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Lessons Learned From The Nilotinib/Parkinson's Study
Is Nilotinib safe and effective for Parkinson’s disease patients? This very question has stirred controversy since Moussa and colleagues published encouraging results5 about Nilotinib as a treatment for Parkinson's. The study enrolled 12 participants with Parkinson's or Dementia with Lewy Bodies. The patients were randomized to either 150
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Agomelatine Review: The Truth about Agomelatine Use in Affective Disorders
What is Agomelatine? In this article, I'll review agomelatine and share what I've learned about this novel antidepressant. Agomelatine's unique pharmacology and favorable side effect profile make it a boon for depressed patients, especially those who have not responded to conventional antidepressants. If you read nothing else, you may find
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Is Cannabis Linked To Depersonalization?
There's no question that symptoms of depersonalization are linked to cannabis use. Cannabis can reliably and dose-dependently induce depersonalization symptoms, such as feeling detached from your body. Depersonalization is the third most common condition, after anxiety and depression, yet it's rarely discussed. Cannabis has demonstrated therapeutic potential for various conditions.
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Modafinil Enhances Attention and Alerting Performance in Healthy Volunteers
Subjects with the modafinil treatment were significantly more alert (p = 0.016), energetic (p = 0.018), and quick-witted (p = 0.015) compared to those with the placebo treatment. So say Suzuki and colleagues1 in their recently published a study on the effects of modafinil in healthy volunteers. Suzuki's study
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What I learned Reading Hundreds of Strattera Reviews
What is Strattera, Anyway? Atomoxetine (brand name Strattera ) is a selective norepinephrine reuptake inhibitor (SNRI) used to treat attention deficit hyperactivity disorder (ADHD)3 . Unlike Adderall and Ritalin, atomoxetine is a non-stimulant treatment for ADHD. Atomoxetine may be less effective than psychostimulants for ADHD23 , but is also much less
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The Ambien High: America's Favorite Intoxicating Sleep-Aid
Ambien is the most prescribed sleep aid in the United States. Take enough of it, and you'll likely get high. That's the thrust of several recently published papers about the recreational potential of Zolpidem. Here are some recent findings: Emergency department visits involving Ambien has increased from 2,400/year
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CX717: An AMPAKine Cognitive Enhancer?
What Are the Properties of CX717? CX717 is a compound discovered by Cortex Pharmaceuticals in 1996. CX717 modulates the glutamatergic system in the brain by interacting with the glutamate receptor AMPA. Hence, CX717 is an ampakine . By acting on the glutamate system, CX717 strengthens synaptic connections. It possess cognitive enhancing
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tDCS: From Clinical To Gaming Applications
What Does tDCS Stand For? tDCS stands for "transcranial direct-current stimulation" - and it looks like something out of a 90's sci-fi movie. You attach electrodes to your scalp and apply a weak electrical current. This current flows through the brain, altering neural activity. The hope is that tDCS may
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Are You Genetically Fated To Be Depressed? What I Learned From Genetic Testing and Personalized Psychiatry
Schrödinger's SNP A few years ago I took the plunge and had some parts of my genome sequenced by a company called GenoMind . GenoMind is a company like 23andMe that leverages genetics for personalized medicine. However, GenoMind is focused on personalized psychiatry in particular. At the time, I was worried
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Seeking A Depersonalization Cure: 5 Treatments For DP/DR
I can't prove it, but my best guess is that depersonalization is an adaption to extreme stress that's gone awry. Excessive stress dysregulates your HPA axis and vagal tone and leads to sustained increases in cortisol. Too much stress for too long and your body begins to adapt by downregulating
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ADHD Check Engine Light ~ Change Your Oil
Food in our Western diet is very different from what our ancestors ate. One remarkable change has to do with polyunsaturated fatty acids (PUFAs) . Primarily omega-6 and omega-3 . PUFAs are considered essential fats (or essential fatty acids ) because we can't synthesize them in our body. We need to
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Cholinergic Crisis: An Overview
What Is A Cholinergic Crisis? Cholinergic crisis is a medical condition characterized by excess stimulation of the neuromuscular junction. The neuromuscular junction is between the axon of a motor neuron and a muscle fiber1 . This phenomenon occurs due to excess activity of the neurotransmitter acetylcholine (Ach). It results from
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Treacherous Side Effects of Lunesta To Watch Out For
It's damn hard to find a reliable sleep aid that can be used in the long-term without fear of ill-health effects. The really effective sleep aids have frightening side effects like withdrawal and dependence, and even neurotoxicity. I'm talking about drugs like GHB . The sleep aids that are relatively benign
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Sulforaphane: A Powerful Medicine of Nature
General Characteristics of Sulforaphane Sulforaphane is a natural occurring agent belonging to the isothiocyanate group of organosulfur compounds. It is present in relatively large quantities within cruciferous vegetables, such as broccoli. Sulforaphane is associated with modulation of cellular events, positively impacting cell function, and therefore has been associated with overall
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PowderCity Shutdown: Future of Nootropics in US Looks Bleak
On March 15th, PowderCity announced that it is shutting down. As of this writing, it is no longer possible to order from PowderCity.com. PowderCity's sister sites Supplementastic and Nootrostop have also been discontinued. Since March 15th, PowderCity has been referring customers to NootropicsDepot . PowderCity's announcement to shut down comes
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My Experience With NSI-189
We're living in unusual times. The internet has empowered courageous (foolish?) individuals to jump the gun on clinical trials. If a drug looks promising, you can put in a request for a custom synthesis of the compound, assay the purity of the sample via HPLC for $200 in a lab
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