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A Guide to VIREAD / Tenofovir Disoproxil Fumarate Online Purchases - Everything You Need to Know

Navigating online VIREAD / Tenofovir Disoproxil Fumarate to get it on demands caution and awareness. Prioritize licensed stores, verify security protocols, and confirm product authenticity. Research potential side effects, consult health professionals, and beware of fake products. Safeguard personal information and ensure encrypted transactions. A vigilant approach ensures a secure and reliable online health product experience.

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Viread (Tenofovir Disoproxil Fumarate) for HIV Treatment & PrEP: Everything You Need to Know

https://www.thebody.com/health/hiv-viread-tenofovir-tdf

Viread (generic name: tenofovir disoproxil fumarate; often abbreviated as TDF) is an anti-HIV medication taken as one pill once a day in combination with other medications. Viread is in a class of drugs called “nucleoside / nucleotide reverse transcriptase inhibitors” (NRTIs), which stop HIV from making copies of itself.

Viread is available as a stand-alone drug, but it is usually used in combination with other drugs. Viread is included in a fixed-dose combination (FDC) pill called Truvada, which also includes an HIV drug called Emtriva (emtricitabine, FTC). Viread is also part of several other FDCs, including these single-dose treatment regimens (STRs) for HIV:

Atripla (TDF + FTC + Sustiva [efavirenz])

Complera (TDF + FTC + Edurant [rilpivirine])

Stribild (TDF + FTC + elvitegravir + cobicistat)

Viread was first approved by the U.S. Food and Drug Administration as a treatment for HIV in 2001. Generic versions of Viread are available in the U.S., and are included in a number of FDCs and STRs.

Viread is generally taken by adults as a single 300 mg pill orally once a day. Although the drug will work just as well whether it’s taken with or without food, taking Viread on an empty stomach can lead to abdominal pain or discomfort.

Some adults who have issues with their kidneys may be instructed to take Viread less frequently. Always follow your medical provider’s instructions for how and when to take Viread. For children who weigh at least 22 lbs (10 kg) and cannot swallow a tablet, Viread is also available in a powder form.

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Renal and Bone Effects of Tenofovir Disoproxil Fumarate (TDF) for Children and Adolescent with Hepatitis B.

https://www.sfda.gov.sa/sites/default/files/2023-10/VireadBrochure.pdf

There are uncertainties associated with the long-term effects of bone and renal toxicity. Moreover, the reversibility of renal toxicity cannot be fully ascertained. Therefore, a multidisciplinary approach is recommended to adequately weigh on a case by case basis the benefit/risk balance of treatment, decide the appropriate monitoring during treatment (including decision for treatment withdrawal) and consider the need for supplementation.

In clinical studies and post-marketing safety surveillance of TDF in adults, events of renal failure, renal impairment, and proximal renal tubulopathy (including Fanconi syndrome) have been reported. In some patients proximal renal tubulopathy has been associated with myopathy, osteomalacia (manifested as bone pain and infrequently contributing to fractures), rhabdomyolysis, muscle weakness, hypokalaemia and hypophosphataemia.

TDF is not recommended for use in children and adolescents with renal impairment. TDF should not be initiated in children and adolescents with renal impairment and should be discontinued in children and adolescents who develop renal impairment during TDF therapy. The recommendations for monitoring renal function in children and adolescent patients without renal risk factors prior to and during TDF therapy are provided in Table 1. In patients at risk for renal impairment a more frequent monitoring of renal function is required.

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Tenofovir Disoproxil Fumarate

This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you are taking another drug that has the same drug in it. If you are taking adefovir. If you are taking any drugs that can raise the chance of kidney problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. If you are breast-feeding or plan to breast-feed. This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

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What is tenofovir?

Tenofovir, sold under the brand name Viread, is a once-daily treatment for HIV infection. Tenofovir is also co-formulated with other medicines:

• Truvada: tenofovir + FTC

• Atripla: tenofovir + FTC + efavirenz

 • Complera: tenofovir + FTC + rilpivirine

• Stribild: tenofovir + FTC + cobicistat + elvitegravir

When HIV infects a cell, it takes control of that cell. HIV then forces the cell to make many more copies of the virus. To make these copies, the cell uses proteins called enzymes. When the activity of these enzymes is reduced the production of HIV slows.

Tenofovir belongs to a group (or class) of drugs called nucleotide analogues. Tenofovir interferes with an enzyme called reverse transcriptase, which is used by HIV-infected cells to make new viruses. Since tenofovir inhibits, or reduces, the activity of this enzyme, this drug causes HIV-infected cells to slow down or stop producing new viruses.

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VireadÒ (tenofovir disoproxil fumarate) 300 mg Tablets

https://www.tga.gov.au/sites/default/files/auspar-tenofovir-disoproxil-fumarate-131014-pi.pdf

Tenofovir disoproxil fumarate is a white to off-white crystalline powder with a solubility of 13.4 mg/mL in water at 25°C. The partition coefficient (log P) for tenofovir disoproxil is 1.25 and the pKa is 3.75. The active pharmaceutical product is a single enantiomer that does not undergo racemisation either in vitro or in vivo.

VIREAD tablets contain the following ingredients as excipients: Core: microcrystalline cellulose (E460), pregelatinised maize starch, croscarmellose sodium, lactose and magnesium stearate (E572). Coating: Opadry II Y-30-10671-A-(ARTG3968).

Each VIREAD tablet is light blue and almond-shaped. Each tablet is debossed on one side with the markings “GILEAD” and “4331” and on the other side with the marking “300”. The tablets are supplied in bottles with screw cap closures.

Tenofovir disoproxil fumarate is a water soluble ester prodrug of the active ingredient tenofovir. Tenofovir is converted intracellularly to tenofovir monophosphate and tenofovir diphosphate. The pharmacokinetics of tenofovir disoproxil fumarate have been evaluated in healthy volunteers and HIV-1 infected individuals. Tenofovir pharmacokinetics are similar between these populations.