cell Centre, Lund University, Lund, Sweden

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife (reviewed preprint), January 2025

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[reasonsforhope]

"A team at Northwestern University has come up with the term “dancing molecules” to describe an invention of synthetic nanofibers which they say have the potential to quicken the regeneration of cartilage damage beyond what our body is capable of.

The moniker was coined back in November 2021, when the same team introduced an injection of these molecules to repair tissues and reverse paralysis after severe spinal cord injuries in mice.

Now they’ve applied the same therapeutic strategy to damaged human cartilage cells. In a new study, published in the Journal of the American Chemical Society, the treatment activated the gene expression necessary to regenerate cartilage within just four hours.

And, after only three days, the human cells produced protein components needed for cartilage regeneration, something humans can’t do in adulthood.

The conceptual mechanisms of the dancing molecules work through cellular receptors located on the exterior of the cell membrane. These receptors are the gateways for thousands of compounds that run a myriad of processes in biology, but they exist in dense crowds constantly moving about on the cell membrane.

The dancing molecules quickly form synthetic nanofibers that move according to their chemical structure. They mimic the extracellular matrix of the surrounding tissue, and by ‘dancing’ these fibers can keep up with the movement of the cell receptors. By adding biological signaling receptors, the whole assemblage can functionally move and communicate with cells like natural biology.

“Cellular receptors constantly move around,” said Northwestern Professor of Materials Sciences Samuel Stupp, who led the study. “By making our molecules move, ‘dance’ or even leap temporarily out of these structures, known as supramolecular polymers, they are able to connect more effectively with receptors.”

The target of their work is the nearly 530 million people around the globe living with osteoarthritis, a degenerative disease in which tissues in joints break down over time, resulting in one of the most common forms of morbidity and disability.

“Current treatments aim to slow disease progression or postpone inevitable joint replacement,” Stupp said. “There are no regenerative options because humans do not have an inherent capacity to regenerate cartilage in adulthood.”

In the new study, Stupp and his team looked to the receptors for a specific protein critical for cartilage formation and maintenance. To target this receptor, the team developed a new circular peptide that mimics the bioactive signal of the protein, which is called transforming growth factor beta-1 (TGFb-1).

Northwestern U. Press then reported that the researchers incorporated this peptide into two different molecules that interact to form supramolecular polymers in water, each with the same ability to mimic TGFb-1...

“With the success of the study in human cartilage cells, we predict that cartilage regeneration will be greatly enhanced when used in highly translational pre-clinical models,” Stupp said. “It should develop into a novel bioactive material for regeneration of cartilage tissue in joints.”

“We are beginning to see the tremendous breadth of conditions that this fundamental discovery on ‘dancing molecules’ could apply to,” Stupp said. “Controlling supramolecular motion through chemical design appears to be a powerful tool to increase efficacy for a range of regenerative therapies.”"

-via Good News Network, August 5, 2024

[mindblowingscience]

An international research team led by the University of California, Irvine has discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering. Most cartilage relies on an external extracellular matrix for strength, but "lipocartilage," which is found in the ears, nose and throat of mammals, is uniquely packed with fat-filled cells called "lipochondrocytes" that provide super-stable internal support, enabling the tissue to remain soft and springy—similar to bubbled packaging material. The study, published in the journal Science, describes how lipocartilage cells create and maintain their own lipid reservoirs, remaining constant in size. Unlike ordinary adipocyte fat cells, lipochondrocytes never shrink or expand in response to food availability.

Continue Reading.

[catholicsapphic]

Blessed is the cardiac striated muscle tissue that contracted out of Love for us. Blessed is the left ventricle which allowed the blood of the Saviour to reach every part of His body, and blessed is the aorta that branched out to take it there. Blessed is the Vena Cava that gathered all that most holy blood to bring it back to the Heart, and blessed are the right atrium and ventricle for pumping it into the lungs. Blessed are the pulmonary arteries that took it to receive the oxygen it needed for this wondrous, mercyful, painful, incomprehensible task of reconciliation. Blessed are the pulmonary veins, which brought this revitalized blood back to the left atrium, so that it could once more run through His body and give Him the strenght He needed purely because He chose to need it. Blessed are the valves that opened and closed when necessary to allow this process, and blessed are the tendinous cords and the sinoatrial node that made it rhythmic. Blessed are the coronary arteries, which supplied His very Heart with the nutrients demanded to keep It alive and beating. Blessed is the pericardium, which filled with water and blood at the Sorrowful Passion and blessed is every layer - epicardium, myocardium and endocardium - that was ripped open by a spear. Blessed is the Heart of Our Lord, which burned with love for the littlest of creatures. And blessed is every single cell, electric impulse, and extracellular matrix that permitted It to se Its mission through.

(pride flags version)

[glassamphibians]

mutuals we are clustering on a surface and producing a matrix of extracellular polymeric substances together