asciencegirlinscienceworld

[asciencegirlinscienceworld]

Galaxy Room commission ☆ﾟ.*･｡ﾟYou can DM for work info

Insta: @debbiebalboa

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study like paris geller

start early

to get as much done as possible, you may need to start waking up earlier. this can be hard, but once you start, it will get easier and easier until it is part of your routine. wake up earlier, start earlier, get it done.

try not to see others as competition, but use them as motivation

while paris saw rory as competition at first, she finished knowing that no one could compare to her and just because rory was also very intelligent, it doesn’t mean that she wasn’t. there will always be others that are getting better grades than you or studying better than you, but try not to get caught up in that. she’s top of the class? use her to motivate yourself to do better. if you’re feeling low and comparing yourself to others, there’s probably a reason for that. find what it is within yourself, fix it, and come back better than ever.

use all resources available to you

paris wouldn’t let one opportunity to better her education or further her intelligence pass, and neither should you. use every resource and opportunity handed to you and work for the ones that aren’t.

stay determined

there will always be times where you don’t feel like studying or you’re feeling discouraged, but do not let these moments or days keep you from doing what you need to do. it’s okay to rest your brain when needed, but never quit. your future self will thank you for it.

have a plan and stick to it

take time to make a plan that will work realistically and effectively for you. once you have your plan, stick to it. again, there will always be times where you aren’t feeling like it, but don’t let these moments negatively impact your habits and goals. stick to your routine and you will get to a point where you don’t even think twice about it anymore.

go above and beyond

when it comes to studying, it isn’t always enough to just do the bare minimum. most of the time, it will benefit you far more to put some extra time and work in. research further than just a chapter of a textbook or a few slides of a powerpoint. you will never regret being more well-read.

get out of your comfort zone

paris knows that to be the best, you will have to do some things that you have never done before. you will have to talk to new people, present your research to a big group of strangers, travel if needed, learn things you never thought you would have to learn, etc. your comfort zone will be your downfall. realize that you will have to do things you aren’t enthusiastic about, and that’s okay.

[asciencegirlinscienceworld]

Jupiter by Hubble & by Webb

© H: visible/IR; W: IR (2 filters/3 filters)

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[asciencegirlinscienceworld]

💘👩🏽‍⚕️💌 🌿☕️💐🥼✨

[asciencegirlinscienceworld]

It’s not messy , I am just focussed ! 🙇‍♀️📖📚

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Current shelf look 🖤🧡

[asciencegirlinscienceworld]

GILMORE GIRLS REWATCH ↳ “Dear Emily and Richard” (3x13)

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[asciencegirlinscienceworld]

[asciencegirlinscienceworld]

Yes, this is real. I’m astounded and scared — view on Instagram https://ift.tt/3mfm3EE

[asciencegirlinscienceworld]

09/20/21 • 100 days of productivity (31/100)

no, i wasn’t up till 1am, just watching series’, doing math and reading this masterpiece of a book…

okay, it doesn’t really matter when i sleep if i choose not to go anywhere the next day, but let’s be real, i probably should. i’m just so in love with reading right now, i feel like i’ve fallen into a time loop, where everyday i just fall inside a book all over again and i love it. isn’t this what autumn is all about?

btw, i just love how those notes turned out… and now i probably have to read Lord of the Ring with this knew analysis in my other hand

[asciencegirlinscienceworld]

A weak heart makes a suffering brain

Heart problems cause disturbed gene activity in the brain’s memory center, from which cognitive deficits arise. Researchers at the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center Göttingen (UMG) and the German Center for Cardiovascular Research (DZHK) come to this conclusion based on laboratory studies. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. In mice, a specific drug which is known to affect gene activity alleviated the mental deficits. The involved experts see these results as potential approaches for therapies. The study data are published in the scientific journal “EMBO Molecular Medicine”.

In Germany, about four million people are affected by what is called “heart failure”: Their heart muscle is too weak to pump enough blood through the body and is therefore abnormally enlarged. Physical fitness and quality of life suffer as a result. Moreover, affected individuals have an increased risk of developing dementia. “People with cardiological problems and heart failure in particular may experience noticeable cognitive deficits and increased risk of developing Alzheimer’s disease. Possible reasons include impaired blood supply to the brain and dysfunction of the hippocampus, which is the memory’s control center,” explained André Fischer, research group leader at the DZNE’s Göttingen site and professor at the Department of Psychiatry and Psychotherapy at UMG. “Yet, there is a lack of therapies to effectively treat cognitive deficits in people with heart problems. This is because it is completely unclear which deficiencies are triggered in neurons. There was no data on this so far.”

Stressed Cells

Now, a team led by Prof. André Fischer and Prof. Karl Toischer (Clinic of Cardiology and Pneumology at UMG and DZHK’s Göttingen site) is presenting findings on this subject for the first time. The researchers observed in mice that impaired gene activity developed in the hippocampus as a result of heart problems. “In memory tests, mice with heart failure performed significantly worse than their healthy mates,” Fischer explained. “We then examined the neurons of the hippocampus. In the mice with heart failure, we found increased cellular stress pathways and altered gene activity in neurons.”

Tight Windings

The genome of a mouse - and also of humans - comprises around 20,000 genes. In any given cell, however, only a part of them is active, switched on, so to speak. This is not a mere on or off state: the activity can be strong or less strong. This depends, among other things, on how tightly the DNA (the thread-like molecule that carries the genome) is wound and how accessible the genes on it are. In both mice and humans, the DNA is more than a meter long. But in a cell, the molecule is so tightly packed that it fits into the nucleus. “Genes can only be active if they are accessible to the cell’s machinery. To this end, the DNA needs to be wound a little more loosely at the relevant sites. This is similar to a ball of yarn with loops sticking out of it,” said Fischer. In the current study, the DNA was found to be more tightly wound in neurons of mice with heart problems than in healthy mates. Various genes important for hippocampal function were therefore less active than in healthy mice.

A Drug Improved Memory

The scientists identified chemical changes in the histones as the cause of the tight winding. Histones are special proteins: The DNA wraps around them, much like yarn around a spool of thread. Fischer’s research group has been studying histones and other players that influence gene activity for quite some time - in technical jargon they are called “epigenetic mechanisms”. In this context, the researchers are also investigating drugs. In previous studies, they were able to show that the cancer drug “vorinostat” can alleviate genetically driven as well as age-related memory problems in mice. Currently, vorinostat is being investigated for the therapy of people with Alzheimer’s in a clinical trial of the DZNE. In the current study, the scientists treated mice with heart failure with this drug. They found that the heart’s pumping capacity did not change significantly, but memory performance improved.

Interdisciplinary Cooperation

“Vorinostat has been shown to act on histones and thus on gene activity. Our study thereby provides initial clues about the molecular processes that contribute to cognitive dysfunction following heart problems, and it indicates potential approaches for therapy,” Fischer commented on the results. “Fact is, however, that we do not yet understand why, as a result of heart failure, gene activity in the hippocampus is disturbed. What is the role of the deficient blood supply to the brain? Does the troubled heart release substances that affect the histones? We intend to investigate this in patients with heart problems. As with our current study, which involved experts from neuroscience and cardiac research, we aim to address these questions in an interdisciplinary way.”

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[85/100] I tracked 5:11h in Forest so far and will take a break to read now. I made oven baked veggies (sweet potato, broccoli and onion) with hummus for lunch, so that I would not eat so many sugar based meals all the time.

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september 15th, 2021 • 9:47am

i can’t believe we’re already halfway through september (mostly because the weather certainly isn’t acting like it here in new england…). i just finished my only class for the day and i’m gearing up for the week ahead :) happy studying everyone!

[asciencegirlinscienceworld]

Lecturer during a recorded presentation that I absolutely have to watch as soon as possible because I'm writing a test on it: I've been drinking coffee since 4am

Me, throwing my earphones over my microscope and running out the door: ooh yes that's a good idea! Coffee!

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9.18.21 | been a tough week. i had an anatomy exam, a bunch of classes, and now i’m studying for my module final. sorry i haven’t been so active recently, it’s just been very chaotic on my end rn sfkjkdfs. i hope i can get back into bullet journaling some time soon

🎶 I am listening to: have mercy, chloe