#Corneal Ulcer Treatment Market Growth

[techninja]

Rising Adoption To Treat Ophthalmic Disorders Projected to boost growth of the Amniotic Membrane Market

The global Amniotic Membrane Market is estimated to be valued at US$ 3.62 Bn in 2023 and is expected to exhibit a CAGR of 13% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: The amniotic membrane is the innermost layer of the placenta which consists of epithelial cells, a thick basement membrane, and an avascular stroma. It possesses properties such as anti-inflammatory, anti-scarring, antimicrobial, anti-angiogenic and pain-relieving properties. This makes it ideal for use in wound healing applications including wounds, burns, ophthalmic disorders, surgical wounds etc. It acts as a biological scaffold and releases growth factors that aid in tissue regeneration. Compared to synthetic skin substitutes or skin grafts, amniotic membrane grafts have lesser probability of developing infection and rejection. With increasing cases of trauma, accidents and chronic wounds worldwide, the demand for effective wound care treatments is growing steadily. This is expected to propel the amniotic membrane market growth over the forecast period. Market key trends: One of the key trends gaining traction in the amniotic membrane market is the rising adoption of amniotic membrane for ophthalmic disorders. Amniotic membrane plays a crucial role in ocular surface reconstruction due to its anti-angiogenic, anti-inflammatory and anti-scarring properties. It is increasingly being used to treat ocular disorders like keratitis, corneal ulcers, persistent epithelial defects and corneal perforations. Also, continuous efforts by market players to develop new amniotic membrane products through advanced processing techniques like cryopreservation, lyophilization etc. is expected to drive the market growth. Development of amniotic membrane tissue engineered products for regenerative therapies is another emerging trend in the market. Porter’s Analysis Threat of new entrants: Low, as the market requires high capital investment and regulatory approvals for entering. Bargaining power of buyers: Moderate, as the presence of substitute products provides options to buyers. Bargaining power of suppliers: High, as raw materials have limited sources of supply globally. Threat of new substitutes: Moderate, as new substitutes are emerging but amniotic membrane has established use cases over years. Competitive rivalry: High, as the key players compete on the basis of quality, price and technology. Key Takeaways The global amniotic membrane market size is expected to witness high growth at a CAGR of 13% over the forecast period 2023 to 2030, due to increasing cases of ocular surface disorders. Regional analysis: North America dominates the global market currently owing to increasing healthcare expenditure and growing patients' population. However, Asia Pacific is expected to grow at the fastest pace during the forecast period with rising medical tourism and improving healthcare infrastructure in emerging countries. Key players operating in the amniotic membrane market include Smith & Nephew, Applied Biologics, Organogenesis Holdings Inc., Osiris Therapeutics, Inc., Alliqua BioMedical, Inc., Amnio Technology, LLC, Next Biosciences, Integra LifeSciences, MiMedx, LifeCell International, Human Regenerative Technologies, LLC, Amniox Medical, Inc, Skye Biologics Inc., Wright Medical, TissueTech, Katena Products, Inc., NuVision Biotherapies, Surgenex, and Ventris Medical. Key players are focused on new product launches and regulatory approvals to strengthen their market position.

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Corneal Ulcer Treatment Market Size and Growth, Industry Analysis, Trends, CAGR, Segmentation, Opportunities, and Forecast 2022 To 2029

The Corneal Ulcer Treatment Market is anticipated to develop as a result of rising contact lens usage, novel treatment options, such as anti-amoebic medications, and well-established supply chain operations. The market for corneal ulcer therapy is expected to grow significantly at 5.7% CAGR from 2022 to 2029, reaching an estimated market value of about US$ 867.3 Million as of 2022.

According to Future Market Insights, the market share for antibiotics is predicted to reach a huge 76.4% in 2021.The general public as well as ophthalmologists are becoming more aware of corneal ulcers because to a number of activities by international as well as regional organisations, governments, etc. to end preventable blindness caused by contact lens use.

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Further, universities and non-profit organizations arranging eye check-up camps further aids in enhancing awareness about corneal ulcers.

FMI – a well-established name in the market research domain – forecasts that, the corneal ulcer treatment market will experience a major upturn in the coming years, reaching a valuation of US$ 1.27 Bn by 2029.Key Takeaways of Corneal Ulcer Treatment Market StudyTreatment of broad-spectrum corneal ulcers using antibiotics is expected to gain traction and contribute more than 75% of revenue share during the forecast period.Growing bacterial keratitis requiring antibiotics for treatment will contribute significantly to the revenue share of the segment.Eye drops or eye ointments dominate the market by form type, as these are relatively cheaper and do not require other interventional and oral route for drug delivery.By distribution channel, retail pharmacies are expected to gain more than 50% of market share during the forecast period.North America is dominating the global corneal ulcer treatment market, while East Asia is expected to offer lucrative growth opportunities, owing to rising healthcare infrastructure and industrialization.Acquisition – Key Strategy Followed by Leading ManufacturersLeading manufacturers in the corneal ulcer treatment market are focusing on geographical expansion as well as increased product offerings through partnerships and acquisitions.

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Key Market Segments Covered In Corneal Ulcer Treatment Industry ResearchBy Drug class:AntibioticsAntifungalsAntiviralsCorticosteroidsNSAID’sBy Form:TabletEye Drops/ OintmentsVialsBy Route of Administration:OralTopicalInjectablesBy Indication:Bacterial KeratitisFungal KeratitisViral KeratitisAcanthamoeba KeratitisBy Distribution ChannelHospital PharmaciesRetail PharmaciesDrug StoresOnline PharmaciesBy RegionNorth AmericaLatin AmericaEuropeSouth AsiaEast AsiaOceaniaMiddle East and Africa (MEA)

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Corneal Ulcer Treatment Market Share, Size, Research, CAGR, and Growth - Forecast 2029

Global Corneal Ulcer Treatment Market, By Treatment (Medication, Surgery, Others), Diagnosis (Fluorescein Eye Stain Test, Slit-Lamp Exam, Others), Symptoms (Redness, Tears, Discharge from Eye, Blurry Vision, Swollen Eyelids, Vision Changes, Severe Pain, Others), Dosage (Eye Drops, Tablets, Others), Route of Administration (Oral, Topical, Others), End-Users (Clinic, Hospital, Others), Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Online Pharmacy) Industry Trends and Forecast to 2029

The consistent Corneal Ulcer Treatment market report analyzes many points that help businesses to solve the toughest questions in less time. The major topics of this business report are global growth trends, market share by manufacturers, market size by type, market size by application, production by region, consumption by region, company profiles, market forecast, value chain and sales channels analysis, opportunities & challenges, threat and affecting factors. The report gives market definition in the form of market driving factors and market restraints which helps estimating the demand of particular product depending on several aspects. Corneal Ulcer Treatment market survey report studies the global market status and forecast, categorizes the global market size, market value & market volume by key players, type, application, and region.

Key Players

Some of the major players operating in the corneal ulcer treatment market are Pfizer Inc., GlaxoSmithKline plc, Sanofi, Novartis AG, Allergan, Merck & Co., Inc., Mylan N.V., Teva Pharmaceutical Industries Ltd., Bayer AG, Sun Pharmaceutical Industries Ltd., Aurobindo Pharma, Lupin, AbbVie Inc., Cumberland Pharmaceuticals Inc., Melinta Therapeutics LLC, Eli Lilly and Company, Cipla Inc., Dr. Reddy’s Laboratories Ltd., AstraZeneca, and Johnson & Johnson Private Limited, among others.

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One of the principal objectives of a high-ranking Corneal Ulcer Treatment industry report is to analyze and study the global sales, value, status, and forecast. The market report also analyzes the global and key regions market potential and advantage, opportunity and challenge, restraints and risks. The report assists to define, describe and forecast the market by type, application and region. It estimates the region that is foretold to create the most number of opportunities in the global Corneal Ulcer Treatment market. This market research report comprises of estimations of CAGR values which are quite significant and aids businesses to decide upon the investment value over the time period. An insightful Corneal Ulcer Treatment market report assists clients to stay ahead of the time and competition.

Key questions answered in the report:

Which product segment will grab a lion’s share?

Which regional market will emerge as a frontrunner in coming years?

Which application segment will grow at a robust rate?

Report provides insights on the following pointers:

Market Penetration: Comprehensive information on the product portfolios of the top players in the Corneal Ulcer Treatment Market.

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Table Of Content

Part 01: Executive Summary

Part 02: Scope Of The Report

Part 03:  Global Market

Part 04: Global Market Sizing

Part 05: Global Market Segmentation By Product

Part 06: Five Forces Analysis

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Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market

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Amniotic Membrane Market: Significance & Global Performance

Amniotic membrane or amnion, a thin membrane on the inner side of the fetal placenta and composed of the epithelium, has emerged as an ideal source for tissue transplantation. Moreover, amnion has an array of biological properties, making it attractive for use in various surgical procedures, including ocular surface reconstruction and tissue engineering.

The advancements in anatomy have triggered significant investments in research and development of amniotic membrane applications. While AM has shown beneficial results in burn injuries, the upsurge in R&D investments has increased its use in eye surgery, cell therapy, stem cell research, and more, boosting the amniotic membrane market growth prospects.

In fact, the identification of new stem cells has increased the membrane’s potential, making it ideal for developing regenerative medicines. For instance, Organogenesis Holdings Inc, a leading regenerative medicine company, gained approval from the US FDA for ReNu, a cryopreserved amniotic suspension allograft, to manage symptoms related to knee osteoarthritis.

Amniotic Membrane Market - Global & Regional Trends

As per estimates, the global amniotic membrane market will display revenue growth at a CAGR of 7.01% during the forecast period 2022-2028.

Considering the evolving healthcare sector, the amniotic membrane market is expected to witness tremendous growth in the Asia-Pacific nations. Estimates suggest that approximately half a billion people in the region will be 65 or older by 2025. This change in demographics, in addition to a shift in consumer expectations, will widen the market’s scope. In this regard, the growing demand for chronic care management will expand amnion application in ophthalmology, burn injuries, and cosmetic surgeries, among others.

Additionally, amniotic membrane transplantation has gained momentum in various conjunctival and corneal diseases, signaling opportunistic growth for players in the APAC region. Considering its growth in North America, amnions have proven advantageous in treating limbal stem cell deficiency, providing support and protection to transplanted limbal tissues and stem cells. Recently, in Canada, numerous techniques have been developed to dehydrate amnion while preserving the wound-healing properties to formulate a temperature-stable allograft.

Furthermore, the United Kingdom is the center of research and development of amniotic membrane applications in Europe. Several hospitals, such as NuVision, have gained expertise in providing AM treatments. Amniotic membrane treatments are gaining center stage across the nation, given the technological advancements. For instance, in November 2021, several ophthalmologists shared their innovations of AM application in treating ocular surface conditions through a webinar sponsored by NuVision Biotherapies Ltd.

Market by Application – Expert Outlook

Surgical Wounds: Human amniotic membrane has been used for treating acute and chronic wounds, decreasing infection and pain while accelerating the healing time. The surgical wound segment dominates the overall market and is expected to maintain its stronghold till 2028. Although a plethora of wound dressings are available, chronic wounds remain a major medical concern. As a result, chronic wounds awareness programs largely support amnion application. For instance, the Wound Healing and Hyperbaric Center at Carteret Health Care, a Healogic Network member, is engaged in raising awareness of chronic wounds, providing advanced therapies.

Ophthalmology: The rise in chronic and infectious diseases has resulted in a global rise in surgeries, boosting the market’s potential. Amniotic membrane is rapidly used in ophthalmic surgeries to initiate faster recovery and decrease inflammation. Amnion has become crucial in eye treatments, given its anti-scarring and anti-inflammatory properties. For instance, Bio Tissue Inc offers AmnioGraft to treat ocular surface indications like corneal ulcers, dry eye, chemical burns, etc. Besides, AM is highly preferred in developing regions since it is cheaper than allografts.

Competitive Analysis

For any company, acquisitions and agreements ensure expansion in business footings. Acquisitions, for instance, are quicker, cheaper, and less risky compared to other methods to extend volume sales. On the other hand, agreements are crucial to eliminating disagreements, confusion, or changes that may transpire during the course of the business period.

Notable acquisitions and agreements that support the market’s development:

In February 2021, Katena Products Inc, a leading provider of premium ophthalmic instruments and devices, announced the acquisition of ASICO LLC to expand the ophthalmic surgical product line and lead in the innovation of new products.

Integra LifeSciences Corporation, in January 2021, acquired ACell Inc and its proprietary MatriStem UMB to offer comprehensive wound management solutions.

Celularity Inc and Oncternal Therapeutics Inc entered into a research partnership in September 2021 to examine placental-derived cellular treatments.

Celularity also collaborated with Imugene Ltd in August 2021 to employ Imugene’s CD19 oncolytic virus technology and its CD19 CYCART-19 to remedy solid tumors.

In Conclusion,

The amniotic membrane market has shown rapid and promising results in healing damaged tissues. From chemical burns to ulcers to the cornea, amnions have emerged as suitable membranes in wound care management. This indicates that the use of AM in medicine and therapies is expanding in various branches of medicine.

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The photophobia drug market is expected to gain market growth at a potential rate of 13.95% in the forecast period of 2021 to 2028. Rise in the ongoing clinical trial studies being carried out by many pharmaceuticals industries is the vital factor escalating the photophobia drug market growth.

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Corneal Transplant Market Professional Survey Report by 2023

Corneal Transplant Market Highlights :

Corneal transplant is a surgical procedure performed for the treatment of diseased cornea. Important indications for corneal transplant are keratoconus, keratitis, and corneal stromal dystrophies. The success rate of the treatment is found to be high, which support the market growth.

Rising prevalence of vision impartment and eye diseases such as diabetic retinopathy in geriatric population and diabetes across the globe drive the global market. Additionally, rising awareness about organ donation and its importance, especially, in the developing countries likely to propel the market growth.

Cost of corneal transplant market varies depending upon the region, availability of services, and skilled and qualified professionals. Major difference in the cost is observed, i.e. it is found to be high in the developed countries and low in developing countries still maintaining qualitative care. Therefore, cost effective of the treatment would affect the market growth.

The global corneal transplant market is expected to grow at a CAGR of 10.8% during the forecast period.

Major Players in Corneal Transplant Market:

Some of the key players in the global market are CryoLife, Inc. (U.S.), Exactech, Inc. (U.S.), Köhler GmbH (U.S.), Lifeline Scientific (U.S), LifeCell Corporation (U.S.), Medtronic (U.S.), and Organogenesis Inc. (U.S.).

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Corneal Transplant Market Regional Analysis :

Europe is the largest market for corneal transplant which will exhibit positive growth in the near future due to rising prevalence of diabetes in the European countries and availability of treatment options. According to the World Health Organization, about 60 million Europeans have diabetes and its prevalence is relatively high among people over 25 years.

America is the second leading corneal transplant market across the globe owing to an increasing demand for corneal transplant surgery, and rising prevalence of eye diseases, and vision impairment among people in the U.S.

Asia Pacific market is expected to grow rapidly owing increasing prevalence of chronic diseases such as diabetes, diabetic retinopathy, and obesity. India is one of the international medical tourism destinations across the world, which further exhibits growth opportunities for the corneal transplant market due to availability of cost-effective treatment and rising success rates. Furthermore, the increasing healthcare expenditure by developing countries in Asia Pacific region also contributes to the market growth.

The Middle East & African market is growing steadily owing to rising demand for ophthalmic products and services, and available treatment options.

Corneal Transplant Market Segmentation :

The global corneal transplant market is segmented on the basis of type, indication, and end user.

On the basis of type, the market is segmented into penetrating keratoplasty, endothelial keratoplasty, descemet stripping automated endothelial keratoplasty (DSAEK), corneal graft, corneal limbal stem cell transplant, and others.

On the basis of indication, the market is segmented into fungal corneal ulcer, bullous keratopathy, keratoconus, keratitis, corneal stromal dystrophies, and others.

On the basis of end user, the market is segmented into hospitals, eye clinics, and others.

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[pranalipawarshinde]

Neurotrophic Keratitis Market Prospects and Growth Assessment Report by 2027

Neurotrophic Keratitis Market: Introduction

Transparency Market Research has published a new report titled, “Global Neurotrophic Keratitis Market”. According to the report, the global neurotrophic keratitis market was valued at US$ 91.6 Mn in 2018 and is projected to expand at a CAGR of ~17% from 2019 to 2027. Rise in reported cases of keratitis, increase in research & developmental activities, surge in awareness, and rise in co-morbidities & risk factors boost the growth of the global neurotrophic keratitis market.

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Pharmacotherapies using Drugs to Lead Global Market

In terms of treatment type, the drugs segment accounted for major share of the global neurotrophic keratitis market in 2018. The segment is anticipated to witness strong growth from 2019 to 2027. The drugs segment has been sub-segmented into artificial tears, recombinant human nerve growth factor eye drop, antibiotics, bandage contact lens, and others. The artificial tears sub-segment accounted for major share of the drugs segment in 2018. However, the recombinant human nerve growth factors eye drops sub-segment is expected to account for major share by 2027, as these eye drops restore the normal healing process of the eye and repair corneal damage. The drugs segment’s major market share is due to increase in clinical studies, approvals, and launch of various novel products. In February 2019, ReGenTree initiated the ARISE-3 study, the phase 3 clinical trial of the new drug RGN-259 for the treatment of dry eye syndrome. In August 2018, Dompé announced the U.S. Food and Drug Administration (FDA) approval for cenegermin (Oxervate), a breakthrough therapy for neurotrophic keratitis (NK), which is a rare and progressive eye disease that can lead to corneal scarring and vision loss.

Stage II Neurotrophic Keratitis to Remain Significant

Based on application, the stage I segment held major share of the global neurotrophic keratitis market in 2018. However, the stage II segment is projected to capture the largest share of the global market by 2027. Dominance of the stage I segment in 2018 can be ascribed to off-label availability of products for stage I, high prevalence of early symptoms in stage I, and high demand for preservative-free artificial tears during the first half of the forecast period. Symptoms of stage II neurotrophic keratitis help in diagnosis of the disease. A study published in 2014 titled, “Diagnosis and management of neurotrophic keratitis”, stated that stage II NK is characterized by recurrent and/or persistent epithelial defects (PED) with an oval or circular shape, most frequently localized at the superior half of the cornea. Diagnosis of NK is primarily based on the clinical history of conditions associated with trigeminal impairment, presence of PED or ulcers, and decreased corneal sensitivity.

A study published in Elsevier, Inc. in November 2017 indicated that around 34% of total studied patients in Italy were affected by persistent epithelial defects (PED) of stage II. Hence, the growth of the stage II segment can be ascribed to rise in awareness about and rate of diagnosis of the disease, launch of products which are effective in stage II persistent epithelial defects treatment, and surge in inclination of patients toward specialized centers for receiving advanced treatment.

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Neurotrophic Keratitis Market: Prominent Regions

North America held the largest share of the global neurotrophic keratitis market in 2018. The market in the region is projected to grow at a rapid pace during the forecast period, driven by presence of key players, technological advancements, and highly structured healthcare industry. Increase in clinical trials, product launches, and approvals, and rise in investment by key players are projected to propel the neurotrophic keratitis market in North America. The U.S. is anticipated to dominate the neurotrophic keratitis market in the region during the forecast period, owing to early adoption of technologies. The country is expected to be the most attractive market for neurotrophic keratitis treatment products, with high attractiveness index. Well-equipped hospitals, technological advancements, rise in research & development on neurotrophic keratitis for novel treatment and appropriate cure, and surge in demand for novel products & treatments are likely to augment the neurotrophic keratitis market in the U.S.

Neurotrophic Keratitis Market: Key Players

Key players in the global neurotrophic keratitis market focus on strengthening their positions in the global market. Players are collaborating with other companies, actively conducting research studies, participating in mergers & acquisitions, and increasing product approvals and launches to secure and strengthen their positions in the global neurotrophic keratitis market. In April 2019, Neuroptika announced positive data from the company's phase 1 clinical trial to determine the safety, tolerability, and pharmacokinetics of topical NRO-1 in healthy subjects. NRO-1 is a novel therapeutic, with the potential to protect and regenerate corneal nerves in ophthalmic diseases. In July 2017, Dompé announced that the European Commission had granted marketing authorization of cenegermin eye drops for the treatment of moderate to severe neurotrophic keratitis.

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Major players operating in the global neurotrophic keratitis market include Dompe farmaceutici S.p.A., Allergan, ReGenTree, LLC, Alcon, Bausch & Lomb Incorporated (Bausch Health Companies Inc.), CONTACARE, ROHTO Pharmaceutical Co., Ltd., Pfizer, Inc., Neuroptika, Santen Pharmaceutical Co., Ltd., Johnson & Johnson, Grand Pharma (China) Co., Ltd., and Zhejiang CONBA Pharmaceutical Co., Ltd.

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Transparency Market Research is a global market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. Our experienced team of analysts, researchers, and consultants, uses proprietary data sources and various tools and techniques to gather and analyze information.

Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports.

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Corneal Transplant Market Size, Scope, Growth, Competitive Analysis 2027

Market Highlights

According to MRFR, the Global Corneal Transplant market is expected to perceive exponential growth, registering CAGR of 10.8% during the forecast period.

The global market for Corneal Transplant is growing pervasively over last decade. Factors such as increasing prevalence injuries & diseases related to the eye/ sight that fuel the transplants cases are fuelling the market growth to an extent. Also the risk factors for the blindness & eye sight disorders are creating the demand for the better Corneal Transplants and treatment methods in turn, speed up the market growth.

Accrediting the kind of growth the market is witnessing and the growth prospect the market is demonstrating, Market Research Future (MRFR), has recently published a brilliant study report.

Major Players in Corneal Transplant Market:

Some of the key players in the global market are CryoLife, Inc. (U.S.), Exactech, Inc. (U.S.), Köhler GmbH (U.S.), Lifeline Scientific (U.S), LifeCell Corporation (U.S.), Medtronic (U.S.), and Organogenesis Inc. (U.S.).

Regional Analysis

Globally, Europe is the largest market for the corneal transplant rejection rate. Factors such as the availability of multiple treatment options, prevention strategy as well as rising influence of organ donation programs, coupled with the increased government emphasis on organ donation policies drive the regional growth of the market. Moreover, increasing prevalence of diabetes in the region are providing impetus to the market growth.

While North America region stands as the second-largest market for Corneal Transplant. This growth attributes to the increasing demand for corneal transplant surgery coupled with the growing prevalence of eye diseases, and vision impairment among people in the region drive the regional market growth. Moreover, growing Centers for Disease Control and Prevention, coupled with the age-related eye diseases such as age-related macular degeneration, cataract, diabetic retinopathy, and glaucoma are leading causes of blindness and vision imparity especially in the United States; such factors foster the regional market growth.

On the other hand the developing regions markets particularly Asia Pacific will be the fastest growing market for Corneal Transplant. Risk factors for the eye diseases such as the ever-increasing prevalence of chronic diseases such as diabetes, diabetic retinopathy, and obesity provide impetus to the growth of the regional market. Attributing to the availability of qualitative eye care treatment and skilled medical professionals, India has become one of the international medical tourism destinations across the world. This, in turn fuels the growth of corneal transplant market in India resultantly, fostering the growth of the APAC market.

Market Segmentation:

The global corneal transplant market is segmented on the basis of type, indication, and end user.

On the basis of type, the market is segmented into penetrating keratoplasty, endothelial keratoplasty, descemet stripping automated endothelial keratoplasty (DSAEK), corneal graft, corneal limbal stem cell transplant, and others.

On the basis of indication, the market is segmented into fungal corneal ulcer, bullous keratopathy, keratoconus, keratitis, corneal stromal dystrophies, and others.

On the basis of end user, the market is segmented into hospitals, eye clinics, and others.

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[dailytophealth-blog]

Stroke: Preventing the damage by acting on the neuronal environment?

To protect neurons and limit the damage after a stroke, researchers from the CNRS, the University of Caen-Normandie, University Paris-Est Créteil, and the company OTR3 have targeted the matrix that surrounds and supports brain cells. Their results, just published in the journal Theranostics, have confirmed this strategy on rats, and will lead to a clinical study between now and late 2019.

With over 300 cases per day in France, stroke is the leading cause of handicap among adults, and the second cause of death. Eighty to 85 percent are caused by the occlusion of a cerebral artery by a blood clot (ischemic stroke), with nearby neurons dying because of oxygen deprivation. The only existing treatment involves eliminating the blood clot, which is only possible during the first few hours following a stroke, and consequently available only for a minority of patients. Moreover, brain lesions can persist and worsen long after the start of a stroke, with no treatment being currently available to slow them, or to improve functional recovery.

Numerous avenues of research are studying how to protect neurons from this degeneration. However, treatments attacking this degeneration have only met with clinical failure, which prompted a team led by a CNRS researcher, Myriam Bernaudin, to take an interest in a little explored domain: the environment of the cells, known as the extracellular matrix. This matrix, which offers the cells structural support and houses growth factors, ends up being disorganized following a stroke, thereby amplifying neuronal death. The team from the laboratory Imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (CNRS/UNICAEN/CEA) thus approached colleagues specializing in the extracellular matrix at the laboratory Croissance, réparation et régénération tissulaires (CNRS/UPEC), along with the biotechnology company OTR3, which had already brought to market “matrix therapy” treatments for the healing of cutaneous or corneal ulcers.

The researchers demonstrated on rats the effectiveness of this new approach in protecting the brain and improving functional recovery after an ischemic stroke. The intravenous injection of an agent that mimics certain structural components of the extracellular matrix, known as heparan sulfates, protects and reconstitutes this matrix, promotes the development of new neurons and the regeneration of blood vessels, and improves the recovery of sensory and motor functions.

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Global Persistent Corneal Epithelial Defects Treatment Market

The persistent corneal epithelial defects treatment market is expected to witness market growth at a rate of 4.75% in the forecast period of 2021 to 2028. Persistent corneal epithelial defect refers to a multifactorial disorder which is caused due to failure of corneal epithelialization mechanism. The corneal condition results in the disturbance of the corneal surface and exposed the eyes vulnerable to the stromal ulceration, scarring, and infections.

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Corneal Transplant Market is to grow at approximately 10.8% CAGR by 2027

Market Highlights

Corneal transplant is a surgical procedure performed for the treatment of diseased cornea. Important indications for corneal transplant are keratoconus, keratitis, and corneal stromal dystrophies. The success rate of the treatment is found to be high, which support the market growth.

Rising prevalence of vision impartment and eye diseases such as diabetic retinopathy in geriatric population and diabetes across the globe drive the global market. Additionally, rising awareness about organ donation and its importance, especially, in the developing countries likely to propel the market growth.

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Cost of corneal transplant varies depending upon the region, availability of services, and skilled and qualified professionals. Major difference in the cost is observed, i.e. it is found to be high in the developed countries and low in developing countries still maintaining qualitative care. Therefore, cost effective of the treatment would affect the market growth.

The global Corneal Transplant Market is expected to grow at a CAGR of 10.8% during the forecast period.

Major Players in Corneal Transplant Market:

Some of the key players in the global market are CryoLife, Inc. (U.S.), Exactech, Inc. (U.S.), Köhler GmbH (U.S.), Lifeline Scientific (U.S), LifeCell Corporation (U.S.), Medtronic (U.S.), and Organogenesis Inc. (U.S.).

Regional Analysis

Europe is the largest market for corneal transplant which will exhibit positive growth in the near future due to rising prevalence of diabetes in the European countries and availability of treatment options. According to the World Health Organization, about 60 million Europeans have diabetes and its prevalence is relatively high among people over 25 years.

America is the second leading Corneal Transplant Market across the globe owing to an increasing demand for corneal transplant surgery, and rising prevalence of eye diseases, and vision impairment among people in the U.S.

Asia Pacific market is expected to grow rapidly owing increasing prevalence of chronic diseases such as diabetes, diabetic retinopathy, and obesity. India is one of the international medical tourism destinations across the world, which further exhibits growth opportunities for the Corneal Transplant Market due to availability of cost-effective treatment and rising success rates. Furthermore, the increasing healthcare expenditure by developing countries in Asia Pacific region also contributes to the market growth.

The Middle East & African market is growing steadily owing to rising demand for ophthalmic products and services, and available treatment options.

Segmentation

The global Corneal Transplant Market is segmented on the basis of type, indication, and end user.

On the basis of type, the market is segmented into penetrating keratoplasty, endothelial keratoplasty, descemet stripping automated endothelial keratoplasty (DSAEK), corneal graft, corneal limbal stem cell transplant, and others.

On the basis of indication, the market is segmented into fungal corneal ulcer, bullous keratopathy, keratoconus, keratitis, corneal stromal dystrophies, and others.

On the basis of end user, the market is segmented into hospitals, eye clinics, and others.

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Corneal Ulcer Treatment Market is poised for a healthy CAGR over 2019-2029

An open source develops on the cornea, a thin membrane that lies over the iris. The most common cause of corneal ulcers is infection that includes bacterial, viral and fungal infection. Bacterial infection is the most common of them all. People who wear contact lenses are the most prone to infection and are most susceptible to corneal ulcers. Other risk factors include participation in activities that may result in damage to eye such as contact sports, exposure to chemicals and other eye conditions such as dry eye or Bell’s palsy.

Corneal ulcers can be prevented by protecting the eyes, maintaining hygiene and following recommendations of the doctors prescribe especially ones who use contact lens. Corneal ulcers treatment must be given at earliest once diagnosed. Some of the symptoms corneal ulcers include pain and discharge from eyes along with sensation of foreign particle in the eye. Corneal ulcers treatment depends on the severity of the condition. In mild conditions, corneal ulcer treatment involves the use of cold compression and some non-prescription pain medicines to help with the discomfort. In severe conditions, the corneal ulcer treatment involves the treatment of the infection.

Antibiotics, antifungals and antiviral eye drops are recommended corneal ulcer treatment based on the type of infection. In some cases the corneal ulcer treatment also included oral antifungal/antibiotics as corneal ulcer treatment. These antibiotic corneal ulcer treatment products are available in the form of ointment that can be applied around the eye. In worse conditions the corneal ulcer treatment recommended is the surgical treatment. A corneal transplant is recommended to replace the damaged tissue with a healthy donor cornea tissue. Steroids and anti-inflammatory eye drops are generally prescribes once the infection subsides.

However, the use of steroids as corneal ulcer treatment is controversial and is recommended to be used under close supervision since this form of corneal ulcer treatment can worsen an infection. Among all the corneal ulcer treatment options, oral medications and ointments are most commonly used. The corneal ulcer treatment products are available in hospital pharmacies, retail pharmacies, drug stores and e-commerce stores. Some of the common modes of corenal ulcer treatments include the use of prednisone, ciprofloxacin, ofloxcin and others. Some of the companies that manufacture the corneal ulcer treatments include Pfizer, Alcon Laboratories, INC., GlaxoSmithKline plc, Allergan PLC, Johnson & Johnson, Vistakon Pharmaceuticals, H.L. Healthcare among other key players.

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Corneal Ulcer Treatment Market: Dynamics

Technological advancements and growing adoption of contact lenses are driving the growth of the corneal ulcers treatment market. The availability of soft lenses that can be used for longer duration is becoming more and more popular among contact lens users, however, use of contact lens for longer duration increases the risks of development of corneal ulcers. The increase in infectious diseases and poor hygiene in the emerging regions are the other driving factors for the growth of the corneal ulcers treatment market. Furthermore, growing awareness regarding corneal ulcer has resulted in increased diagnosis rate thereby driving the growth of the corneal ulcer treatment market.

Corneal Ulcer Treatment Market: Regional Outlook

On the basis of geography, the global corneal ulcer treatment market is segmented into seven key regions, namely North America, Latin America, Western Europe, Eastern Europe, Asia Pacific excluding Japan, Japan, and Middle East & Africa. North America is projected to hold large share in the global corneal ulcer treatment market primarily due to growing awareness about pelvic inflammatory disease, and improved healthcare scenario. The increased healthcare spending in North America is another factor driving the growth of the corneal ulcer treatment market.

Corneal Ulcer Treatment Market: Segmentation

The global pelvic inflammatory disease therapeutics market is segmented by administration, distribution channel and region:

Oral

Ointment

Eye Drops

Intravenous

Hospital Pharmacies

Retail Pharmacies

Drug Stores

E-Commerce

Corneal Ulcer Treatment Market: Key Players

Examples of some of the key players in the global pelvic inflammatory disease therapeutics market are Pfizer, Akorn Inc, Alcon Laboratories, INC., H.L. Healthcare, GlaxoSmithKline plc, Allergan PLC, Johnson & Johnson, Vistakon Pharmaceuticals, among other key players.

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Amniotic Membrane Market: Significance & Global Performance

Amniotic membrane or amnion, a thin membrane on the inner side of the fetal placenta and composed of the epithelium, has emerged as an ideal source for tissue transplantation. Moreover, amnion has an array of biological properties, making it attractive for use in various surgical procedures, including ocular surface reconstruction and tissue engineering.

The advancements in anatomy have triggered significant investments in research and development of amniotic membrane applications. While AM has shown beneficial results in burn injuries, the upsurge in R&D investments has increased its use in eye surgery, cell therapy, stem cell research, and more, boosting the amniotic membrane market growth prospects.

In fact, the identification of new stem cells has increased the membrane’s potential, making it ideal for developing regenerative medicines. For instance, Organogenesis Holdings Inc, a leading regenerative medicine company, gained approval from the US FDA for ReNu, a cryopreserved amniotic suspension allograft, to manage symptoms related to knee osteoarthritis.

Amniotic Membrane Market - Global & Regional Trends

As per estimates, the global amniotic membrane market will display revenue growth at a CAGR of 7.01% during the forecast period 2022-2028.

Considering the evolving healthcare sector, the amniotic membrane market is expected to witness tremendous growth in the Asia-Pacific nations. Estimates suggest that approximately half a billion people in the region will be 65 or older by 2025. This change in demographics, in addition to a shift in consumer expectations, will widen the market’s scope. In this regard, the growing demand for chronic care management will expand amnion application in ophthalmology, burn injuries, and cosmetic surgeries, among others.

Additionally, amniotic membrane transplantation has gained momentum in various conjunctival and corneal diseases, signaling opportunistic growth for players in the APAC region. Considering its growth in North America, amnions have proven advantageous in treating limbal stem cell deficiency, providing support and protection to transplanted limbal tissues and stem cells. Recently, in Canada, numerous techniques have been developed to dehydrate amnion while preserving the wound-healing properties to formulate a temperature-stable allograft.

Furthermore, the United Kingdom is the center of research and development of amniotic membrane applications in Europe. Several hospitals, such as NuVision, have gained expertise in providing AM treatments. Amniotic membrane treatments are gaining center stage across the nation, given the technological advancements. For instance, in November 2021, several ophthalmologists shared their innovations of AM application in treating ocular surface conditions through a webinar sponsored by NuVision Biotherapies Ltd.

Market by Application – Expert Outlook

Surgical Wounds: Human amniotic membrane has been used for treating acute and chronic wounds, decreasing infection and pain while accelerating the healing time. The surgical wound segment dominates the overall market and is expected to maintain its stronghold till 2028. Although a plethora of wound dressings are available, chronic wounds remain a major medical concern. As a result, chronic wounds awareness programs largely support amnion application. For instance, the Wound Healing and Hyperbaric Center at Carteret Health Care, a Healogic Network member, is engaged in raising awareness of chronic wounds, providing advanced therapies.

Ophthalmology: The rise in chronic and infectious diseases has resulted in a global rise in surgeries, boosting the market’s potential. Amniotic membrane is rapidly used in ophthalmic surgeries to initiate faster recovery and decrease inflammation. Amnion has become crucial in eye treatments, given its anti-scarring and anti-inflammatory properties. For instance, Bio Tissue Inc offers AmnioGraft to treat ocular surface indications like corneal ulcers, dry eye, chemical burns, etc. Besides, AM is highly preferred in developing regions since it is cheaper than allografts.

Competitive Analysis

For any company, acquisitions and agreements ensure expansion in business footings. Acquisitions, for instance, are quicker, cheaper, and less risky compared to other methods to extend volume sales. On the other hand, agreements are crucial to eliminating disagreements, confusion, or changes that may transpire during the course of the business period.

Notable acquisitions and agreements that support the market’s development:

In February 2021, Katena Products Inc, a leading provider of premium ophthalmic instruments and devices, announced the acquisition of ASICO LLC to expand the ophthalmic surgical product line and lead in the innovation of new products.

Integra LifeSciences Corporation, in January 2021, acquired ACell Inc and its proprietary MatriStem UMB to offer comprehensive wound management solutions.

Celularity Inc and Oncternal Therapeutics Inc entered into a research partnership in September 2021 to examine placental-derived cellular treatments.

Celularity also collaborated with Imugene Ltd in August 2021 to employ Imugene’s CD19 oncolytic virus technology and its CD19 CYCART-19 to remedy solid tumors.

In Conclusion,

The amniotic membrane market has shown rapid and promising results in healing damaged tissues. From chemical burns to ulcers to the cornea, amnions have emerged as suitable membranes in wound care management. This indicates that the use of AM in medicine and therapies is expanding in various branches of medicine.

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The photophobia drug market is expected to gain market growth at a potential rate of 13.95% in the forecast period of 2021 to 2028. Rise in the ongoing clinical trial studies being carried out by many pharmaceuticals industries is the vital factor escalating the photophobia drug market growth.

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Global Nerve Growth Factor (NGF) Market

Global Nerve Growth Factor (NGF) Market

was valued $XX Mn in 2019 and is expected to reach $XX Mn by 2026, at a CAGR of XX% during forecast period.

Global Nerve Growth Factor (NGF) Market Overview:

Nerve growth factor (NGF) is a neurotrophic protein, which is primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.It is known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons.

Global Nerve Growth Factor (NGF) Market Dynamics:

Growing cases of various neurological disorders, corneal ulcer and other autoimmune diseases are the main factors driving the market growth. Neurological disorders like Alzheimer’s disease and other diseases like a corneal ulcer, various autoimmune diseases present globally are responsible for damaging the tissue of the immune system. This factor primarily drives the Nerve Growth Factor market. Alzheimer's is most prevalent in the US, where approximately 5.5 million people are affected, and the prevalence worldwide is estimated to be as high as 24 million. Along with this, increased government funding, and ongoing research studies for the development of novel treatments using NGF for the treatment of various diseases will also boost the market growth. Another advantage of NGF such as it controls the regulation of the nervous system in embryos and regulates the growth, function & repair of neurons in adults, and nerve cell recovery after surgical or chemical injuries helps in stimulating the growth of the market. The report has profiled fifteen key players in the market from different regions. However, report has considered all market leaders, followers and new entrants with investors while analyzing the market and estimation the size of the same. Increasing R&D activities in each region are different and focus is given on the regional impact on the cost, availability of advanced technology are analyzed and report has come up with recommendations for future hot spot in APAC region.

Global Nerve Growth Factor (NGF) Market Segment Analysis:

The global Nerve Growth Factor Market is segmented on the basis of Type, Application and End-Users. Based on Application, the nerve growth factor market segmented into neurodegenerative disorders, spinal cord injuries, tissue healing, and autoimmune diseases. Neurodegenerative disorders segment is expected to dominate the market owing to numerous studies which have shown that NGF contributes to the survival and regeneration of neurons during aging and in age-related diseases such as Alzheimer’s.

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Global Nerve Growth Factor (NGF) Market Regional Insights:

North America is expected to account for highest market share during forecast period. The presence of advanced technology and favourable reimbursement policies offered by the government encourages the growth of the market in the region. Besides this, the high prevalence of the population suffering from neurodegenerative disorders, ongoing R&D activities for novel treatment development, and high healthcare expenditure contribute to the market growth. Europe is considered the second-largest market for nerve growth factor due to strategic collaboration between academic research institute and pharmaceutical giants to develop new drugs. The report also helps in understanding Global Nerve Growth Factor (NGF) Market dynamics, structure by analyzing the market segments and project the Global Nerve Growth Factor (NGF) Market size. Clear representation of competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence in the Global Nerve Growth Factor (NGF) Market make the report investor’s guide.

Global Nerve Growth Factor (NGF) Market Scope: Inquire before buying

Global Nerve Growth Factor (NGF) Market, by Region:

• North America • Europe • South America • MEA • APAC

Global Nerve Growth Factor (NGF) Market Key players:

• Dompe farmaceutici S.p.A. • Pfizer Inc • Regeneron • Astellas Pharma Inc. • Merck KGaA • Promega Corporation • Alomone Labs • Bio-Rad Laboratories, Inc. • Enzo Life Sciences, Inc. • Prospec-Tany Technogene Ltd. • CUSABIO TECHNOLOGY LLC • Biocare Medical, LLC. • Eli Lilly & Company • Teva Pharmaceutical Industries • Mitsubishi Tanabe Pharma Corporation