Forensic Toxicology Resources: This includes resources for what Forensic Toxicology is, how it works, what it does, and how it helps the court system. This will hopefully help people interested in pursuing Forensic Toxicology or wanting to learn about it.
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Toxicology and Poisons -- Singh
"Over time, the legal scrutiny of deaths with poisoning followed stages of post-mortem findings, extraction/isolation of poison, result interpretation, and expert testimony in the court of law." (Singh, 2022, Paragraph 2)
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Mass Spectrometry -- Zarrouk, El Balkhi, Saint-Marcoux
"The main difference between HRMS and LRMS is the precision in the determination of the mass; the so-called “mass accuracy”." (Zaarouk, 2023, Page 24)
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Toxicology Lab -- Raisys
"The fact that many samples are volatile, even at rather low temperature, has made gas chromatography a most important tool in the laboratory. GC methods have been developed for the separation of many classes of toxicological substances." (Raisys, 1985, Page 1)
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Exhumed Specimen Analysis -- Chaudhary, Wattoo, Ashiq, Afzal, Sarwar, Tahir
"Forensic toxicologists receive a variety of biological samples, but exhumed biological specimens with varying degrees of putrefaction pose a greater challenge for analysis." (Chaudhary, 2016, Page 1)
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Validation of Analysis -- SWGFACT
"Analytical procedure validation is often a complex, iterative process that requires scientific judgment. The goal of these guidelines is to provide the laboratory with information on steps that are commonly used when validating an analytical procedure." (SWGFACT, 2005, Paragraph 3)
https://archives.fbi.gov/archives/about-us/lab/forensic-science-communications/fsc/april2005/standards/2005_04_standards01.htm
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Using Hair in Analysis -- Darmetko, Leśków, Tarnowska, Sarnowska, Wysocki, Pieńkowski, Szopa
"Biological materials used in toxicological analyses are usually blood, urine and the vitreous body of the eye. In addition to the above-mentioned classic materials used for tests aimed at determining the presence of a given xenobiotic, alternative materials, such as hair, are increasingly being used." (Darmetko, 2017, Page 1)
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Biological Trace Evidence -- Di Candia, Giordana, Boracchi, Bailo, Primignani, Piccinini, Zoja
"We developed an experimental study to evaluate the feasibility of analyzing DNA extraction residues obtained from DNA extraction procedures to perform toxicological analysis, with the aim to extract both genetic and toxicological information without affecting or compromising the genetic sample and/or DNA extraction." (Di Candia, 2023, Page 1)
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Alternative Samples in Toxicology -- Gallardo, Queiroz
"It is not surprising... that a large number of papers dealing with the determination of... drugs in saliva, sweat, meconium and hair have been published... owing to the fact that chromatographic equipment is becoming more and more sensitive..." (Gallardo, 2008, Page 1)
https://ubibliorum.ubi.pt/bitstream/10400.6/624/1/BIOMEDICAL%20CHROMATOGRAPHY.pdf
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Specific Case of Multiple Lab Analysis-- John, van der Schanz, Koller, Spruit, Worek, Thiermman, Noort
"The two laboratories did not know of each other’s involvement, in order to guarantee fully independent analysis and reporting to the OPCW. Procedures applied were established individually in both laboratories." (John, 2018, Page 2)
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Database Development of Chemicals -- Ogawa, Zaitsu, Kokaji, Suga, Kondo, Iwai, Suzuki, Ishii, Seno
"The present study aims to develop a forensic toxicological library to identify 56 natural toxic substances by liquid chromatography-quadrupole time-of-fight tandem mass spectrometry (LC–QTOF-MS/MS)." (Ogawa, 2019, Page 1)
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Identification Criteria Changes -- Sarkisian
"The described method uses five levels of identification and confirmation, and three types of mass spectral libraries consisting of a main of an in-house curated library, updated quarterly." (Sarkisian, 2022)
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Forensic Toxicology Overview -- Drummer
"Forensic toxicology represents a number of related disciplines aimed to assist in the detection and interpretation of drugs and poisons for medico legal purposes." (Drummer, 2010, Page 1)
https://link.springer.com/content/pdf/10.1007/978-3-7643-8338-1.pdf#page=582
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Toxicology Sample Collection Overview -- Dinis-Olivera, Duarte, Remião, Marques, Santos, Magalhães
"In the present article, an overview is given on sampling procedures for routinely collected specimens as well as on alternative specimens that may provide additional information on the route and timing of exposure to a specific xenobiotic." (Dinis-Olivera, 2010, Page 1)
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Modern Instrumental Methods -- Smith, Vorce, Holler, Shimomura, Maglulio, Jacobs, and Huestis
"A brief description of the theory [of technology use for analysis] and inherent strengths and limitations of each methodology is included. The focus is on new technologies that address current analytical limitations." (Smith, 2007, Page 1)
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QTrap Method For Drug Analysis in Blood Samples -- Herrin, McCurdy, Wall
"Such comprehensive drug databases allow for the screening of large numbers of drugs and when properly applied, could prove enormously useful for the detection of drugs, particularly in plasma or urine." (Herrin, 2005, Page 1)
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Modern Technology in the Lab -- Aebi and Bernhard
"[GC-MS] offers the possibility to screen biological and illicit drug samples for unknown compounds, to identify, confirm, and to quantitate them." (Aebi, 2002, Page 1)
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Drug Analysis -- Ribeiro, Santos, Gonçalves, Ramos, Afonso, Tiritan
"Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field." (Ribeiro, 2018, Page 1)
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