#me: hm the wiki doesnt seem to go into this very in-depth

[cantheykillmacbeth]

Spoilers, though it's kinda impossible to even mention this one without them:

Liriel Rain Bryer from Rain could kill Macbeth. In addition to being a girl (Gender Clause), it is revealed in the last few chapters of the comic that her "mother" was actually a closeted trans man, qualifying her for the Birth Parent Clause. (This also qualifies Rain's siblings, Kellen and Aiken Flaherty.)

... Can't recall if the comic ever mentioned anything that would explicitly confirm the Unconventional Birth Clause one way or the other. I don't think it did?

Yes, Liriel Rain Bryer from the eponymous Rain webcomic could kill Macbeth!

She is a trans girl born from a trans man, applying her for the Gender Clause and Birth Parent Clause! Thank you for your submission!