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Brigham and Women’s study: Drug-free nasal spray could protect against COVID, flu - Published Sept 25, 2024

The problem with such drugs is that they do not and cannot work in the throat and lung, other notable infection sites of both these viruses. Masking remains the best way to protect yourself from airborne pathogens, but this is an interesting development for prophylaxis. Studies have shown that neuro-covid symptoms are worst for people whose ACE2 receptors in the sinuses were infected. This could help combat that. The idea that it could also offer drug-free protection from allergens is also interesting. Further study is needed.

By Grace Zokovitch

A new study found a new drug-free nasal spray may protect against respiratory infections like COVID and the flu, according to Brigham and Women’s Hospital.

“The COVID pandemic showed us what respiratory pathogens can do to humanity in a very short time,” said Jeffrey Karp, co-senior author of the study and chair in Anesthesiology at Brigham and Women’s Hospital. “That threat hasn’t gone away.

“We need new, additional ways to protect ourselves and reduce the transmission of the disease,” Karp added.

The preclinical studies show the nasal spray called Pathogen Capture and Neutralizing Spray or PCANS may be able to block respiratory illnesses, the hospital announced. The study was done out of Brigham and Women’s Hospital and published in the journal Advanced Materials.

The hospital stated that protection methods like vaccines and masks can be beneficial but aren’t perfect, noting that “influenza and COVID-19 infections cause thousands of deaths and hundreds of thousands of cases of severe disease every year.”

Most viruses enter through human’s noses, the release stated, spreading when infected people breathe out tiny droplets of fluid. Healthy people inhale the droplets, the hospital said, infecting “cells that line the nasal passageways.”

Researchers formulated the nasal spray to stop the infection in the nose using ingredients that the FDA has approved for use in other nasal sprays or determined safe. The spray was tested in a laboratory setting using replicas of human noses and mice and has not been tested on humans.

“We developed a drug-free formulation using these compounds to block germs in three ways — PCANS forms a gel-like matrix that traps respiratory droplets, immobilizes the germs, and effectively neutralizes them, preventing infection,” said co-senior author Nitin Joshi, an Assistant Professor of Anesthesiology.

When sprayed in a nasal cavity replica, the release stated, “PCANS captured twice as many droplets as mucus alone.” Mice treated with the spray showed it block the influenza virus at 25 times the lethal dose, giving them “complete protection,” researchers said.

“PCANS forms a gel, increasing its mechanical strength by a hundred times, forming a solid barrier,” said primary author John Joseph, a former postdoctoral fellow at Brigham and Women’s Hospital.

“It blocked and neutralized almost 100% of all viruses and bacteria we tested, including Influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more.”

Researchers added that the inflammatory cells and cytokines in the lungs of animals treated with the spray were “normal.”

The hospital stated that the study “provides a strong foundation for future research” into PCANS and researchers are already exploring whether the spray may block allergens.

[mageofsleep]

Let's play a game. ♦️♠️

[mageofsleep]

Hope Mike Parsons never knows a day of fucking peace

[mageofsleep]

Thinking Renko is a direct granddaughter-grandmother descendant of Sumireko is a giant leap to me. Do these people honestly think Sumireko would calm down enough to not only get married to (presumably a man but who knows science is wonderful), stay in that marriage, and have kids? She is the estranged childless great-aunt of the situation, I cannot see it another way.

the thing is that i could have seen sumireko chilling out and becoming a regular adult with a stable marriage if she hadn't been told at the age of 16 that actually she was completely right about everything. that completely fucked up all her possible chances of integrating into society in a normal way. she has to be the weird estranged great-aunt. she simply has to be.

[mageofsleep]

Can you fucking imagine knowing not only exactly when you'll die, but also knowing you will become GOD after you die, and you are 13 years old

[mageofsleep]

Elegant Maid Izayoi Sakuya

[mageofsleep]

[mageofsleep]

Please do not neglect my letter and I am really sorry to ask for help from you I want you to help us, to get through the suffering of this war, we need money in order to be able to buy the simplest requirements of life and treatment everything is expensive my family consists of Mariam 12 years old, my father is 80 years old with a stroke and needs treatment and physiotherapy 100 dollars at a time twice a week mom is 69 years old with chronic diseases, I have no source of income and I am the person who supports them we want to live, I want to give Mariam , dad and mom a better life. Help us get through this ordeal I trust in your humanity and I ask you to participate in my campaign and donate to me

My campaign was checked by 90 ghosts

https://gofund.me/a8383601

[mageofsleep]

who the fuck taught her that word

[inspiration]

[mageofsleep]

rich of this website to be weird little freaks about poly people existing. do the three weed-smoking girlfriends mean nothing to you people?

[mageofsleep]

Hello dear .. My name is Abdul Rahman Halas, married to the martyred journalist Alaa Al-Dahdouh. My journalist wife works for the Watan News Agency and we had a beautiful child named Karam. The real disaster began on Wednesday, May 31, 2024, when my wife, my child and I were surprised by a huge missile that fell on us and exploded in the place where we were, targeting the house we fled to and other neighboring houses

. At that moment, my journalist wife Alaa hugged our child Karam to protect him from the hell of the missile, but she turned into pieces and died immediately. My child Karam and I miraculously escaped certain death when the pressure of the missile threw me a long distance, which resulted in me being injured by numerous shrapnel and multiple injuries that led to severe fractures in my leg and damage to the nerves in my hand and foot and various shrapnel in different parts of my body

. My wife is a journalist covering the crimes of genocide against defenseless civilians in the Gaza Strip. With the intensification of the bombing and the scarcity of food and water, my wife and I struggled daily to secure food for our only child Karam, who was also suffering from severe fear because of The brutal bombing of the Gaza Strip.

Now after the disaster that befell my family, I need your generous support to overcome my ordeal and pay for my treatment and surgeries. I need several surgeries outside the Gaza Strip that cost a lot of money, and I am in dire need of your tears and support.

I am confident that after reading my sad story, you will sympathize with me and share with me and will not leave me and my child Karam alone.

Donate to me or share my campaign with your friends to donate to me

No matter how small your donation is, it means to me a chance for me and my child to be treated and to stay safe.

[mageofsleep]

a day used to be 24hrs and cost $5 but nowadays a day only lasts 5hrs and they charge ya $20 just to live it. and you have to pay with an app

[mageofsleep]

🆘🆘SToP Don't SKiP🇵🇸

A small donation can make a big difference 🙏🍉🇵🇸

I am Noureddine from Gaza, I am 32 years old, and I stand before you as a person trying to achieve healing.

I am married and the father of two children. My wife gave birth to my second son, 4 months old, in the war

He was born during the war and in very harsh conditions that no human being can bear. Our family moved from the hospital directly to the tent, and I cannot describe the extent of the suffering and difficulty of living in the tent

‎We have been forced to go to Al-Hawl more than 7 times, and the burden has been completely lifted, and there is not enough cheese, medicine, and vitamins for my children. Now he specializes in the livestock in Khan Yunis, south of the Gaza Strip, in the tent. Life is very difficult in the tent, there are harmful insects.

It is difficult for me to find the words to describe what we face every day in Gaza. No food, no medicine, no clean drinking water, oppression, helplessness, psychological pressures, doubts, and daily trauma due to the loss of loved ones. In Gaza, it's not just hunger and fear; Rather, it means actual death.

During the ten months, I have no source of income at all.

Every day I struggle to bring in food for my children

@90-ghost @appsa @

[mageofsleep]

welcome to synthesizer v! specify your gender in domain {x∈ℚ | -1 ≤ x ≤ 1}

[mageofsleep]

I will cross an orbit, time is tinted silver

[mageofsleep]

i think ppl in the imperial core especially need to stop thinking of things like petitions as communicating our wishes to our politicians, and start thinking of them as threats by which we enforce our demands

[mageofsleep]

“Communism will definitely work this time, guys, trust me! It’s just that no one else ever did proper communism, and we’re completely immune to making any mistakes or having any flaws in our system!”

I’m just saying, historically it hasn’t worked out. The Soviet Union collapsed, China isn’t communist in any practical way, and North Korea is the laughingstock of the world, even among its allies.

Cool. Maybe it hasn't worked for your bourgeoisie ass but it sure has for mine.

We were 500 million peasants until the CPC came and turned that around. In Shanghai arguably the richest city in China, before the revolution, people would die in scores in the streets and designated people had to come around and collect bodies. Before 1949 no steel was produced in China. The average lifespan in China was 36 years. The Soviet Union turned a backwaters feudal monarchy into the second strongest nation on the planet in 50 years. It electrified and motorized a nation which only a couple decades earlier were serfs. The Soviets killed millions of fascists and was the leading power in defeating the nazis. It was the communists who kicked out the french and usamericans in Vietnam. It was the communists who kicked out the fascists in Yugoslavia and built a multiethnic nation.

Communism has worked wonders that liberals can only dream of and they have never forgiven us for it. You just don't see the lifting of the poorest people up as success and that speaks volumes to your class allegiance. You are not the target audience of communism. You are a labor aristocrat at best; a traitor and an enemy to the working people the world over.