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A bit of information on DMT

DMT, or N,N-Dimethyltryptamine, is a psychoactive chemical alkaloid that occurs naturally in both plants and animals, from exceedingly simple underwater organisms, to large, complex, and intelligent land mammals. DMT is also the primary active hallucinogenic compound in Ayahuasca, which is a psychotropic brew consisting of Banisteriopsis caapi and Psychotria viridis among other plants. Ayahuasca has been used for ritual purposes by indigenous people in the Amazon rainforest for hundreds, if not thousands of years.

People also ingest DMT in crystal or "freebase" form, smoking it in a pipe. bong, or more recently vaporizer cartridges. This form of ingestion produces a powerful but short-lasting hallucinogenic state, considered by many to be one of the most intense psychedelic experiences in existence.

DMT is also a fundamental "building block" of many other psychedelic substances, including psilocybin (4-PO-HO-DMT) and it is structurally analogous to both serotonin and melatonin. This similar structure is what it allows to bind with 5-HT (serotonin) receptors and cause physiological effects.

Many often confuse N,N- DMT with 5-MeO-DMT, or 5-Methoxy-N,N-Dimethyltryptamine. 5-MeO-DMT looks exactly like N,N-DMT on both a macro and micro level, but the former has a few extra atoms attached. Although these two substances are nearly chemically identical, the experience can be significantly different. At the moment, you can only buy N,N- DMT from Psychedelia.io, however we plan to offer 5MeO-DMT in the coming months.

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The DMT Experience

DMT becomes psychoactive when a dose of 0.2 mg/kg or higher is ingested. When smoked or vaporized DMT is a very fast-acting substance with the "peak" of the experience occurring between 2 and 4 minutes after ingestion, and completely resolving within 15 to 20 minutes. When taken orally (ayahuasca brew), the effects can take up to an hour to appear and may last for up to 12 hours. It's important to note that DMT on it's own is not orally active (meaning you will not feel any effects if you eat or snort it) but when combined with Banisteriopsis caapi (which is an MAO inhibitor) it can be orally psychoactive.

Mixing DMT into the liquids found in vape pens is a newer form of ingestion with significant benefits - namely the ease of consumption. Because the intensity of DMT depends on the dose, vaping it can cause hallucinations that are as or more intense than consuming it in more traditional ways, as long as proper dosage is received within a short period of time (this sometimes takes several "pulls" or "hits" on a DMT vaporizer).

Low doses (0.05 to 0.1 mg/kg) of DMT primarily affect physical and emotional states with few to no perceptual hallucinations. For most people this is between 10-20mg of freebase DMT

High doses (2.0 to 3.0 mg/kg) of DMT will produce rapid, often rotating or pulsating, kaleidoscopic images filled with rich and vividly coloured abstract patterns. Auditory hallucinations are less common and usually aren’t a very prominent feature of the experience but have been reported. For most people this is between 30-40mg of freebase DMT

Out-of-body experiences (defined as the dissociation of awareness from the physical body) are also commonly reported with high doses of DMT, and this is actually considered one of the "hallmarks" of a high-dose DMT experience.

In his 2000 book, The Spirit Molecule, psychedelic researcher and psychologist Rick Strassman describes studies during which approximately half of the study subjects reported interactions with “intelligent beings”, “entities”, “aliens”, “guides” or “helpers”. Ethnobotanist and psychonaut Terrence McKenna called these beings “machine elves.” According to Strassman’s work, they take the form of “clowns, reptiles, mantises, bees, spiders, cacti, and stick figures.” They have also been described on several online forums as being "made of geometric patterns".

DMT Pharmacology

Dimethyltryptamine is primarily a serotonin (5-HT) receptor agonist, with the highest affinity for the 5-HT2A receptor in specific. It does affect many other receptor types (including dopamine and sigma receptors), but the consequences of these interactions are not well understood.

In a study that administered low, medium, or high doses to 12 volunteers, the psychedelic threshold for DMT was found to be 0.2 mg/kg. At this level, most biological effects were detectably altered. Adrenocorticotropin hormone, beta-endorphin, prolactin, growth hormone (GH), and cortisol were all elevated. Pupil diameter, heart rate, and blood pressure all peaked within 2 minutes of administration, as did subjective experiences. A later trial found that the body does not build a tolerance to DMT, meaning there’s no need to take more to repeat the same effects, unlike other psychedelics such as LSD and psilocybin.

To learn more, check out https://psychedelia.io