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Dorsal-Ventral Axis in the Neural Tube The notochord produces Shh and induces the neural tube to become floor plate and to produce Shh The ectodermal cells produce BMP4, 7, 5, Dorsalin and Activin and induce the dorsal neural tube to become roof plate and to start to produce the same proteins Two gradients are created the TGF-B family and the Shh gradients Different concentrations of these proteins activate the expression of different sets of genes These genes are responsible for the different cell fate of the neural cells along the D/V axis in sensory neurons, interneurons and motorneurons
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