#Also you're supposed to label pictures and add links to them

[wolfjackle]

Hey guys, so I'm a pharmacist in the US and this is desperately needed! I'm gonna tag on a ton of information about dangerous supplements and herbal remedies. Sorry, not sorry.

When I was doing my clinical rotations as a pharmacy student, I spent 10 weeks in a hospital as was required for all students in my state. My preceptor was an amazingly intelligent guy who I ended up having all to myself despite the fact that he was supposed to have 2 students. We had a patient one day who was in his twenties. He was in for liver failure. Want to know why? Supplements. I believe in his case, it was supplements designed to help build muscle. Some of those from the GNC store. My preceptor told me that basically every single time a young person gets admitted to the hospital for liver failure, it's due to supplements. And there's no recourse. The company that makes them only has to give the barest proofs of safety to the FDA.

But, hey, anyone can OD on an OTC. You can get liver failure from Tylenol/acetaminophen/paracetamol (depending on which name is used in your country), too!

Alright, let's look at another supplement. St. John's Wort. Ever heard of that one? It's promoted as being good for depression and mood. And, you know what, it works! It works so well that back in the 50s or whatever, scientists figured out a way to isolate and purify it and we got our first class of antidepressants ever: tricyclic antidepressants! Most common TCA is Amitriptyline. Only....we don't use them anymore. At least not as antidepressants. Occasionally, you'll see them as a sleep aid. Why not? Many, many reasons. But mostly interactions and side effects. I'll start with interactions because those are the scariest. Not only do they interact with basically every drug ever, they also interact with a ton of foods. Anything that's been fermented or aged. These are your cured meats like salami or pepperoni. Canned foods. I mean your cheeses and wines. All of those have interactions that lead to the build up of a dangerous amino acid byproduct called tyramine in your body. This buildup can lead to a hypertensive emergency that will hospitalize you. TCAs also have so many side effects. Most obvious is the drowsiness which is why our primary use for them today is as a sleep aid. They aren't addictive like zolpidem (Ambien) at least. But let's look at the other side effects. They can affect eye sight, interfere with urination, give feelings of nervousness or excitability. People generally don't feel great when they're on them. And this is sold as a supplement under the name of St. John's Wort where there is no standardized dosing or oversight. When we make a pharmaceutical out of an herb, we make it better. We get the dosing nailed down, we get rid of impurities that add side effects, and we figure out how to best use it. Even after doing all that, we've decided "let's not" with these drugs! Yet I can buy a bottle of several hundred tablets of it right off the shelf in the grocery store.

And final point. This is brought up by OP and in the linked articles, but I'm gonna restate it. THERE IS NO OVERSIGHT IN THE MANUFACTURING OF THESE PRODUCTS!!!! When you buy a bottle of supplements or vitamins, the only quality testing that has been done on it was done by the manufacturer. And do you think that if they found a quality issue that affected some thousands of bottles of pills that they would just throw out all that product? Of course not! There is literally zero incentive to do that! They just label it and ship it out. Maybe they adjust their process so the next batch is better, maybe not. Some companies do pay a third party to validate their products and I do recommend those. You can be reasonably sure you're getting what the bottle says in those cases. They will have a badge on them that says USP verified. Picture below. These vitamins and supplements usually cost a bit more, but you're talking less than $10 for a bottle of 100 that will last 3 months. If you can, I recommend searching for any brand that has this label. Nature made, nature bounty, and sundown are the 3 most common brands that pay for this extra testing. But be careful, because they only test some of their products, not all.

they're finally doing something about the fact that supplements are completely unregulated and companies can literally just put Whatever in there as long as they call it a supplement and not a drug

you know, this thing, where if you actually test them they're just full of beans

the fake covid cures and other cure-alls peddled by people like alex jones are also able to get away with it due to the way the FDA has been hamstrung

the best way to support this bill is to contact your senator and tell them you are someone who buys supplements and you would like them to not be secretly full of whatever the manufacturer happened to find on the side of the road that day. this is especially helpful if your senator is on the health committee.

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[snebleps]

On one hand I losing my shit how scared I am of doing a presentation, because the professor was out one week and sick the other, so I didn't get to feel out what's the vibe there.

On the other hand this specific presentation is gonna be 0.5% of my final grade so I should not be giving half a shit.

On the THIRD hand, all of my class is gonna see it and oh god what if they think I'm stupid and dumb. Not even for the presentation. But because I don't understand how to correctly format the slides.