sickandvomiting

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This one is for my snzfuckers out there, seen in the wild (on FB, not mine) and absolutely obscene

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Felt bad for the torment, here’s a little happy

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Just off my most recent M*A*S*H watch through, and as the Goodbye, Farewell, and Amen anniversary was not too long ago, I wanted to do my own little tribute.

Charles and Father Mulcahy are character who are written very differently, but both rely on music (in their own ways) to keep their sanity throughout the war. And in the end, they both lose their connection to it in different ways. After Charles works with the Korean POW musicians on the Mozart quintet (pictured), and they are killed, the safety of his connection to music is shattered, and all he can think about when listening is the violence and bloodshed. This is explicitly addressed in the finale.

However, Father Mulcahy’s loss is not. Yes, they address his going deaf after the explosion, but throughout the entire show he is shown playing the piano, singing, writing war songs. His connection to music is much less emphasized, but it persists through the entire series, and although he may not be a technical prodigy, it brings him joy. And then he loses it, along with the ability to take confessions, and a number of other facets of his job and life that gave him meaning and brought him comfort. Earlier in the show, during a particularly difficult moment, he is consoled by his colleagues performing Dona Nobis Pacem (also pictured). After he loses his hearing, he begins to question God. “Are you Deaf too?” I think this shaken faith and may have festered into an anger that contributed to his problems after the war (he was shown struggling in AfterMASH).

Anyways! Enjoy my angst fest (also I am VERY open to requests, especially for this show rn)

(I’m just gonna tag a few people I thought might like these (I’m a long time lurker, despite the lifelong love of the show) @major-charlie @thebreakfastgenie @statictwoo @hawkeye-pierce-4077 @frankburns-eatsworms

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Whumpee with a sinus infection BEGGING their caretaker for a warm towel to lay across their eyes. Their cheekbones hurt. Their forehead hurts. So do their teeth and ears. Their head feels so heavy, the throbbing driving them mad.

A warm towel would feel so good... and then caretaker approaches them, the heated fabric feeling like heaven. It feels so nice that whumpee shivers slightly, pleased.

"Is your fever worsening, whumpee? You're trembling."

"Maybe. Or maybe you're just really good at taking care of me."

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Did anyone make this meme before?

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Damn I cannot BELIEVE that this fucking game gave me a lovers to enemies amoral hot elf AND they whumped him

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I sometimes get on my separate main blog where it feels like I’m just screaming into the void and then I come back to this one and all my little phone friends are here and people have interacted with shit in my absence and it just makes me happy!!

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bring back tumblr ask culture let me. bother you with questions and statements

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If you're reading this, give your blorbo meningitis

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If anyone has any art prompts / scenarios for any of the things that were in the art poll, please send them my way! My big exam is tomorrow so I’ll have a little extra time this coming week, might try and do a lil sumn sumn, and the best way for me to motivate is to get Inspired™️

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Yeah, absolutely don’t let it stop you! There are so many different varieties of sex and ways to engage in it that no matter what you write, if it works for you, you’re golden! Personally I typically write sex differently than most allos would as well, but the beauty of writing is that it can be whatever you want it to be! And if you’re concerned about realism, there are plenty of allos out there to consult, if you feel comfortable with doing so

gods I just saw an nsfw story with "virgin asexual author" as a content warning tag and idk as an aroace smut writer who just doesn't do that shit irl it was. kind of funny. maybe I should slap that in all my fics as a warning lmao.

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Did I, upon first watching it years ago, make a whole thing in my head of him coming down with something in the following days and, being essentially strangers, Vikt/or does not know how to handle it really but the situation brings them closer together? Yes. Do I have the energy or confidence to actually write it out? No 😭. Does it still live in my mind rent free? Absolutely.

Hey Jay/ce fans...remember this scene. 😏

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Semi-related, but one time @lickstynine and I were writing together live on a Google doc and we got to a sex scene and he watched the cursor abruptly stop, and after about a minute and a half of starting sentences and erasing he had to be like “you want me to get this one, bud” and I was like GOD YES THANK YOU

gods I just saw an nsfw story with "virgin asexual author" as a content warning tag and idk as an aroace smut writer who just doesn't do that shit irl it was. kind of funny. maybe I should slap that in all my fics as a warning lmao.

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Ooh I actually know a little bit about this!

Little bit of molecular cell biology: there are cell surface transmembrane receptors called G-protein coupled receptors, or GPCRs, that are abundant pretty much everywhere and allow for intracellular signaling that is triggered by molecules that don’t actually enter the cell (like many neurotransmitters and hormones). The most relevant of these here is a GPCR that is bound to the G-alpha-q, or Gq, a heterotrimeric G protein that when activated by the GPCR will in turn dissociate into a few pieces. The alpha subunit, now active, interacts with an enzyme called phospholipase C, turning it on. Phospholipase C then cleaves a plasma membrane lipid called PIP2 into two secondary messengers that have further downstream effects. The first of these is IP3, which is freed from the membrane and floats through the cell to the endoplasmic reticulum, where it triggers the release of the calcium inside (there’s one part of your calcium involvement! Calcium itself is a potent second messenger). The other second messenger produced is a diacylglycerol (DAG) that is still stuck in the membrane but will activate a different enzyme called protein kinase C, or PKC, using some of the released calcium. PKC will then phosphorylate a bunch of different intracellular enzymes, either activating or deactivating them, and causing huge downstream effects.

So!! All of that being said and done, now we’re stuck with a bunch of free IP3 and DAG, so we need to regenerate the original lipid, PIP2. There is a long series of events to get there, but towards the end, you are left with something called inositol monophosphate, or IMP, or myo-inositol-monophosphate. In order to fully regenerate the PIP2 to be used in a new signal proliferation cascade, we need something to whack off that last phosphate group and free the myo-inositol.

Enter: inositol-monophosphatase, or IMPase.

IMPase has, we believe, a magnesium binding site on it, that, when occupied by lithium, inhibits it, thereby making it more difficult to initiate a signal / longer to regenerate the molecules needed for strong signal proliferation. This is especially important in the brain, as we will see in a minute.

So in the brain there is a protein called calbindin, that (as you might guess) binds calcium in the cytosol. Calbindin is very common in neurons in the hippocampus, prefrontal cortex, temporal cortex, and anterior cingulate gyrus (so memory, emotion, inhibition, attention, complex learning, sensory processing, emotional processing, and behavior regulation, oooooooh). The protein is especially highly expressed in dendritic spines that depend on phosphadtidyl inositol for signaling between each other, and has been shown to amplify IMPase activity multifold, which shows the importance of this particular enzyme in these regions. Therefore, if lithium inhibits IMPase, it will decrease signaling in the regions listed above.

They are still doing research on why exactly it works and everything, but this is the general idea that they have so far, which is pretty cool!

Thanks for reading my nerd novel

I was doing some research into lithium and everything I found said we don't know how it works?

Like, we're pretty sure it increases serotonin, but we're not sure why or what the mechanism is. We're very sure it's not an SSRI.

(please correct me if I'm wrong on any of these, I only did very cursory research onto it. It made me almost throw up and i got depressed for an hour when I drank lithia water in ashland, or when I was a kid and I was curious. I'm pretty sure excess serotonin makes me depressed, so these findings weren't surprising to me.)

Yeah, we basically know it does something with calcium channels in the brain, which helps regulate some neurotransmitters. But like, how it specifically treats bipolar disorder and some forms of depression we don't really know.

But honestly this is not uncommon in medicine. Especially with older drugs, the drug came first and we learned what it worked for, and then later we figured out how and why it worked. We still don't really know how acetaminophen (Tylenol, paracetamol) works, despite it being one of the most commonly used drugs worldwide. Or, like, we know a little about how it might work but the exact mechanism is unclear, like for things like modafinil, cannabidiol, methocarbamol, lamotrigine, memantine, alcohol, metformin, ketamine, some general anesthetics, topiramate, etc...

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Why do I only have the motivation to make art when I have no time for it? Why must fate play such cruel jokes?

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we should call it this again

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Do you know Good Omens? sweet Angel and adorable gay Demon. I would love to see a Fanart Sick Azi or Crowley in your wonderful style. Absolutely no obligation, I do not want to be rude! I love your art so much, it's so beautiful.

Thank you so much!! I do love those characters, so I will add them to the potential list! Though with everything going on with Neil, I’m not sure whether it would be in poor taste. But I do absolutely love the series, so definitely it goes on the “might do” list!!

If you have any specific scenarios floating around, I work almost entirely off inspiration so if I’m inspired and I have time, I am WAY more likely to actually sit down and work haha