#sources of urolithin A

[knowledge-graphs-blog]

Everything you need to know about urolithin A

Aging can cause a decline in energy, impacting our ability to handle everyday activities. We may also deal with health challenges as our food intake decreases and digestion becomes less effective, affecting our gut health. In this situation, Urolithin A plays an important role. It is a compound found in whole foods and is also available as a supplement. It functions at the cellular level to enhance muscle strength and aid in nutrient absorption. This article will discuss Urolithin A, its sources, and its advantages in detail.

What is urolithin A

Urolithin A (UA) is a natural substance that comes from plant compounds called polyphenols. You won't find it directly in foods, but it is present in those high in ellagic acid or ellagitannins. When you consume these foods, they travel through the large intestine. The gut microbiome has specific enzymes that break down ellagic acid and ellagitannins into smaller compounds, including urolithins. Instead of being absorbed, it moves through the bloodstream. Any urolithin A or other byproducts that are not absorbed are eventually removed from the body through urine.

Where urolithin A is found

Foods do not have this compound directly. However, fruits and nuts like pomegranates, strawberries, raspberries, and walnuts contain it. You can also take urolithin A supplements. Since we can't get this compound from food alone, a healthy gut is needed to produce it. Ellagic acid can be effectively broken down by different microbes in a healthy gut. Poor diet, stress, and sedentary lifestyles create an imbalance in the gut, which may stop ellagic acid from turning into urolithin A. 

What are benefits of urolithin A

Improving mitochondrial health

Most of the energy cells need comes from mitochondria, often called the "powerhouses" of the cell. They create ATP (adenosine triphosphate) through cellular respiration, which is the main energy source for cells. If mitochondria are damaged or age, they generate less energy and release harmful substances that increase stress. The body fixes damaged mitochondria by getting rid of them through a process called mitophagy. Urolithin A plays an important role in helping remove these faulty mitochondria

Enhance muscle strength

Urolithin A is important for muscle recovery, especially after hard workouts. It helps improve how mitochondria work and increases ATP production. Mitochondria are the energy centers of muscle cells, supplying the energy needed for muscle movement and repair. ATP is the energy that powers all cell functions, including muscle growth. When ATP levels drop, muscles find it hard to recover, which can cause fatigue and slow healing. Urolithin A boosts ATP levels, providing muscles with more energy to recover and grow, particularly after intense exercise.  It improves muscle performance and recovery by reducing inflammation, promoting muscle repair, and increasing energy metabolism

Improved cellular energy production

Urolithin A boosts mitochondrial function, which improves ATP (adenosine triphosphate) production, the main energy source for cells. This can enhance physical performance, improve muscle function, and raise overall energy levels

Anti aging effects

As we age, our energy decreases because mitochondria become less effective at removing damaged cells. Urolithin A helps boost this process, fighting this decline and supporting cell renewal.

Brain health

As we become older, our cognitive skills also become obsolete. Some research suggests that urolithin A may have neuroprotective properties, potentially protecting brain cells from damage associated with aging and cognitive decline.

Anti inflammatory and antioxidant properties

Urolithin A has antioxidant qualities that help lower stress caused by harmful molecules. It works by removing these molecules and protecting cells from harm. Furthermore, it might also reduce chronic inflammation associated with diseases like heart disease, diabetes, and neurodegenerative disorders.

Improves gut health

Urolithin A may contribute to a healthy gut microbiome, indirectly supporting overall digestive health[1]. Its effects on mitochondrial health may extend to the cells lining the intestines, promoting better gut function and integrity.

Cardiovascular health

The anti-inflammatory effects help heart health by lowering stress and inflammation from harmful substances. This can reduce the chance of heart disease, enhance blood vessel function, and boost overall heart health

Metabolic health and fat loss

Urolithin A might enhance insulin sensitivity and assist in controlling blood sugar levels, which is good for metabolic health[2]. It could also help lower excess fat and stop the onset of obesity-related issues, such as type 2 diabetes.

Conclusion

To sum up, Urolithin A plays a significant role in promoting health and vitality. It boosts mitochondrial function, which helps gut health, increases muscle strength, reduces stress from harmful molecules, and supports heart health. Urolithin A is seen as a promising compound because of its anti-inflammatory and neuroprotective properties.

[xianinnovbiotechnology]

Pomegranate: Nature’s Antioxidant Powerhouse—How Its Nutrients Support Heart Health, Brain Function, and More

Pomegranates are a nutritious superfood, prized for both their juicy flavor and high antioxidant content. Urolithin A, a compound formed by gut bacteria from pomegranate compounds, may reverse aging and boost immunity. They're also diabetic-friendly: low glycemic index and insulin-sensitizing effects make them a smart diet choice. Still, diabetics should moderate intake and avoid processed pomegranate products.

Pomegranates, with their vibrant red color and juicy, delicious taste, are not only loved for their rich nutritional value but also have a long history of use in traditional medicine. Known as a "superfood," one of the most prominent features of pomegranates is their high content of antioxidants, particularly polyphenolic compounds like punicalagins and ellagic acid. These natural components effectively neutralize free radicals, slow down the aging process, enhance immune function, and protect cells from oxidative damage. Additionally, pomegranates are a great source of Vitamin C, Vitamin K, and folate, which support immune health and skin vitality.

In recent years, however, another compound found in pomegranates has started to gain significant attention: Urolithin A. This compound is produced when gut microbiota metabolize ellagic acid and other polyphenols in pomegranates. Its potential health benefits are truly remarkable.

Urolithin A

On August 31, 2023, scientists from the University of Lausanne in Switzerland published a groundbreaking study in the prestigious journal Nature Aging titled "Induction of mitochondrial recycling reverts ageassociated decline of the hematopoietic and immunesystems"

The research revealed that supplementing with Urolithin A, a mitochondrial regulator, could enhance mitochondrial function in hematopoietic stem cells. This process reverses the aging of these stem cells, improves their regenerative capabilities, and increases the resistance of older mice to viral infections.

In other words, the latest studies show that Urolithin A can significantly delay aging and enhance the body’s immune function.

What is Urolithin A?

Urolithin A is a natural metabolic product primarily generated by gut microbiota that convert the ellagic acid in pomegranates. Research suggests that Urolithin A has notable antioxidant and anti-inflammatory properties and can support cellular health and slow down the aging process. Pomegranates, which are rich in this compound, offer a range of health benefits, including antioxidant, blood pressure-lowering, and anti-cancer properties.

Pomegranate and Diabetes Management

Pomegranates are also an excellent choice for people with diabetes due to their unique properties. Despite being relatively sweet, pomegranates have a low glycemic index (GI) of around 53, classifying them as a low-GI fruit (foods with a GI of ≤55 are considered low GI).

Studies have found that the antioxidants and various vitamins in pomegranates can help improve insulin sensitivity, promote insulin secretion, and aid in blood sugar regulation. As a result, they can be a valuable addition to a diabetes-friendly diet.

Important Considerations When Eating Pomegranates

Although pomegranates offer many benefits, it’s important to consume them in moderation, especially for people with diabetes. Here are some key points to consider:

Control Portion Size While pomegranates have a low glycemic index, they still contain sugar and carbohydrates. Therefore, people with diabetes should consume them in moderation, aiming for 100-150g (about 1/5 to 1/4 of a pomegranate) per serving.

Avoid Over-Processed Products Diabetics should avoid overly processed pomegranate products such as pomegranate juice or dried pomegranate, which often contain added sugars and preservatives.

Time and Pairing Matters The best time to eat pomegranates is during breakfast or as a snack between meals. Pairing pomegranate with protein-rich foods or fiber can help slow down the absorption of sugars.

Caution for Diabetic Nephropathy Patients Pomegranates are rich in potassium, which can be problematic for individuals with diabetic nephropathy (kidney disease). High potassium levels can lead to hyperkalemia, so diabetic nephropathy patients should consume pomegranates cautiously or avoid them altogether.

Conclusion

Pomegranates are an incredibly nutrient-dense fruit, offering a wealth of antioxidants, vitamins, and essential nutrients that can support overall health. With their potential to enhance mitochondrial function and immune health through compounds like Urolithin A, they have emerged as a key player in slowing down aging and improving well-being. Pomegranates also offer notable benefits for blood sugar regulation, making them a great option for individuals with diabetes. However, it’s crucial to consume them in moderation and be mindful of portion sizes, especially for those managing blood sugar levels or kidney health.

Incorporating pomegranates into your diet can be a simple yet powerful step toward better health. Whether you're enjoying them fresh or as part of your favorite recipe, these ruby-red gems offer a delicious and nutritious way to boost your wellness.

[allthenews808]

ICYMI: 7 Best natural sources of urolithin A for your health - Longevity.Technology || #EasyMealIdeas and #HealthyFoodNews Courtesy of EasyMealIdeasForYou.com Quick Easy Meal Ideas! http://dlvr.it/T2Wh7t

[ugly-by-nature]

A report published on January 9, 2019 in Nature Communications suggests a benefit for urolithin A, a metabolite derived from #pomegranate and #berries, in the prevention and treatment of inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis and are characterized by inflammation due to gut leakage of toxins. Researchers affirm: urolithin A (UroA), a major microbial metabolite derived from polyphenolics of berries and pomegranate #fruits displays anti-inflammatory, antioxidative, and anti-aging activities. Here, we show that urolithin A and its potent synthetic analogue (UAS03) significantly enhance gut barrier function and inhibit unwarranted inflammation. Microbiota in our gut has evolved to generate beneficial microbial metabolites in the proximity of the gut barrier. However, the exact role of these metabolites has not been identified and the mechanism in which they exert their function is elusive. In rodent studies, the researchers found that administration of urolithin A or its synthetic analog protected against and reduced colonic inflammation in acute and chronic colitis. A series of experiments demonstrated that the molecules decreased gut permeability by increasing the expression of tight junction proteins that are lost in IBDs. Researchers add: Restoring the gut barrier and reducing the inflammation using a small-molecule will provide a better therapeutic output in the treatment of IBDs. A synthetic analog overcomes the stability limitation that a microbial metabolite poses, thus enhancing the efficacy. The general belief thus far in the field is that urolithins have a beneficial effect only through their anti-inflammatory property. We have for the first time discovered that their major mode of function is repairing the gut barrier dysfunction. Source: https://ift.tt/2PC0rk0 . . . https://instagr.am/p/CIjaMYMnbPE/

[wisepowder]

1000KG Urolithin A Urolithin Powder Urolithin B Factory Supply In Stock

Wisepowder have the capability to produce and supply large quantity of Urolithin powder series, include Urolithin A, Urolithin B, Urolithin C...All Urolithin powder production under cGMP condition and strict quality control system, all testing documents and sample available. Full in stock, monthly production capacity more than 800KG-1000KG.Welcome inquiry and discuss cooperation. 

Urolithin A Powder CAS 1143-70-0

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. Urolithin A is not known to be found in any food source. Its bioavailability mostly depends on individual microbiota composition, as only some bacteria are able to convert ellagitannins into urolithins.

Manufacture:  Batch Production

Package:  1KG/bag, 25KG/drum

Urolithin A powder Base Information

Name Urolithin A Powder

CAS 1143-70-0

Purity 98%

Chemical name 3,8-Dihydroxybenzo[c]chromen-6-one

Synonyms 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-DIHYDROXYDIBENZO-(B,D)PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo[c]chromen-6-one; Castoreum pigment I; Urolithin A; 6H-Dibenzo(B,D)pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A(UA;3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one

Molecular Formula C13H8O4

Molecular Weight 228.2

Melting Point >300 °C

InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N

Form solid

Appearance Light Yellow powder

Half Life /

Solubility Soluble in DMSO (3 mg/mL).

Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Application Urolithin A is a metabolite of ellagitannin; Pharmaceutical Intermediates

Testing Document Coa, MSDS, HPLC..

Testing Sammple   available

Urolithin A Sample 

Urolithin A Powder General Description

Urolithin A powder is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria and is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.

Urolithin A powder can improve the quality and function of mitochondria, and increase the strength and endurance of aging muscles. It is the only natural product that has been proven to restart mitochondrial autophagy and reverse muscle aging.

Urolithins are microflora human metabolites of dietary ellagic acid derivatives，such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine.

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites.

Urolithins are found in plasma mostly as glucuronides at low concentrations.

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella

Urolithin A powder History

In laboratory studies, urolithin A powder was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[14] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).

Urolithin A powder Application

Urolithin A powder is intended for use as an ingredient in select foods or for special dietary uses in meal replacement products based on its nutritive activity in supporting general mitochondrial health.

Urolithin A powder More research

Urolithin A is not known to be found in any food. It forms as the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagic acid itself results from the hydrolysis of ellagitannins in the gut in the presence of water.[citation needed]

Sources of ellagitannins are: pomegranates, nuts, some berries (raspberries, strawberries, blackberries, cloudberries), tea, muscadine grapes, many tropical fruits, and oak-aged wines (table below).

The conversion of the ellagic acids into urolithin A depends on individual microflora composition and can vary significantly.

Urolithin B powder CAS 1139-83-9

Urolithin B is a natural metabolite of ellagitannin present in pomegranates and other fruits and nuts. Recognized by scientists as an anti-aging drug, oral administration can restore mitochondria and reverse muscle aging, and is a potent intestinal metabolite.

Manufacture:  Batch Production

Package:  1KG/bag, 25KG/drum

Urolithin B powder base information

Name Urolithin B Powder

CAS 1139-83-9

Purity 98%

Chemical name 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one

Synonyms AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR

Molecular Formula C13H8O3

Molecular Weight 212.2 g/mol

Melting Point 247 °C

InChI Key WXUQMTRHPNOXBV-UHFFFAOYSA-N

Form Solid

Appearance Light brown powder

Half Life /

Solubility soluble5mg/mL, clear (warmed)

Storage Condition 2-8°C

Application Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.

Testing Document Coa,MSDS,HPLC…etc

Urolithin B sample: available

Urolithin B powder General Description

Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Urolithin B can also display estrogenic and/or anti-estrogenic activity.

Urolithin B powder History

Urolithin B can be used as an drug for antitumor and anticancer. Urolithin B( CAS NO :1139-83-9) is an urolithin ,it is also produced in the human gut after absorption of ellagitannins from pomegranate. Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet.

Urolithin B powder is  also an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. It has anti-inflammatory and antioxidant effects. Urolithin B is also used be a regulator of skeletal muscle mass.

And Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin B powder More research

Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.

When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.

Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%. The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.

This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.

Buy Urolithin A Urolithin B powder In Stock From Wisepowder

[jainkidukan]

Why Should You Consume Akhrot Giri?

Akhrot giri  or walnuts are kind of round, single-seeded stone fruits . These are the nuts that grow from the walnut tree. These nuts are a wonderful source of beneficial fats, protein, and even that of fibre. These could even enhance heart and bone health and help in weight management too, amidst many other benefits.

You can look for akhrot giri american online and you should make it a part of your life. After all, it is going to make your life better in many ways. For your information, you can find these walnuts both raw or even roasted, and salted or even that of unsalted. You would fin these nuts really amazing once you eat them.

These nuts can boost your health

Yes, the monounsaturated and polyunsaturated fatty acids that are discovered in walnuts have been displayed to decrease ldl (harmful) cholesterol and that of triglyceride levels. There has been studies that show the danger of heart disease for ones consuming it much higher than ones who don’t.There have also been researches that indicated:

-          Walnut oil might benefit endothelial function

-          Whole walnuts might augment the process of eliminating “bad” ldl cholesterol

You can manage your weight with walnut

You know what, in the trials that compared weight loss making use of diets that include or exclude nuts, the diets that encompassed nuts in moderation showed huger weight loss. The point is once you are consuming akhrot giri, you might experience a great level of weight loss.  Of course, you need to take it in limit and it would help you get the best outcomes for your weight loss aspirations.

Boosts brain health

The omega-3 fatty acids that are found in walnuts are even great for the brain. Having foods rich in necessary fatty acids (such as omega-3 fatty acids)could slow down cognitive decline.In one study on the elderly, day today consumption of walnuts had displayed improvement in cognitive function.  In simple words, if you want that your brain works in a more effective manner then you should go for these nuts.

Reduced risk of cancer

Walnuts are completely rich in plant compounds like polyphenols, omega 3-fatty acids, and urolithins. These bio-active mechanisms may have anticancer properties.Walnuts could reduce the risk of certain types of cancers such as that of colon, breast, and prostate. There has been researches that show consuming a couple of walnuts every single day could help diminish the danger of breast cancer .

May lessen inflammation gallstoneillnesses

Walnuts could combat inflammation and lessen the risk of coronary heart disease. The polyphenols in walnuts could help in fighting inflammation as well. Of course, if you are having any doubt about this nut and your condition it would always be great to consult your doctor before you consume it. However, a limited consumption of this nut is going to be effective for you.

Conclusion

So, get akhrot giri american and ensure that you are making the most out of this powerful and inviting nut. The perk is that the taste of this nut is good to!

[justbeingnamaste]

How Pomegranate Puts Chemo & Radiation To Shame !

Ever since chemotherapy and radiation became the 'standard of care,' oncology has been in the Dark Ages, often causing more harm and human suffering than it alleviates. Could the scientific community finally be waking up to the incomparable cancer-killing power of foods to cure what conventional treatment only makes worse?

One of the most important discoveries in biology and medicine of the past fifteen years is that cancer stem cells are largely responsible for the failure of conventional cancer treatment. These cells, which represent a small population of tumor cells (~ 1:1000), are cancer cells characterized by stem cell properties such as self-renewal and the ability to give rise to all cell types found in a particular cancer sample. These cells drive tumor development, progression, metastasis and drug resistance and are highly resistant to chemotherapy and radiotherapy treatments. To the contrary, these conventional treatments actually increase their number and malignancy.1,2   Worse, conventional radiotherapy appears capable of converting non-cancerous breast cells into cancer stem cells.  You can learn more about this by reading Study: Radiation Therapy Can Make Cancers 30x More Malignant.

Pomegranate Confirmed To Be A Cancer Stem Cell Killer

Two recent studies have looked at the effects of a pomegranate extract on cancer stem cells.

The first, titled, “In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer,” and published in the journal Food and Chemical Toxicology proposes that colon cancer stem cells (CSCs) “offer a novel paradigm for colorectal cancer (CRC) treatment.”

Pomegranate has been extensively researched to possess a wide range of therapeutic properties. Learn more by visiting our database on the topic: Pomegranate Health Benefits.

Source Read More ~ http://www.greenmedinfo.com/blog/pomegranate-strikes-heart-cancer-malignancy

[biotechtimes]

RGCB scientists find pomegranate husk can prevent breast cancer

New Post has been published on https://biotechtimes.org/2020/03/18/rgcb-scientists-find-pomegranate-husk-can-prevent-breast-cancer/

RGCB scientists find pomegranate husk can prevent breast cancer

Dr. Bilqeesa Bhat

Pomegranate has a recorded history of medicinal properties which can be attributed to the presence of a large number of phytochemicals present in it. With a lot of information available, Dr. Sreeja S and her colleagues at the Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram established the tremendous potential of pomegranate outer hard husk (pericarp) to prevent breast cancer, which is the second leading cause of cancer-related deaths in women.

Dr. Sreeja’s team demonstrated the role of pomegranate pericarp methanolic extract in reducing proliferation in breast cancer cells by binding to the estrogen receptor (ER) safely. Pomegranate pericarp extract displays a Selective Estrogen Receptor Modulators (SERM) profile. The SERM are ER ligands used in the hormonal therapy for ER-breast cancers.

Like estrogen, the methanolic extract also reduces low-density lipid (LDL) levels increased after surgical removal of ovaries. Dr. Sreeja discovered that it could prevent the cell proliferation induced by 27 hydroxycholesterol (27HC), an endogenous SERM that can act through ER-mediated mechanisms. Cholesterol metabolite 27HC has been found to act via ER and result in breast cancer cell proliferation leading to cancers. Most of the findings, therefore, indicate that pomegranate extracts can act as potent phytoestrogens, and act via various means to reduce estrogen carcinogenesis.

Different types of breast cancers occur depending on the source, aggressiveness and expression of different types of protein receptors present on breast cancer cells. Depending on the presence or absence of estrogen receptor (ER), breast cancer is called as ER-positive or negative, respectively. For ER-positive breast cancer, one of the major treatment regimes involves the use of tamoxifen, a selective ER modulator or SERM. The tamoxifen acts like estrogen or opposes its action depending on the tissue it acts upon. It has opposite effects of estrogen and may protect against breast cancer. Furthermore, tamoxifen also retains its positive effects like that of estrogen in the cardiovascular system and may cause endometrium cancer. Hence, ideal SERM must retain the positive effects of estrogen and have minimal side effects.

Pomegranate is rich in polyphenols and has an abundant amount of ellagitannins, which are broken down to ellagic acid within the body. The ellagic acid is further metabolized to urolithins by gut microflora. The past decade has witnessed extensive research on these polyphenolic metabolites with huge health benefits such as cardiovascular health, neurodegenerative diseases, muscle strengthening, increasing lifespan and preventing cancers. Dr. Sreeja’s team is now on the journey of finding how this compound can act as an ideal SERM.

[allthenews808]

7 Best natural sources of urolithin A for your health - Longevity.Technology || #EasyMealIdeas and #HealthyFoodNews Courtesy of EasyMealIdeasForYou.com Quick Easy Meal Ideas! http://dlvr.it/T2TF2Q

[ugly-by-nature]

A report published on January 9, 2019 in Nature Communications suggests a benefit for urolithin A, a metabolite derived from #pomegranate and #berries, in the prevention and treatment of inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis and are characterized by inflammation due to gut leakage of toxins. Researchers affirm: urolithin A (UroA), a major microbial metabolite derived from polyphenolics of berries and pomegranate #fruits displays anti-inflammatory, antioxidative, and anti-aging activities. Here, we show that urolithin A and its potent synthetic analogue (UAS03) significantly enhance gut barrier function and inhibit unwarranted inflammation. Microbiota in our gut has evolved to generate beneficial microbial metabolites in the proximity of the gut barrier. However, the exact role of these metabolites has not been identified and the mechanism in which they exert their function is elusive. In rodent studies, the researchers found that administration of urolithin A or its synthetic analog protected against and reduced colonic inflammation in acute and chronic colitis. A series of experiments demonstrated that the molecules decreased gut permeability by increasing the expression of tight junction proteins that are lost in IBDs. Researchers add: Restoring the gut barrier and reducing the inflammation using a small-molecule will provide a better therapeutic output in the treatment of IBDs. A synthetic analog overcomes the stability limitation that a microbial metabolite poses, thus enhancing the efficacy. The general belief thus far in the field is that urolithins have a beneficial effect only through their anti-inflammatory property. We have for the first time discovered that their major mode of function is repairing the gut barrier dysfunction. Source: https://ift.tt/2PC0rk0 . . . https://instagr.am/p/CBtRwFLFPbW/

[we-future-first]

First Human Clinical Trial Results on the Anti-Aging Compound, Urolithin A, PUblished by Amazentis and Researchers From the EPFL and SIB

submitted by /u/StcStasi [link] [comments]

source https://www.reddit.com/r/Futurology/comments/c1wgoa/first_human_clinical_trial_results_on_the/

[wisepowder]

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. Urolithin A is not known to be found in any food source. Its bioavailability mostly depends on individual microbiota composition, as only some bacteria are able to convert ellagitannins into urolithins.

https://www.wisepowder.com/product-details/urolithin-a-powder-1143-70-0/

[healthnewstop]

Amazentis announces successful phase 1A/1B study results for urolithin A in healthy elderly subjects

Lausanne, Switzerland, April 27, 2017 -- Amazentis SA, an innovative life sciences company pioneering scientific breakthroughs in nutrition to manage health conditions linked to aging, announced today Phase 1 clinical data on the safety, bioavailability, and biological activity of Urolithin A... Source: Amazentis announces successful phase 1A/1B study results for urolithin A in healthy elderly subjects

[digitalyogesh]

Anti aging foods

Anti aging foods Trusted Source that eating leafy foods is the most secure and best approach to battle dull compositions and scarce differences. Prepared to sparkle? Here are 10 of the best enemy of maturing food sources to feed your body for a sparkle that comes from the inside.

Watercress

The medical advantages of watercress don’t baffle! This supplement thick hydrating verdant green is an extraordinary wellspring of:

calcium

potassium

manganese

phosphorus

nutrients A, C, K, B-1, and B-2

Watercress goes about as an inward skin disinfectant and builds the course and conveyance of mineralsTrusted Source to all cells of the body, bringing about improved oxygenation of the skin. Loaded with nutrients An and C, the cell reinforcements in Anti aging foods trusted Source may kill hurtful free extremists, assisting with fending almost negligible differences and wrinkles off.

To attempt: Add a small bunch of this tasty green to your plate of mixed greens today for sparkling skin and generally improved wellbeing!

OTHER YOUTHFUL BENEFITS

This flavorful green may likewise help immunityTrusted Source (as found in trouts), help digestionTrusted Source (in one cell study), and offer thyroid help because of its iodine content.

Red chime pepper

Red chime peppers are stacked with antioxidantsTrusted Source which rule with regards to against maturing. Notwithstanding their high substance of nutrient C — which is useful for collagen creation — red chime peppers contain incredible cancer prevention agents called carotenoids.

Carotenoids are plant shades answerable for the radiant red, yellow, and orange shadings you see in numerous leafy foods. They have an Anti aging foods of mitigating propertiesTrusted Source and may help shield skin from sun damageTrusted Source, contamination, and natural poisons.

To attempt: Slice chime peppers and plunge them in hummus as a tidbit, add them into a crude plate of mixed greens, or concoct them in a pan fried food.

Papaya

This delightful superfood is plentiful in an assortment of cancer prevention agents, nutrients, and minerals that may serve to improveTrusted Source skin flexibility and limit the presence of scarce differences and wrinkles. These include:

nutrients A, C, K, and E

calcium

potassium

magnesium

phosphorus

B nutrients

The wide scope of cell reinforcements in papaya assists with battling free extreme harm and may postpone indications of agingTrusted Source. Papaya likewise contains a compound called papain, which gives extra enemy of maturing benefits by functioning as one of nature’s best calming specialists. It’s likewise found in many peeling items.

So indeed, eating papaya (or utilizing items containing papain) may help your body shed dead skin cells, leaving you with sparkling, dynamic skin!

To attempt: Drizzle new lime juice over a major plate of papaya as a component of your morning meal or make a papaya veil at home for your one night from now in!

Blueberries

Blueberries are plentiful in nutrients An and C, just as an age-resisting cell reinforcement called anthocyanin. This is the thing that gives blueberries their profound, excellent blue tone.

These incredible antioxidantsTrusted Source may help shield skin from harm because of the sun, stress, and contamination by directing the incendiary reaction and forestalling collagen lossTrusted Source.

To attempt: Throw this delightful, Anti aging foods product into a morning smoothie or organic product bowl, and let it’s anything but an embellishing punch!

Broccoli

Broccoli is a calming, against maturing force to be reckoned with loaded with:

nutrients C and K

an assortment of cancer prevention agents

fiber

folate

lutein

calcium

Your body needs nutrient C for the creation of collagen, the principle protein in skin that invigorates it and versatility.

To attempt: You can eat broccoli crude for a speedy bite, yet in the event that you have the opportunity, tenderly steam prior to eating. From scorched chomps to pesto sauces, cooking broccoli really helps discharge more medical advantages for your body.

OTHER YOUTHFUL BENEFITS

The supplement lutein, has been linkedTrusted Source to the safeguarding of the mind’s memory work, just as nutrient K and calcium (which are fundamental for bone wellbeing and the counteraction of osteoporosis). Is there anything this enemy of maturing cruciferous veggie can’t do?

Spinach

Spinach is super Anti aging foods and loaded with cancer prevention agents that assistance to oxygenate and renew the whole body. It’s additionally rich in:

nutrients A, C, E, and K

magnesium

plant-based heme iron

lutein

This flexible verdant green’s high nutrient C substance upgrades collagen creation to keep skin firm and smooth. Yet, that is not all. The nutrient An it gives may advance solid, sparkly hair, while nutrient K has been shownTrusted Source to help lessen aggravation in cells.

To attempt: Add small bunches of spinach to a smoothie, salad, or sauté. More thoughts? Look at our #1 spinach plans, including spinach chips and messy burgers.

Nuts

Numerous nuts (particularly almonds) are an extraordinary wellspring of nutrient E, which may help fix skin tissue, hold skin dampness, and shield Anti aging foods from harming UV beams. Pecans even containTrusted Source mitigating omega-3 unsaturated fats that may help:

reinforce skin cell layers

secure against sun harm

give skin a lovely gleam by saving its normal oil obstruction

To attempt: Sprinkle a blend of nuts on top of your servings of mixed greens, or eat a small bunch as a bite. Try not to eliminate the skin, either, as studies show that 50% or moreTrusted Source of the cell reinforcements are lost without the skin.

EATING NUTS IS LINKED TO:

• decreased danger for coronary illness (pecans) and type 2 diabetes (pistachios)

•potential avoidance of psychological decrease in more established grown-ups (almonds)

Avocado

Avocados are high in aggravation battling unsaturated fats that advance smooth, graceful skin. They likewise contain an assortment of fundamental supplements that may forestall the adverse consequences of agingTrusted Source, including:

nutrients K, C, E, and A

B nutrients

potassium

The high substance of nutrient An in avocados can help us shed dead skin cells, leaving us with dazzling, shining skin. Their carotenoid substance may likewise help with obstructing poisons and harm from the sun’s beams and furthermore help to ensure against skin malignancies.

To attempt: Throw some avocado into a serving of mixed greens, smoothie, or simply eat it’s anything but a spoon. Anti aging foods when you thought you’ve attempted every one of the approaches to eat an avocado, we have 23 more. You can likewise attempt it’s anything but an inconceivable saturating cover to battle aggravation, decrease redness, and help forestall wrinkles!

Yams

The orange shade of the yam comes from a cancer prevention agent called beta-carotene which is changed over to nutrient A. Nutrient ATrusted Source may help reestablish skin versatility, advance skin cell turnover, and at last add to delicate, young looking skin.

This scrumptious root vegetable is additionally an incredible wellspring of nutrients C and E — the two of which may shield our skin from destructive free extremists and keep our composition brilliant.

To attempt: Whip up one of these yam toast plans that will up your morning meal or tidbit game like no other. Thanksgiving Anti aging foods the lone opportunity to add this veggie to your eating regimen!

Pomegranate seeds

Pomegranates have been utilized for quite a long time as a mending restorative organic product. High in nutrient C and an assortment of intense antioxidantsTrusted Source, pomegranates may shield our body from free extreme harm and diminish levels of aggravation in our framework.

These sound natural products likewise contain a compound called punicalagins, which may assist with saving collagen in the skin, easing back indications of maturing.

To attempt: Sprinkle these sweet little gems onto a child spinach pecan salad for an enemy of maturing treat!

OTHER YOUTHFUL BENEFITS

Examination has likewise shown that a compound called urolithin ATrusted Source, which is created when pomegranates cooperate with gut microscopic organisms, may revive mitochondria. It was even seen to switch muscle agingTrusted Source in rodent considers.

Flood your Anti aging foods with incredible supplements

By supporting ourselves with these enemy of maturing food varieties, we can acquire fuel to look and feel our best.

In case you’re searching for more flavorful plants to attempt, pick foods grown from the ground somewhere down in shading. The rich shades are generally an indication of more grounded extremist battling capacities to keep your skin sound and dynamic. The more shadings you can fit on your plate, the better.

It’s an ideal opportunity to hinder indications of maturing and really gleam from Anti aging foods the inside!

[hunzabazar]

What is Walnut Akhrot?

A walnut hard shell (Akhrot) is the edible seed of a drupe, and thus not a real botanical nut. It’s often eaten as a nut. After complete ripening for its edible seed, once the shell was discarded, it’s used as a garnish or a bite. Nuts of the eastern black walnut and butternuts are less commonly consumed.

Characteristics of Walnuts (Akhrot)

Walnuts (Akhrot) are rounded, single-seeded stone fruits of the walnut tree widely used for the meat after completely ripening. After full ripening, the elimination of the husk shows the wrinkly walnut shell, which is typically commercially discovered in 2 sections (three or four-segment shells can also form). During the ripening process, the husk will get brittle and also the shell tough.

The shell encloses the kernel, which is usually made up of two halves separated by a partition.  The seed kernels — generally accessible as polyunsaturated fats — are enclosed in a brown seed coat that contains antioxidants. The antioxidants protect the oil-rich seed out of atmospheric oxygen, thus preventing rancidity.

Walnuts are late to mature leaves, typically not until over halfway through the spring. They exude chemicals into the soil to protect against competing plant from growing. As a result of this, flowers or vegetable gardens shouldn’t be planted near to them.

1. Walnut Akhrot are Rich in Antioxidants:

Walnuts (Akhrot) have higher antioxidant activity than any other common nut.

This activity comes from Vitamin E, melatonin and plant compounds known as polyphenols, which are especially high in the papery skin of walnuts.

A preliminary, little study in healthy adults revealed that consuming a walnut-rich meal prevented oxidative damage of “bad” LDL cholesterol after ingestion, whereas a refined-fat meal did not.

That is valuable because oxidized LDL is more likely to build up in your arteries, causing atherosclerosis. [Benefits of Soft Almonds]

2. Walnuts are Super Plant Source of Omega-3s:

Walnuts are significantly higher in omega-3 fat than any other nut, Supplying 2.5 G per 1-ounce (28-gram) serving.

Omega-3 fat from plants, including walnuts (Akhrot), is called alpha-linolenic acid (ALA). It is a Vital fat, significance You need to get it from your diet.

According to the Institute of Medicine, adequate intake of ALA is 1.6 & 1.1grams every day for women and men respectively. A single serving of Akhrot meets that principle.

Observational studies show that each g of ALA you consume Daily reduces your chance of dying from heart disease by 10 percent.

3. Akhrot May Decrease Inflammation:

Inflammation is at the root of various diseases, including type 2 diabetes, heart diseases, Alzheimer’s disease, and cancer, and can be caused by oxidative stress.  

The polyphenols in Walnut can help combat this oxidative stress and inflammation. A subgroup of polyphenols known as ellagitannins may be particularly involved.

Beneficial bacteria in your digestion convert ellagitannins to compounds known as urolithins, which are utilized to protect against inflammation.

ALA omega-3 fat, magnesium and the amino acid arginine in walnuts may also decrease inflammation. [Benefits of Pistachio Nuts]

4. Walnuts Promote a Healthy Gut:

Studies also suggest that if your gut is Full of health-promoting Germs and other microbes (your gut microbiota), you are more inclined to have a healthy intestine and great overall health.

An unhealthy Composition of your microbiota can give rise to inflammation and disease in your gut and elsewhere in the human body, increasing your risk of obesity, cardiovascular disease, and even cancer.

What you eat can significantly influence the makeup of your microbiota. Eating walnuts might be one way to encourage the wellness of your microbiota along with your gut.

When 195 healthy adults ate 1.5 ounces (43 grams) of walnuts (Akhrot) daily for eight weeks, they had an increase in bacteria that are beneficial, in comparison to an period of not eating walnuts.

This included an increase in bacteria that create butyrate, a Fat that nourishes your gut and boosts gut health. [Benefits of Mix Dry Fruits]

5. Walnuts May Reduce Risk of Some Cancers:

Eating walnuts can lower your risk of certain cancers, including prostate, breast, and colorectal cancers.

As mentioned before, walnuts are abundant in the polyphenol ellagitannins. Particular gut microbes can convert these to compounds called urolithins.

Urolithins can have anti-inflammatory properties in your gut, which may be one way that consuming walnuts with hardshell helps to protect against colorectal cancer. Urolithins anti-inflammatory actions could also help to protect against other cancers.

What’s more, urolithins have hormone-like properties that enable them to obstruct hormone receptors in the body. This might help lower your chance of hormone-related cancers, especially prostate and breast cancers.

More studies are needed to confirm the effects of eating Akhrot (Walnut) on diminishing the danger of these and other cancers, as well as to clarify all of the manners or mechanisms by which they may help. [Benefits of Pure Honey]

6. Walnut Supports Weight Control:

Walnuts (Akhrot) are calorie-dense, but researchers suggest that the energy absorbed from them is 21 percent lower than would be anticipated according to their own nutrients.

What is more, eating walnuts may even help curb your hunger.

In a well-controlled research in 10 obese individuals, drinking a Smoothie made with approximately 1.75 ounces (48 grams) of carbohydrates once a day for five days diminished appetite and hunger, compared to a placebo drink equal in nutrients and Calories.

Furthermore, after five days of eating the walnut smoothies, Brain scans revealed that the participants had improved activation in a region of the mind that helped them resist highly tempting food cues, like cake and French fries.

Even though larger and longer-term studies are needed, this provides some initial insight concerning how walnuts may help control hunger and weight.

[healthtimetaylor]

Neuroprotective effects of pomegranate juice against Parkinson's disease.

PMID:  Int J Mol Sci. 2019 Dec 27 ;21(1). Epub 2019 Dec 27. PMID: 31892167 Abstract Title:  Neuroprotective Effects of Pomegranate Juice against Parkinson's Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain. Abstract:  Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate's health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate's effects against Parkinson's disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability of pomegranate juice for protection against PD in a rat model of parkinsonism induced by rotenone. To evaluate its efficiency, assessment of postural instability, visualization of neurodegeneration, determination of oxidative damage to lipids andα-synuclein level, as well as markers of antioxidant defense status, inflammation, and apoptosis, were performed in the midbrain. We also check the presence of plausible active pomegranate ETs-derived metabolite, urolithin A, in the plasma and brain. Our results indicated that pomegranate juice treatment provided neuroprotection as evidenced by the postural stability improvement, enhancement of neuronal survival, its protection against oxidative damage and α-synuclein aggregation, the increase in mitochondrial aldehyde dehydrogenase activity, and maintenance of antiapoptotic Bcl-xL protein at the control level. In addition, we have provided evidence for the distribution of urolithin A to the brain.

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