#medication resistent

[4tntbf4tb24tb2rvb]

[reasonsforhope]

"A new study evaluated a low-cost yet effective way to combat bacterial resistance using curcumin–the natural yellow plant compound in turmeric.

In 2017, a tragic death in a Nevada hospital was linked to a new strain of bacteria that had developed a resistance to 26 different antibiotics. Called ‘superbugs’, such antibiotic-resistant bacteria (including MRSA) remains a pressing public health threat.

Now researchers at Texas A&M University have shown that curcumin, the compound that gives turmeric its characteristic bright yellow color, can be used to reduce this antibiotic resistance.

They showed that when curcumin is intentionally given to bacteria as food, and then activated by light, it can trigger deleterious reactions within these microbes, eventually killing them. They demonstrated that this process reduces the number of antibiotic-resistant strains and renders conventional antibiotics effective again.

The results of the study were published this week in the journal Scientific Reports.

“We need alternative ways to either kill the superbugs or find a novel way to modify natural processes within the bacteria so that antibiotics start to act again,” said Dr. Vanderlei Bagnato, professor in the Department of Biomedical Engineering and senior author on the study.

Photodynamic inactivation, a technique that has shown promise in combating bacterial resistance, uses light and light-sensitive molecules, called photosensitizers, to produce reactive oxygen species that can kill microorganisms by disrupting their metabolic processes.

In the new experiments, the team used curcumin, which is also a natural food for bacteria. They tested this technique on strains of Staphylococcus aureus (MRSA) that are resistant to amoxicillin, erythromycin, and gentamicin.

The researchers exposed the bacteria to many cycles of light exposure and then compared the minimum concentration of antibiotics needed to kill the bacteria after light exposure versus those that did not get light exposure.

“When we have a mixed population of bacteria where some are resistant, we can use photodynamic inactivation to narrow the bacterial distribution, leaving behind strains that are more or less similar in their response to antibiotics,” Bagnato told Texas A&M News.

“It’s much easier now to predict the precise antibiotic dose needed to remove the infection.”

MORE PROGRESS ON SUPERBUGS: • The Humble Potato Could Hold Key to Beating Hospital Superbugs and Crop Diseases • Compounds in Amber Could Help Fight Drug-Resistant Bacteria Superbugs, Say Scientists • When Antibiotics Failed, She Found a Natural Enemy of the Superbug to Save Husband’s Life

The team noted that photodynamic inactivation using curcumin has tremendous potential as an adjuvant or additional therapy with antibiotics for diseases, like pneumonia, caused by antibiotic-resistant bacteria.

“Photodynamic inactivation offers a cost-effective treatment option, which is crucial for reducing medical expenses not only in developing countries but also in the United States,” said Dr. Vladislav Yakovlev, professor in the Department of Biomedical Engineering and author on the study..."

-via Good News Network, February 8, 2025

[bonefall]

[ID: Ask from @storiesandsquirrels, transcribed in alt text]

also: link to Cow Lore

There's one major misconception here I've gotta correct before answering earnestly; Holsteins do need Super Duper Food. This is one of their major problems as a breed, you need to give them high quality feed for high quantity, low quality milk.

But! That said! These are valid questions that deserve real responses. In spite of the quick correction, I actually want to answer them as you phrased them because I think it would be more illuminating. I'm going to try and summarize them as I go along;

Question 1: "Why wouldn't we want to use The Most Efficient Cow?"

The simplest answer is disease. My ""prediction"" came true, and bird flu has mutated to spread extremely easily through the infected udders of Holsteins. No one has died of bovine-contracted HPAI yet, but with Brainworm Bobby and his love of raw milk in charge of the CDC...

well. my last prediction was prophetic. let's hope this one's not.

Minmaxing a breed for one specific purpose always means intensive inbreeding. Like I mentioned, 9 million Holsteins are genetically equivalent to 60 individuals. A more genetically diverse population is one that will be better at preventing disease outbreaks, and reducing their severity when they do.

And what even is the Most Efficient Milk Cow? If you're only selecting for pure milk production to drive down its cost, you get a breed of cattle that lacks every other important trait that would make it good livestock;

They get sick more often, due to inbreeding depression and lack of physical fitness, requiring more antibiotics and veterinary care.

They are bad parents who will need more human intervention to birth and raise calves

They won't be good grazers, meaning they need a specific food grown for them, increasing how much "functional" land is actually dedicated to cattle husbandry.

Their carcass won't yield as much meat, so more cattle have to be raised and slaughtered to meet demand.

Their bodies will burn out much quicker than a healthier animal, meaning you need to replace your livestock more often.

When it comes to living beings, "efficiency" is "fragility." It's not a stable system to begin with.

Even with the pure logic aside, just, step back here and look at the situation with a heart. We'd be making unhealthy, short-lived animals lacking critical instincts to lead good social lives. AND we probably haven't even fixed the "less land" problem, just shifted the land off-site.

For what? For more milk? We have SO MUCH milk we don't even know what to do with it!

Question 2: "Isn't an overabundance of cheap milk a good thing?"

no.

Under the infinite genius of Capitalism, thousands of gallons of milk just gets poured into the sewer daily because there's too much of it. Transporting it to a processor would cost more than it's worth, sometimes the processors turn milk away because they don't want to overproduce products, and even the US government can't subsidize every last drop; it still has 1.4 billion pounds of cheese in various caves and warehouses across the country.

The price of milk cannot get any lower because it's already being sold below the cost it takes to produce it, and yet, we're still here literally pouring it down the drain.

[photo from bill ulrich who photographed a farmer dumping milk back during the pandemic. this isn't even a recent photo. this happens every time there's a milk surplus. im using this photo because i like the farmer's cunty little pose. look at him. "just ain't right"core.]

And milk being dumped into the sewer is more than just wasteful. It's a biohazard.

Milk doesn't stop rotting when it's dumped. If you live downstream of a milkhouse, improper milk disposal reeks.

It's full of nutrients, too, which causes diatoms, cyanobacteria, and other types of algae to go into overdrive-- causing a Harmful Algal Bloom event in the water, or HAB.

HABs are horrific. There's HUNDREDS of different types. They can suck up oxygen and create "dead zones" which kills all aquatic life, they can poison the water supply for an entire town, and some can even cause toxic fumes that make it hard to breathe on land.

Now, listen, I don't want to scare you into never dumping out rotten milk or anything! It's that on an industrial scale, it's REALLY REALLY bad if a farm overproduces milk-- especially crummy milk that can't be made into decent cheese or other dairy products.

In fact, if we did produce milk on a smaller scale, it would be better for everyone! Unless you're a Milk Guzzling Fiend like I am, you probably wouldn't need to buy a whole gallon at a time. In countries like Italy, it's sold fresh and in smaller containers, and you're just expected to pick it up as you need it.

This is why milkmen used to exist, and still do in places that are cool; they'd deliver your supply fresh from the creamery. Less waste, less stress! The "subscription model" is actually sooooooooooo much better for milk production, since it helps to stagger out those "surges and drops" of demand that leads to milk dumps.

Question 3: "If the cow eats less, doesn't that mean less land for pasture, which is a good thing?"

There's a lot to unpack within this sentiment. It's actually based on a couple of common assumptions on a few levels, which are incorrect in fascinating ways. Challenging this means opening up your worldview on how complex keeping livestock actually is!

I'll start with the simpler part;

You could cut fresh pasture out of the equation entirely and shove a cow into a concrete pen with a food box-- but are you counting the land growing the fodder?

When you grow corn the way that we do on industrial farms in the US, it's unbelievably destructive. Unending oceans of monoculture. Fogged with pesticide, pumped full of fertilizer which causes HABs like dumped milk does, sprayed with thousands of gallons of wasted water.

When you look at this image, I need you to understand you are looking at a dead zone. Like a suburban lawn, just because it's green doesn't mean it's good. Nothing grows here but corn and pests of corn, which gets poisoned and dies without returning any of that energy to the ecosystem.

This is usually what is being given to "grain-fed cattle," either when they're sent to a feedlot to hit their slaughter weight, or when they're lactating so they need the extra nutrition. It's also so nasty it's inedible to human beings.

Now, a lot of cattle farmers will just supplement their cow's diet, doing a mix of pasture feeding (much cheaper) and grain feeding (quicker gains). But the facts on this are clear; pasture-kept cattle result in LESS emissions and need LESS total space than cows in confinement.

In fact, there were a LOT of benefits!

Overall gas emissions from the cows dropped by 8%

Ammonia pollution was down by 30%

Not needing to run farm equipment for fodder planting and harvest reduced carbon dioxide emissions by 10%

Rotated crop fields didn't sequester carbon; but the newly converted perennial grasslands store as much as 3,400 pounds per acre.

The outside cows did produce less milk volume, but the milk they did produce was higher quality. So, looking at all the benefits here, it's clear that pasture is actually something that should be embraced for ecological reasons, not rejected.

In FACT, it should be EMPHASIZED. Because, this is the mind-blowing part,

Pasture can ALSO be an ecosystem.

In fact, I'm a Warrior Cats guy who once did a deep dive on moorlands just so I could write WindClan better. There are entire biomes that only exist because of grazing, and British lowland heath is one of them!

Keeping cattle in a sustainable, ecologically sound way is going to look different depending on where in the world you're doing it. So many earnest, good-willed people have bought into the lie that humans are a problem, and that everything "associated" with us becomes a barren wasteland as if we are tainted. YOU are not the problem! The problem is, and always has been, exploitation. Unsustainable relationships with the land we're part of.

Indigenous people in Europe, Asia, and Africa have been keeping cattle for thousands of years. In North America, cattle can be used to maintain ecosystems that have been badly affected by the colonial eradication of the American Bison. In South America, Brazil specifically has been making incredible advances with highly efficient integrated crop-livestock-forestry farming.

Generally, pastures here in the US are not as intensely managed as an equivalent crop field. Some people fertilize them, or water them mid-summer, but absolutely not to the same extent as industrial corn farms. Cattle are typically rotated between pastures, allowing each to re-grow before they come back to graze again.

Obviously, yes, overgrazing can be an issue. Not every open space should be converted into a pasture, and the destruction of other environments to turn into cow land is a problem. But that is an issue of bad land stewardship, not the mere practice of keeping livestock.

Bottom line, though? Cattle who can graze and survive outside are better for the environment than cattle that can't.

...but hey, you know what Holsteins happen to be really bad at?

EVERYTHING. GRAZING.

They are notoriously terrible grazers. They can't do megan THEEEEE thing that cows are known for. Fragile frames, a lack of fat to keep them warm outside, increased demand for food, distaste for any rough forage, horrible mothering instincts, the list goes on. Holsteins are a NIGHTMARE to try and keep outside all year round compared to other breeds.

(especially heritage breeds, like the Milking Devon, Florida Cracker, or Texas Longhorn. Between these three, you'd be totally covered in 80% of American climates.)

I've already explained why it's not actually very good or important that we minmax milk volume, but even if that was actually something we should value, there are so many downsides that they would absolutely not be the dominant cow breed in a truly "efficient" system.

"Less cows means less cow food and cow land" is sound logic, but Holsteins are not the right cow for that job.

Question 4: "How could this be done in a way that doesn't increase cost of living?"

I'm not sure how to answer this question, simply because I'm not Bonestar, Leader of AmericaClan. Wish I was. I would rule tyrannically.

It's worth noting that Brazil is the second largest producer of beef in the entire world, AND the number one largest exporter of it, AND only puts 30% of its land to total agricultural use. The USA dedicates over 50%. And also Brazil is net reducing its amount of agricultural land while increasing output.

It seems clear to me that the USA actually has a massive food waste and resource distribution problem, to the point where the price we pay for stuff is actually wildly disconnected from the actual value of the goods and labor.

I think the way that us Americans tend to frame our conversations on these topics as "growth" vs "cuts" instead of asking how to minimize waste by making existing systems more efficient prevents us from solving problems. We're also just... really culturally resistant to the idea of anything being more "expensive," even if it ends up costing us a lot more money in waste or mismanagement later.

Penny wise and dollar foolish ass country.

Question 5: "What can we personally do about this?"

I mean, I wasn't making a call to action in Cow Lore, I was just explaining to one of my regulars why I don't like Holsteins LMAO. Since you're asking though...

I don't think we can change the wider trend in the dairy industry without actual government intervention and regulation, though, and that's very unlikely in the current political environment. they just sent random dudes to Ausalvador-Birkenau and when the Supreme Court said "bring this specific person back" they said "nuh uh." fellas I don't think we're getting better dairy regulations in the foreseeable future.

So I think the most productive thing to do is focusing on supporting small farms and heritage breeds. Get involved in your community garden or heritage society if you have one.

Not only is that generally a very rewarding thing, but it will be helpful to you in case The Situation Gets Worse. Knowing your neighbors and having real human connection is your best defense against economic recession.

Supporting the locals is always a great thing to do, which can be as simple as going to farmer's markets. You don't need to buy fancy food every day to make an impact on your community-- it can be a treat sometimes!

You could also subscribe to the Livestock Conservancy's free newsletter, where they talk about the work they're doing and upcoming events. If you're a knitter, crocheter, or any other kind of fiber artist, you could even join in on a challenge they're running where you make items out of rare wool for prizes!

Should you end up liking the work they do, you can become a member for 4$ a month, or go to one of their educational events.

Even just talking about the problem can do a lot! Did you know the Highland Cow was actually critically endangered in the USA within the past 10 years? It was the work of the Livestock Conservancy, plus a surge in their popularity, that helped to bring their numbers up. Word of mouth is a powerful thing.

All that said, remember, you can't solve every problem. It's a big world and there's a lot of them. Being made aware of an issue doesn't mean you have to drop what you were previously doing-- just care a lot about something that you want to improve, and let that guide you.

[vi-138]

[boy-oneder]

[fexjam]

🐺🐻

[fairytailfanatic]

Modern Au where Gajeel is anemic and needs iron supplements, Wendy has asthma, and Natsu has hypogeusia so all his food is extra spicy so he can taste it

[whatiswhump]

TW needles

Song: Amsterdam by Daughter

Clips in no particular order: Roswell , The Messenger, the Theory of Everything, Stonehearst Asylum, A Beautiful Mind, Bad and Crazy, Stargate SG-1, Awakenings, the Queens Gambit, Vienna Blood, Mädät Omenat, the Iron Fist, and a few vintage psychiatric case study videos from YouTube for some of the soundbites

This video is about misunderstood and mislabeled psychiatric whumpees, aka Alfie, Max, Averil etc. everyone says they’re dangerous and they’re sick and twisted but they’re just holding on for dear life. I love it when they call one of my oc’s a monster when it couldn’t be further from the truth… but he gets still treated accordingly…. :)

[prince-liest]

A little bit of celebratory light in the current political climate: I'm working with a local endocrinologist who is versed in gender-affirming care as well as my local LGBTQ+ resource organization to start a quarterly pride clinic that I'm going to run with and staff with the aforementioned endocrinologist. I don't know yet how successful it will be, but we're in a really under-served area and a lot of the local federally qualified health centers are pulling back their gender affirming care offerings due to the recent federal policies so that they can retain their funding, which after speaking to my residency program directer he seems to believe is unlikely to affect us. So I'm going to be working with our program attendings and this endocrinologist to help refer more queer and especially trans patients to myself and one of my seniors who is also really involved in LGBTQ+ health goals for gender-affirming care.

The clinic itself is only going to be quarterly at this time (hopefully monthly in the future) due to the limitations of patient panel sizes and also residency scheduling, but we're hoping that we can also follow these patients in our actual primary clinic, since it will all be in the same building and part of the same system, and the endocrinologist has said she is willing to co-precept these patients (aka. have us forward her the notes and look over them to make sure the care plans are copacetic, as well as get curbsided by us when needed) when we work on hormone therapy in the primary care clinic. I think the main challenge is going to be 1) making sure we have the resources and access to a good multidisciplinary team (main points are mental health resources (gonna ask one of the psych program attendings, he is both openly queer and invested) and infectious disease specialist options that aren't going to result in bad experiences for the patients that we refer that way) and 2) making sure we have appropriate follow-up for patients, which I think on my end is just going to mean me telling our clinic coordinator, "Hey, if it's for this patient panel specifically, you can book me an extra patient per half-day for continuity."

We're also going to be doing internal-ish referral advertising through the LGBTQ+ org, as well as training through the organization and also just through research done by myself and my senior for our co-residents for things like cancer screening guidelines adjusted for risk factors we see in queer people (anal paps, three-site testing, when to screen for breast cancer in trans women, etc, etc). Waiting on my program director to talk to our clinic coordinator to see if there's any way for people to self-refer straight to the pride clinic (probably insurance-dependent) but otherwise it's just...happening.

I think my main wish is that I had more days to directly work with this endocrinology attending to pick her brain. She said she's game for any [redacted weekday] for the clinic once we get things going and I'm on my endocrinology rotation, but I'm mostly working with another endo and only see her twice this month due to her work schedule. She's a great teacher and next time I see her this month I'm going to see if she has time to give me a crash-course on HRT management that will help me synthesize the gender dysphoria treatment clinical practice guidelines I'm reading through from the Journal of Clinical Endocrinology and Metabolism. My PD actually specifically referred a trans patient to us to see that day because he knows I really want more experience with this (and, y'know, she's a great endo doc) so that will be the perfect opportunity.

Anyway! It's a great time to be working on offering more medical resources to LGBTQ patients.

[rxttenfish]

hm hm hmmm. redesign liam sketches for the day.

vampirism, in the context of the redesign universe, is a magic-derived virus that ends up "regurgitating" the "memory" contained in the traces of the magic that makes it up to alter its hosts' features. its very poorly understood why the virus does this, or if there are any benefits at all, as usually the results end in simply killing the host. vampirism specifically is a bloodborne illness, facilitated through blood-blood or blood-saliva contact, and has been known to have a major non-symptomatic foothold in populations of blood-eating insects, as well as many animals that are also known rabies vector species.

every vampire was born a human, and still fundamentally is one in every way. they don't get any special abilities from the illness — liam has to wear a medical corset because his ribs moved upwards and began to fuse together, so his diaphragm is weak and he requires the additional structure, as well as having braces for his hands and knees/hips. they aren't a separate species, and if you ask one, they will call themselves human.

however, due to stigma, there is the preconceived notion in other humans that vampires have ceased to be one.

[buskingalbatross]

human bodies are weird! so is this quiz I made! which dan and phil medical emergency are you

[mishy-mashy]

Bruce is actually really attractive, and I have enough reasoning to make a list

He's:

Tall (. Tall enough to hit his head on the vault doorframe)

Long-legged

Has a straight nose bridge

Has high cheekbones (more noticeable in 2nd pic below)

Has a strong jawline

Sharp eyes, but they aren't small (plus eyebags if you're into that)

Overall, he has strong, attractive facial features

Has broad, refined shoulders. You can tell he works out (or he did, when he was alive)

Even has a thick, muscly neck

He has MUSCLE. Is SCULPTED. NOICE. VERY NOICE. (nice arms. Nice shoulders. Nice neck. Nice legs. Nice butt-)

(There are actually panels where you can see some of his muscles. Other than those already shown here, he's got bricky thighs-

-and in the panels where we first get his name dropped, he's got those shoulder blades too-)

The one time we see him smile, and he actually has a scary one

Has small, kinda sharp pupils, and his eyes remind me of a cat. We only ever saw him tense or defensive, so his resting/listening face is really cute

Other than the physical appearance stuff, he also:

Takes shit without batting an eye (patience, knowing it's just how Kudo is, etc)

Kudo being all "Cut the crap Bruce and give it to me straight", after Bruce tests his blood and is rightfully Concerned because they just faced AFO

Put up with Kudo's experimenting and testing over Yoichi's transferable Factor

Did ya'll see the look on Kudo's face when he realized he had Yoichi's Factor/will? Kudo was going to start in nonsense and Bruce just dealt with that.

Also something I noticed when looking back at the images here; Bruce has bandages on his arms in the void. But not when he faced AFO in the sewers.

Were he and Kudo cutting their arms open in their experimenting over Yoichi's theory? Is this why Kudo has two gauntlets instead of his one? Why we never see his bare arms in the void? That he always keeps his arms down so there's no slip?

Is smart enough to run blood tests, plus has enough common sense to pick Shinomori as his successor

He picked a guy who avoids society, has an Ability to detect danger so he can always stay away from AFO, is also a coward so he's never going to go throw himself into danger, even without knowing instinctively he stands no chance, etc.

Meanwhile, Kudo chose Bruce, who he played Hot Potato Yoichi with; but he did also trust Bruce, and put the only pure combative Ability in OFA through Bruce.

These two made their choices based on what they valued and saw the Factor needed.

Is logical, analytical, and calm.

He tried advising Midoriya on their Abilities in One For All, especially his own.

Midoriya then tried ignoring him about using Fa Jin for the first time, but found he was right, thinking: "Dammit!! I had [Lady Nagant] right where I wanted her, but... ugh! The Third was right. My parallel Quirk processes are all screwed up!" (ch. 314).

Plus, when Midoriya fixed his processing mistakes, Bruce was analyzing the way he reached his new conclusion. Pure facts, no bias, very calm, just saying it as it was.

We never see him panic. When he's caught by surprise in the sewers by AFO, Kudo, and Yoichi's little bubble event, he immediately reacts. He doesn't falter, he just knows he has to do something right now.

Was more willing to listen than Kudo to Yoichi's beckon, and probably was just following Kudo's rejection of Midoriya

While we don't see Kudo's face, we see Bruce's eyes when Yoichi calls on his heroes. Bruce was more open and receptive, or at least more impacted.

Bruce was also the one to start talking, while Kudo just kept quiet.

He actually communicates a lot

When Yoichi called them to support Midoriya, Bruce started talking to paint a picture of why they thought the way they did, so Yoichi understood where they were coming from.

(Though he seems to beat about the bush sometimes, since Kudo spoke up to be direct on how they couldn't just put their trust in some starry-eyed teenager. Plus, when Kudo tells him to just tell him what's wrong [double Factors])

When Midoriya first used Fa Jin against Nagant, Bruce came out just to tell him he knew what he was trying, but that Midoriya wasn't ready; and Midoriya found he was right. Midoriya just didn't want to listen to him then.

He asks Kudo for clarification after finding Kudo had two Factors in him after the sewer incident ("Just to be sure, All For One didn't touch you, right?") Kudo knew him well enough to go "stop beating around the bush and tell me", so Bruce was probably gonna start with questions, theories, and trying to understand everything in general, before saying "yeah you have two Factors. Don't know why".

Is strong-willed and loyal.

He followed Kudo, even to death, carrying on the cause he started until it ended with him.

Plus, when talking about how AFO needs a strong will to override OFA's own, we first see Bruce, Kudo, and Yoichi.

AFO couldn't steal OFA because the will was too strong for him, and that was back during Banjo's time. Since Shinomori never actually tried opposing AFO and just hid, we can assume the first Three (Yoichi, Kudo, Bruce) already had an accumulation of strong willpower that made OFA un-stealable. Those three are a strong enough foundation, and the main wills, that the other users just become bonuses.

Kudo, also saying that Midoriya needs allies with the same will and drive as him... hey Kudo, you're talking about yourself and your old allies, aren't you? That's why you look at Yoichi and Bruce when you say this.

Not only is Bruce attractive, but he's got good character. THE END.

[theworldoffostering]

Completed week one of esketamine. No change. 😭 Like, I had to wake DH up at 10am this morning and tell him to get up and he still didn’t get out of bed.

The nurse practitioner decided yesterday that they will increase his esketamine dose. He goes back Monday so the change will probably not go through until Thursday due to insurance lag time.

I am beyond despair at this point. I’m not sure what comes after that. DH basically said he didn’t want to face the day today which is why he couldn’t get out of bed. Meanwhile I’ve been up with kids doing all of the chores, herding them through their routines and getting them out the door to where they need to be since 7am.

I’m tired. And just completed defeated. I’m married to someone who cannot find the energy to face the day for his wife or his kids. It’s a 💩y feeling and difficult to want to keep trying.

Meanwhile, he is refusing to job hunt because he doesn’t want to do something he doesn’t like. If you ask him what he wants to do, he’ll tell you he doesn’t know. New worry unlocked—I will be financially supporting us through the actual duration of our working years AND our retirement.

[gophergal]

FEMHEAVY TF2 TUMMY ‼️‼️‼️

Shes a whole lotta woman :3

[triptychofvoids]

ohh this is so fun!! the lighting, the poses, the perspective, the little heart... grins normally. i love this very much hehe

[wikipediapictures]

Vancomycin-resistant Staphylococcus aureus

“Staphylococcus aureus colonies on blood agar. Note the golden yellow pigment and beta hemolysis around it.” - via Wikimedia Commons