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DMT cartridges are structurally similar to Tryptamine, which is structurally similar to Serotonin, which is also structurally similar to Psilocybin( which is the active ingredient in magic mushrooms). Basically, all of these chemicals act like Neurotransmitters in the brain.

Binding to receptors and altering your thoughts. But the effects of DMT are rapid onset, there are really intense but there are short-lived. It’s like having a really quick trip. When you take a DMT vape pen, you feel it within the first couple of minutes but within 30 to 45 minutes, it’s all over. That’s why is also called 45-minute psychosis.

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DMT or N, N-dimethyltryptamine in medical talk — is a hallucinogenic tryptamine that produces effects similar to those of psychedelics, like LSD and Psilocybin. The use of DMT can be traced back hundreds of years and is often associated with religious practices or rituals. DMT is used primarily for its psychoactive, hallucinogenic effects.

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And while the intensity of the experience is dose-dependent, vaping DMT can cause similarly intense hallucinations as consuming it in more traditional ways.

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As with cannabis, vaping DMT has its benefits, like convenience, ease of use, and a degree of control over how big of a hit you can take. But also, as with cannabis, the question remains: Is vaping safe when it comes to DMT?

There’s plenty of reason to be concerned about the health effects of inhaling DMT-infused e-liquid in light of the new, deadly lung disease that’s been tied to vaping.

Since August of 2019, the Centers for Disease Control and Prevention (CDC) have reported 60 confirmed deaths and another 2,668 hospitalizations in America due to EVALI (which stands for e-cigarette or vaping product use-associated lung injury).

EVALI causes severe lung infections in otherwise healthy individuals. Health experts have found that vaping cannabis and/or tobacco e-liquid is a common thread among patients with EVALI. Since making that discovery, researchers have begun analyzing the chemicals used to produce cannabis and tobacco e-liquid, but they haven’t given the same attention to the potential health risks of vaping other substances, like DMT.

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“I don’t know of any research on DMT vape pens,” Thomas Anderson, research director of the Psychedelic Studies Research Program at the University of Toronto, tells DoubleBlind. “As far as I know, there is zero research on that topic. As such, honest scientists could not authoritatively comment on whether DMT vape pens are especially safe or dangerous or anywhere in between.”

Read: Rick Strassman on DMT and the Mystical State

While there is no hard evidence on this issue, there are reasons to be wary of inhaling DMT-infused vape juice. The CDC notes that cannabis vape pens purchased through “informal sources” (including the black market) “are linked to most EVALI cases and play a major role in the outbreak.” Those findings suggest that cannabis consumers could drastically reduce the risk of developing EVALI if they stick to using regulated vaping products purchased through licensed sources in states that have legalized marijuana. By sticking to regulated products, consumers can rest assured that what they are vaping does not contain vitamin E acetate, a cutting agent that has been strongly linked to cases of EVALI.

But that solution won’t work for anyone using DMT, which is still prohibited throughout America and most of the world, so there are no regulated devices or licensed retailers for DMT vape pens. Without regulation, consumers cannot be 100 percent certain that DMT vape juice acquired from an informal source is free of vitamin E acetate or other harmful additives.

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The only way for a consumer to know what is in their DMT vape juice is if they make it themselves. There are plenty of recipes for DMT e-liquid available online, including ones that use propylene glycol (PG) and vegetable glycerin (VG), which are key ingredients found in JUUL pods. Neither PG or VG has been connected to EVALI (though one recent study suggests that vaping either chemical can cause lung inflammation over time).

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Mike Tyson first tried 5-MeO-DMT — also called “the toad” — he said it knocked him off his feet, profoundly changing his life. “I came across this thing called the toad. I smoked this medicine, drug, whatever you want to call it, and I’ve never been the same,” Tyson said on the Joe Rogan Experience podcast last year, viewed by nearly 10 million people. “I look at life differently, I look at people differently. It’s almost like dying and being reborn… It’s inconceivable. I tried to explain it to some people, to my wife, I don’t have the words to explain it. It’s almost like you’re dying, you’re submissive, you’re humble, you’re vulnerable — but you’re invincible still in all.”

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It has also been found to occur naturally in humans. DMT mainly comes from South America, specifically the Amazon rainforest.

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DMT cartridges are structurally similar to Tryptamine, which is structurally similar to Serotonin, which is also structurally similar to Psilocybin( which is the active ingredient in magic mushrooms). Basically, all of these chemicals act like Neurotransmitters in the brain.

Binding to receptors and altering your thoughts. But the effects of DMT are rapid onset, there are really intense but there are short-lived. It’s like having a really quick trip. When you take a DMT vape pen, you feel it within the first couple of minutes but within 30 to 45 minutes, it’s all over. That’s why is also called 45-minute psychosis.

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More so, to an extent. The act of collecting and refining the materials to make the medicine accessible may be called urban shamanism.’ I have been named several times. But I do not see myself, or refer to myself, as a shaman. I don’t, mentally, do ceremonies.

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