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The US Investing $500M On Universal Vaccine Project
The United States is investing $500 million in a vaccine project, with the goal of making "universal" vaccines that protect against multiple strains of a virus at once, the Wall Street Journal reported on Thursday, citing emails.
The project involves producing vaccines from chemically inactivated whole viruses, reminiscent of how flu vaccines were made decades ago, WSJ said.
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The move is part of what the Department of Health and Human Services (HHS) calls 'Generation Gold Standard', a universal-vaccine technology that represents a shift in funding from COVID-19 projects to studies of more viruses, the paper reported.
https://www.reuters.com/business/healthcare-pharmaceuticals/us-bets-500-million-universal-vaccines-wsj-reports-2025-05-01/
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Moderna Is Deprioritizing It’s Combination Flu/Covid 19 Vaccine
Moderna is deprioritizing its flu/COVID combination vaccine in younger adults amid a push to cut around $1.5 billion from its operating expenses. The biotech disclosed the changes alongside news of a delay to the expected approval of the vaccine in older adults.
Massachusetts-based Moderna filed for FDA approval of its mRNA-1083 combination shot last year. As of February, the mRNA specialist was aiming to win approval in adults aged 50 years and older this year and expand the label to cover younger adults in 2027. Moderna axed both targets in its first-quarter results Thursday.
https://www.fiercebiotech.com/biotech/modernas-flucovid-combination-vaccine-hit-deprioritization-fda-delay
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HHS To Require Placebo Testing Of All New Vaccines
The US Department of Health and Human Services said it will require that all new vaccines be tested in placebo-controlled trials before they’re licensed for use, raising urgent questions about the system used to clear updated Covid-19 boosters each respiratory virus season.
“Under Secretary Kennedy’s leadership, all new vaccines will undergo safety testing in placebo-controlled trials prior to licensure — a radical departure from past practices,” HHS said in a statement Wednesday.
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Many African Children Still Lack Life Saving Vaccines
Despite the proven power of vaccines to save lives, over 500,000 children under five in Africa continue to die each year from preventable diseases, including measles, diphtheria, tetanus, polio, and whooping cough—diseases that have been nearly eradicated in much of the world.
Providing effective protection against these illnesses should be straightforward, yet across the continent, vaccination remains out of reach for millions. Limited domestic health funding, low trust in vaccines, political instability, and the challenge of accessing remote communities all contribute to the problem.
In 2023, just 16 African countries achieved over 90% coverage for essential childhood vaccines, including the third dose of diphtheria, tetanus, and pertussis (DTP3), and the first dose of the measles-containing vaccine (MCV1). As a result, millions of children remain vulnerable to preventable diseases. A vial of measles vaccine, for instance, costs only USD 2.85. Yet since 2018, 28 African countries have experienced large, disruptive measles outbreaks.
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An Increase In Seasonal Flu Vaccine Amongst Minorities
Uptake of the seasonal influenza vaccine has held mostly steady in recent years, but Black and Hispanic adults have seen more uptake, according to an analysis published earlier this month in JAMA Network Open.
The study is based on responses to the 2019 and 2022 Medicare Consumer Assessment of Healthcare Providers and Systems surveys, which were used to create a weighted sample of 285,265 community-dwelling Medicare Advantage and Medicare Fee-for-Service enrollees aged 65 years or older.
More than half, 54.5%, of respondents were women. Two-thirds, 76.2%, were White; 8.0% were Black; 6.9% were Hispanic; and 4.2% were Asian, Native Hawaiian, or other Pacific Islander.
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A Small Increase In Measles Vaccinations Could Prevent New Cases
Measles cases are continuing to spread throughout the U.S. with outbreaks in at least six states.
Public health experts have previously said lagging vaccination rates are to blame for the rise in cases, at least partly due to vaccine hesitancy and vaccine fatigue left over from the COVID-19 pandemic.
https://abcnews.go.com/amp/Health/small-uptick-vaccination-prevent-millions-us-measles-cases/story?id=121270669
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Injection Site On Body May Determine Immune Response To Vaccine
Sydney scientists have revealed why receiving a booster vaccine in the same arm as your first dose can generate a more effective immune response more quickly. The study, led by the Garvan Institute of Medical Research and the Kirby Institute at UNSW Sydney and published in the journal Cell, offers new insight that could help improve future vaccination strategies.
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Scientists Organize To Counter Vaccine Misinformation
A group of public health experts and scientists is mobilizing to counter vaccine misinformation from federal agencies, in an effort backed by Walmart heiress Christy Walton that could eventually produce independent product evaluations and clinical guidelines.
Why it matters: It's the latest bid to push back against vaccine skepticism the group's founders contend is threatening to compromise federal public health agencies and the information they disseminate.
The initiative is led by former FDA commissioner Margaret Hamburg and former National Academy of Medicine president Harvey Fineberg and will operate as part of the University of Minnesota's Center for Infectious Disease Research and Policy (CIDRAP).
https://www.axios.com/2025/04/29/public-health-experts-watchdog-vaccines
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FDA May Be Slowing Down Vaccine Approvals
Former government health officials fear the Trump administration is moving to slow-walk vaccine approvals, including by imposing new regulatory hurdles on drugmakers, such as changing the requirements for approval or seeking additional clinical trial data.
The Food and Drug Administration confirmed Monday it was requiring drugmaker Novavax to run another clinical trial as part of the approval process for its Covid vaccine, which has been available under emergency use authorization since 2022. Dr. Marty Makary, the FDA’s commissioner, said the company is asking the agency to approve “a new product” based on old data.
https://www.nbcnews.com/news/amp/rcna202596
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Major Tuberculosis Vaccine Trial Hits Enrollment Target Ahead Of Schedule
A closely watched clinical trial testing what could be the world’s first new tuberculosis vaccine in a century has hit its enrollment target, ahead of expectations.
The Phase 3 study of the M72/AS01E vaccine, which is taking place at 54 sites across five countries, started delivering shots to volunteers last March. While its sponsors had originally said it may take up to two years to complete enrollment, they announced Monday that the sites in South Africa, Kenya, Malawi, Zambia, and Indonesia have successfully recruited the 20,000 participants needed for the study.
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Scientist Working Towards A Vaccine For Filoviruses
Filoviruses are among the globe's most lethal—indeed, so dangerous they can be handled only in high-security laboratories. Yet, more than five decades after the discovery of the Marburg virus and nearly 50 years after the first outbreak involving its infamous cousin—the Ebola virus—questions still abound about the family Filoviridae.
https://medicalxpress.com/news/2025-04-scientists-vaccine-filoviruses-ebola-deadly.html#google_vignette
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FDA May Request Novavax To Conduct Additional Trails Of Its Covid 19 Vaccine Prior To Approval
The US Food and Drug Administration has discussed with vaccine-maker Novavax the need for an additional trial of its Covid-19 vaccine as a post-approval commitment, a source familiar with the matter told CNN.
The terms need to be negotiated before Novavax’s vaccine could be granted full approval, the source said, declining to be named because they weren’t authorized to speak on behalf of the FDA.
Novavax had anticipated full approval of its vaccine by April 1, but the FDA delayed the decision because it sought more data, a source told CNN at the time.
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Sales Of Mercks MMR Vaccine Drops
Proquad is rarely a newsmaker from Merck’s earnings, but this time around, the U.S. has had a series of measles outbreaks. Sales of the vaccine were $539 million for the quarter, a 5% decline from the same period in 2024.
Sales of Merck’s measles, mumps, rubella and chicken pox vaccine Proquad dropped in the first quarter after the U.S. dipped into its six-month pediatric vaccine supply amid a handful of measles outbreaks, the company announced Thursday.
Overall, Merck’s worldwide sales declined 2% to $15.5 billion compared to the same period a year earlier, according to a first quarter earnings report released Thursday morning. Also contributing to the decline is a steep drop in revenue from the human papillomavirus (HPV) vaccine Gardasil/Gardasil 9 that continues to be impacted by supply challenges in China. Sales of the vaccine fell 41% to $1.3 billion for the quarter. While the decline was steep, Merck said it could have been worse had demand not increased in other regions, particularly in Japan, and the higher pricing in the U.S. also helped offset the losses.
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WHO Warns That Eradicated Diseases May Return Due To Funding Cuts
Cuts to global health funding are leading to a rise in outbreaks of diseases that vaccines had nearly wiped out, the UN health agency, WHO, is warning on Thursday.
In Africa’s “meningitis belt”, which spans parts of sub-Saharan Africa, vaccination campaigns had successfully eliminated meningitis A. Similarly, improved routine immunization and emergency vaccine stockpiles drastically reduced cases of yellow fever and related deaths.
But this progress is now at risk. “Funding cuts to global health have put these hard-won gains in jeopardy,” warned Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization.
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Novavax Shares Rise On Hopes Of Covid 19 Vaccine Approval
Novavax (NVAX.O), opens new tab said on Wednesday U.S. regulators asked the company to produce more data on its COVID-19 vaccine if it gets full approval, sending the drugmaker's shares soaring and easing concerns around the future of the shot.
Shares gained nearly 20% to $7.48 on Wednesday after the request, which Novavax said it would address promptly so it "move to approval as soon as possible."
https://www.reuters.com/business/healthcare-pharmaceuticals/fda-asks-novavax-commitment-post-approval-studies-covid-vaccine-2025-04-23/
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Funding Cuts Threaten Free Vaccines For Children
Dr. Ali Sherif normally gives about 50 doses of the measles vaccine to children each month at his clinic in Hobbs, New Mexico, near the Texas state line.
The number of shots at his clinic has surged about 25%, however, in recent weeks as local parents seek immunizations to protect their toddlers and school-age children from a growing measles outbreak that has infected more than 600 people and led to three deaths.
https://www.reuters.com/business/healthcare-pharmaceuticals/trump-cuts-threaten-free-vaccine-program-kids-amid-measles-outbreak-2025-04-23/
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A Deal To Jointly Develop An Avian Flu Vaccine
The University of Cambridge–based DioSynVax and Singapore's ACM Biolabs have signed a deal to jointly develop a next-generation universal avian flu vaccine with the potential for mucosal delivery.
The mRNA vaccine targets all major clades of the H5 avian flu subtype and is scalable for rapid, global distribution, according to a press release from DioSynVax. Delivery via a nasal spray could help increase uptake of the vaccine.
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