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covid-safer-hotties · 15 days

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The Latest Research About Paxlovid: Effectiveness, Access, and Possible Long COVID Benefits - Published Sept 6, 2024

By: Rita Rubin, MA

As another COVID-19 summer surge hit the US this year, many infected people likely were prescribed the antivirals nirmatrelvir and ritonavir, better known as Paxlovid, for the first time. Or for the fourth time. Or somewhere in between.

Nirmatrelvir-ritonavir, the only approved oral therapy for COVID-19, is recommended for treating mild to moderate SARS-CoV-2 infections among people who are at high risk of progression to severe disease. This includes people aged 50 years or older, especially those 65 years or older, as well as younger individuals who have any of a long list of comorbidities that increase the risk of severe COVID-19.

The clinical trials leading to the US Food and Drug Administration (FDA) authorizing emergency use of nirmatrelvir-ritonavir in December 2021 and approving it in May 2023 were conducted with unvaccinated people who were infected with the now long-gone SARS-CoV-2 Delta variant. This has led to questions about its effectiveness for people who have been vaccinated or have been infected with subvariants of Delta’s successor Omicron, which have been circulating for nearly 3 years.

But recent observational studies suggest nirmatrelvir-ritonavir still protects people at high risk against hospitalization and death from COVID-19. That is if they’re able to get a prescription for it—research has uncovered racial and ethnic disparities in which eligible patients get a prescription for the treatment.

And as the number of people with postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, grows, scientists have been investigating whether nirmatrelvir-ritonavir might be useful in protecting against or treating the condition.

Does It Still Prevent Severe COVID-19?

Because the nirmatrelvir-ritonavir phase 2 and 3 trial involved unvaccinated adults without prior COVID-19 infection when the Delta variant dominated, questions have remained about its relevance today.

Scientists from Pfizer, which markets nirmatrelvir-ritonavir, and coauthors recently published a systematic literature review examining that question. They searched for real-world studies reported from December 2021 through March 2023 and identified 18 that met their final selection criteria.

The evidence showed that nirmatrelvir-ritonavir was effective regardless of age, underlying high-risk conditions, or vaccination status. The treatment significantly reduced the postinfection risk of all-cause and COVID-19–related mortality both within the first 30 days and in the long-term. Treatment started within 5 days of symptom onset, as recommended on the label, was associated with the greatest reduction in postinfection risk.

“We remain very confident in Paxlovid’s clinical effectiveness at preventing severe outcomes, including hospitalization and death, from COVID-19 in patients at high risk of severe disease,” Pfizer spokesperson Kit Longley said in an early August email.

Another recently published study reached a somewhat different conclusion. That study, conducted by University of Manitoba researchers, analyzed results from 4 randomized trials and 16 real-world studies, some of which had not yet been peer-reviewed, with a total of nearly 2 million adults aged 18 years or older.

The evidence suggested nirmatrelvir-ritonavir has a small but significant efficacy in reducing COVID-19 hospitalization and all-cause mortality among people with laboratory-confirmed mild to moderate infections, but the evidence is weak, so more studies are needed, the authors concluded.

At Risk but No Script

COVID-19 laid bare health disparities in the US, and nirmatrelvir-ritonavir has been no exception, according to a study published in August.

Using National COVID Cohort Collaborative (N3C) data, researchers studied individuals 18 years of age or older who were diagnosed with COVID-19 between January 2022 and December 2023; up until the end of that period, the US government covered the cost of nirmatrelvir-ritonavir for everyone who needed it.

About 1.26 million people in the N3C cohort were at high risk of progressing to severe disease, making them eligible for nirmatrelvir-ritonavir treatment. But overall, nearly two-thirds of those who were eligible weren’t prescribed the treatment, the authors observed. After accounting for age, sex, and clinical characteristics, the researchers found that non-Hispanic Black and Latino individuals were nearly a third less likely to have used nirmatrelvir-ritonavir than non-Hispanic White individuals.

Patients may not seek care or may not seek it out early enough for the treatment to be effective, coauthor Hemalkumar Mehta, PhD, a core member of the N3C, speculated in an interview with JAMA Medical News.

Another reason could be that patients don’t have a regular source of primary care whom they could ask for a prescription, noted Mehta, a pharmacist and epidemiologist at the Johns Hopkins Bloomberg School of Public Health. They likely don’t know that the FDA has authorized state-licensed pharmacists to prescribe nirmatrelvir-ritonavir, he said.

Mehta acknowledged that until he conducted his study, even he didn’t realize that pharmacists could prescribe the COVID-19 treatment. Publicizing that fact by simply hanging a sign in pharmacies would help, he pointed out.

However, the FDA created an obstacle to quick prescribing of nirmatrelvir-ritonavir by pharmacists, a 2023 article noted. Prior to prescribing, pharmacists must assess patients’ liver and kidney function through health records from the previous 12 months or consultation with their clinician. Other prescribers can simply ask patients about their liver and kidney function and take their word for it, the authors explained. In addition, there is no standardized pathway for pharmacists to bill payors for assessing patients to see if they’re eligible for nirmatrelvir-ritonavir, which typically takes 15 to 30 minutes, according to the American Pharmacists Association.

When people do get a prescription for nirmatrelvir-ritonavir, most get it filled, a recently published study of Walgreens pharmacies nationwide data found. The retrospective study included people 12 years of age or older for whom a nirmatrelvir-ritonavir prescription was ordered from Walgreens pharmacies between December 2021 and August 2023.

A total of about 2.1 million nirmatrelvir-ritonavir prescriptions were ordered for about 2 million individuals. Among the 95% of people who were prescribed only 1 course of the treatment, 88% filled their prescription. Improving uptake of nirmatrelvir-ritonavir requires increasing patient and prescriber awareness, reducing prescribing disparities, and ensuring treatment initiation within 5 days of symptom onset, the authors concluded.

Treat Acute Infection, Prevent Long COVID?

Taking nirmatrelvir-ritonavir for acute COVID-19 might protect against long COVID, although research into that topic has had mixed results.

For example, 2 recent studies, neither of which had yet been peer-reviewed, reached different conclusions.

A preprint posted in June reported observational study results from the Researching COVID to Enhance Recovery (RECOVER) initiative funded by the US National Institutes of Health (NIH). The study population included nearly 500 000 people who tested positive for SARS-CoV-2 between March 2022 and February 2023. Of those, about 165 000 were treated with nirmatrelvir-ritonavir within 5 days after becoming infected.

Compared with no treatment, nirmatrelvir-ritonavir therapy was associated with a 12% lower risk of developing long COVID within 180 days of infection, or an absolute risk reduction of about 3 cases per 100 people. However, no such risk reduction was seen in people at low risk of severe COVID-19 infection who received nirmatrelvir-ritonavir.

“There are quite a few patients who are not at risk but who received a Paxlovid prescription,” first author Fei Wang, PhD, explained in an interview with JAMA Medical News. “This provides us an opportunity to evaluate a low-risk population that got COVID.”

Another preprint, posted this summer, used N3C electronic health records. It found that nirmatrelvir-ritonavir treatment of acute COVID-19 was not significantly associated with reducing long COVID overall, although it was linked to fewer cognitive and fatigue symptoms.

The mixed findings between the 2 studies aren’t surprising, said Wang, an assistant professor of health care policy and research at Weill Cornell Medicine.

Some information, such as COVID-19 vaccination history and nirmatrelvir-ritonavir use, isn’t always encoded in electronic health records, Wang pointed out. Although he and his colleagues “spend a lot of effort” to make sure they have complete patient information, Wang explained, “there’s no way we can evaluate how complete that is.”

He added that not having a consensus definition of long COVID is another critical issue. The N3C’s definition isn’t the same as RECOVER’s, and the 2 cohorts have different patient populations. “All these can lead to different results,” he said.

For Wang, it makes sense that taking nirmatrelvir-ritonavir, an antiviral, for acute COVID-19 would protect against long COVID. The severity of acute SARS-CoV-2 infections is correlated with the risk of long COVID, he said, and one theory about the cause of PASC is the persistence of SARS-CoV-2 in the body.

However, Yale cardiologist Harlan Krumholz, MD, SM, pointed out that unidentified confounders, not nirmatrelvir-ritonavir itself, might be at play in the relationship between treating acute SARS-CoV-2 infection and long COVID risk. “People who take Paxlovid might be different in many other ways,” he noted.

A Long COVID Treatment?

Many individuals with long COVID didn’t have the opportunity to take nirmatrelvir-ritonavir when they first became ill with acute COVID-19. They might have been infected before the treatment became available, or they weren’t considered to be at high risk for severe disease, so they weren’t eligible for it.

Some case reports have suggested that it might not be too late for people who’ve had long COVID for months to benefit from nirmatrelvir-ritonavir. For example, in early 2023 internist Linda Geng, MD, PhD, codirector of Stanford’s PASC clinic, and coauthors reported the case of a patient who’d had long COVID for 7 months, around which time the symptoms of acute COVID-19 returned. Although rapid antigen test results were negative, the patient had been exposed to multiple people with COVID-19, so a primary care physician prescribed nirmatrelvir-ritonavir. Not only did the acute flu-like symptoms resolve, but so did the long COVID symptoms, which included severe fatigue and cognitive difficulties.

That patient spurred Geng and her colleagues to conduct what they say is the first published randomized trial of nirmatrelvir-ritonavir to treat PASC, which appeared in June in JAMA Internal Medicine. The trial enrolled 155 participants with long COVID, all but 2 of whom had received the primary COVID-19 vaccination series. On average, the time between their initial SARS-CoV-2 infection and randomization into the trial was about a year and a half.

The trial found that the longer 15-day course of nirmatrelvir-ritonavir it used was generally safe. However, the treatment didn’t significantly improve long COVID symptoms compared with the control group.

It’s far from the final answer about nirmatrelvir-ritonavir’s effectiveness against long COVID, though, Geng noted. “This is just the first step in many investigations that need to be done.”

The NIH is funding several clinical trials targeting long COVID under the RECOVER initiative umbrella. One, the Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms (RECOVER-VITAL), is testing an even longer course of nirmatrelvir-ritonavir among an estimated 900 participants at centers throughout the US.

And Krumholz and colleagues at Yale University are in the process of analyzing data from their placebo-controlled randomized trial of nirmatrelvir-ritonavir in 100 patients with long COVID. (The trial received funding and design input from Pfizer.)

“We’re not sure it works,” said Krumholz, founder and director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation. “What I think we need are a lot more studies of 100 people or 200 people, trying a lot more things” to treat long COVID.

Participants in the Yale trial were all highly symptomatic and lived throughout the contiguous US. Instead of having them go to participating centers, the trial came to them. “Setting up centers is expensive,” Krumholz explained, noting that the trial’s decentralized design could help cut costs and could work for a variety of conditions and treatments.

Participants were shipped the medication. They gave blood and saliva samples at a local laboratory or at home and answered questions about their symptoms in a digital diary. Yale colleague Akiko Iwasaki, PhD, who studies antiviral immunity and viral disease pathogenesis, is looking at the blood and saliva samples for differences between people who appeared to respond to nirmatrelvir-ritonavir and those who didn’t.

Paxlovid 2.0?

Meanwhile, Pfizer is working to eliminate what one recent publication referred to as nirmatrelvir-ritonavir’s Achilles’ heel: the limited metabolic stability of nirmatrelvir, a protease inhibitor that requires ritonavir to boost it to the target therapeutic range.

The problem is that ritonavir boosts the plasma levels of a long list of other medications beyond the therapeutic range, so nirmatrelvir-ritonavir is contraindicated for people taking them, unless they can temporarily stop or reduce the dose of the concomitant drugs while taking the COVID-19 treatment. Ritonavir is also the source of the metallic taste many individuals who take Paxlovid experience.

Pfizer’s second-generation protease inhibitor for treating COVID-19 is called ibuzatrelvir. Although it’s structurally related to nirmatrelvir, ibuzatrelvir has greater bioavailability when taken orally, so it doesn’t require a ritonavir boost.

Pfizer has completed a phase 2B trial testing the safety and efficacy of a 5-day course of ibuzatrelvir treatment. Participants were nonhospitalized individuals aged 18 to 65 years with confirmed COVID-19 whose symptoms began within 5 days of randomization. Ibuzatrelvir showed robust antiviral activity in the trial, with statistically significant, dose-dependent decreases in viral load at days 3 and 5 compared with placebo, Pfizer researchers reported in April at the European Congress of Clinical Microbiology and Infectious Diseases.

“It is premature to speculate on potential timing of phase 3, but we are considering next steps and plan to share updates as they are available,” Pfizer spokesperson Longley said.

Meanwhile, SARS-CoV-2 continues to evolve along with attitudes toward COVID-19, Krumholz said. Many people “are treating it like a head cold,” he explained. “They’ve obviously made the determination that it’s not dangerous, but it is dangerous.”

Published Online: September 6, 2024. doi:10.1001/jama.2024.16432

#covid #mask up #pandemic #covid 19 #wear a mask #coronavirus #sars cov 2 #public health #still coviding #wear a respirator

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darkmaga-retard · 5 days

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The Public Health Agency of Canada (PHAC) has ordered provinces to destroy Pfizer and Moderna Wuhan coronavirus (COVID-19) mRNA vaccine vials provided last season to "make way for updated shots" that the federal regulator has yet to approve.

Quebec, Ontario, Manitoba, Saskatchewan and Alberta public health officials said they removed doses targeting the old omicron XBB variant. Provinces that ordered the jabs withdrawn as of Aug. 31 or Sept. 1 said they did so at the behest of PHAC. The new vaccines that are a closer match for the current variants are expected to be rolled out in late September or early October.

Canada is reportedly in the middle of a late-summer wave of COVID-19, driven by waning immunity and a variant called KP.3.1.1, which accounted for an alleged estimated 62.2 percent of variants in Canada as of Aug. 25.

In Ontario, Chief Medical Officer of Health Kieran Moore issued a memo on Aug. 27 saying that the PHAC ordered a market withdrawal of all doses targeting the XBB variant effective Sept. 1. Julie Kryzanowski, Saskatchewan's deputy chief medical health officer, issued a memo similar to Ontario's on Aug. 28. Dale Hunter, a spokesman for that province's Health Ministry, confirmed that "all health care facilities, pharmacies and physician offices in Saskatchewan" disposed of their remaining XBB shots on Aug. 31.

In Quebec, the health ministry said some vaccine appointments would have to be canceled as a result of PHAC's withdrawal order but Quebec anticipates the access gap will last as little as two weeks. Meanwhile, the Manitoba government said it asked vaccine providers to return unused XBB doses to the province as of the end of August.

"Specific requests for patients that may still need a dose of the current vaccine within a short time frame can still be considered on a case-by-case basis," the province said in an unattributed email.

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redjacketficrecs · 1 year

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tenderness grows

leavethebes

Summary: Nolan wouldn’t say that landing a job as the Philadelphia Flyers’ psychotic and probably clinically insane mascot was a childhood dream of his. Maybe tangentially: playing pond hockey in –30°C weather and pretending to be Sidney Crosby is practically a rite of passage when you grow up in Manitoba. That, and experiencing the distinct displeasure that is thousands of mosquitoes sucking your blood out when your father drags you on a father-son camping trip into the backwoods of the northern Canadian Prairies.

Recommendation: Really fun Nolpat/TK romance where TK is a Flyer and Patty isn’t. Because Patty is Gritty. Great dialogue and Philly feels very real. There’s a chaotic nature to this fic that just. Really works for it. It's hard to describe but it’s good. It’s also lowkey about how you can love a place and love a place and it might not love you back (except in the ways that they do). And there’s an excellent phone sex scene.

#tk/nolpat #travis konecny #nolan patrick #hockey!#au #GRITTY

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playingwithgifs · 2 years

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How to grow your own marijuana

Following quite a while of attempting to take part in male-overwhelmed web-based pot developing networks, April Brett was finished with the lack of regard that was aimed at her since she was a lady. Along these lines, in February 2020, she chose to make her own Facebook bunch: O'Cannabis: Canadian Women Becoming Together.

"I needed to make a gathering only for ladies where they can have a solid sense of security and have no show and figure out how to develop," says Brett, who resides and lives in Hamilton, Ont. "We construct each other up and uphold one another, which is what ladies should do."

Brett's timing was immaculate. A month after she sent off her gathering, pandemic lockdowns cleared the nation and individuals started getting locally established side interests to fight growing pressure and fatigue, and searching for local areas on the web. Numerous ladies chose to establish pandemic nurseries with weed, and Brett watched her enrollment shoot up in large numbers to in excess of 3,500 today.

"Developing is so remedial," says Brett, who utilises marijuana to deal with her nervousness, discouragement, headaches and persistent agony. "It's an enormous pressure reliever. I feel so settled when I'm in my nursery, watching my plants develop and thrive."

Brett sees many advantages to developing her own weed: it tastes preferable and is more affordable over getting it from dispensaries or clinical pot providers and she knows precisely every thing she's getting and what she put into it. She takes note of the fact that business cultivators might utilise substance manures, pesticides and form inhibitors — and purchasers have absolutely no chance of knowing. (Wellbeing Canada manages the utilisation of these substances and requires authorised makers to have their items tried.)

While developing weed might appear to be overwhelming, Brett says it's straightforward on the off chance that you follow a couple of fundamental standards. "Individuals who can't keep houseplants alive can develop weed," she says. "Keep it basic."

Terese Bowors, a weed mentor situated in Canada's marijuana developing capital, Nelson, B.C., reverberates Brett. "In the event that you can develop tomatoes and lettuce, you can develop a pot," she says.

We got the soil on what you really want to be aware of to take your pandemic nursery to a more significant level from ladies in the loop.

Figure out the standards

Under the government Weed Act, you can grow up to four marijuana plants for sporting use per family. In any case, a few common, neighbourhood and Native legislatures, as well as property managers and stratas, have their own standards.

Manitoba and Quebec deny sporting development. In any case, in 2019, a Quebec Predominant Court judge decided that the territory's boycott was illegal. The Quebec government has pursued the decision; its site actually says sporting development is a no, yet Éducaloi, a Quebec good cause attempting to work on lawful education, says green thumbs are great to develop — for the time being. "In the event that you choose to develop pot at home, make certain to keep awake to date on any changes!" Éducaloi merrily alerts on its site.

In the meantime, Newfoundland and Labrador doesn't permit outside development and different territories have severe rules on how it may very well be finished. In B.C., for example, your yield can't be noticeable to people in general, while in New Brunswick, your mystery garden should be encircled by a locked nook that is no less than five feet tall.

Bowers put deer fencing around her nursery and fixed it with a light, white cultivating texture. "It seems to be a major marshmallow," she says, adding that the texture additionally traps the intensity, which the plants like.

On the off chance that you use marijuana for clinical reasons, you might have the option to get a remedy from a medical care supplier and a clinical endorsement to develop, which might permit you multiple plants. (There are numerous clinical weed centres that can assist you with the cycle.) The quantity of plants you can develop depends on the quantity of everyday grams you're endorsed and whether you intend to develop inside, outside or both.

It's simply legitimate to develop marijuana from seeds or little plants called clones bought from authorised retailers or makers or skilled to you by lawful sporting producers. Sporting producers can buy seeds from authorised retailers for about $30 to $60 for a pack of four. Clones are gradually coming on the rec market and go for about $40 a pop. Clinical cultivators can get their beginning materials from authorised makers and access better mass costs and more assortment in clones.

While there are many web-based seed banks selling a much more extensive assortment of seeds for less expensive than authorised retailers and makers, it's critical to take note of that they're not lawful. Ashleigh Brown, organiser behind SheKan, a computerised network for ladies intrigued by clinical and legitimate marijuana, alerts that when individuals pay off the unlawful market, they may not be getting what they think and could wind up with a lot more grounded strain, comparing it to "a container of wine instead of a light brew."

Select your strains

There are many types of marijuana, however just a handful accessible through authorised retailers and makers. Mikela Moore, a Chilliwack, B.C., producer and O'Cannabis bunch manager, says ladies can keep away from choice weariness by thinking about two key things: what sort of high you need and your environment, as well as the two fundamental subspecies: indica and sativa.

As a general rule, indicas ground you with a weighty body stone, while sativas lift you up with an invigorating head high. There are likewise half breeds, which are some in the middle between.

"They like to say, 'Indica put you in-da-sofa,'" says Moore, who has a clinical test to develop a pot to assist with treating her sleeping disorder. "Though with sativas, you will have the option to do your clearing or go out for a walk."

Sativas are commonly taller and flourish in warm, wet, sticky regions and have longer developing seasons. Indicas, then again, are bushier and can all the more likely endure the cold and have more limited developing seasons. There are likewise ruderalises, a.k.a. autoflowers, which begin blooming in view, are old enough as opposed to on light and have an eight-to 10-week lifecycle, making them the littlest of the bundle. Autoflowers are great for places that have more limited developing seasons and for individuals with more modest spaces. "Autoflowers are fundamentally on a hereditary clock — they'll simply do their thing regardless of how much sun they get," Moore says.

No matter what the strain, marijuana will not do well in that frame of mind under 12 C or over 30 C, and is most joyful between 20 C and 25 C.

Assuming you purchase standard seeds, it's vital to take note of that you have a 50-50 possibility of getting male or female plants. Just female plants produce buds, while male plants fertilise female plants, making them produce seeds in their buds and basically destroying your yield. Therefore you need to hack down male plants. It's feasible to sort out the sex of your plants when they're around a month and a half old (female plants have wispy white hairs while guys have dust sacks), yet it's not generally simple for novices.

You can keep away from the mistake of having male plants by buying feminised seeds, which is what Andrea Meharg, a marijuana mentor and teacher situated in Parkhill, Ont., encourages beginners to do. "Beginning with a decent quality feminised seed puts you 70% of the way to a decent development," she says.

Retailers and seed organisations frequently share every one of the critical insights concerning their seeds in the portrayals on their sites.

Plan your nursery

The two significant choices you really want to make while arranging your nursery is where you will put your plants and whether you will establish them in pots or in the ground. Moore says the main thing is to choose a spot that gets a great deal of direct daylight. She likewise suggests tracking down a spot that offers a great wind stream and insurance from the components. Tomato confines, garden stakes and fences can offer help.

"Weed is a quite intense plant, however it is as yet defenseless to weighty downpours and high breezes," she says. "You need to find some place that is to some degree protected, yet where it can in any case get a light breeze to assist with reinforcing it."

With regards to choosing whether to fill in pots or the ground, Moore suggests contemplating your dirt and your space. "On the off chance that you have soil with a great deal of earth or sand, it won't be excellent for the plants, so you may be in an ideal situation to fill in pots," she says. "Furthermore, on the off chance that you put a plant in the ground, you could wind up with a tree. In the event that you put it in a pot, you have some command over how huge it will get."

You can likewise move pots around if, say, your partners are coming over for a grill or your children are having a playdate and you need to keep your new side interest on the DL.

Moore, who fills in pots on her bright deck, suggests utilising seven-or 10-gallon pots for photoperiod plants and five-gallon pots for autoflowers. She encourages ladies to painstakingly think about what, regardless, to establish near your pot. A few plants — like tomatoes, pumpkins and squash — are inclined to fine mould, which can move to weed plants. Different plants — like marigolds, hay and spices — create extraordinary neighbours as they can be vermin and infection hindrances.

You likewise need to conclude what sort of soil and manure to utilise. Moore says Favourable to Blend HP, a peat greenery and perlite soil, is famous, yet she utilises coconut coir, which is produced using coconut husks, since she found it's less inclined to bugs.

For manure, you can pick compound, natural or Do-It-Yourself (think fertiliser teas, eggshells and coffee beans). Plants need various measures of the enormous three supplements — nitrogen, phosphorus and potassium — during the vegetative and blooming stage, so you'll need to change around your compost, as well.

While Moore suggests utilising compost, she says it's excessive. "You can grow a plant with regular water and daylight, however if you need to get more out of your plant, that is the point at which the supplements prove to be useful," she says.

Moore likewise suggests placing your plants in a solid spot out of general visibility (whether or not it's a prerequisite locally) in light of the fact that burglary is tragically normal. Notwithstanding, she recommends limiting surrounding light — like security lights — so your plants get the dull periods they need.

#marijuana growing #cannabis grower #weed grower #420weed

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isupportonlinedoctor · 4 days

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Online Treatment of Heart health in Alberta

Gotodoctor.ca provides virtual care services for cardiac conditions. A doctor will take a comprehensive in-depth history and provide you with prescriptions. Depending on the symptoms further recommendations will be provided. If a patient is suffering from a heart condition, the doctor will direct him/her to clinic treatment.

#online doctor appointment

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sutrala · 8 days

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(NaturalNews) TheÂ Public Health Agency of Canada (PHAC) has ordered provinces to destroy Pfizer and Moderna Wuhan coronavirus (COVID-19) mRNA vaccine vials...

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astromedical455 · 14 days

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Convenient Care: Walk-In Clinics in Winnipeg

In today's fast-paced world, accessibility to healthcare is crucial. Walk-in clinics in Winnipeg offer a convenient solution for residents who need medical attention without the need for an appointment. Whether you have a minor injury, require a prescription, or need to consult a healthcare professional, Walk in Clinic Winnipeg serve as an essential healthcare resource in the city.

What is a Walk-In Clinic?

A walk-in clinic is a healthcare facility that provides medical services without requiring patients to book an appointment. These clinics offer services on a first-come, first-served basis, making them ideal for individuals seeking immediate care for non-life-threatening issues. Commonly treated conditions include colds, flu, minor cuts, sprains, and infections. Walk-in clinics in Winnipeg can also offer a range of services such as vaccinations, routine check-ups, and lab tests.

Why Choose a Walk-In Clinic?

One of the main benefits of walk-in clinics is their flexibility. Unlike traditional doctor’s offices, where appointments can be booked out weeks in advance, walk-in clinics offer same-day care. This is particularly helpful for people who experience sudden illnesses or injuries but do not require emergency room treatment.

The clinics are designed to provide efficient, cost-effective care. They reduce the burden on hospital emergency departments, which are better suited for severe injuries and critical conditions. Walk-in clinics offer an alternative for those who need quick medical attention but don’t want to endure long waiting times or deal with the formalities of scheduling an appointment.

Services Provided at Walk-In Clinics in Winnipeg

Walk-in clinics in Winnipeg cater to a wide variety of medical needs, offering services that range from basic healthcare to specialized treatments. Here are some of the most common services you can expect:

General Medical Care Walk-in clinics provide care for common conditions such as cold and flu symptoms, fevers, coughs, and sore throats. They also treat minor injuries like cuts, burns, or sprains, offering a quick solution to everyday health issues.

Prescriptions and Medications Doctors at walk-in clinics can prescribe medication for various ailments, saving you time when you need an immediate remedy. These clinics also offer prescription refills, which can be particularly useful if you’re between family doctors or waiting for a specialist appointment.

Vaccinations and Immunizations Many walk-in clinics provide vaccines for flu, hepatitis, tetanus, and other diseases. For travelers, clinics may offer vaccinations to protect against conditions specific to certain regions.

Routine Health Screenings Routine health screenings such as blood pressure checks, cholesterol testing, and diabetes management are available at many walk-in clinics. These services ensure that your health is monitored regularly without requiring the extensive process of booking an appointment with a family physician.

Lab Testing Some clinics have on-site laboratory services that offer diagnostic tests like urine analysis, blood tests, and X-rays. This is an added convenience for those who need quick diagnostics without the need for a hospital visit.

Who Can Visit a Walk-In Clinic?

Walk-in clinics are open to everyone, from children to seniors. These clinics are an excellent option for individuals who do not have a family doctor or those new to Winnipeg who need immediate care. Some clinics offer services covered under Manitoba’s public health insurance plan, while others might offer private pay options.

For visitors to Winnipeg, walk-in clinics are an ideal choice if you fall ill or suffer a minor injury during your stay. Whether you are in the city for work, school, or vacation, walk-in clinics provide a reliable way to access medical care on short notice.

How to Find a Walk-In Clinic in Winnipeg

Finding a walk-in clinic in Winnipeg is relatively easy. Many clinics are conveniently located throughout the city, often in shopping centers or near residential neighborhoods. You can search online or use mobile apps to find clinics based on proximity, hours of operation, and services provided. Some primary care Clinic Winnipeg also offer online check-in services, allowing you to reserve your spot and reduce wait times.

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pharmacybrandca · 1 year

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Clinic Manitoba -Clinic Saskatchewan-Alberta Pharmacy

Clinic services in Saskatchewan, Canada, are provided by various healthcare facilities, including hospitals, medical clinics, and specialized healthcare centers. Saskatchewan has a publicly funded healthcare system, so residents typically do not need to pay for most medically necessary services. Here's some information about clinics in Saskatchewan:

Primary Care Clinics: Primary care clinics are the first point of contact for most residents seeking medical care. These clinics are staffed by family physicians, nurse practitioners, and other healthcare professionals who provide a wide range of general healthcare services, including routine check-ups, vaccinations, and management of chronic conditions.

#Clinic Manitoba #Clinic Saskatchewan #Alberta Pharmacy #pharmacybrandscanada]

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winnipegwinterpeg · 2 months

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The Manitoba government is taking steps to improve accessibility to gender-affirming care and also ensure health-care providers are up to date on the latest information.

Health Minister Uzoma Asagwara (they/them) made the announcement on Wednesday, saying the province is working to ensure patients receive care as quickly as possible.

“I’ve often said that love is action and today our government is demonstrating our love for the queer and trans community by taking action to improve gender-affirming health-care in Manitoba,” Asagwara said at a news conference on Wednesday.

“As your minister of health, I want to be very clear about one thing – affirming, supporting and lifting up the gender identity of Manitobans is a part of essential health-care.”

Some of the steps the province is taking to improve wait times for transgender patients include removing the requirement for a patient to obtain two medical referrals to access specialist care, as well as expanding the number of primary-care providers who can refer patients for gender-affirming care.

Manitoba is also creating a working group that will connect communities to services around the province.

“Gender-affirming care allows for folks to be their true selves, have appropriate supports and feel at home in their bodies,” Asagwara said.

“We also know that gender-affirming health-care saves lives.”

The Manitoba government devised these steps in collaboration with Klinic Community Health. These steps are aligned with the World Professional Association for Transgender Health’s latest clinical guidelines.

#news #Manitoba

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naturallygoals · 17 days

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Discover the Secret to Effortless Weight Loss with LeanBiome: Your Path to a Naturally Lean Body

In the ever-evolving world of weight loss, finding a solution that truly works can feel like searching for a needle in a haystack. Fad diets come and go, and trendy supplements often fail to deliver on their promises. However, there’s a revolutionary product that’s making waves in the health and wellness community for its ability to help users achieve sustainable weight loss. This game-changer is called LeanBiome.

What is LeanBiome?

LeanBiome is not just another weight loss supplement; it's a scientifically-backed formula designed to optimize your gut microbiome for weight loss. Unlike traditional supplements that focus solely on burning fat, LeanBiome takes a different approach by addressing the root cause of weight gain—an imbalanced gut microbiome.

Developed by Ivy League scientists, LeanBiome Supplement contains a unique blend of nine clinically-researched ‘lean bacteria’ species, combined with Greenselect Phytosome®, a next-generation green tea extract. This potent mix not only promotes a leaner body but also supports overall health by restoring balance to your gut flora.

Why Your Gut Microbiome Holds the Key to Weight Loss

Recent research from top institutions like Harvard, Yale, and Stanford has uncovered a startling truth: the bacteria in your gut can significantly impact your ability to gain or lose weight. Studies have shown that individuals with a diverse and balanced gut microbiome are more likely to be lean, while those with a less diverse microbiome tend to struggle with weight gain.

The reason for this lies in the types of bacteria that dominate your gut. ‘Lean bacteria’ help suppress hunger, reduce cravings, and boost metabolism, leading to natural and sustained weight loss. On the other hand, ‘fat bacteria’ can have the opposite effect, ramping up hunger, fueling cravings, and slowing down your metabolism.

LeanBiome works by introducing the right kind of ‘lean bacteria’ into your system, helping to flip the balance in favor of weight loss. This approach not only helps you shed pounds but also maintains long-term results by promoting a healthier gut environment.

The Power of LeanBiome’s Ingredients

LeanBiome Reviews effectiveness is rooted in its carefully selected ingredients, each chosen for their proven ability to support weight loss and gut health.

1. Lactobacillus Gasseri

This strain of lean bacteria has been shown to significantly reduce belly fat in clinical studies. In a 12-week trial, participants who consumed Lactobacillus Gasseri lost an average of 8.5% of their abdominal fat without making any other changes to their diet or exercise routine. This is equivalent to losing 15 pounds of stubborn fat in just three months!

2. Lactobacillus Rhamnosus

Another powerful lean bacteria, Lactobacillus Rhamnosus, has been proven to help women lose weight more effectively. In a study conducted at the University of Laval in Canada, participants who took this strain lost twice as much weight as those who received a placebo.

3. Lactobacillus Fermentum

In a study at the University of Manitoba, this strain tripled the rate of fat loss compared to a placebo group. Participants lost 3% of their body fat in just 43 days, demonstrating its potent fat-burning properties.

4. Greenselect Phytosome®

Greenselect Phytosome® is a caffeine-free green tea extract that enhances the body’s ability to burn fat. In a 90-day clinical trial, participants who took Greenselect Phytosome® lost an average of 30 pounds—nearly three times more than those who only followed a calorie-controlled diet.

These ingredients work synergistically to create a powerful formula that not only promotes weight loss but also supports overall health and well-being.

How LeanBiome Supports Long-Term Weight Loss

One of the key advantages of LeanBiome is its ability to support long-term weight loss. Many weight loss supplements offer short-term results, only to have the weight pile back on once you stop using them. LeanBiome is different.

Because it works by balancing your gut microbiome, LeanBiome helps you maintain your weight loss by improving your metabolism, reducing cravings, and supporting healthy digestion. This means you’re less likely to experience the dreaded yo-yo effect that’s so common with other weight loss methods.

Real People, Real Results

LeanBiome has already helped thousands of people achieve their weight loss goals. Users consistently report losing weight, feeling more energetic, and experiencing fewer cravings. But don’t just take our word for it—here’s what some of our satisfied customers have to say:

Sarah M. from California says, “LeanBiome has completely transformed my life. I’ve lost 25 pounds in three months, and I feel amazing. I’ve tried so many other products in the past, but nothing has worked like LeanBiome.”

David R. from Texas shared, “After struggling with my weight for years, I finally found something that works. LeanBiome helped me lose 40 pounds, and I’ve kept it off for over six months. I can’t recommend it enough.”

These testimonials highlight the life-changing potential of LeanBiome and show that with the right support, anyone can achieve their weight loss goals.

Why Choose LeanBiome?

With so many weight loss products on the market, it can be difficult to know which one to choose. Here’s why LeanBiome stands out:

Scientifically-Backed: LeanBiome is formulated based on the latest research from Ivy League scientists and leading health institutions.

Natural Ingredients: The formula contains only natural, clinically-researched ingredients that are safe and effective.

Sustainable Results: By balancing your gut microbiome, LeanBiome helps you achieve long-term weight loss without the rebound effect.

Risk-Free: With a 180-day money-back guarantee, you can try LeanBiome with confidence, knowing that you have nothing to lose—except for those extra pounds!

Take the First Step Toward a Leaner, Healthier You

If you’re ready to take control of your weight and achieve the body you’ve always wanted, now is the perfect time to try LeanBiome. This groundbreaking supplement offers a natural and effective way to lose weight by addressing the root cause of fat storage—your gut microbiome.

Don’t wait another day to start your weight loss journey. Click the link below to order LeanBiome and discover how easy it can be to become naturally lean.

Order LeanBiome Today and Transform Your Body from the Inside Out!

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allthecanadianpolitics · 12 days

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A former family doctor has been sentenced to 12 years for sexually assaulting seven women during medical appointments and examinations in Ste. Anne, Man. Court of King's Bench Justice Sadie Bond delivered the sentence for Arcel Bissonnette on Thursday morning in Winnipeg. "Dr. Bissonnette took advantage of the opportunity that was afforded to him by his position as a family doctor to sexually assault the victims" in his medical clinic, Bond said. The defence had wanted a nine-year sentence, while Crown prosecutors argued for 18 years.

Tagging: @newsfromstolenland

#tw sex assault #tw assault #medical malpractice #doctors #family doctor #winnipeg #manitoba #cdnpoli #canadian politics #canadian news #canada

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canadaimmigration1 · 1 month

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Unlocking New Opportunities: How Four Canadian Provinces Are Attracting Skilled Healthcare Workers with Irresistible Incentives

Introduction: The Vital Need for Skilled Healthcare Workers in Canada

Canada is actively working to strengthen its healthcare system by attracting skilled professionals from around the world. With a growing demand for healthcare services, particularly in underserved regions, Immigration, Refugees, and Citizenship Canada (IRCC) has implemented various measures to address critical shortages. To further enhance these efforts, several provinces have introduced unique financial incentives aimed at drawing skilled workers to their healthcare sectors.

In this blog, we’ll explore four Canadian provinces offering compelling incentives to healthcare professionals. These programs not only alleviate financial burdens but also provide a pathway to a rewarding career in Canada’s thriving healthcare industry.

Manitoba: Leading the Charge with Comprehensive Financial Support

Manitoba’s Health Human Resource Action Plan Launched in November 2022, Manitoba’s Health Human Resource Action Plan aims to employ 2,000 healthcare providers across the province. As part of this ambitious program, Manitoba offers a range of incentives designed to attract and retain healthcare professionals.

Key Incentives:

Wellness Incentive: Full-time employees receive a one-time boost of $500 to their Health Spending Accounts, while part-time employees are eligible for a $250 increase. This incentive supports healthcare workers in covering eligible medical expenses, ensuring their well-being is a top priority.

Licensure Reimbursement: Manitoba provides reimbursement for professional license and association membership fees for the 2023-24 and 2024-25 licensure years. This is a significant financial relief for healthcare professionals who must maintain their credentials.

Weekend Premium: Healthcare workers in Manitoba who work on eligible weekends receive an $8.00 premium. This incentive, retroactive to November 2022, rewards employees for their dedication to providing care during critical times.

These incentives are part of a broader package designed to make Manitoba a desirable destination for healthcare professionals. For more details, explore the full program benefits here.

Newfoundland and Labrador: A Warm Welcome for Healthcare Professionals

Newfoundland and Labrador’s Come Home Initiative Newfoundland and Labrador (NL) offers a variety of incentives for healthcare professionals, particularly those with previous ties to the province. The Come Home Initiative is a standout program that encourages skilled workers to return to the province with attractive financial rewards.

Key Incentives:

Physicians: A $100,000 incentive is available for those committing to a five-year return-in-service agreement.

Nurse Practitioners: A $60,000 incentive for a three-year commitment, providing significant financial support to those in this critical role.

Other Healthcare Professionals: Registered Nurses, Licensed Practical Nurses, Primary Care Paramedics, and Clinical Pharmacists can receive $50,000 for a three-year commitment.

The Come Home Initiative is also available to healthcare professionals without prior connections to NL, though the incentives vary. This program underscores Newfoundland and Labrador’s commitment to strengthening its healthcare workforce by offering robust financial incentives and a welcoming environment.

Prince Edward Island: Recruiting the Best with Competitive Offers

PEI’s Allied Health Professional Recruitment Incentive Prince Edward Island (PEI) has recently enhanced its Allied Health Professional Recruitment Incentive, making it one of the most attractive offers for healthcare professionals seeking new opportunities in Canada.

Key Incentives:

Up to $10,000 Financial Incentive: Eligible health professionals in 11 different occupations can receive up to $10,000 for committing to a return-in-service agreement of 1,950 working hours or one year of full-time work.

Eligible Occupations Include:

Medical Laboratory Technologists (MLTs)

Medical Radiation Technologists (MRTs)

Respiratory Therapists (RTs)

Pharmacists and more.

PEI’s recruitment incentive is designed to attract top talent to the island, offering substantial financial rewards to those who are new to the workforce or have not been employed by Health PEI in the past two years. This program is a crucial part of the province’s strategy to build a strong and sustainable healthcare system.

Saskatchewan: Supporting Graduates with Financial Rebates

Saskatchewan’s Graduate Retention Program (GRP) Saskatchewan is committed to retaining healthcare talent through its Graduate Retention Program (GRP), which offers substantial financial incentives to graduates who choose to live and work in the province.

Key Incentives:

$20,000 Tuition Rebate: Eligible graduates who live and file an income tax return in Saskatchewan can receive up to $20,000 in tuition rebates, making it easier for new healthcare professionals to manage student debt and establish their careers.

Eligibility Requirements:

Graduates must have completed an approved post-secondary program and applied for the GRP within seven years of graduation.

The program is open to graduates from a variety of healthcare-related fields, making it a versatile option for those looking to start their careers in Saskatchewan.

Saskatchewan’s GRP is a powerful tool in the province’s efforts to attract and retain healthcare professionals, offering significant financial incentives that make the province an attractive destination for recent graduates.

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