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crownjimin · 3 years

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summary: the enemies to lovers social media au where min yoongi refuses to date a cheerleader, but yoon haryun might be able to change that.

fandom: bangtan sonyeondan / bts

genre: college au universe! / enemies to lovers

ship(s): min yoongi x female!oc / jung hoseok x female!oc / kim seokjin x female!oc / more to come...

status: complete

before you read: this is the first book in the walking cliches series, the others will follow soon. the length is currently undetermined.

there will be an attempt at humor

angst is included

fluff too

read at your own risk

pleath enjoy!

☆ ⁄⁄ ★ accounts : female ( twitter / instagram )

☆ ⁄⁄ ★ accounts : male ( twitter / instagram )

☆ ⁄⁄ ★ additional accounts : snu

☆ ⁄⁄ ★ 001 | the whole fucking store

☆ ⁄⁄ ★ 002 | chef boyardee

☆ ⁄⁄ ★ 003 | hand in marriage

☆ ⁄⁄ ★ 004 | first day of classes

☆ ⁄⁄ ★ 005 | jealous and lonely

☆ ⁄⁄ ★ 006 | dance team vs cheer team

☆ ⁄⁄ ★ 007 | namgguk birthday bash

☆ ⁄⁄ ★ 008 | kim geummi (derogatory)

☆ ⁄⁄ ★ 009 | jung hoseok [ written ]

☆ ⁄⁄ ★ 010 | believe in the process

☆ ⁄⁄ ★ 011 | broken table chronicles

☆ ⁄⁄ ★ 012 | ikea is swedish

☆ ⁄⁄ ★ 013 | party time

☆ ⁄⁄ ★ 014 | the start of something terrible [ written ] ( part one / part two )

☆ ⁄⁄ ★ 015 | min yoongi no more

☆ ⁄⁄ ★ 016 | never see her again

☆ ⁄⁄ ★ 017 | joonie’s birthday

☆ ⁄⁄ ★ 018 | a nice challenge

☆ ⁄⁄ ★ 019 | cheer practice [ written ]

☆ ⁄⁄ ★ 020 | twitter is the new instagram

☆ ⁄⁄ ★ 021 | quintuple shots of espresso [ written ]

☆ ⁄⁄ ★ 022 | to the library

☆ ⁄⁄ ★ 023 | battle of the textbook [ written ]

☆ ⁄⁄ ★ 024 | who is haryun?

☆ ⁄⁄ ★ 025 | hickey on his face

☆ ⁄⁄ ★ 026 | blocked, unblocked

☆ ⁄⁄ ★ 027 | min yoongi = whipped

☆ ⁄⁄ ★ 028 | luda’s shit list

☆ ⁄⁄ ★ 029 | yoongi’s :] smile

☆ ⁄⁄ ★ 030 | day one [ written ]

☆ ⁄⁄ ★ 031 | about soyeon (day two)

☆ ⁄⁄ ★ 032 | day three [ texts / written ]

☆ ⁄⁄ ★ 033 | haryun the unaliver

☆ ⁄⁄ ★ 034 | day five

☆ ⁄⁄ ★ 035 | we stay hungry, we devour

☆ ⁄⁄ ★ 036 | day six / basketball practice [ written / texts ]

☆ ⁄⁄ ★ 037 | day 8 [ texts / written ]

☆ ⁄⁄ ★ 038 | day 9

☆ ⁄⁄ ★ 039 | the after math ( part one / part two )

☆ ⁄⁄ ★ 040 | day 11 [ written ]

☆ ⁄⁄ ★ 041 | game day ( part one / part two )

☆ ⁄⁄ ★ 042 | seokyun + 3 randos

☆ ⁄⁄ ★ 043 | day 12 [ texts / written ]

☆ ⁄⁄ ★ 044 | day 13 [ written ]

☆ ⁄⁄ ★ 045 | day 14 [ written ]

☆ ⁄⁄ ★ 046 | moonhee’s an empath

☆ ⁄⁄ ★ 047 | kim seokjin the boat captain

☆ ⁄⁄ ★ 048 | yoongi’s pov

☆ ⁄⁄ ★ 049 | no deadlines

☆ ⁄⁄ ★ 050 | gifts for jimin [ written ]

☆ ⁄⁄ ★ 051 | and we party ( part one / part two )

☆ ⁄⁄ ★ 052 | a simple solution [ written ]

☆ ⁄⁄ ★ 053 | instagram stalking

☆ ⁄⁄ ★ 054 | men are dumb

☆ ⁄⁄ ★ 055 | you’re all dead to me

☆ ⁄⁄ ★ 056 | haryun = geummi

☆ ⁄⁄ ★ 057 | the prelude to an apology

☆ ⁄⁄ ★ 058 | start at the end

☆ ⁄⁄ ★ 059 | how espresso drips down [ written ]

☆ ⁄⁄ ★ 060 | sweet like a caramel macchiato ( part one / part two )

☆ ⁄⁄ ★ 061 | yunyoon / yoonyun

☆ ⁄⁄ ★ 062 | code red

☆ ⁄⁄ ★ 063 | family dinner

☆ ⁄⁄ ★ 064 | music about you

☆ ⁄⁄ ★ 065 | an extended family dinner ( part one / part two )

☆ ⁄⁄ ★ epilogue | baby you're caramel macchiato

[ google doc poll for next story ]

#coffee social media au #min yoongi #kim namjoon #kim seokjin #jung hoseok #park jimin #kim taehyung #jeon jungkook #bts social media au #bts aus #coffee masterlist #min yoongi x female oc #humor #from crownjimin

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newssplashy · 6 years

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Tech: Stanford researchers are figuring out how ketamine fights depression — and why the drug has been called 'the most important discovery in half a century'

A new Stanford study is the first to illuminate how ketamine works in the brain to alleviate depression. The research suggests that the drug engages the opioid system — the same one that's activated by opioid painkillers — in addition to affecting the glutamate system.

A new study from Stanford sheds light on how ketamine works in the brain to alleviate depression.

The research suggests that the drug not only impacts a network of switches called the glutamate system, but also engages the opioid system — the same one that's activated by opioid painkillers.

The finding could have big implications for plans to turn ketamine into the next blockbuster antidepressant.

Ketamine's unique ability to staunch the symptoms of depression has earned it a new reputation in recent months. No longer seen solely as an illicit party drug, the compound is the focus of research into a novel class of antidepressants that could yield the first new depression drug in more than 30 years.

But the science of how ketamine stonewalls depression symptoms has remained murky. For years, researchers believed it worked by acting on a network of brain receptors called the glutamate system, which other popular antidepressants ignore. But a new study suggests that ketamine also influences the brain's opioid network — the same one engaged by opioid painkillers.

That could have implications for plans to turn the drug into a pharmaceutical. Drug companies including Allergan, Johnson & Johnson, and a San Francisco-based drug maker called VistaGen have all been looking to ketamine as inspiration for the next blockbuster antidepressant.

"When we say this is a new generation of drugs, we mean it. This drug is fundamentally different from all the other antidepressants that have been approved so far," Shawn Singh, VistaGen's CEO, told Business Insider in May.

The new paper, published Tuesday night in the American Journal of Psychiatry and funded by the National Institutes of Health, is the first to illuminate how ketamine exerts its effects in the brain.

Alan Schatzberg, a co-author on the paper and a professor of psychiatry at Stanford, told Business Insider that he hopes drug makers can use his team's discovery to streamline their efforts and avoid the pitfalls of antidepressant drug candidates that have failed.

"Before we did the study, I had some doubts about ketamine's use for treating depression," Schatzberg said. "Now I've seen the drug work, but I've also seen it doesn't work the way people originally thought."

How ketamine is distinct from existing depression drugs

Most existing antidepressants, from Abilify to Zoloft, work by plugging up the places where our brain takes up serotonin, a chemical messenger that plays a key role in mood. The result is more free-floating serotonin and, in some people, relief from a dark curtain of depressive symptoms.

But those effects don't occur in everyone who tries the drugs. In fact, up to 80% of the people who try existing antidepressants fail to see results. Plus, the drugs take four to six weeks to work. As a result, depression remains one of the world's leading causes of death.

Ketamine, on the other hand, affects key switches in the brain called NMDA receptors. Collectively, these switches are part of a larger network in the brain called the glutamate system. Like serotonin receptors, those for NMDA play an important role in our mood and help keep our emotions in check. But NMDA receptors also keep our brain's synapses — the delicate branches that serve as the ecosystem for our thoughts — flexible and resilient.

Depression appears to cause those synaptic branches to shrivel up and in some cases even die. Scientists think existing antidepressant drugs send help to those branches indirectly over time by way of serotonin. Ketamine, by contrast, delivers its aid directly by plugging up NMDA receptors like a cork and nipping depressive symptoms within hours.

This mechanism of action spurred some scientists to call ketamine "the most important discovery in half a century" in 2012.

The new study suggests that in addition to affecting the glutamate system, ketamine also impacts the same switches that are targeted by opioid painkillers.

For their work, the Stanford researchers gave 12 adults whose depression failed to respond to multiple treatments two infusions of ketamine. Before the first infusion, the participants took a drug that blocks the brain's opioid receptors. Before the second infusion, the participants got a placebo. (The participants and researchers were never told whether they were getting the drug or the placebo — a double-blind setup designed to minimize the chance that observed results were merely psychological.)

In more than half the cases in which the participants got the placebo, the ketamine appeared to reduce depressive symptoms by roughly 90%; the effects lasted about three days. Conversely, when the patients got the opioid-blocker before the ketamine, the ketamine had virtually no antidepressant effects.

This finding led the researchers to hypothesize that ketamine's activity takes place in different phases. In the first, the drug activates the brain's opioid receptors, quickly smothering depressive symptoms, one of the researchers suggested in the paper. In the second phase — which is thought to be key for ketamine's lasting antidepressant qualities — the drug appears to engage the brain's glutamate system.

What the next blockbuster antidepressant needs

Several drug companies have tried and failed to create a new depression drug that targets the NMDA receptors in the glutamate system. Pharmaceutical giant Roche pulled the plug on a drug called basimglurant in 2016 after it failed to show results in a Phase II study; AstraZeneca discontinued its work on a heavily-promoted candidate called lanicemine in 2013.

Yet ketamine's rapid-fire ability to stymie depressive symptoms has continued to baffle and inspire researchers looking for an alternative to current treatments.

Allergan, Johnson & Johnson, and VistaGen are all currently working to develop new ketamine-inspired drugs. In fact, two of the authors on the latest paper previously consulted for these companies: Schatzberg received a grant from Janssen, Johnson & Johnson's neuroscience partner, and study author Carolyn Rodriguez has consulted for Allergan.

None of the three drug candidates target the brain's opioid system, however.

Mark Smith, VistaGen's chief medical officer, said that although the results of the study are "intriguing," they would not directly impact the company's work on its new drug.

Similarly, a representative from Janssen, whose work with Johnson & Johnson has focused on a nasal-spray version of esketamine (the chemical mirror image of ketamine), told Business Insider in a statement that the Stanford study would not impact the direction of their work. They added that there were several issues with the study, including the fact that it was small and did not include "relevant control conditions."

But overall, the new study sheds light on important questions about why — and how — ketamine works to fight depression in the brain.

"I think this paper points us in the direction that the [opioid system] is an area for potential interest," Schatzberg said. "The question is, can we have a rational discussion about this in an era when there’s an opioid crisis?"

source http://www.newssplashy.com/2018/08/tech-stanford-researchers-are-figuring_29.html

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newssplashy · 6 years

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Senate President Bukola Saraki has dumped the APC for the PDP. Here's why.

Senate President Bukola Saraki on Tuesday, July 31, 2018, dumped the All Progressives Congress (APC) for the Peoples Democratic Party (PDP).

Saraki first announced his decision to leave the APC via a Tweet on the evening of Tuesday.

In a statement personally signed by him, Saraki described his exit from the ruling APC as a “difficult decision” he arrived at after extensive consultations with stakeholders.

Pulse lists five reasons why he left the APC for the PDP.

1. No peace in the APC

Saraki alleged that certain forces within the APC prevented true reconciliation of aggrieved members in the ruling party.

“While I take full responsibility for this decision, I will like to emphasise that it is a decision that has been inescapably imposed on me by certain elements and forces within the APC who have ensured that the minimum conditions for peace, cooperation, inclusion and a general sense of belonging did not exist,” Saraki announced.

“They have done everything to ensure that the basic rules of party administration, which should promote harmonious relations among the various elements within the party were blatantly disregarded. All governance principles which were required for a healthy functioning of the party and the government were deliberately violated or undermined.

“And all entreaties for justice, equity and fairness as basic precondition for peace and unity, not only within the party, but also the country at large, were simply ignored, or employed as additional pretext for further exclusion.”

2. Three years in the APC has not been rosy.

The Senate President accused 'some elements within the APC' of making the party uncomfortable for him and his associates.

Recall that Saraki had battled the Federal Government at the Code of Conduct Tribunal within same period.

He recently won his case of asset declaration at the Supreme Court.

“The experience of my people and associates in the past three years is that they have suffered alienation and have been treated as outsiders in their own party,” Saraki said.

“Thus, many have become disaffected and disenchanted. At the same time, opportunities to seek redress and correct these anomalies were deliberately blocked as a government-within-a-government had formed an impregnable wall and left in the cold, everyone else who was not recognized as ‘one of us’. This is why my people, like all self-respecting people would do, decided to seek accommodation elsewhere,” he added.

3. Executive/Legislature friction

Saraki noted that the anti-corruption war was being used by the Executive to “silence some members of the Legislature.”

“The framers of our constitution envisage a degree of benign tension among the three arms of government if the principle of checks and balances must continue to serve as the building block of our democracy,” Saraki said.

“In my role as the head of the legislature, and a leader of the party, I have ensured that this necessary tension did not escalate at any time in such a way that it could encumber Executive function or correspondingly, undermine the independence of the legislature.

“Over the years, I have made great efforts in the overall interest of the country, and in spite of my personal predicament, to manage situations that would otherwise have resulted in unsavoury consequences for the government and the administration. My colleagues in the Senate will bear testimony to this.

“However, what we have seen is a situation whereby every dissent from the legislature was framed as an affront on the executive or as part of an agenda to undermine the government itself. The populist notion of anti-corruption became a ready weapon for silencing any form of dissent and for framing even principled objection as ‘corruption fighting back’.

“Persistent onslaught against the legislature and open incitement of the people against their own representatives became a default argument in defence of any short-coming of the government in a manner that betrays all too easily, a certain contempt for the Constitution itself or even the democracy that it is meant to serve.

“Unfortunately, the self-serving gulf that has been created between the leadership of the two critical arms of government based on distrust and mutual suspicion has made any form of constructive engagement impossible. Therefore, anything short of a slavish surrender in a way that reduces the legislature to a mere rubber stamp would not have been sufficient in procuring the kind of rapprochement that was desired in the interest of all.

“But I have no doubt in my mind, that to surrender this way is to be complicit in the subversion of the institution that remains the very bastion of our democracy. I am a democrat. And I believe that anyone who lays even the most basic claim to being a democrat will not accept peace on those terms; which seeks to compromise the very basis of our existence as the parliament of the people.”

4. Osinbajo, Oshiomhole tried but…

Saraki who expressed gratitude to Vice President, Yemi Osinbajo and the newly elected chairman of the APC, Adams Oshiomhole, for their efforts in reconciling aggrieved members of the party.

ALSO READ: Kwara Governor dumps APC for PDP

But, the Senate President said their efforts came rather late.

“The emergence of a new national party executives a few weeks ago held out some hopes, however slender. The new party chairman has swung into action and did his best alongside some of the Governors of APC and His Excellency, the Vice President. I thank them for all their great efforts to save the day and achieve reconciliation. Even though I thought these efforts were coming late in the day, but seeing the genuine commitment of these gentlemen, I began to think that perhaps it was still possible to reconsider the situation. “However, as I have realized all along, there are some others in the party leadership hierarchy, who did not think dialogue was the way forward and therefore chose to play the fifth columnists. These individuals went to work and ensured that they scuttled the great efforts and the good intentions of these aforementioned leaders of the party. Perhaps, had these divisive forces not thrown the cogs in the wheel at the last minutes, and in a manner that made it impossible to sustain any trust in the process, the story today would have been different.”

5. No change

Saraki said he was heading back to the PDP due to the lack of justice, equity and inclusion in the APC.

He maintained that the PDP had learnt from its past mistakes and would bounce back even stronger.

“When we left the PDP to join the then nascent coalition of All Progressives Congress (APC) in 2014, we left in a quest for justice, equity and inclusion; the fundamental principles on which the PDP was originally built but which it had deviated from. We were attracted to the APC by its promise of change. We fought hard along with others and defeated the PDP. “In retrospect, it is now evident that the PDP has learnt more from its defeat than the APC has learnt from its victory. The PDP that we return to is now a party that has learnt its lessons the hard way and have realized that no member of the party should be taken for granted; a party that has realized that inclusion, justice and equity are basic precondition for peace; a party that has realized that never again can the people of Nigeria be taken for granted. “I am excited by the new efforts, which seeks to build the reborn PDP on the core principles of promoting democratic values; internal democracy; accountability; inclusion and national competitiveness; genuine commitment to restructuring and devolution of powers; and an abiding belief in zoning of political and elective offices as an inevitable strategy for managing our rich diversity as a people of one great indivisible nation called Nigeria. “What we have all agreed is that a deep commitment to these ideals were not only a demonstration of our patriotism but also a matter of enlightened self-interest, believing that our very survival as political elites of this country will depend on our ability to earn the trust of our people and in making them believe that, more than anything else, we are committed to serving the people. “What the experience of the last three years have taught us is that the most important task that we face as a country is how to reunite our people. Never before had so many people in so many parts of our country felt so alienated from their Nigerianness. Therefore, we understand that the greatest task before us is to reunite the county and give everyone a sense of belonging regardless of region or religion,” the Senate President added.

Saraki urged the APC to “respect his choice and understand that even though we will now occupy a different political space, we do not necessarily become enemies unto one another.”

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