#RNAinterference

[prateekcmi]

RNAi Technology Market Set for Robust Growth Owing to Rising R&D Investments

RNA interference (RNAi) technology has revolutionized gene silencing by harnessing small interfering RNAs to selectively downregulate disease-causing genes. This market analysis underscores advantages such as high specificity, minimal off-target effects, and the ability to tackle previously “undruggable” targets. RNAi-based therapeutics and research tools are increasingly adopted in drug discovery, personalized medicine, and agricultural biotechnology, driving market growth. Enhanced delivery systems lipid nanoparticles, conjugates, and viral vectors have improved cellular uptake, boosting clinical success rates.

Get More Insights on RNAI Technology Market https://www.patreon.com/posts/rnai-technology-129601167    

[cytgen]

Abstract RNA interference (RNAi) is a new potential tool for plant breeding by introducing small noncoding RNA sequences with the possibility of silencing gene expression in a sequence-specific manner. The ability to decrease the expression of a certain gene provides the possibility of acquiring a new characteristic through the elimination or accumulation of certain plant traits, which leads to biochemical or phenotypic changes that the original plants do not have. A progress (reached over the past decades) in the application of RNAi for the creation of cereal crops with improved economically valuable traits is described in this literature review. The main stages of the mechanism of gene silencing mediated by short interfering RNAs (siRNAs), peculiarities of their biogenesis, mode of action, and distribution are briefly presented. Numerous examples of the development of different biotechnological approaches to the improvement of cereals using gene transformation and exogenous double-stranded RNA (dsRNA) molecules are summarized. The possibilities of using RNAi technology for changing the agronomic traits of plants, increasing the nutritional value and quality of the grain, and reducing the number of toxic compounds and allergens are highlighted. Considerable attention is paid to the practical results of different applications of RNAi to increase the resistance of grain crops to biotic stress factors (particularly, viruses, bacteria, fungi, pest insects, and nematodes). The examples of using siRNA-mediated RNAi to improve the cereal resistance to abiotic stresses (including drought and salinity) are given.

[india24h]

A bio drug developed by a Kerala researcher shows promise for cancer treatment.

https://india24.live/business/a-bio-drug-developed-by-a-kerala-researcher-shows-promise-for-cancer-treatment/

[evoldir]

Fwd: Postdoc: IndianaU.EvoDevoHornedBeetles

Begin forwarded message: > From: evoldir@evol.biology.mcmaster.ca > Subject: Postdoc: IndianaU.EvoDevoHornedBeetles > Date: 22 November 2020 at 07:29:15 GMT > To: rdmpage@gmail.com > > > > > POSTDOC POSITION IN EVO DEVO AND ECO DEVO OF HORNED BEETLES > (Moczek-Lab, Indiana University, Bloomington) > > A full-time postdoctoral position is available in Armin Moczekąs lab > (https://ecoevodevo.com/), Department of Biology, Indiana University, > Bloomington. Our lab conducts research in the evolutionary developmental > (evo-devo) and ecological developmental (eco-devo) biology of insects. We > focus on the genetic, developmental, and ecological mechanisms, and their > interactions, that mediate the origins and diversification of novel > complex traits (such as beetle horns, firefly lanterns, or treehopper > helmets) and functions (such as nutrition-responsive development, sexual > dimorphisms, or alternative reproductive tactics). > > The position will focus on identifying the genes and pathways underlying > the origin and diversification of horns and other complex traits in > the extraordinarily diverse beetle genus Onthophagus. Specifically, > the work will use genomic and candidate-gene approaches to identify > and functionally characterize the developmental-genetic mechanisms > that regulate horn morphology (size, shape, position, integration), > context-dependent expression of horns (sex- and nutrition-specificity), > and how evolutionary changes in these mechanisms have mediated > diversification within and among species. This position is fully funded > by a multi-year grant from the National Science Foundation. > > The postdoctoral candidate would have opportunities to develop additional > independent lines of research in these and related areas. > > We seek a collegial, self-motivated, independent, and intellectually > curious individual with a recent PhD in Evolutionary Biology, > Developmental Biology, or related fields required at the time of > appointment. Applicants must have strong bench skills, and familiarity > with techniques such as RNAinterference, CRISPR-Cas9, qPCR, cloning, > immuno-histochemistry, and the bioinformatic analyses of next-gen > sequencing data is strongly desirable (though training in these techniques > will also be provided as necessary).  In addition, candidates must have > demonstrated excellent written and oral communication skills. Experience > working with insects is helpful but not required. The position is > initially available for 12 months, with likely extension for a second and > third year funds permitting. Salary will be commensurate with experience, > and full benefits are included. > > Indiana University has a large and interactive group at the interface > of evolutionary and developmental biology and ecology. Bloomington > is situated in scenic, hilly southern Indiana, near several parks and > wilderness areas. The cultural environment provided by the University > is exceptionally rich in art, music, and theater. > > To apply, please submit a letter of application, a CV, a statement of > research interests, and the contact information for three references to > https://ift.tt/3lSvxTq start date > is January 4, 2021 (though exact start date is flexible), with best > consideration to those applying prior to December 4, 2020. Note that > applications arriving after this date will continue to receive full > consideration until the position is filled. Inquiries can be directed > to Armin Moczek (armin@indiana.edu). > > The College of Arts and Sciences is committed to building and supporting > a diverse, inclusive, and equitable community of students and scholars. > > Indiana University is an equal employment and affirmative action employer > and a provider of ADA services. All qualified applicants will receive > consideration for employment without regard to age, color, disability, > ethnicity, sex, gender identity, gender expression, genetic information, > marital status, national origin, race, religion, sexual orientation, > or veteran status. > > > > Armin Moczek > Fulbright Distinguished Chair in Science, Technology, and Innovation > > Professor of Biology, Indiana University > http://ecoevodevo.com/ > > https://ift.tt/30UeSVG > > https://afrisnet.org/ > > Immigrants - we get the job done! > > > "Moczek, Armin P" > via IFTTT