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Dr Mwele Ntuli Malecela’s complete (and quite long) list of scholarly publications

PUBLICATIONS

1.Baldwin C.I., Medieros F, Malecela M.N. and Denham D.A (1994) Humoral responses in cats repeatedly infected with Brugia pahangi. Parasite 1,1S

2.Malecela (1995): Microfilariae and the immune response in cats repeatedly infected with Brugia pahangi. Ph.D. thesis, University of London.

3.Malecela M.N., Aililio M.S and Kitua A.Y (2000): An Organizational Analysis of the National Institute for Medical Research: Narrowing the Gap Between objectives and Achievements. Tanzania Health Research Bulletin Vol 2. No.2.pp 17-23.

4.P.E.Simonsen, D.W Meyrowitsch, W.G.Jaoko,M.N.Malecela, D.Mukoko, E.M.Pedersen, J.H. Ouma, R.T.Rwegoshora, N.Masese, P.Magnussen, B.B.A Estambale and E.Michael (2001) Bancroftian Filariasis infection,Diseaese and Specific Antibody Response Patterns in a high and a low endemicity community in East Africa. Parasite Immunology 23: 373-388

5.M.E.Charles, M.N.Malecela,J.Mcharo,A.Kitua (2001) Milestones in the control of Bancroftian filariasis in Tanzania. Tanzania Medical JournalVol 16 no1. pp 10

6. V.P.Mvungi, J.K.Ikingura, K.Senkoro, M.N.Malecela, A.Y.Kitua (2001) Information and Communication for enhancing Health Research and development at NIMR. Tanzania Medical Journal Vol 16 no1 pp15

7.M.N.Malecela,J.K.Ikingura and A.Y.Kitua( 2001) National Institute for Medical Research and the other side of health research: Research coordination, Monitoring and Promotion. Tanzania Medical Journal Vol 16 no1 pp19

8.M.Malecela, E.Charles,N.Manzi, and C.D Mackenzie (2001) Lymphatic filariasis in the Tanzanian Archipelago. Journal of The American Society of Tropical Medicine and Hygiene vol. 65 (3)pp 193

9.S.M.Magesa,L.EGMboera,A.J.Mwisongo,W.J.Kisoka,G.M.Mubyazi,H.Malebo, K.P.Senkoro,J.Mcharo, E.A.Makundi, J.Mwanga, A.K.Mushi, P.Hiza, M.Malecela-Lazaro and A.Y.Kitua (2001) Major Health problems in some selected districts of Tanzania. Tanzania Health Research Bulletin Vol3.no2 pp 1

10. Michael E., Simonsen P.E., Malecela M., Mukoko D., Pedersen E.M., Rwegoshora R.T., Meyrowitsch D.W, Jaoko W.G., (2001)Transmission intensity and immunoepidemiology of bancroftian filariasis in East Africa. Parasite Immunology No 23. Pp 373-388

11. C.D.Mackenzie, M.Malecela,I.Mueller and M.A Homeida (2002): Approaches to control and elimination of clinically important filarial diseases in KleiT and Rajan V (editors) World Class Parasites: The Filaria.

12. C.F.Curtis, M.Malecela-Lazaro, R.Rueben and C.A. Maxwell (2002) Use of floating layers of polystyrene beads to control populations of the filarial vector Culex quinquefasciatus. Annals of Tropical Medicine & Parasitology, Vol 96 supplement no.2 S97-S104

13. Paul Simonsen,Peter Bernhard, Walter Jaoko, Dan Meyerowitsch, Mwele N.Malecela- Lazaro, Pascal Magnussen and Edwin Michael (2002) Filaria Dance sign and subclinical hydrocele in two East African communities with Bancrfotian filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene

14.Simonsen,P.E, Meyerowitsch, D.W, Jaoko W.G., Malecela, M.N., Mukoko, D., Pedersen, E.M., Ouma,J.H., Rwegoshora, R.T., Masese.N Magnussen, P., Estambale, B.B.A & Michael E. (2002) Bancroftian filariasis infection disease and specific antibody responses patterns in a high and low endemicity community in East Africa. American Journal of Tropical Medicine and Hygiene Vol 66(5) pp550-559

15.Simonsen P.E Meyrowitsch D.W., Mukoko D, Pedersen E.M., Malecela-Lazaro M.N., Rwegoshora R.T., Ouma J.H., Masese, N. , Jaoko W.G., Michael E., (2004) The effect of repeated half-yearly mass treatment on Wuchereria bancrofti infection and transmission in two East African communities with different levels of endemicity. American Journal of Tropical Medicine and Hygiene No 70 pp. 63-71

16. Paul E. Simonsen, Stephen M. Magesa, Samuel K. Dunyo, Mwele N. Malecela-Lazaro, Edwin Michael (2004) The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene 98,462-472

17. Mwele N. Malecela-Lazaro & Nana Twum Danso (2004) Towards a strategic plan for Research to Support the global Program to eliminate Lymphatic Filariasis: Programme Implementation. American Journal of Tropical Medicine and Hygiene 71 (suppl 5) pp16-19

18. Simonsen,P.E., Meyerowistch D.W., Mukoko,D., Rwegoshora,R.T., Pedersen,E.M., Malecela Lazaro M.N., Jaoko W.G., and Michael E.(2005) The effect of eight half-yearly single-doses treatments with DEC on Wuchereria bancrofti circulating antigenaemia. Transactions 99,541-547

19.Stuik SS, Maxwell, C.A, Malecela-Lazaro M., Eckstein S., Porter J.D.H, and Riley E.M (2005) Intergrating HIV testing into immunological studies of non-HIV related diseases. Nature Immunology 6,423-426.

20. Rwegoshora R.T, Pedersen E.M, Mukoko D.A, Meyrowitsch D.W., Masese N., Malecela- Lazaro M.N., Ouma J.H., Michael. E., Simonsen P.E., (2005) Bancroftian Filariasis: Patterns of vector abundance and transmission in two East African Communities with different levels of endemicity. Annals of Tropical Medicine and Parasitology No. 99 pp 253-265

21. Edwin Michael, Mwele Malecela-Lazaro, Conrad Kabali, Lucy. C. Snow and James W.Kazura (2006) Mathematical models and lymphatic Filariasis control: endpoints and optimal interventions. Trends in Parasitology, Volume 22 (5) pp 226-233.

22. Edwin Michael, Mwele N. Malecela-Lazaro, Bertha T.A Maegga, Peter Fischer and James Kazura (2006) Mathematical models and lymphatic Filariasis control: monitoring and evaluating interventions. Trends in parasitology Volume 22 (11 ) pp 529-535

23. Walter G, Jaoko, Paul E.Simonsen, Dan W.Meyerowitsch, Benson B.A. Estambale, Mwele N.Malecela-Lazaro,and Edwin Michael(2006) Filarial Specific Antibody Reponses in East African Bancroftian filariasis:Effects of host infection, clinical disease and filarial endemicity. American Journal of Tropical Medicine and Hygiene 75 (1) 97-107.

24. Rwegoshora R.T, Simonsen, P.E, Meyrowitsch, D.E, Malecela-Lazaro, M.N., Michael, E., and Pederson E.M (2007) Bancroftian Filariasis: house to house variation in the vectors and transmission-and the relationship to human infection –in an endemic community of coastal Tanzania. Annals of Tropical Medicine and Parasitology vol. 101 No.1,51-60.

25. Jaoko WG; Michael E; Meyrowitsch DW; Estambale BBA; Malecela MN; Simonsen PE. (2007). Immunoepidemiology of Wuchereria bancrofti infection: Parasite transmission intensity, filaria-specific antibodies, and host immunity in two east African communities. Infect Immun. 75:5651-5662

26. Michael, E., Malecela-Lazaro, M.N. & Kazura, J.W. (2007) Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. Advances in Parasitology . 65:191-237

27. Goldman A.S, Guisinger V.H., Aikins M., Amarillo L.E., Bellizario V.Y., Garshong B., Gyapong J., Kabali C., Kamali S.K., Kyelem D., Lizardo J., Malecela M., Mubyazi G., Nitiema P.A., Ramzy R., Streit T., Wallace A., Brady M.A, Rheingens R., Ottesen E.A & Haddix A.C. (2007). National mass drug administration costs for lymphatic filariasis elimination. Plos NTD vol1 (1) e67

28. Smith, M., Madon, S., Anifalaje, A., Malecela-Lazaro, M. & Michael, E. (2007). Integrated health information systems in Tanzania: experience and challenges. Information Technologies and International Development The Electronic Journal on Information Systems in Developing Countries. 32:1-21-26.

29. Malecela M.N., Kilima P., and Mackenzie C.D., (2008): Implementation and management of lymphatic filariasis control and elimination programmes: the Tanzanian experience. In Lymphatic Filariasis : research and control in eastern and southern Africa ed Simonsen P.E, Malecela M.N., Michael E. and Mackenzie C.D. DBL- Center for Health Research and Development pp 111-123

30. Mackenzie C.D., Mwakitalu E. , Mandara W.L. , Mwingira U. & Malecela M.N. The morbidity of lymphatic filariasis in Eastern and Southern Africa.In Lymphatic Filariasis : research and control in eastern and southern Africa ed Simonsen P.E, Malecela M.N., Michael E. and Mackenzie C.D. DBL- Center for Health Research and Development pp 59-75

31. Michael, E., Malecela, M.N., Zervos, M., & Kazura, J.W (2008) Global Eradication of Lymphatic Filariasis: The value of chronic disease control in parasite elimination programmes. Plos One vol.3 (8)

32. Malecela M.N, Lazarus W., Mwingira U., Mwakitalu E., Makene C., Kabali C., & Mackenzie C (2009): Eliminating LF: A Progress Report from Tanzania. Journal of Lymphoedema Vol 4. No .1 pp 10- 12

33. Malecela M.N, Mwingira U., Mwakitalu E, Kabali C, Micahel E., & Mackenzie C.D (2009): The sharp end- experiences from the Tanzanian Programme for the elimination of Lymphatic Filariasis: notes from the end of the road. Annals Vol103, suppl 1 S53-S57.

34. Simonsen P.E,Pedersen E.M. Rwegoshora R.T, Malecela M.N, Derua Y.A, and Magesa S.M (2010):Lympahtic Filariasis Control in Tanzania: Effect of Repeated Mass Drug Administration with Ivermectin and Albendazole on infection and Transmission. PLOS Neglected Tropical Diseases. Vol 4 no 6(e696)

35. Kabataraine N., Malecela M., Lado M., Zaramba S., Amiel O., Kolaczinski J.H.(2010) How to or not to Integrate Vertical Programmes for the Control of Major Neglected Tropical Diseases in sub Saharan Africa. PLOS Neglected Tropical Diseases Vol. 4(e755).

36.Dan W Meyrowitsch, Erling M Pedersen, Michael Alifrangis, Thomas H Scheike, Mwelecele N Malecela, Stephen M Magesa, Yahya A Derua, Rwehumbiza T Rwegoshora, Edwin Michael and Paul E Simonsen (2011) Is the current decline in malaria burden in Sub-Saharan Africa due to a decrease in vector population? Malaria Journal. Jul 13; 10:188

37.Bloch P, Nielsen NO, Meyrowitsch DW, Malecela MN, Simonsen PE (2011). A 22 year follow-up study on lymphatic filariasis in Tanzania: analysis of immunological responsiveness in relation to long-term infection pattern. Acta Trop. 120(3):258-67.

38. Molyneux DH, Malecela MN (2011). Neglected tropical diseases and the millennium development goals: why the “other diseases” matter: reality versus rhetoric. Parasit Vectors. 4:324.

39. Pate MA, Gyapong JO, Dowdle WR, Hopkins A, Hozuni D, Malecela M, and Tyson S.(2011). Designing Elimination or Eradication Initiatives that Interface Effectively with Health Systems. Strongman Forum Reports. MIT Press 273-286

40. Exavery A, Mubyazi GM, Rugemalila J, Mushi AK, Massaga JJ, Malebo HM, Tenu F, Ikingura JK, Malekia S, Makundi EA, Ruta AS, Ogondiek JW, Wiketye V, Malecela MN (2012).Acceptability of condom promotion and distribution among 10-19 year-old adolescents in Mpwapwa and Mbeya rural districts, Tanzania. BMC Public Health 12:569.

41. Munga MA, Kilima SP, Mutalemwa PP, Kisoka WJ, Malecela MN (2012). Experiences, opportunities and challenges of implementing task shifting in underserved remote settings: the case of Kongwa district, central Tanzania. BMC Int Health Hum Rights, 12(1):27.

42. Mwakitalu ME, Malecela MN, Pedersen EM, Mosha FW, Simonsen PE.(2013) Urban lymphatic filariasis in the city of Tanga, Tanzania after seven rounds of Mass Drug Administration. Acta Trop;128(3):692-700.

43. Mwakitalu ME, Malecela MN, Pedersen EM, Mosha FW, Simonsen PE. (2013) Urban Lymphatic Filariasis in the metropolis of Daresalaam Tanzania Parasit Vectors 30;6:286. doi: 10.1186/1756-3305-6-286.PMID: 24289718

44. Simonsen PE, Derua YA, Kisinza WN, Magesa SM, Malecela MN, Pedersen EM (2103) Lymphatic filariasis in Tanzania: effect of six rounds of mass drug administration with ivermectin and albendazole on infection and transmission.BMC Infect Dis 21;13:335. doi: 10.1186/1471-2334-13-335.

45. Madon S, Amaguru JO, Malecela MN, Michael E. (2014) Can mobile phones help control Neglected Tropical Diseases ? Experiences from TanzaniaSoc Sci Med. 2014 Feb;102:103-10.

46. Kisoka WJ, Simonsen PE, Malecela MN, Tersbøl BP, Mushi DL, Meyrowitsch DW.(2014): Factors Influencing Drug Uptake during Mass Drug Administration for Control of Lymphatic Filariasis in Rural and Urban Tanzania. Munirathinam G, ed. PLoS ONE. ;9(10):e109316. doi:10.1371/journal.pone.0109316.

47. Mubyazi, G. M., Exavery, A., Tenu, F., Massaga, J. J., Rugemalila, J., Malebo, H. M., ... Malecela, M. N. (2015). Determinants of demand for condoms to prevent HIV infections among barmaids and guesthouse workers in two districts, Tanzania. BMC Research Notes, 8, 630. http://doi.org/10.1186/s13104-015-1621y.

48. Malebo, H. M., Wiketye, V., Katani, S. J., Kitufe, N. A., Nyigo, V. A., Imeda, C. P., ... Kitua, A. Y. (2015). In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania. Malaria Journal, 14, 79. http://doi.org/10.1186/s12936-014-0525-y

49. De Silva, N., Ahmed, B.-N., Casapia, M., de Silva, H. J., Gyapong, J., Malecela, M., & Pathmeswaran, A. (2015). Cochrane Reviews on Deworming and the Right to a Healthy, Worm-Free Life. PLoS Neglected Tropical Diseases, 9(10), e0004203. http://doi.org/10.1371/journal.pntd.0004203

50. Vairo, F., Mboera, L. E. G., De Nardo, P., Oriyo, N. M., Meschi, S., Rumisha, S. F., ... Ippolito, G. (2016). Clinical, Virologic, and Epidemiologic Characteristics of Dengue Outbreak, Dar es Salaam, Tanzania, 2014. Emerging Infectious Diseases, 22(5), 895– 899. http://doi.org/10.3201/eid2205.151462

51. Kroidl I, Saathof E, Maganga L, et al.(2016) Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co- infection in Southwest-Tanzania. van Griensven J, ed. PLoS Neglected Tropical Diseases. 10(4):e0004618. doi:10.1371/journal.pntd.0004618.

52. Yao Sodahlon, Mwele Malecela and John. O Gyapong (2016) Lymphatic Filariasis in J. Gypong, B. Boatin (eds) Neglected Tropical Diseases- Sub-Saharan Africa pp160- 249

53. Hotez PJ, Pecoul B, Rijal S, Boehme C, Aksoy S, Malecela M, et al. (2016) Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies. PLoS Negl Trop Dis 10(3): e0003895. doi:10.1371/journal.pntd.0003895

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Profile of Dr Mwele Ntuli Malecela

Mwelecele Ntuli Malecela PhD, FTAAS

Dr Malecela holds the post of Chief Research Scientist and was formerly the Director General of the National Institute for Medical Research Tanzania. She is the first woman to hold this position and is also Director of the Tanzania Lymphatic Filariasis Elimination Program.

Mwele holds a Bsc (Hons) in Zoology from the University of Dar-es-salaam and an Msc and PhD in Parasitology from the University of London (London School of Hygiene and Tropical Medicine). Her area of specialization was filarial immunology specifically on filarial immune evasion mechanisms. Dr Malecela is a Fellow of the Tanzania Academy of Sciences.

Mwele has worked at the National institute for Medical Research for 30 years, where she started off as a junior scientist, mainly in the field of Lymphatic Filariasis immunoepidemiology. As Director General, her work had focused on research capacity strengthening and building of strong national research systems.

As DG Mwele chaired the Medical Research Coordinating Committee (MRCC), which is the main body responsible for oversight of health research in the country. Mwele is the member of serves on several committees and boards in country related to Health Research, Science and Technology and is a strong advocate of increasing the number of women working in science related fields.

Mwele is currently Vice President of the International Association of Public Health Institutes (IANPHI) and a member of the WHO Strategic and Technical Advisory Committee for Neglected Tropical Diseases. Dr Malecela is also Chair of the African Regional Program Review for Neglected Tropical Diseases. Dr Malecela is also on the International Advisory Board of Grand Challenges Canada, and serves on the council of the University of Dodoma. Mwele is also a member of the Trachoma Expert Committee. 

Until June 2010 Mwele was President of the Global Alliance to Eliminate Lymphatic Filariasis and Chair of the Representative contact group of the Alliance. Mwele is also involved in several philanthropic organizations, and is a member of several professional bodies and has several publications in peer -reviewed journals. Dr Malecela has received several awards including the Global NTD Champions award for her work in the fight against Neglected Tropical Diseases. Dr Malecela was recently recognized as the 100 women in Global Health featured in the Lancet

Key words: Parasite immunology, NTDs, Global Health, Research capacity strengthening

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February 2016: Interviewed by Fatema Dewji Jaffer