onyekaagwu-blog

[onyekaagwu-blog]

Here is an overview of my Botanical Kombucha Analogues Project. If you need any clarification please ask your questions in the Discussion box!

[onyekaagwu-blog]

ABSTRACT

Computational Modeling of Bioactivity in Botanical Kombucha Analogues: How to Survive the Post-antibiotic Era Using Fick’s Second Law of Diffusion

     A major problem with HIV treatment is that economically disadvantaged individuals can't afford the expensive treatment for several antibiotics. As a result, many people are left to die because of opportunistic diseases. For those that are able to afford the treatment, it soon becomes ineffective because of bacteria resistance to antibiotics. Consequently, many have resorted to Kombucha which was first used in Asia to boost the immune system. Since not enough research has been conducted to study the bioactivity of Kombucha as a possible adjuvant for antibiotics, this study has been dedicated to investigate the antimicrobial activity of Kombucha analogues using various medicinal herbs. Bioactivity was determined by agar-well diffusion using Escherichia coli and Citrobacter freundii. The herbal leaves used to supplement the Kombucha analogues were Ginkgo, Meadowsweet, and Calendula. Differences between Zone of Inhibition of 100% Kombucha, Chloramphenicol, and treated groups were determined using variance analysis, at a significance level of p < 0.05. Using Fick’s Law of Diffusion the activity of the samples were modeled. Bioactivity was on average greater in the analogs . However, only in Meadowsweet was there significant bioactivity against C. Freundii as compared to the other herbs because it had a p-value <0.05. This suggests the presence of a chemical in the herb with greater antimicrobial activity. Experts are searching for a safe and effective alternative to antibiotics. Though Kombucha may not be as bioactive as Chloramphenicol, I have developed botanical Kombucha mixtures that are effective against multiple strains of bacteria.  

Computational Modeling of Bioactivity in Botanical Kombucha Analogues from onyaagwu