#Chronic Idiopathic Constipation Treatment Market

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Chronic Idiopathic Constipation Treatment Market 

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Advancing Gastrointestinal Wellness with Targeted Relief for Chronic Constipation

Plecanatide is a medication that belongs to a class of drugs known as guanylate cyclase-C agonists. It is primarily prescribed for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). As an innovative therapeutic option, plecanatide has shown efficacy in relieving symptoms associated with these gastrointestinal conditions.

The drug works by binding to and activating the guanylate cyclase-C receptors in the lining of the gastrointestinal tract. This activation leads to an increase in cyclic guanosine monophosphate (cGMP) levels, which, in turn, promotes the secretion of chloride and bicarbonate into the intestinal lumen. This enhanced secretion helps to soften the stool, increase fluid content, and stimulate bowel movements, thereby alleviating constipation.

One of the notable advantages of plecanatide is its specificity for guanylate cyclase-C receptors in the intestines. By targeting these receptors locally, plecanatide minimizes systemic effects and reduces the risk of unwanted side effects in other parts of the body.

Clinical trials have demonstrated the efficacy of plecanatide in improving bowel habits and providing relief to individuals suffering from chronic idiopathic constipation and irritable bowel syndrome with constipation. Patients often experience increased frequency of bowel movements, reduced straining during defecation, and an overall improvement in the quality of life.

The safety profile of plecanatide is generally favorable, with common side effects being mild to moderate in nature. These may include diarrhea, abdominal pain, and flatulence. It is crucial for healthcare providers to assess each patient's medical history and individual needs before prescribing plecanatide to ensure its appropriateness and minimize potential adverse effects.

Plecanatide's introduction into the market has provided healthcare professionals with an additional tool to address the challenges associated with chronic idiopathic constipation and irritable bowel syndrome with constipation. Its mechanism of action, focusing on the gastrointestinal tract, underscores the importance of targeted therapies in managing specific conditions, thereby minimizing systemic impact.

As with any medication, patients should use plecanatide under the guidance of a healthcare professional. Individuals with a history of bowel obstructions, severe gastrointestinal conditions, or allergies to plecanatide components should exercise caution and inform their healthcare provider. Regular follow-up visits and open communication between patients and healthcare providers are essential to monitor the medication's effectiveness and manage any potential side effects.

In conclusion, plecanatide represents a valuable addition to the therapeutic options available for individuals suffering from chronic idiopathic constipation and irritable bowel syndrome with constipation. Its targeted approach, activating guanylate cyclase-C receptors in the intestines, offers a tailored solution to address these specific gastrointestinal conditions, providing relief and improving the overall quality of life for patients.

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The report, the global chronic idiopathic constipation treatment market was valued over US$ 7.8 Bn in 2021. It is projected to expand at a CAGR of ~7% from 2022 to 2030

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Analysis of the Chronic Idiopathic Constipation (CIC) market size, share, outlook, and opportunity, 2018-2026

Analysis of the Chronic Idiopathic Constipation (CIC) market size, share, outlook, and opportunity, 2018-2026

Constipation is a condition in which stool frequency decreases to three times per week and transit of stool becomes difficult. Constipation is a common functional gastrointestinal disorder that can disrupt a patient’s life. Chronic idiopathic constipation is the development of persistent constipation symptoms with no well-defined underlying cause. Chronic idiopathic constipation is characterized…

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Chronic Idiopathic Constipation (CIC) Treatment Market Till, 2018-2026 - New Study By Coherent Market Insights

Constipation is condition wherein the stool frequency reduces up to three times per week with difficulty in stool passing. Chronic constipation is a highly common functional gastrointestinal disorder that adversely affects patient’s life. Chronic idiopathic constipation is defined as the presence of chronic symptoms of constipation with no well-defined underlying cause. The symptoms of chronic idiopathic constipation includes infrequent bowel movements, hard stools, straining during defecation, feeling of incomplete evacuation, abdominal discomfort, and bloating sensation. Chronic idiopathic constipation is diagnosed by laboratory tests, endoscopy, radiological tests, magnetic resonance imaging, and physiological testing. Currently, very few approved treatment options are available for chronic idiopathic constipation, which is expected to be a major factor restrain growth of the chronic idiopathic constipation treatment market. However, this gives opportunity for the market player to come up with the novel treatment to grab the foothold in growing chronic idiopathic constipation treatment market.

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Chronic Idiopathic Constipation (CIC) Treatment Market Dynamics

Increasing clinical trials and approval of drug candidates by pharmaceutical companies to fulfil unmet medical needs of the chronic idiopathic constipation treatment is a key factor driving the market growth over the forecast period. For instance, March 2018, Shire plc received new drug application from U.S. FDA for its drug candidate, SHP555 (prucalopride) for the indication of chronic idiopathic constipation in adults. Moreover, in 2015, SHP555 (prucalopride)received approval from European Commission for the symptomatic treatment of chronic constipation in adults with failure of laxative treatment. Furthermore, Renexxion is conducting phase 2 clinical trial for Naronapride (ATI-7505) for the treatment of multiple gastrointestinal disorders, which includes chronic idiopathic constipation. In 2017, FDA approved Ironwood and Allergan’s Linzess (linaclotide) for the treatment of chronic idiopathic constipation. However, 50% of patients with chronic constipation dissatisfied with their current treatment, mainly because of the lack of efficacy, which highlights a continued medical need for more effective and safer therapeutic agents.

However, the use of alternate therapy such as home-based remedies and herbal medication such as herbal laxative, probiotic foods etc. are expected to be major factors hindering the chronic idiopathic constipation treatment market growth.

Chronic Idiopathic Constipation (CIC) Treatment Market – Regional Analysis

Regional segmentation of chronic idiopathic constipation treatment market by Coherent Market Insights includes North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America chronic idiopathic constipation treatment market holds dominant position owing to high percentage of population suffering from chronic constipation. For instance, according to European Journal of Pharmacology, 2017, in the U.S. 12%–19% of population suffers from chronic constipation. This is expected to aid in growth of the market in the region over the forecast period. However, Asia Pacific is expected to witness the fastest growth, owing to increasing prevalence of constipation in the Asian countries. According to Journal of Neurogastroenterology and Motility article 2016, in Asian countries such as China, Korea, Hong Kong, and India, the prevalence of constipation reportedly ranges from 8.2% to 16.8%. This is expected to support growth of the chronic idiopathic constipation treatment market size over the forecast period.

Chronic Idiopathic Constipation (CIC) Treatment Market – Competitive Analysis

Key players in chronic idiopathic constipation treatment market are Ironwood Pharmaceuticals, Allergan, Synergy Pharmaceuticals, Inc., Shire plc, and Mallinckrodt plc. The presence of very few market player provides wide opportunity for new entrant in chronic idiopathic constipation market. Moreover, in February 2018, Mallinckrodt plc, global specialty pharmaceutical company, announced acquisition of Sucampo Pharmaceuticals, Inc., a biopharmaceutical company. The acquisition assets includes its FDA approved blockbuster drug Amitiza (lubiprostone) for the treatment of chronic idiopathic constipation (CIC) in adults, irritable bowel syndrome with constipation (IBS-C). The Sucampo Pharmaceuticals, Inc. also partnered with Par Pharmaceuticals, Inc. and Dr. Reddy’s Laboratories Ltd. As a part of the agreement both the partners were granted a non-exclusive license to market Par’s generic version of lubiprostone in the U.S. from January, 2021. Such inorganic strategies of market players are expected to boost growth of the market significantly over the forecast period. In 2012, Ferring Pharmaceuticals acquired the rights for development and commercialization of Elobixibat, first-in-class compound for chronic idiopathic constipation from Albireo AB, a Swedish biotechnology company. Further, in 2013, Ferring Pharmaceuticals, initiated phase III clinical trials of Elobixibat.

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Global Analysis On Chronic Idiopathic Constipation Treatment Market Based On Current Market Trends And Future Insights

 Chronic Idiopathic Constipation Treatment Market

·         The global chronic idiopathic constipation treatment market is segmented on the basis of route of administration, drug class, distribution mode and end-users

·         The report covers in-detail insights about the competitor’s overview, key findings and their key strategies

 Chronic idiopathic constipation (CIC) is a gastrointestinal disorder which is due to difficulty in defecating. Since it is chronic the symptoms are worse which include gastric pain, bloating, abdominal discomfort, hard stool, incomplete evacuation and strain during the bowel movement. Since the cause is unclear, however it can be cause due to neurological, psychological and psychosomatic conditions. It is a major problem occurring to the adults or geriatric people.

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 Factors such as increased cases of chronic idiopathic constipation due to change in lifestyle and food habits, rise in awareness about the CIC treatment, increase in the demand for CIC drugs, and availability of the over-the-counter CIC drugs in the market are driving the CIC treatment market. Moreover, various pipeline drugs for the CIC treatment and frequent product approvals from various drug regulatory bodies are propelling the market. However, lack of physiological symptoms for the disease and less number of drugs available for CIC treatment are the factors anticipated to hinder the growth of CIC market.

The Chronic idiopathic constipation treatment market is divided into following categories-  

1.      Drug class

·         Emollients

·         Laxatives

·         Bulk-forming agents

·         Chloride channel activators

·         Osmotic products

·         Others

2.     Route of administration

·         Oral

·         Parenteral

3.      Distribution mode

·         Prescription mode

·         Over-the-counter drugs

4.     End-users

·         Hospital pharmacies

·         Retail pharmacies

·         Online pharmacies

·         Drug Stores

And lastly, on the basis of geographical regions, the global Chronic Idiopathic Constipation (CIC) treatment market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa.

North America has a significant share in chronic idiopathic constipation treatment market owing to increased cases of CIC disease, change in lifestyle, recent FDA approvals for CIC treatment drugs, an increase in healthcare expenditure.

In Europe, increase in ageing population, rise in R&D activities for CIC treatments, availability of over-the-counter CIC drugs, an increase in per capita income might bolster the market. However, Asia-Pacific exhibiting lucrative growth owing to the rise in geriatric population, an increase in adoption of CIC treatments.

Some of the key players in CIC treatment market are GlaxoSmithKline Plc. (U.K.), Bayer AG (Germany), Allergan Plc. (Ireland), Ironwood Pharmaceuticals, Inc. (U.S.), Astellas Pharma, Inc. (Japan), Sanofi S.A. (France), and  Pfizer, Inc. (U.S.) to name a few. Some of the market developments include Astellas Pharma, Inc. submitting the Supplemental new drug application in 2017 for Linaclotide for patients with chronic idiopathic constipation in Japan. 

Acquisitions and mergers, product approvals, and product launchings are the key strategies adopted by the companies for increasing their revenue share in the market. For e.g. in 2017, FDA approved Tulane manufactured by Synergy Pharmaceuticals used in the treatment of chronic idiopathic constipation.

 Key Questions Answered

·         What is the current and future CIC market outlook worldwide? What trends are affecting the global market?

·         What is the competitive landscape and market share of major players in the chronic idiopathic constipation globally?

·         What are the key, high growth markets that CIC manufacturers should expand into? Which market segments are growing the fastest?

·         What are the unmet needs with the chronic idiopathic constipation currently on the market? How will emerging technologies fulfil these unmet needs?

·         What is physician perception and market outlook of CIC?

·         What are the challenges and barriers that have hindered widespread adoption of chronic idiopathic constipation?

Reasons to buy chronic idiopathic constipation market Report:

·         Global, regional and country-level analysis and forecasts of the study market; providing Insights on the geographical areas in which this industry is prospering

·         Segment-level analysis on basis of product type, application, colour along with market size forecasts and y-o-y estimations to detect key areas of industry growth in detail

·         Identification of key drivers, restraints, opportunities, and challenges (DROC) in the market and their impact on shifting market dynamics

·         Study of macro and micro environmental factors that affect the market presented in an extensive strategic analyses section containing PESTLE and Porter’s Five Forces Analyses

·         A comprehensive listing of key market players along with company overview, product portfolios, key financial information (subjected to availability), SWOT analysis and Analyst overview to study and sustain the market environment

·         Competitive landscape analysis listing out the mergers, acquisitions, collaborations in the field along with new product launches, comparative financial studies and recent developments in the market by the major companies

·         Expertly devised Market Outlook along with Investment opportunities to provide both individuals and organizations a strong financial foothold in the market

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Chronic Obstructive Pulmonary Disease Treatment Market will touch a new level in upcoming year 2027

Chronic Obstructive Pulmonary Disease (COPD) Market Overview:

Chronic Obstructive Pulmonary Disease (COPD) Market Size is expected to register a CAGR of 4.5% to touch USD 25.7 Billion from 2020 TO 2027.

COPD is a progressive and long-term lung disease which involves thickening and inflammation of the airways. The airways over time become increasingly blocked, thus making it difficult to breathe. Chronic Obstructive Pulmonary Disease comprises of two chronic conditions namely chronic bronchitis and emphysema. The former causes persistent cough combined with mucus and inflammation of airways and the latter is caused through a damage in the lung tissue resulting in shortness of breath. Along with air pollution and tobacco smoke, the other factors that can cause COPD directly or indirectly include dietary factors, poor socio-economic status, impaired lung growth, chronic asthma, poor nutritional status, respiratory infections, smoke from burning of biomass, exposure to passive smoking or second-hand smoking, outdoor pollution and occupational exposure. Besides, there are other factors such as rare genetic disorders and old age that can contribute to the prevalence of chronic obstructive pulmonary disease.

Chronic Obstructive Pulmonary Disease (COPD) Market Top Companies:

Abbott Laboratories (US), Almirall (Spain), Astellas Pharma (Japan), AstraZeneca (UK), Boehringer Ingelheim (Germany), Circassia Pharmaceuticals (UK), GlaxoSmithKline (UK), Novartis AG (Switzerland), Pfizer, Inc. (US), and Teva Pharmaceutical Industries Ltd (Israel) are some of the key players operating in the global chronic obstructive pulmonary disease (COPD) market.

Chronic Obstructive Pulmonary Disease (COPD) Market Segmental Analysis:

The global market for chronic obstructive pulmonary disease (COPD) is segmented into a type of COPD, type of treatment, end-user, and region.

The global demand for chronic obstructive pulmonary disease (COPD) was divided into emphysema and chronic bronchitis, based on type COPD.

The global market for chronic idiopathic constipation medication has been segmented into drugs, surgery, and oxygen therapy, by treatment. The drugs group is further segmented into the bronchodilator monotherapy and anti-inflammatory products. Bronchodilator monotherapy is further sub-segmented into short-acting beta2-agonists (SABAs), long-acting beta2-agonists (LABAs), and anticholinergic agents. The sub-segment of anti-inflammatory drugs is further known as oral & inhaled corticosteroids, and anti-leukotrienes. The surgery segment is sub-segmented into surgery for the reduction of lung volume (LVRS), lung transplantation, bullectomy, and others.

Based on end-users, the global demand for chronic obstructive pulmonary disease (COPD) has been segmented into hospitals and clinics, home care facilities, and others.

Chronic Obstructive Pulmonary Disease (COPD) Market Regional Overview:

Regionally, the global chronic obstructive pulmonary disease (COPD) market is divided into North America, Europe, the Asia Pacific, Latin America, and the Middle East and Africa. North America is projected to capture a substantial share of the global market for chronic obstructive pulmonary disease (COPD) in the forecast period due to the highly advanced healthcare system and growing cases of chronic obstructive pulmonary disease (COPD) in the region. COPD, for example, is the leading cause of death in the United States, affecting 16 million Americans. Emphysema and chronic bronchitis are the two most severe forms of COPD. More than 8.9 million Americans Reliable Source were diagnosed with chronic bronchitis in 2016, and almost 75% of cases included people over the age of 45.

Europe is projected to be second-largest in the global market for chronic obstructive pulmonary disease (COPD) due to its well-developed market.

The Asia Pacific is projected to be the fastest-growing regional market due to the high number of patients suffering from types of chronic wounds and the increasing prevalence of respiratory diseases.

The market for chronic obstructive pulmonary disease (COPD) in the Middle East and Africa is projected to rise gradually due to the growth of the healthcare infrastructure.

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Chronic Idiopathic Constipation Treatment Market 

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Peptide-Based Gastrointestinal Disorders Therapeutics Market Analysis-2027

Peptide-Based Gastrointestinal Disorders Therapeutics Market Regional Analysis

North America Peptide-Based Gastrointestinal Disorders Therapeutics Market is expected to exhibit good growth over the forecast period, owing to presence of major players and adoption of strategies such as mergers and collaborations by them for novel peptide-based therapeutics. For instance, in February 2018, Cipher Pharmaceuticals Inc. acquired exclusive Canadian rights of the U.S. Food and Drug Administration approved drug Trulance (plecanatide) from Synergy Pharmaceuticals Inc. After the acquisition, Cipher Pharmaceuticals Inc. will develop, market, distribute, and sell Trulance (plecanatide) in the Canadian Market.

Asia Pacific peptide-based gastrointestinal disorders therapeutics market is expected to exhibit significant growth over the forecast period, owing to increasing investments made by players in the region to receive approval of novel peptide-based therapeutics. For instance, in 2014, Ironwood Pharmaceuticals, Inc. received US$ 15 million from Astellas Pharma Inc., a Japan-based pharmaceutical company, for initiating Phase III clinical trial of Linzess (linaclotide) in Japan, and receive its approval from Japanese Ministry of Health, Labor, and Welfare in 2016. Ironwood Pharmaceuticals, Inc. and Astellas Pharma Inc. were under strategic partnership since 2009 for developing and commercializing linaclotide in Japan.

Peptides are short chains of amino acid monomers linked by peptide (amide) bonds. Peptide-based gastrointestinal (GIT) disorders therapeutics are drugs that are used for the treatment of various GIT disorders such as short bowel syndrome, chronic constipation, and irritable bowel syndrome. In the recent past, some peptide-based therapeutics such as Trulance, Linaclotide, and Teduglutide received approval for the treatment of GIT disorders.

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Trulance is a guanylate cyclase-C agonist indicated for the treatment of chronic idiopathic constipation in adults. Linaclotide is a 14 amino acid peptide that acts as an agonist of guanylate cyclase C receptors in the intestine. It is a minimally absorbed agonist of guanylate cyclase C receptors in the intestine and is used for the treatment of chronic constipation and irritable bowel syndrome. Teduglutide is a new recombinant analogue for glucagon-like peptide (GLP) -2, a natural occurring peptide, which is secreted primarily by the lower gastrointestinal tract.

Peptide-Based Gastrointestinal Disorders Therapeutics Market Dynamics

Frequent approval and launch of novel peptide-based gastrointestinal disorders therapeutics in key regions is expected to drive the global peptide-based gastrointestinal disorders therapeutics market growth over the forecast period.

For instance, in 2017, Synergy Pharmaceuticals Inc. received the U.S. Food and Drug Administration (FDA) approval for its new drug TRULANCE (plecanatide) 3 mg tablet. This drug is indicated for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

In 2012, Ironwood Pharmaceuticals, Inc. and Forest Laboratories, Inc. received the U.S. Food and Drug Administration approval for its drug called Linzess (linaclotide). Linzess (linaclotide) is a guanylate cyclase-C agonist used for the treatment of adults suffering from irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).

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In 2016, Ironwood Pharmaceuticals, Inc.’s partner, Astellas Pharma Inc., received marketing approval from the Japanese Ministry of Health, Labor, and Welfare for Linzess (linaclotide), and in 2017, Astellas Pharma Inc. launched Linzess (linaclotide) in Japan.

In 2012, NPS Pharmaceuticals, Inc. received approval from the U.S. Food and Drug Administration (FDA) for its drug Gattex (Teduglutide (rDNA origin)). Gattex 0.05 mg/kg/d injection is a new, recombinant analog of human glucagon-like peptide 2, a protein involved in the rehabilitation of the intestinal lining. It is indicated for the treatment of adult patients with short bowel syndrome (SBS) who are dependent on parenteral support. Sucg frequent approval is expected to cather peptide-based gastrointestinal disorders therapeutics market growth in near future.

Furthermore, increasing prevalence of gastrointestinal disorders is expected to rise the demand for peptide-based drugs, which will in turn drive the global peptide-based gastrointestinal disorders therapeutics market growth. For instance, according to the data published by the International Foundation for Functional Gastrointestinal Disorder in 2016, irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder and globally, around 10-15% of the population suffers from IBS.

Peptide-Based Gastrointestinal Disorders Therapeutics Market Key Players

Key players operating in the global peptide-based gastrointestinal disorders therapeutics market include Ironwood Pharmaceuticals, Inc., NPS Pharmaceuticals, Inc., Synergy Pharmaceuticals Inc., Astellas Pharma Inc., Allergan plc., and Cipher Pharmaceuticals Inc.

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Global Opioid-Induced Constipation Treatment MarketAnalysis, Historic Data and Forecast 2020

Opioid-Induced Constipation Treatment Market Reports

Global Opioid-Induced Constipation Treatment Market are the drugs used for its pain relieving properties in non-cancer and chronic pain. The adverse effects associated with the opioids are decreasing gastrointestinal tract’s motility, making patient’s strain, and making of solid discharges. Furthermore, long-term use of opioids cause harm to the sensory system, limits the release of endogenous opioids such as endorphins. Adults are most likely to prone to opioid-induced constipation owing to less immobility, poor diet, and fluid intake. The symptoms associated with the opioid-induced constipation are included dry and hard tools, leathery feeling, painful defecation, bulged abdomen, and loss of appetite.

ALSO READ : https://icrowdnewswire.com/2021/01/06/opioid-induced-constipation-treatment-industry-treatment-outlook-analysis-research-review-to-2023/

The opioid-induced constipation treatment market growing at a significant CAGR due to rise in the aging population using opioid analgesics for chronic pains. Increase in the illicit use of medications, prolonged usage of opioids in the treatment of pain, an increase in the prevalence of cancer is anticipated to boost the global opioid-induced constipation treatment market. Furthermore, launching of newer drugs, growing FDA approvals, positive outcomes in clinical trials, and rise in the healthcare expenditure are expected to propel the opioid-induced constipation treatment market over the forecast period. However, lack of awareness regarding opioid-induced constipation in patients, the absence of treatment innovations, a high cost of newer pharmaceuticals, adverse effects, including nausea, a risk of heart problems and strokes associated with these drugs and unfavorable reimbursement policies expected to hamper the growth of the opioid-induced constipation treatment market.

ALSO READ : http://www.marketwatch.com/story/specialty-insurance-market-key-players-industry-size-trend-share-and-global-growth-opportunities-forecast-to-2026-2021-01-29

The opioid-induced constipation treatment market is segmented on the basis of drug type, formulation type, route of administration, and distribution channel

Based on drug type, opioid-induced constipation treatment market has been segmented into the following

Peripherally restricted μ-opioid receptor antagonists

Non-selective opioid antagonists

μ -opioid receptor antagonists

Locally acting chloride channel activators

Based on formulation type, opioid-induced constipation treatment market has been segmented into the following

Solids

Semi-solids

Liquids

Based on route of administration, opioid-induced constipation treatment market has been segmented into the following

Oral

Parenteral (Subcutaneous Injection)

Based on distribution channel, opioid-induced constipation treatment market has been segmented into the following

Drugstore

Retail pharmacies

Hospital pharmacies

ALSO READ :http://www.marketwatch.com/story/car-rental-market-2021-industry-size-share-price-trend-and-forecast-to-2026-2021-01-27

The Global Opioid-Induced Constipation Treatment Market is in the growing stage, several players are actively engaged in the development of the opioid-induced constipation treatment market products. Major acquisitions and collaborations among companies to commercialize opioid-induced constipation treatment market products to drive the market growth. For instance, in March 2015, the co-commercialization agreement for Movenpick signed by AstraZeneca and Daiichi Sankyo, and in October 2014, the entry of Takeda and Sucampo into a global licensing, development, and commercialization agreement for Amitiza are expected to boost the global opioid-induced constipation treatment market. Launching of new products, approval of new drugs from various regulatory bodies, and pipeline products under clinical trials are the key factors fuelling the growth of the opioid-induced constipation treatment market. For instance, Linaclotide was approved by the FDA in August 2012 and by the European Medicines Agency for the treatment in adults with constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.

Geographically, Global Opioid-Induced Constipation Treatment Market has been segmented into following regions Viz. North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa. North America holds the largest share in the opioid-induced constipation treatment market followed by Europe and Asia-Pacific. North America holds the largest share due to expanding the base of opioid-induced constipation patients, According to the American Society of Interventional Pain Physician, in 2013, the U.S. alone was responsible for nearly 80% of the global consumption of opioids. Europe accounts for the significant share in the opioid-induced constipation treatment market owing to increased demand for opioid analgesics in various European countries such as UK, France, Spain, Germany etc. However, growing elderly population in India and China, and rise in healthcare spending are creating the huge growth opportunity for the players in Asia-Pacific region. Apart from that, Latin America and the Middle East are the potential areas for the growth of opioid-induced constipation treatment market because of the increase in opioid-induced constipation sufferers.

ALSO READ : http://www.marketwatch.com/story/global-hydropower-generation-market-industry-analysis-size-share-growth-trends-and-forecast-2021-2027-2021-01-23

Some of the players in the opioid-induced constipation treatment market are GlaxoSmithKline plc (U.K.), AstraZeneca U.K), Pfizer Inc. (U.S.), SLA Pharma AG (U.K.), AIKO Biotechnology, Inc. (U.S.), Cubist Pharmaceuticals (Merck & Co.) (U.S.), Takeda Pharmaceutical Company Limited (Japan), Boehringer Ingelheim GmbH (Germany), Bayer AG (Germany), Valeant Pharmaceuticals International Inc. (Canada), Abbott Laboratories (U.S.), Purdue Pharma LP (U.S.) Shionogi Inc. (U.S.) and Cosmo Pharmaceuticals N.V. (Ireland) to name a few.

In March 2017, FDA approved Symphonic (Naldemedine) for the treatment of Opioid-Induced Constipation, which was manufactured by Purdue Pharma LP and Shionogi

In March 2016, AstraZeneca announced that it has entered into an agreement with ProStrakan Group, a subsidiary of Kyowa Hakko Kirin Co. Ltd., for the rights to Moventig (Naloxegol) in the European Union (EU)

Report Outline:

The report provides granular level information about the market size, regional market share, and forecast from 2017-2023

The report covers in-detail insights about the competitor’s overview, key findings, and their key strategies

The report outlines drivers, restraints, challenges, and trends that are currently faced by the industry

The report tracks recent innovations, key developments and startup’s details that are working in the industry

The report provides plethora of information about market entry strategies, regulatory framework and reimbursement scenario

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[dbmronkar]

Global ELISA Tests Market is Rising Market to Rapidly Growing $2529.27 million by 2026 with Top Key Players Ortho Clinical Diagnostics, Thermo Fisher Scientific, ZEUS Scientific,  ALPCO, Bio-Rad Laboratories, bioMérieux, Merck KGaA,  BioLegend, LOEWE Biochemica, Creative Diagnostics., Arigo biolaboratories Corp.

Analysis of Global ELISA Tests Market report:

Global ELISA tests market is expected to rise from to an estimated value of USD 2529.97 million by 2026 registering a substantial CAGR in the forecast period of 2019-2026. This rise in the market can be attributed to rising prevalence of cancer, rising ageing population and technological advancements.

Definition:

ELISA Tests (Enzyme Linked Immunosrbent Assay) is a test that identifies detects and measures antibodies, proteins, peptides, hormones in the biological samples. It serves as a diagnostic tool detecting whether sample has antibodies that are related to a particular infectious condition. ELISA is a biochemical reaction in which antigen is adsorbed on a solid surface. ELISA test is used extensively in the diagnosis of HIV, varicella-zoster virus, which causes chickenpox and shingles, rotavirus, Zika virus, syphilis, pregnancy tests, in the measurement of cytokine, soluble proteins etc. ELISA is mostly used as screening device prior to in-depth tests.

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Leading Key players profiled in this report are:

Few of the major market competitors currently working in the ELISA tests market are Ortho Clinical Diagnostics, Thermo Fisher Scientific, ZEUS Scientific, Inc., ALPCO, BD, Bio-Rad Laboratories, Inc., bioMérieux SA, Enzo Life Sciences, Inc., Merck KGaA,  BioLegend, Inc., LOEWE Biochemica GmbH, Creative Diagnostics., Arigo biolaboratories Corp., ELISA Technologies, Inc., RayBiotech, Inc., R&D Systems, Inc., AESKU.GROUP GmbH & Co. KG, Cell Technology., Arbor Assays, Eurofins Scientific and Biogenuix amongst others.

Market Drivers

·        The rising prevalence of cancer due to unhealthy lifestyle, lack of exercise and increased consumption of drugs and alcohol, would foster the growth of enzyme-linked immunosorbent assay (ELISA) testing market

·        Rising expenditure in R&D activities in the drug discovery market would boost the growth of this market

·        Rising ageing population enhances the growth of this market as they are more prone to communicable and non-communicable diseases such as cardiovascular disease, lung disease, and cancer, which drives the demand for the prevention, diagnosis, and treatment of such diseases

·       Advancements in technology and automations in the healthcare industry would drive the growth of this market

Market Restraints

·        Lack of availability and cost-effective diagnostic tests hinders the growth of this market.

·        Substitution by new technologically advanced techniques including multiplex proteomic array platforms would restrain its growth

Global ELISA Tests Market Segmentation:

By Test Type

·        Direct ELISA

·        Sandwich ELISA

·        Indirect ELISA

·        Multiple & Portable ELISA

·        Competitive ELISA

By Application

·        Immunology

·        Inflammation

·        Diagnostics

·        Vaccine Development

·        Toxicology

·        Drug Monitoring & Pharmaceutical Industry

·        Transplantation

·        Infectious Diseases

·        Cancer

·        Protein Quantitation

·        Other

By Technology

·        Chemiluminescent

·        Colorimetric

·        Fluorescent

By End-User

·        Hospitals & Diagnostic Centers

·        Research Laboratories

By Geography

·        North America

·        South America

·        Europe

·        Asia-Pacific

Company Share Analysis:

Global ELISA tests market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of ELISA tests market for global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

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The Global ELISA Tests Market report provides the global market size of the main players in each region. Moreover, the report provides knowledge of the leading markets players within the Global ELISA Tests Market. The industry changing factors for the market segments are explored in this report.  This analysis report covers the growth factors of the worldwide market based on end-users. Market opportunities and recommendations for new investments are also encompassed in this report.

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[dbmronkar08]

Global ELISA Tests Market is Booming Market to Rapidly Growing $2529.27 million by 2026 with Top Key Players Ortho Clinical Diagnostics, Thermo Fisher Scientific, ZEUS Scientific,  ALPCO, Bio-Rad Laboratories, bioMérieux, Merck KGaA,  BioLegend, LOEWE Biochemica, Creative Diagnostics., Arigo biolaboratories Corp.

Analysis of Global ELISA Tests Market report:

Global ELISA tests market is expected to rise from to an estimated value of USD 2529.97 million by 2026 registering a substantial CAGR in the forecast period of 2019-2026. This rise in the market can be attributed to rising prevalence of cancer, rising ageing population and technological advancements.

Definition:

ELISA Tests (Enzyme Linked Immunosrbent Assay) is a test that identifies detects and measures antibodies, proteins, peptides, hormones in the biological samples. It serves as a diagnostic tool detecting whether sample has antibodies that are related to a particular infectious condition. ELISA is a biochemical reaction in which antigen is adsorbed on a solid surface. ELISA test is used extensively in the diagnosis of HIV, varicella-zoster virus, which causes chickenpox and shingles, rotavirus, Zika virus, syphilis, pregnancy tests, in the measurement of cytokine, soluble proteins etc. ELISA is mostly used as screening device prior to in-depth tests.

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Market Drivers

·        The rising prevalence of cancer due to unhealthy lifestyle, lack of exercise and increased consumption of drugs and alcohol, would foster the growth of enzyme-linked immunosorbent assay (ELISA) testing market

·        Rising expenditure in R&D activities in the drug discovery market would boost the growth of this market

·        Rising ageing population enhances the growth of this market as they are more prone to communicable and non-communicable diseases such as cardiovascular disease, lung disease, and cancer, which drives the demand for the prevention, diagnosis, and treatment of such diseases

·       Advancements in technology and automations in the healthcare industry would drive the growth of this market

Market Restraints

·        Lack of availability and cost-effective diagnostic tests hinders the growth of this market.

·        Substitution by new technologically advanced techniques including multiplex proteomic array platforms would restrain its growth

Leading Key players profiled in this report are:

Few of the major market competitors currently working in the ELISA tests market are Ortho Clinical Diagnostics, Thermo Fisher Scientific, ZEUS Scientific, Inc., ALPCO, BD, Bio-Rad Laboratories, Inc., bioMérieux SA, Enzo Life Sciences, Inc., Merck KGaA,  BioLegend, Inc., LOEWE Biochemica GmbH, Creative Diagnostics., Arigo biolaboratories Corp., ELISA Technologies, Inc., RayBiotech, Inc., R&D Systems, Inc., AESKU.GROUP GmbH & Co. KG, Cell Technology., Arbor Assays, Eurofins Scientific and Biogenuix amongst others.

Global ELISA Tests Market Segmentation:

By Test Type

·        Direct ELISA

·        Sandwich ELISA

·        Indirect ELISA

·        Multiple & Portable ELISA

·        Competitive ELISA

By Application

·        Immunology

·        Inflammation

·        Diagnostics

·        Vaccine Development

·        Toxicology

·        Drug Monitoring & Pharmaceutical Industry

·        Transplantation

·        Infectious Diseases

·        Cancer

·        Protein Quantitation

·        Other

By Technology

·        Chemiluminescent

·        Colorimetric

·        Fluorescent

By End-User

·        Hospitals & Diagnostic Centers

·        Research Laboratories

By Geography

·        North America

·        South America

·        Europe

·        Asia-Pacific

Company Share Analysis:

Global ELISA tests market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of ELISA tests market for global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

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The Global ELISA Tests Market report provides the global market size of the main players in each region. Moreover, the report provides knowledge of the leading markets players within the Global ELISA Tests Market. The industry changing factors for the market segments are explored in this report.  This analysis report covers the growth factors of the worldwide market based on end-users. Market opportunities and recommendations for new investments are also encompassed in this report.

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Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge Market Research provides appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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[researchindustry]

Global Induced Pluripotent Market Growth, Trends and Absolute Opportunity up to 2026

Global induced pluripotent market is expected to rise to an estimated value of USD 2.33 billion by 2026, registering a substantial CAGR in the forecast period of 2019-2026. This rise in market value can be attributed to the increasing prevalence of chronic diseases and ailments requiring the development of modern technologically advanced therapeutic options.

Key Market Competitors: Global Induced Pluripotent Market

Few of the major competitors currently working in the induced pluripotent market are Bristol-Myers Squibb Company; CELGENE CORPORATION; Astellas Pharma Inc.; Thermo Fisher Scientific; Cell Applications, Inc.; Axol Bioscience Ltd.; Organogenesis Holdings; Merck KGaA; FUJIFILM Holdings Corporation; Fate Therapeutics; KCI Licensing, Inc.; Japan Tissue Engineering Co., Ltd.; Vericel; ViaCyte, Inc.; STEMCELL Technologies Inc.; Horizon Discovery Group plc; Lonza; Takara Bio Inc.; Promega Corporation and QIAGEN.

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Induced pluripotent are a specialized form of stem cells that are extracted from either skin or blood cells, and are then modified into the pluripotent form which gives them the capability of being used for the treatment where any different kind of human cells are required. In the pluripotent form, they can be modified to any kind of cell form that is utilized for the treatment of different diseases/disorders.

Competitive Analysis: Global Induced Pluripotent Market

Global induced pluripotent market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of induced pluripotent market for global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Market Segmentation: Global Induced Pluripotent Market

·         By Product Category (Cell Culture, Differentiation, Reprogramming, Engineering, Cell Analysis, Others)

·         By Cell Type (Hepatocytes, Fibroblasts, Keratinocytes, Amniotic Cells, Neurons, Others)

·         By Application (Drug Development, Regenerative Medicine, Toxicity Testing, Academic Research, Stem Cell Bio-Banking)

·         By End-User (Academic & Research Institutes, Biotechnology Companies, Hospitals)

·         By Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa)

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Market Drivers

·         Rise in the expenditure incurred by various private and government sources on R&D is expected to drive the growth of the market

·         High levels of understanding and awareness regarding the composition of the iPSC (Induced Pluripotent Stem Cell) has resulted in a rise of demand of the product from various end-users; this factor is expected to drive the growth of the market

·         Utilization of these cells for the creation of customized tissues and helping in understanding of human development; this factor is expected to drive the growth of the market

Market Restraints

·         Complications and large costs associated with the development and manufacturing of these products are expected to restrain the growth of the market

·         Chances of health risks due to the acceptance of these products in the recipient’s body along with lack of efficiency in the process are factors restraining the growth of the market

Reasons to Purchase this Report

·         Current and future of global induced pluripotent market outlook in the developed and emerging markets

·         The segment that is expected to dominate the market as well as the segment which holds highest CAGR in the forecast period

·         Regions/Countries that are expected to witness the fastest growth rates during the forecast period

·         The latest developments, market shares, and strategies that are employed by the major market players

Customization of the Report:

·         All segmentation provided above in this report is represented at country level

·         All products covered in the market, product volume and average selling prices will be included as customizable options which may incur no or minimal additional cost (depends on customization)

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Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market.

Contact:

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 Global Chronic Idiopathic Constipation Treatment Market

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[martynnx-blog]

Constipation Treatment Industry Key Manufacturers Analysis with Sales, Price, Revenue, Gross Margin Forecasts To 2026

Constipation Treatment Market Overview

Constipation is a disorder that causes issues related to clearing of the bowels and usually leads to hardened feces. It is especially prevalent among the elderly and women. Common symptoms of constipation include lumpy or hard stools, lower abdominal discomfort, straining to have bowel movements, feeling of blockage in rectum that prevents bowel movements, and infrequent bowel movements. Factor that can lead to constipation are aging, dehydration, little or no physical activity, diet low in fiber, and mental conditions such as depression or eating disorder. Constipation treatment starts with lifestyle and change in diet to increase the speed at which stool moves through intestines. If it doesn’t help then the physician recommend medications or surgery. Lifestyle and diet change includes increase in fiber intake and physical activities such as exercise to increase intestinal muscle activities.

Segmentation of Constipation Treatment Market

Constipation treatment market is segmented on the basis of type, treatment, method of administration, and end use. By type, the global constipation treatment market has been categorized into chronic idiopathic constipation (CIC), irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation (OIC). On the basis of treatment, the global constipation treatment market has been categorized into pharmacological treatment and non-pharmacological treatment, which comprises bowel training for constipation relief, fluid intake, dietary fiber intake and regular exercise.

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High prevalence rate in North America drive growth of the Constipation Treatment Market

High prevalence rate in North America due to increasing adoption of unhealthy lifestyle characterized by growing consumption of fast food is leading to increasing obesity and other related health issues. This inadvertently leads to high incidence rate of constipation in the region.

Global players engaged in the constipation treatment market

The major players operating in constipation treatment market include AstraZeneca plc, Takeda Pharmaceutical Company Limited, Abbott Laboratories, Valeant Pharmaceuticals International, Inc., C.B. Fleet Company Inc., Daewoong Co. Ltd., Sucampo Pharmaceuticals Inc., Cosmo Pharmaceuticals, Synergy Pharmaceuticals Inc. Boehringer Ingelheim GmbH, and Ironwood Pharmaceuticals.

[pharmaphorumuk]

FDA advisers back Shire constipation drug

Shire’s constipation drug prucalopride is moving closer to market – advisers to the FDA have just unanimously backed it as a treatment for chronic idiopathic constipation (CIC) in adults.

As is the case with all FDA committees, the recommendation by the Gastrointestinal Drugs Advisory Committee is not binding.

But the regulator will take the vote of the 10-person committee into consideration when it makes a final decision on the drug, due by December 21. It rarely goes against the recommendations of its expert advisers.

The committee also voted unanimously that the potential risk of cardiovascular adverse events with the use of prucalopride in adults with CIC had been addressed by Shire.

Prucalopride, a serotonin type 4 (5-HT4) receptor agonist, is a gastrointestinal prokinetic agent that stimulates colonic peristalsis, increasing bowel motility.

Drugs similar to prucalopride have been associated with adverse cardiovascular (CV) events in the past.

Novartis used to market a drug in this class for irritable bowel syndrome and constipation. But in 2007 the FDA asked Novartis to withdraw Zelnorm (tegaserod) from the market because of concerns about possible cardiovascular events.

A safety analysis found a higher chance of heart attack, stroke, and unstable angina in patients treated with Zelnorm compared with placebo, although the FDA later permitted restricted use in clinical trials.

But the FDA advisers said there were no such concerns with prucalopride after a review of data from five main phase III and one phase IV double-blind, placebo-controlled clinical trials.

The committee reviewed results from an observational, pharmacoepidemiology safety study that Shire sponsored to estimate the risk, as measured by the pooled adjusted incidence rate ratio (IRR), of major adverse CV events (MACE) in adult new users of prucalopride compared to adult new users of polyethylene glycol.

In the integrated efficacy analysis of the six main clinical trials, significantly more patients treated with prucalopride versus placebo achieved an average of three or more spontaneous, complete bowel movements (SCBMs) per week over the 12-week treatment period.

Andreas Busch, head of R&D at Shire, said: “We are pleased with the advisory committee’s vote today supporting prucalopride for the treatment of adults with chronic idiopathic constipation in the U.S., and will continue working with the FDA during the final stages of its review.”

Shire’s $62 billion takeover by Takeda also appears to be on track to go ahead next year – Japan became the latest country to give antitrust clearance to the deal.

However the deal has not been approved by European regulators, who have until November 6 to make a decision.

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