allaboutthemate

[allaboutthemate]

Stop touching grass I need you on my dashboard

[allaboutthemate]

Just tumblring the stress away

[allaboutthemate]

Remember "Reduce, Reuse, Recycle" ? I feel like there's been a distancing from the "reduce" and "reuse" part and a favoritism towards "recycle" by corporate American.

Capitalism can still thrive with recycling in the mix. You buy Plastic Thing 1, throw it away after one use, and they take that and recycle it into Plastic Thing 2 and sell it back to you. All while continuing to harm the environment.

Reusing puts a damper on things. They can't sell you Plastic Thing 2 when you're still using Plastic Thing 1. Plastic forks, for example- there is literally no reason why you can't reuse plastic forks more than once (aside from maybe microplastics, but it's too late for that)

Reducing is the one everyone wants to ignore. Just don't buy Plastic Thing 1. You don't need Plastic Thing 1. Pick up a set of metal forks and use those for years. Convenience is killing the planet

[allaboutthemate]

John Koch (1909-1978) The Sculptor, 1964.

[allaboutthemate]

how am I supposed to tell people that this is my favorite color specifically because of the funny hex code?

[allaboutthemate]

two bros, both alike in sexuality

in a hot tub, where we lay our scene

[allaboutthemate]

Walking around my neighborhood wearing my sick as fuck custom T-shirt that says "I STEAL EVERY FRIENDLY CAT I MEET WITH NO REMORSE I DO IT ALL THE TIME DON'T CALL IT A COMEBACK I BEEN HERE FOR YEARS KEEP THAT BEAST ENCLOSED LEST YE FACE MY LIGHTNING CAT GRASP" and smiling politely while my neighbors' indoor-outdoor cats gently trot down the sidewalk towards me as the neighbors themselves read my shirt with a growing sense of panic.

[allaboutthemate]

Just got jumped by gay bullies and they made me give them my brunch money

[allaboutthemate]

[allaboutthemate]

Watching “The Fellowship of the Ring” for the first time. Yes, really. Gandalf’s tits are smaller than I was led to believe

[allaboutthemate]

Ancient Greek Gold Tiara (diadem), 325-330 BC , Demetrias/Thessaly

Stathatos Collection Gallery, National Archaeological Museum, Athens

📸Gary Todd

[allaboutthemate]

[allaboutthemate]

I love when paranormal investigators appeal to their long experience for credibility. I've been playing pretend for seventeen years, and let me tell you in that time I've imagined some shit you wouldn't believe.

[allaboutthemate]

250616 - igin on instagram

[allaboutthemate]

tiktoks with vine energy pt. 7

[allaboutthemate]

"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.

The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.

Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.

It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.

Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.

It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”

When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.

“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.

“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”

Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.

The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.

“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.

“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”

Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.

Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.

He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.

“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"

-via The Guardian, June 5, 2025

[allaboutthemate]

"bibelfest" is auch so ein tolles rein deutsches wort. wer zur hölle kreiert ein wort dafür, die bibel gut zu kennen. und dann auch noch so ein schön fast handwerker-pragmatisches wort. wie rutschfest oder dingfest oder sowas. geile sprache.